ARTHUR D MILLER

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients
    Ramon Mendoza
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e36073. 2012
  2. pmc Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
    Michael J Metzger
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nucleic Acids Res 39:926-35. 2011
  3. pmc Capsid-expressing DNA in AAV vectors and its elimination by use of an oversize capsid gene for vector production
    C L Halbert
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gene Ther 18:411-7. 2011
  4. pmc Phosphatidylserine treatment relieves the block to retrovirus infection of cells expressing glycosylated virus receptors
    David A Coil
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Retrovirology 2:49. 2005
  5. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
  6. pmc Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses
    Neal S Van Hoeven
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Retrovirology 2:76. 2005
  7. pmc Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV
    Sarah K Wootton
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Retrovirology 3:94. 2006
  8. pmc Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus
    Fuh Mei Duh
    SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
    Retrovirology 2:59. 2005
  9. pmc APOBEC3-mediated hypermutation of retroviral vectors produced from some retrovirus packaging cell lines
    A D Miller
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gene Ther 18:528-30. 2011
  10. pmc Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2
    A Dusty Miller
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    BMC Cancer 4:64. 2004

Collaborators

Detail Information

Publications44

  1. pmc No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients
    Ramon Mendoza
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e36073. 2012
    ..Here we have sought biological evidence that might confirm the presence of XMRV in prostate cancer samples previously having tested positive...
  2. pmc Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
    Michael J Metzger
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nucleic Acids Res 39:926-35. 2011
    ....
  3. pmc Capsid-expressing DNA in AAV vectors and its elimination by use of an oversize capsid gene for vector production
    C L Halbert
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gene Ther 18:411-7. 2011
    ..Elimination of transfer of capsid-expressing DNA may reduce immune responses to AAV vector-transduced cells and promote long-term expression of therapeutic proteins...
  4. pmc Phosphatidylserine treatment relieves the block to retrovirus infection of cells expressing glycosylated virus receptors
    David A Coil
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Retrovirology 2:49. 2005
    ..The latter block to retrovirus infection can be overcome by treatment of cells with compounds such as tunicamycin, which prevent the addition of N-linked oligosaccharides...
  5. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
    ..In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type...
  6. pmc Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses
    Neal S Van Hoeven
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Retrovirology 2:76. 2005
    ..NRI also occurs between xenotropic and polytropic MLV. The common receptor, Xpr1, has been identified, but a specific receptor has yet to be described...
  7. pmc Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV
    Sarah K Wootton
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Retrovirology 3:94. 2006
    ....
  8. pmc Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus
    Fuh Mei Duh
    SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
    Retrovirology 2:59. 2005
    ..Here we have explored the amino acid determinants that account for the difference in receptor function...
  9. pmc APOBEC3-mediated hypermutation of retroviral vectors produced from some retrovirus packaging cell lines
    A D Miller
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gene Ther 18:528-30. 2011
    ..We expect that avoidance of vector hypermutation will be particularly important for vectors used in gene therapy, wherein mutant proteins might stimulate deleterious immune responses...
  10. pmc Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2
    A Dusty Miller
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    BMC Cancer 4:64. 2004
    ..When Env was expressed it bound to Hyal2 causing its degradation, release of RON activity from Hyal2 suppression, and activation of pathways resulting in cell transformation...
  11. ncbi Identification of Hyal2 as the cell-surface receptor for jaagsiekte sheep retrovirus and ovine nasal adenocarcinoma virus
    A D Miller
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Top Microbiol Immunol 275:179-99. 2003
    ..However, its role in JSRV or ONAV tumorigenesis, if any, is still unclear. JSRV vectors are capable of transducing various human cells, and are being further evaluated for gene therapy purposes...
  12. pmc Identification of the myelin protein plasmolipin as the cell entry receptor for Mus caroli endogenous retrovirus
    A Dusty Miller
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 82:6862-8. 2008
    ..Interestingly, mouse PLLP also functioned well as a receptor for McERV but was simply not expressed in the mouse cell types that we originally tested...
  13. pmc Hyaluronidase 2 and its intriguing role as a cell-entry receptor for oncogenic sheep retroviruses
    A Dusty Miller
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Semin Cancer Biol 18:296-301. 2008
    ....
  14. pmc Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity
    Andrew E Vaughan
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Virol 86:1661-9. 2012
    ..Although it now seems clear that the detection of XMRV in humans was the result of sample contamination with a recombinant mouse virus, our findings may have relevance to neurologic disease induced by MCF retroviruses in mice...
  15. doi Lung cancer in mice induced by the jaagsiekte sheep retrovirus envelope protein is not maintained by rare cancer stem cells, but tumorigenicity does correlate with Wnt pathway activation
    Andrew E Vaughan
    Human Biology and Basic Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cancer Res 10:86-95. 2012
    ..Limiting dilution transplant analysis suggests the existence of a large fraction of cells with the ability to propagate tumor growth, with increasing tumor initiation potential correlating with activated Wnt signaling...
  16. ncbi PA 317 retrovirus packaging cells
    A Dusty Miller
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Mol Ther 6:572-5. 2002
  17. pmc Murine retroviruses use at least six different receptors for entry into Mus dunni cells
    A D Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 71:4531-5. 1997
    ..In summary, our results show that murine retroviruses use at least six different receptors for entry into M. dunni cells...
  18. pmc The RD114/simian type D retrovirus receptor is a neutral amino acid transporter
    J E Rasko
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 96:2129-34. 1999
    ....
  19. ncbi Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons
    H P Kiem
    Clinical Research and Molecular Medicine Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 90:4638-45. 1997
    ....
  20. pmc A family of retroviruses that utilize related phosphate transporters for cell entry
    D G Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 68:8270-6. 1994
    ....
  21. pmc Retrovirus vectors bearing jaagsiekte sheep retrovirus Env transduce human cells by using a new receptor localized to chromosome 3p21.3
    S K Rai
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 74:4698-704. 2000
    ....
  22. pmc Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors
    C L Halbert
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, Seattle, WA 98109, USA
    J Virol 75:6615-24. 2001
    ..These results, combined with our previous results showing lower immunogenicity of AAV6 than of AAV2 vectors, indicate that AAV6 vectors may provide significant advantages over AAV2 for gene therapy of lung diseases like cystic fibrosis...
  23. pmc Sequence analysis of Mus dunni endogenous virus reveals a hybrid VL30/gibbon ape leukemia virus-like structure and a distinct envelope
    G Wolgamot
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 72:7459-66. 1998
    ..The receptor specificity domains of the envelope are unique among retroviruses and show no apparent similarity to regions of known proteins...
  24. ncbi Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor
    H P Kiem
    Clinical Research and Molecular Medicine Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 92:1878-86. 1998
    ..The levels of gene transfer obtained with these conditions suggest the potential for therapeutic efficacy in diseases affecting the hematopoietic system...
  25. pmc A novel murine retrovirus identified during testing for helper virus in human gene transfer trials
    A D Miller
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98109, USA
    J Virol 70:1804-9. 1996
    ..MDEV does not belong to any of the known murine leukemia virus groups by interference analysis, and we have called the new group multitropic because of the wide range of cells from different species that MDEV can infect...
  26. ncbi Perfluorochemical liquid enhances adeno-associated virus-mediated transgene expression in lungs
    D J Weiss
    Division of Pulmonary and Critical Care Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 2:624-30. 2000
    ..These results demonstrate that use of the PFC liquid FC-75 improves overall and in situ AAV-mediated gene expression in rodent lungs...
  27. ncbi Envelope fusion protein binding studies in an inducible model of retrovirus receptor expression and in CD34(+) cells emphasize limited transduction at low receptor levels
    P Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Gene Ther 8:593-9. 2001
    ....
  28. pmc Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins
    J Overbaugh
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109 1024, USA
    Microbiol Mol Biol Rev 65:371-89, table of contents. 2001
    ..In this review, we will focus on the various strategies used by mammalian retroviruses to gain entry into the cell. The choice of receptors will also be discussed in light of pressures that drive viral evolution and persistence...
  29. pmc Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD
    H Weintraub
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Proc Natl Acad Sci U S A 86:5434-8. 1989
    ....
  30. pmc Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus
    D G Miller
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Proc Natl Acad Sci U S A 91:78-82. 1994
    ..Identification of this family of receptors will help define the evolutionary relationship between retroviruses and their cellular receptors...
  31. ncbi Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    J V Garcia
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Nature 350:508-11. 1991
    ..Also, nef can downregulate a CD4 triple mutant (Ser----Ala) that is neither phosphorylated nor down-regulated by phorbol esters, indicating that nef is acting by a different mechanism...
  32. ncbi Production of retroviral vectors
    A D Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Curr Protoc Hum Genet . 2001
    ..Vectors that contain sequence for alkaline phosphatase can be assayed histochemically.In this unit, the basic protocol generates stable cell lines, which produce retroviral vectors that carry selectable markers...
  33. pmc Many nonmammalian cells exhibit postentry blocks to transduction by gammaretroviruses pseudotyped with various viral envelopes, including vesicular stomatitis virus G glycoprotein
    C Dirks
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109-1024, USA
    J Virol 75:6375-83. 2001
    ....
  34. pmc A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction
    J L Battini
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 96:1385-90. 1999
    ....
  35. ncbi Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus-pseudotype retroviral vector
    H P Kiem
    Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gene Ther 6:966-72. 1999
    ..Furthermore, these results demonstrate that the monoclonal antibody to canine CD34 used in this study is able to enrich for hematopoietic repopulating cells...
  36. pmc Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation
    S K Rai
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 98:4443-8. 2001
    ..The finding that JSRV env is oncogenic and the identification of HYAL2 as the JSRV receptor provide tools for further investigation of the mechanism of JSRV oncogenesis and its relationship to human bronchiolo-alveolar carcinoma...
  37. pmc Jaagsiekte sheep retrovirus Env protein stabilizes retrovirus vectors against inactivation by lung surfactant, centrifugation, and freeze-thaw cycling
    D A Coil
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 75:8864-7. 2001
    ..However, the JSRV vector was inactivated by standard disinfectants, indicating that JSRV vectors pose no unusual safety risk related to their improved stability under other conditions...
  38. pmc Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8
    J V Garcia
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 65:6316-9. 1991
    ..Here we report that by using human-Chinese hamster somatic cell hybrids and a retroviral vector, we have mapped the receptor for the amphotropic murine leukemia virus to the pericentromeric region of human chromosome 8...
  39. pmc Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
    A D Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 65:2220-4. 1991
    ..These simian virus-based packaging cells extend the host range of currently available murine and avian packaging cells and should be useful for efficient gene transfer into higher mammals...
  40. pmc Inhibitors of retrovirus infection are secreted by several hamster cell lines and are also present in hamster sera
    D G Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 2092
    J Virol 67:5346-52. 1993
    ..Inhibitory factors are also present in the sera of Chinese and Syrian hamsters but were not detected in bovine serum. These results suggest the presence of specific factors that function to inhibit retrovirus infection in hamsters...
  41. pmc The left half of the XMRV retrovirus is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells
    Ramon Mendoza
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 85:9247-8. 2011
    ..These results show that XMRV has clear ancestors in mice and highlight another possible source of contamination in PCR assays for XMRV...
  42. ncbi Downregulation of cell surface CD4 by nef
    J V Garcia
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Res Virol 143:52-5. 1992
  43. ncbi L-histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential
    M A Stockschlaeder
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Hum Gene Ther 2:33-9. 1991
    ..Our results suggest that hisD will be a useful selectable marker for use in studies of keratinocyte differentiation and for transfer of genes into keratinocytes for the purposes of gene therapy...
  44. pmc The prostate cancer-associated human retrovirus XMRV lacks direct transforming activity but can induce low rates of transformation in cultured cells
    Michael J Metzger
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 84:1874-80. 2010
    ....