Research Topics
Genomes and Genes | Cecilia B MoensSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
Research Grants
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Publications
Hox cofactors in vertebrate developmentCecilia B Moens
Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
Dev Biol 291:193-206. 2006....
Pbx homeodomain proteins pattern both the zebrafish retina and tectumCurtis R French
Department of Biological Sciences, University of Alberta, Edmonton, Canada
BMC Dev Biol 7:85. 2007..Although previous results have demonstrated that Pbx is required for proper eye size, functions in regulating retinal cell identity and patterning have not yet been examined...
Reverse genetics in zebrafish by TILLINGCecilia B Moens
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, USA
Brief Funct Genomic Proteomic 7:454-9. 2008..This review summarizes current TILLING methodologies as they have been applied to the zebrafish, ongoing TILLING projects and resources in the zebrafish community, and the future of zebrafish TILLING...- Constructing the hindbrain: insights from the zebrafishCecilia B Moens
HHMI, Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue North, Seattle, WEA 98109, USA
Dev Dyn 224:1-17. 2002..As we will discuss, work in the zebrafish has elucidated inductive events that specify the presumptive hindbrain domain and has identified genes required for hindbrain segmentation and the specification of segment identities... - Semaphorin signaling guides cranial neural crest cell migration in zebrafishHung Hsiang Yu
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Biol 280:373-85. 2005.... - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain developmentRafael E Hernandez
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Development 134:177-87. 2007..We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes... - vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafishRafael E Hernandez
Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
Development 131:4511-20. 2004..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately... - Pbx acts with Hand2 in early myocardial differentiationLisa Maves
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Biol 333:409-18. 2009..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs... - EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keelHilary A Kemp
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, P O Box 19024, USA
Dev Biol 327:313-26. 2009..We propose a model in which Eph and Efn-dependent cell affinity within rhombomeres serve to maintain rhombomere organization during the potentially disruptive process of teleost neurulation... - Eliminating zebrafish pbx proteins reveals a hindbrain ground stateAndrew Jan Waskiewicz
Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Dev Cell 3:723-33. 2002.... - Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiationLisa Maves
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Development 134:3371-82. 2007..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity... - The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrainPaul K Grant
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Neural Dev 5:9. 2010..Here we examine the role of the PAR-aPKC complex in forming the basal structures that guide facial branchiomotor neurons on an appropriate migratory path... - EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafishJulie E Cooke
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, P O Box 19024, Seattle, Washington 98109, USA
Curr Biol 15:536-42. 2005.... - Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migrationGregory S Walsh
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Development 138:3033-42. 2011..These results define a role for Nhsl1b as a neuronal effector of PCP signaling and indicate that proper FBM neuron migration is directly controlled by PCP signaling between the epithelium and the migrating neurons... - Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron developmentKimberly L Cooper
Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Dev Biol 253:200-13. 2003..Thus, Pbx/Hox can function both cell-autonomously and non-cell-autonomously to direct different aspects of hindbrain motor neuron behavior... - Zebrafish foggy/spt 5 is required for migration of facial branchiomotor neurons but not for their survivalKimberly L Cooper
HHMI, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Dev Dyn 234:651-8. 2005..This work provides evidence that transcript elongation is not a global mechanism equivalently required by all loci and may actually be under more strict developmental regulation... - nanos1 is required to maintain oocyte production in adult zebrafishBruce W Draper
Howard Hughes Medical Institute and Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
Dev Biol 305:589-98. 2007..This progressive loss of fertility in homozygous females is not a phenotype that has been described previously in the zebrafish and underlines the value of a reverse genetics approach in this model system... - Modern mosaic analysis in the zebrafishAmanda Carmany-Rampey
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2-152, 1100 Fairview Ave, N. Seattle, WA 98115, USA
Methods 39:228-38. 2006..These attributes, when combined with the accessibility and optical clarity of the zebrafish embryo, facilitate the real time observation of individual cell behaviors and interactions within mosaic embryos... - A high-throughput method for identifying N-ethyl-N-nitrosourea (ENU)-induced point mutations in zebrafishBruce W Draper
Howard Hughes Medical Institute, Seattle, Washington 98109, USA
Methods Cell Biol 77:91-112. 2004 - Boundary formation in the hindbrain: Eph only it were simpleJulie E Cooke
Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Trends Neurosci 25:260-7. 2002..We discuss the contributions of two mechanisms -- cell sorting and plasticity -- to the formation of rhombomere boundaries... - The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle traffickingRuxandra Bachmann-Gagescu
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Hum Mol Genet 20:4041-55. 2011..Our data support a model where Cc2d2a, localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion... 
Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisionsMihaela Zigman
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Curr Biol 21:79-86. 2011....- Cloning and embryonic expression of zebrafish neuropilin genesHung Hsiang Yu
Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, B2 152, Seattle, WA 98109, USA
Gene Expr Patterns 4:371-8. 2004.... - CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290Nicholas T Gorden
Division of Genetics and Developmental Medicine, Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Hum Genet 83:559-71. 2008..These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies... - The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humansDavid M Tobin
Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
Cell 140:717-30. 2010..Our results suggest conserved roles for balanced eicosanoid production in vertebrate resistance to mycobacterial infection... - Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundariesTimothy Erickson
Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton AB, Canada T6G2E9
Dev Biol 301:504-17. 2007..Our data support a novel model of midbrain development in which Pbx and Engrailed proteins cooperatively pattern the mesencephalic region of the neural tube... - Neuropilin asymmetry mediates a left-right difference in habenular connectivityYung Shu Kuan
Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
Development 134:857-65. 2007..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side... - A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in ZebrafishSaskia Houwing
Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
Cell 129:69-82. 2007..Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification...
Research Grants
- GENETIC MECHANISMS OF HINDBRAIN SEGMENTATIONCecilia Moens; Fiscal Year: 2009..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
- Tilling the Zebrafish Genome: A Reverse Genetic ApproachCecilia Moens; Fiscal Year: 2005..abstract_text> ..
- GENETIC MECHANISMS OF HINDBRAIN SEGMENTATIONCecilia Moens; Fiscal Year: 2003....
- Tilling the Zebrafish Genome: A Reverse Genetic ApproachLilianna Solnica Krezel; Fiscal Year: 2010..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..