ANNE M MCTIERNAN

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial
    Kristin L Campbell
    University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Oncol 30:2314-26. 2012
  2. pmc DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis
    Anne Dee
    Department of Preventive Medicine, Room 418D 2001 Soto Street, MC9239, Los Angeles, CA 90089, USA
    BMC Cancer 12:343. 2012
  3. pmc Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
    Ying Huang
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Genome Med 3:42. 2011
  4. pmc Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report
    Huiyan Ma
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    BMC Complement Altern Med 11:109. 2011
  5. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
  6. pmc Weight, physical activity, diet, and prognosis in breast and gynecologic cancers
    Anne McTiernan
    Fred Hutchinson Cancer Center, 1100 Fairview Ave North, M4 B874, Seattle, WA, 98109, USA
    J Clin Oncol 28:4074-80. 2010
  7. ncbi request reprint Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
  8. ncbi request reprint Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1588-97. 2006
  9. ncbi request reprint Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trial
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA
    J Natl Cancer Inst 97:1366-76. 2005
  10. ncbi request reprint No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1020-1. 2005

Research Grants

Detail Information

Publications75

  1. pmc Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial
    Kristin L Campbell
    University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Oncol 30:2314-26. 2012
    ..We evaluated the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women...
  2. pmc DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis
    Anne Dee
    Department of Preventive Medicine, Room 418D 2001 Soto Street, MC9239, Los Angeles, CA 90089, USA
    BMC Cancer 12:343. 2012
    ..This study examines the association between percent body fat and SAA and CRP and the potential interaction with NSAID use and weight change...
  3. pmc Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
    Ying Huang
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Genome Med 3:42. 2011
    ..Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest...
  4. pmc Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report
    Huiyan Ma
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    BMC Complement Altern Med 11:109. 2011
    ..It remains unclear whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes...
  5. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
    ..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...
  6. pmc Weight, physical activity, diet, and prognosis in breast and gynecologic cancers
    Anne McTiernan
    Fred Hutchinson Cancer Center, 1100 Fairview Ave North, M4 B874, Seattle, WA, 98109, USA
    J Clin Oncol 28:4074-80. 2010
    ..The effects of dietary weight loss and increase in physical activity on survival or recurrence in breast and gynecologic cancers are not yet established, and randomized controlled trials are needed for definitive data...
  7. ncbi request reprint Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
    ..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones...
  8. ncbi request reprint Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1588-97. 2006
    ..A hypothesized mechanism for exercise-induced colon cancer risk reduction might be through alterations in colon crypt cell architecture and proliferation...
  9. ncbi request reprint Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trial
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA
    J Natl Cancer Inst 97:1366-76. 2005
    ..Increased mammographic density reduces the sensitivity of screening mammography, is associated with increased breast cancer risk, and may be hormone related. We assessed the effect of estrogen-plus-progestin therapy on mammographic density...
  10. ncbi request reprint No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1020-1. 2005
  11. ncbi request reprint Exercise effect on weight and body fat in men and women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Obesity (Silver Spring) 15:1496-512. 2007
    ..The effect of national exercise recommendations on adiposity is unknown and may differ by sex. We examined long-term effects of aerobic exercise on adiposity in women and men...
  12. doi request reprint Mechanisms linking physical activity with cancer
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:205-11. 2008
    ..Randomized clinical trials have shown that physical activity interventions can change biomarkers of cancer risk. Observational studies can also provide useful information on mechanisms that might link physical activity to cancer...
  13. doi request reprint Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  14. doi request reprint Breast cancer prevention in countries with diverse resources
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 113:2325-30. 2008
    ..Most women can benefit from advice and preventive care for reducing their risk for breast cancer...
  15. pmc No effect of aspirin on mammographic density in a randomized controlled clinical trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1524-30. 2009
    ....
  16. pmc Conjugated equine estrogen influence on mammographic density in postmenopausal women in a substudy of the women's health initiative randomized trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, M4 B874, PO Box 19024, Seattle, WA 98019, USA
    J Clin Oncol 27:6135-43. 2009
    ..We examined the effect of CEE alone on mammographic density in a subsample of the Women's Health Initiative (WHI) clinical trial participants...
  17. pmc Dietary weight loss and exercise interventions effects on quality of life in overweight/obese postmenopausal women: a randomized controlled trial
    Ikuyo Imayama
    Public Health Sciences Division, Fred Hutchison Cancer Research Center, Seattle, WA, USA
    Int J Behav Nutr Phys Act 8:118. 2011
    ..The secondary aim was to investigate predictors of changes in HRQOL...
  18. ncbi request reprint Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004
    ..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones...
  19. ncbi request reprint The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obes Res 12:972-81. 2004
    ..These genes metabolize estrogens and androgens, which are important in body fat regulation...
  20. ncbi request reprint Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    JAMA 290:1331-6. 2003
    ..Women who are physically active have a decreased risk for breast cancer, but the types, amounts, and timing of activity needed are unknown...
  21. ncbi request reprint Behavioral risk factors in breast cancer: can risk be modified?
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Oncologist 8:326-34. 2003
    ..Thus, adoption of lifestyle changes by individuals and populations may have a large impact on the future incidence of this disease...
  22. pmc Adiposity and sex hormones in postmenopausal breast cancer survivors
    Anne McTiernan
    Cancer Prevention Research Program, MP 900, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Clin Oncol 21:1961-6. 2003
    ..This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer...
  23. ncbi request reprint The Physical Activity for Total Health (PATH) Study: rationale and design
    A McTiernan
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Sci Sports Exerc 31:1307-12. 1999
    ..The Physical Activity for Total Health study is testing the effect of a 1-yr moderate intensity physical activity intervention on the endogenous sex hormone profile of postmenopausal women in a randomized controlled study...
  24. ncbi request reprint Intervention studies in exercise and cancer prevention
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Med Sci Sports Exerc 35:1841-5. 2003
    ..The aim of this article is to examine the role of exercise randomized clinical trials and other intervention studies in defining the associations between physical activity and cancer prevention...
  25. ncbi request reprint Physical activity after cancer: physiologic outcomes
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Invest 22:68-81. 2004
    ..The long-term benefits and risks of physical activity in cancer patients and survivors are unknown. Nevertheless, increasing physical activity is probably beneficial and safe in the majority of cancer survivors...
  26. ncbi request reprint Physical activity, exercise, and cancer: prevention to treatment--symposium overview
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Med Sci Sports Exerc 35:1821-2. 2003
  27. ncbi request reprint Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  28. ncbi request reprint Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:1296-301. 2004
    ....
  29. ncbi request reprint Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes
    Cara L Frankenfeld
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, PO Box 19024, Seattle, WA 98109 1024, USA
    Maturitas 53:315-24. 2006
    ..The aim of this study was to evaluate bone mineral density (BMD) in relation to presence of these urinary metabolites...
  30. pmc Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women
    Laura E Hooper
    Department of Epidemiology, University of Washington, USA
    Nutr Res 30:163-70. 2010
    ..01). No independent associations between the concentrations of leptin or estrogens and weight cycling were observed. This study suggests that frequent intentional weight loss may affect hormones involved in energy regulation...
  31. ncbi request reprint Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
    ....
  32. ncbi request reprint Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  33. ncbi request reprint Associations between reproductive and menstrual factors and postmenopausal androgen concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Womens Health (Larchmt) 14:704-12. 2005
    ....
  34. pmc Measurement matters in the association between early adolescent depressive symptoms and body mass index
    Isaac C Rhew
    Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
    Gen Hosp Psychiatry 30:458-66. 2008
    ....
  35. ncbi request reprint Effects of an exercise intervention on other health behaviors in overweight/obese post-menopausal women
    Isaac Rhew
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA, 98109 1024, United States
    Contemp Clin Trials 28:472-81. 2007
    ..If other behaviors do change with increasing physical activity, this would complicate interpretation of differences in study outcomes in exercise intervention trials...
  36. ncbi request reprint Vigorous leisure activity through women's adult life: the Women's Health Initiative Observational Cohort Study
    Kelly R Evenson
    Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Am J Epidemiol 156:945-53. 2002
    ..The perimenopausal period may be a critical juncture at which targeted and tailored interventions may help to achieve maintenance of physical activity into the postmenopausal period...
  37. ncbi request reprint Predictors of diet quality among overweight and obese postmenopausal women
    Alanna Boynton
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 108:125-30. 2008
    ..In addition, these results suggest that the timing of smoking cessation is a possible teachable moment for food and nutrition professionals...
  38. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  39. ncbi request reprint Specimen allocation in longitudinal biomarker studies: controlling subject-specific effects by design
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:1257-60. 2004
    ..These results suggest that bias can be artificially introduced into intervention effect estimates of longitudinal studies if samples from a subject are not assayed in the same batch...
  40. ncbi request reprint Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  41. ncbi request reprint Mailing strategies and recruitment into an intervention trial of the exercise effect on breast cancer biomarkers
    Shelley S Tworoger
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:73-7. 2002
    ..Our study indicates that bulk mail may be more cost-effective than first-class mail for recruitment into intervention trials and that older women are willing to participate in such studies...
  42. doi request reprint Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women
    Julie A Meyers
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    J Endocrinol 199:51-60. 2008
    ..Our study does not support a link between leptin and other immune parameters among overweight or obese, but otherwise healthy postmenopausal women, perhaps because such effects are only present at low or deficient leptin concentrations...
  43. ncbi request reprint Serum steroid hormones, sex hormone-binding globulin concentrations, and urinary hydroxylated estrogen metabolites in post-menopausal women in relation to daidzein-metabolizing phenotypes
    Cara L Frankenfeld
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave N, PO Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    J Steroid Biochem Mol Biol 88:399-408. 2004
    ..These results suggest that interindividual variability in intestinal bacteria may be related to differences in products of hormone metabolism in post-menopausal women...
  44. ncbi request reprint Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:2923-8. 2004
    ..The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens...
  45. pmc Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women
    Andrea Z LaCroix
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Am Geriatr Soc 56:1434-41. 2008
    ..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
  46. pmc Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors
    Brandon L Pierce
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 114:155-67. 2009
    ..Inflammatory status may be an important prognostic factor for breast cancer. Correlates of markers of inflammation in breast cancer survivors have not been thoroughly evaluated...
  47. pmc Higher habitual intake of dietary fat and carbohydrates are associated with lower leptin and higher ghrelin concentrations in overweight and obese postmenopausal women with elevated insulin levels
    Angela Kong
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109, USA
    Nutr Res 29:768-76. 2009
    ....
  48. pmc Serum vitamin D and breast density in breast cancer survivors
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:412-7. 2010
    ..Little is known about vitamin D status, assessed by serum 25-hydroxyvitamin D [25(OH)D], and its relationship to breast density in breast cancer survivors...
  49. ncbi request reprint Effects of risk counseling on interest in breast cancer genetic testing for lower risk women
    Deborah J Bowen
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Med 4:359-65. 2002
    ..A randomized trial was conducted to test the effects of two counseling methods (genetic counseling and group counseling) against a control no-intervention condition on interest in genetic testing in lower risk women...
  50. doi request reprint Dietary fat, tamoxifen use and circulating sex hormones in postmenopausal breast cancer survivors
    Marian L Neuhouser
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nutr Cancer 62:164-74. 2010
    ..Among women not using tamoxifen, fat intake was not associated with hormone concentrations. Further work is needed to confirm the findings and to understand the clinical implications of these observations...
  51. pmc Possible socioeconomic and ethnic disparities in quality of life in a cohort of breast cancer survivors
    Deborah J Bowen
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109, USA
    Breast Cancer Res Treat 106:85-95. 2007
    ..This paper describes the ethnic and socioeconomic correlates of functioning in a cohort of long-term nonrecurring breast cancer survivors...
  52. pmc Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 103:470-7. 2011
    ..Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers...
  53. pmc Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer
    Amanda I Phipps
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:454-63. 2011
    ..Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk...
  54. pmc Dietary fiber, carbohydrates, glycemic index, and glycemic load in relation to breast cancer prognosis in the HEAL cohort
    Fabiën N Belle
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:890-9. 2011
    ..Dietary intake of fiber, carbohydrate, glycemic index (GI), and glycemic load (GL) may influence breast cancer survival, but consistent and convincing evidence is lacking...
  55. pmc Associations of insulin resistance and adiponectin with mortality in women with breast cancer
    Catherine Duggan
    Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MD B306, Seattle, WA 98104, USA
    J Clin Oncol 29:32-9. 2011
    ..Here, we evaluate whether low levels of adiponectin and a greater level of insulin resistance are associated with breast cancer mortality and all-cause mortality...
  56. pmc Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, area
    Lori A Williams
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 117:373-8. 2009
    ..Traffic-related air pollution has been associated with adverse health outcomes, and the immune system may be a biologic mediator of health effects...
  57. ncbi request reprint Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects
    Erin D Shade
    University of Washington Medical Center, University of Washington, Seattle, WA, USA
    J Am Diet Assoc 104:903-12. 2004
    ..The question of whether this pattern has negative health effects is unresolved. The objective of this research was to investigate associations between weight-loss history and current measures of immune function...
  58. ncbi request reprint Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women
    Erin J Aiello
    Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:1411-7. 2005
    ..Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF), and lipids with mammographic density in 88 overweight, postmenopausal women not taking hormone therapy...
  59. ncbi request reprint Human plasma ghrelin levels increase during a one-year exercise program
    Karen E Foster-Schubert
    Department of Medicine, Division of Metabolism, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 90:820-5. 2005
    ..In summary, ghrelin levels increase with weight loss achieved without reduced food intake, consistent with a role for ghrelin in the adaptive response constraining weight loss and, thus, in long-term body weight regulation...
  60. ncbi request reprint Moderate-intensity exercise reduces the incidence of colds among postmenopausal women
    Jessica Chubak
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Wash 98109 1024, USA
    Am J Med 119:937-42. 2006
    ..Our aim was to assess the effect of a moderate-intensity, year-long exercise program on the risk of colds and other upper respiratory tract infections in postmenopausal women...
  61. ncbi request reprint Exercise and biomarkers for cancer prevention studies
    Kristin L Campbell
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA 98109, USA
    J Nutr 137:161S-169S. 2007
    ..Thus, adoption of lifestyle changes by individuals and populations may have a large impact on the future incidence of cancer...
  62. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  63. ncbi request reprint NSAID use and breast cancer risk in the VITAL cohort
    Ann Ready
    Bastyr University, Fred Hutchinson Cancer Research Center, M 4, 19024, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 109:533-43. 2008
    ..We prospectively evaluated the association between average 10-year use of NSAIDs and invasive breast cancer...
  64. ncbi request reprint Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007
    ..There were no associations of leptin receptor genotypes or haplotypes and adenoma risk. The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas...
  65. ncbi request reprint Effect of a 12-month randomized clinical trial of exercise on serum prolactin concentrations in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 16:895-9. 2007
    ..Although the exercise intervention had little effect on prolactin concentrations overall, increasing physical fitness was associated with reduced prolactin concentrations among postmenopausal women...
  66. pmc Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational study
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:1407-15. 2008
    ....
  67. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  68. ncbi request reprint Optimism, perceived risk of breast cancer, and cancer worry among a community-based sample of women
    Bonnie A McGregor
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Health Psychol 23:339-44. 2004
    ..Multiple regression analyses revealed that perceived risk partially mediated the relationship between optimism and cancer worry...
  69. doi request reprint Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women
    Peter T Campbell
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109 1024, USA
    J Appl Physiol 104:1648-55. 2008
    ..This 12-mo randomized, controlled trial showed no effect of aerobic exercise on in vitro immune function, despite excellent retention, high adherence, and demonstrable efficacy of the exercise intervention...
  70. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
    ..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
  71. pmc Estrogen plus progestin therapy and breast cancer in recently postmenopausal women
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:1207-16. 2008
    ..64 (95% confidence interval: 1.00, 2.68) over a 5-year period of use and 2.19 (95% confidence interval: 1.56, 3.08) over a 10-year period of use...
  72. ncbi request reprint Breast cancer risk counseling improves women's functioning
    Deborah J Bowen
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
    Patient Educ Couns 53:79-86. 2004
    ..Cancer worry decreased in both counseling groups by one scale point (P < 0.05). These results indicate that counseling can relieve women's negative reactions to breast cancer risk...
  73. doi request reprint Intentional weight loss and risk of lymphohematopoietic cancers
    Anneclaire J De Roos
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 21:223-36. 2010
    ..We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies...
  74. pmc Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors
    Marian L Neuhouser
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 88:133-9. 2008
    ..Little is known about vitamin D status in breast cancer survivors. This issue is important because vitamin D influences pathways related to carcinogenesis...
  75. ncbi request reprint Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women
    Cara L Frankenfeld
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1156-62. 2004
    ....

Research Grants12

  1. Mechanisms of Energy Balance and Cancer Prevention
    Anne McTiernan; Fiscal Year: 2007
    ..Our investigators have a wealth of expertise in the components of the energy balance and cancer equation, and will provide important scientific leadership, training, and contributions to the overall TREC program. ..
  2. EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMEN
    Anne McTiernan; Fiscal Year: 2007
    ..Intervention adherence will be monitored via exercise and diet logs and weekly weighing. Potential adverse effects will be measured including injuries, overall bone density (DEXA), and Quality of Life. ..
  3. EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTS
    Anne McTiernan; Fiscal Year: 2004
    ..Results from this unique human experimental study will provide important information about mechanisms of exercise effects on colon carcinogenesis and about potential ..