Cecilia B Moens

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Hox cofactors in vertebrate development
    Cecilia B Moens
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
    Dev Biol 291:193-206. 2006
  2. pmc Pbx homeodomain proteins pattern both the zebrafish retina and tectum
    Curtis R French
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    BMC Dev Biol 7:85. 2007
  3. ncbi request reprint Constructing the hindbrain: insights from the zebrafish
    Cecilia B Moens
    HHMI, Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue North, Seattle, WEA 98109, USA
    Dev Dyn 224:1-17. 2002
  4. pmc Reverse genetics in zebrafish by TILLING
    Cecilia B Moens
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Brief Funct Genomic Proteomic 7:454-9. 2008
  5. ncbi request reprint Semaphorin signaling guides cranial neural crest cell migration in zebrafish
    Hung Hsiang Yu
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 280:373-85. 2005
  6. pmc Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
    Rafael E Hernandez
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Development 134:177-87. 2007
  7. ncbi request reprint vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish
    Rafael E Hernandez
    Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Development 131:4511-20. 2004
  8. pmc Pbx acts with Hand2 in early myocardial differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 333:409-18. 2009
  9. pmc EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel
    Hilary A Kemp
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, P O Box 19024, USA
    Dev Biol 327:313-26. 2009
  10. ncbi request reprint Eliminating zebrafish pbx proteins reveals a hindbrain ground state
    Andrew Jan Waskiewicz
    Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 3:723-33. 2002

Research Grants

  1. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2009
  2. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Cecilia Moens; Fiscal Year: 2005
  3. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2003
  4. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Lilianna Solnica Krezel; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Hox cofactors in vertebrate development
    Cecilia B Moens
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
    Dev Biol 291:193-206. 2006
    ....
  2. pmc Pbx homeodomain proteins pattern both the zebrafish retina and tectum
    Curtis R French
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    BMC Dev Biol 7:85. 2007
    ..Although previous results have demonstrated that Pbx is required for proper eye size, functions in regulating retinal cell identity and patterning have not yet been examined...
  3. ncbi request reprint Constructing the hindbrain: insights from the zebrafish
    Cecilia B Moens
    HHMI, Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue North, Seattle, WEA 98109, USA
    Dev Dyn 224:1-17. 2002
    ..As we will discuss, work in the zebrafish has elucidated inductive events that specify the presumptive hindbrain domain and has identified genes required for hindbrain segmentation and the specification of segment identities...
  4. pmc Reverse genetics in zebrafish by TILLING
    Cecilia B Moens
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Brief Funct Genomic Proteomic 7:454-9. 2008
    ..This review summarizes current TILLING methodologies as they have been applied to the zebrafish, ongoing TILLING projects and resources in the zebrafish community, and the future of zebrafish TILLING...
  5. ncbi request reprint Semaphorin signaling guides cranial neural crest cell migration in zebrafish
    Hung Hsiang Yu
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 280:373-85. 2005
    ....
  6. pmc Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
    Rafael E Hernandez
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Development 134:177-87. 2007
    ..We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes...
  7. ncbi request reprint vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish
    Rafael E Hernandez
    Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Development 131:4511-20. 2004
    ..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately...
  8. pmc Pbx acts with Hand2 in early myocardial differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 333:409-18. 2009
    ..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs...
  9. pmc EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel
    Hilary A Kemp
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, P O Box 19024, USA
    Dev Biol 327:313-26. 2009
    ..We propose a model in which Eph and Efn-dependent cell affinity within rhombomeres serve to maintain rhombomere organization during the potentially disruptive process of teleost neurulation...
  10. ncbi request reprint Eliminating zebrafish pbx proteins reveals a hindbrain ground state
    Andrew Jan Waskiewicz
    Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 3:723-33. 2002
    ....
  11. ncbi request reprint Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
    ..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity...
  12. pmc The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain
    Paul K Grant
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Neural Dev 5:9. 2010
    ..Here we examine the role of the PAR-aPKC complex in forming the basal structures that guide facial branchiomotor neurons on an appropriate migratory path...
  13. ncbi request reprint EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish
    Julie E Cooke
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, P O Box 19024, Seattle, Washington 98109, USA
    Curr Biol 15:536-42. 2005
    ....
  14. pmc Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration
    Gregory S Walsh
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 138:3033-42. 2011
    ..These results define a role for Nhsl1b as a neuronal effector of PCP signaling and indicate that proper FBM neuron migration is directly controlled by PCP signaling between the epithelium and the migrating neurons...
  15. ncbi request reprint Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron development
    Kimberly L Cooper
    Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Dev Biol 253:200-13. 2003
    ..Thus, Pbx/Hox can function both cell-autonomously and non-cell-autonomously to direct different aspects of hindbrain motor neuron behavior...
  16. pmc Zebrafish foggy/spt 5 is required for migration of facial branchiomotor neurons but not for their survival
    Kimberly L Cooper
    HHMI, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Dyn 234:651-8. 2005
    ..This work provides evidence that transcript elongation is not a global mechanism equivalently required by all loci and may actually be under more strict developmental regulation...
  17. pmc nanos1 is required to maintain oocyte production in adult zebrafish
    Bruce W Draper
    Howard Hughes Medical Institute and Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Biol 305:589-98. 2007
    ..This progressive loss of fertility in homozygous females is not a phenotype that has been described previously in the zebrafish and underlines the value of a reverse genetics approach in this model system...
  18. ncbi request reprint Modern mosaic analysis in the zebrafish
    Amanda Carmany-Rampey
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave, N Seattle, WA 98115, USA
    Methods 39:228-38. 2006
    ..These attributes, when combined with the accessibility and optical clarity of the zebrafish embryo, facilitate the real time observation of individual cell behaviors and interactions within mosaic embryos...
  19. ncbi request reprint A high-throughput method for identifying N-ethyl-N-nitrosourea (ENU)-induced point mutations in zebrafish
    Bruce W Draper
    Howard Hughes Medical Institute, Seattle, Washington 98109, USA
    Methods Cell Biol 77:91-112. 2004
  20. ncbi request reprint Boundary formation in the hindbrain: Eph only it were simple
    Julie E Cooke
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Trends Neurosci 25:260-7. 2002
    ..We discuss the contributions of two mechanisms -- cell sorting and plasticity -- to the formation of rhombomere boundaries...
  21. pmc The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking
    Ruxandra Bachmann-Gagescu
    HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Hum Mol Genet 20:4041-55. 2011
    ..Our data support a model where Cc2d2a, localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion...
  22. doi request reprint Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions
    Mihaela Zigman
    Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 21:79-86. 2011
    ....
  23. pmc RNA-seq-based mapping and candidate identification of mutations from forward genetic screens
    Adam C Miller
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 23:679-86. 2013
    ..Overall, we show that RNA-seq is a fast, reliable, and cost-effective method to map and identify mutations that will greatly facilitate the power of forward genetics in vertebrate models...
  24. ncbi request reprint Cloning and embryonic expression of zebrafish neuropilin genes
    Hung Hsiang Yu
    Howard Hughes Medical Institute, Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, B2 152, Seattle, WA 98109, USA
    Gene Expr Patterns 4:371-8. 2004
    ....
  25. pmc CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290
    Nicholas T Gorden
    Division of Genetics and Developmental Medicine, Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 83:559-71. 2008
    ..These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies...
  26. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
    ..Our results suggest conserved roles for balanced eicosanoid production in vertebrate resistance to mycobacterial infection...
  27. pmc Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries
    Timothy Erickson
    Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton AB, Canada T6G2E9
    Dev Biol 301:504-17. 2007
    ..Our data support a novel model of midbrain development in which Pbx and Engrailed proteins cooperatively pattern the mesencephalic region of the neural tube...
  28. ncbi request reprint Neuropilin asymmetry mediates a left-right difference in habenular connectivity
    Yung Shu Kuan
    Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 134:857-65. 2007
    ..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side...
  29. ncbi request reprint A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish
    Saskia Houwing
    Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
    Cell 129:69-82. 2007
    ..Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification...

Research Grants15

  1. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2009
    ..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
  2. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Cecilia Moens; Fiscal Year: 2005
    ..abstract_text> ..
  3. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2003
    ....
  4. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Lilianna Solnica Krezel; Fiscal Year: 2010
    ..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..