K E Malone

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer
    Kerryn W Reding
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop M4 B874, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 123:491-8. 2010
  2. pmc Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study
    Alexa J Resler
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Cancer 13:219. 2013
  3. pmc Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status
    Huiyan Ma
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    BMC Cancer 13:225. 2013
  4. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
  5. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
  6. pmc Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
    Danielle M Friedrichsen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R629-35. 2004
  7. ncbi Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 66:8297-308. 2006
  8. pmc Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98006, USA
    J Clin Oncol 28:2404-10. 2010
  9. ncbi BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history
    K E Malone
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 279:922-9. 1998
  10. pmc Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer
    Kathleen E Malone
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:2560-71. 2011

Research Grants

  1. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
  2. Adiposity Related Biomarkers and Breast Tumor Size
    Kathleen Malone; Fiscal Year: 2002
  3. FACTORS AFFECTING SURVIVAL OF YOUNG CANCER PATIENTS
    Kathleen Malone; Fiscal Year: 2002
  4. Breast cancer prognostic factors/pathobiology
    Kathleen Malone; Fiscal Year: 2009

Detail Information

Publications92

  1. pmc Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer
    Kerryn W Reding
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop M4 B874, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 123:491-8. 2010
    ..However, given the higher absolute CBC risk in mutation carriers, the potentially greater impact of adjuvant therapy in reducing CBC risk among mutation carriers should be considered when developing treatment plans for these patients...
  2. pmc Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study
    Alexa J Resler
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Cancer 13:219. 2013
    ..Toll-like receptors (TLRs) and the transcription factor nuclear factor-κB (NFκB) are important in inflammation and cancer...
  3. pmc Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status
    Huiyan Ma
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    BMC Cancer 13:225. 2013
    ..Furthermore, it is not known whether additional consideration of p53 protein status influences black-white differences in mortality risk observed when considering subtypes defined by ER, PR and HER2 status...
  4. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
    ..A subset of these SNPs, selected upon their main effects on contralateral breast cancer risk was further evaluated for interaction with treatment modalities and estrogen receptor (ER) status...
  5. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
    ..The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest...
  6. pmc Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
    Danielle M Friedrichsen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R629-35. 2004
    ..However, the 1100delC mutation has only been investigated in a few population-based studies and none from North America...
  7. ncbi Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 66:8297-308. 2006
    ....
  8. pmc Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98006, USA
    J Clin Oncol 28:2404-10. 2010
    ..This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation...
  9. ncbi BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history
    K E Malone
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 279:922-9. 1998
    ..Thus, studies of women from the general population are needed to determine the BRCA1 mutation frequency in women perceived to be at high risk, and to develop profiles of those most likely to be carriers...
  10. pmc Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer
    Kathleen E Malone
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:2560-71. 2011
    ..Inherited predisposition may be associated with distinctive breast cancer phenotypes and/or mortality. Past studies have had inconsistent results and little is known about the contributions of screening and treatment...
  11. pmc Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk
    Kerryn W Reding
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98109, USA
    Am J Epidemiol 170:1241-9. 2009
    ..1, 2.2) but not in never users (P(heterogeneity) = 0.02). Interpretation of these subgroup associations must await the results of similar studies conducted in other populations...
  12. ncbi Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history
    S N Teraoka
    Molecular Genetics Program, Virginia Mason Research Center, 1201 Ninth Avenue, Seattle, WA 98101-2795, USA
    Cancer 92:479-87. 2001
    ..CONCLUSIONS: ATM mutations, specifically missense mutations, are more common in breast carcinoma cases selected for first-degree family history and early age at diagnosis...
  13. ncbi Tamoxifen therapy for primary breast cancer and risk of contralateral breast cancer
    C I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 93:1008-13. 2001
    ..Tamoxifen therapy reduces this risk, but it is unclear if this benefit exists for both estrogen receptor (ER)-positive and ER-negative contralateral tumors...
  14. pmc Gene expression array testing of FFPE archival breast tumor samples: an optimized protocol for WG-DASL sample preparation
    C C Ton
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Breast Cancer Res Treat 125:879-83. 2011
    ..These results indicate that a large fraction of decade-old FFPE samples, of diverse institutional origins and processing histories, can yield RNA suitable for gene expression profiling experiments...
  15. ncbi Ovarian cancer risk and polymorphisms involved in estrogen catabolism
    Sarah K Holt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:481-9. 2007
    ..No association of ovarian cancer risk was observed with any of the other polymorphisms examined, either alone or in combination...
  16. pmc Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk
    Kerryn W Reding
    University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1461-7. 2009
    ....
  17. pmc Migraine in postmenopausal women and the risk of invasive breast cancer
    Robert W Mathes
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3116-22. 2008
    ..Given the strong relationship between endogenous estrogen levels and breast cancer risk, migraine sufferers may experience a reduced risk of breast cancer...
  18. ncbi Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women
    Nicola M Suter
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:127-35. 2003
    ..In addition, these data suggest that AR repeat length may be partly responsible for the increased risk for early-onset breast cancer in women who use OCs, although these findings need replication in other populations...
  19. ncbi Case-control differences in the reliability of reporting a history of induced abortion
    M T Tang
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 151:1139-43. 2000
    ..9%, 95% confidence interval of the difference: -15, 14). The authors' data do not suggest that controls are more reluctant to report a history of induced abortion than are women with breast cancer...
  20. ncbi Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma
    J R Daling
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer 92:720-9. 2001
    ..Few studies have focused on premenopausal women or the correlation of body mass index (BMI) to tumor characteristics related to prognosis...
  21. ncbi Hair product use and the risk of breast cancer in young women
    L S Cook
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 10:551-9. 1999
    ..This case-control study evaluated how detailed aspects of hair coloring and hair spray application by reproductive-age women may affect breast cancer risk...
  22. pmc Risk factors for triple-negative breast cancer in women under the age of 45 years
    Jessica M Dolle
    Fred Hutchinson Cancer Research Center, M4 C308 Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:1157-66. 2009
    ....
  23. ncbi The relation of reproductive factors to mortality from breast cancer
    Janet R Daling
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:235-41. 2002
    ....
  24. pmc Psychometric properties of a tool for measuring hormone-related symptoms in breast cancer survivors
    Catherine M Alfano
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Psychooncology 15:985-1000. 2006
    ..Future clinical trials and quality of life and symptom management intervention studies would benefit from accurate assessment of hormone-related symptoms with the five scales from the shortened BCPT checklist...
  25. pmc Timing of menarche and first full-term birth in relation to breast cancer risk
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 167:230-9. 2008
    ..The authors conclude that the interval between age at menarche and age at first birth is associated with the risk of hormonally sensitive types of breast cancer, particularly among White women...
  26. ncbi Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer
    Christopher I Li
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:946-54. 2006
    ....
  27. ncbi Interactions between body mass index and hormone therapy and postmenopausal breast cancer risk (United States)
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Avenue North, M4 C308, 19024, Seattle, Washington 98109 1024, USA
    Cancer Causes Control 17:695-703. 2006
    ..To assess interactions between use of estrogen plus progestin hormone therapy (EPHT) and body mass index (BMI) in relation to risks of different types of breast cancer, based on histology and hormone receptor status...
  28. ncbi Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988-2001
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Epidemiology Program, Seattle, Washington, USA
    Cancer 106:2104-12. 2006
    ..Incidence rates of ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) have been rising, but little is known about which patients will develop invasive breast cancer or what types of tumors these patients may develop...
  29. doi Relationship between menopausal hormone therapy and risk of ductal, lobular, and ductal-lobular breast carcinomas
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:43-50. 2008
    ..Further studies focusing on the etiology of lobular carcinomas are needed...
  30. doi Relationship between histamine2-receptor antagonist medications and risk of invasive breast cancer
    Robert W Mathes
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:67-72. 2008
    ..The few previous studies evaluating this association have been null but have been limited by small sample sizes, and none have evaluated risk by either histologic type or estrogen receptor/progesterone receptor status...
  31. pmc Body size and risk of luminal, HER2-overexpressing, and triple-negative breast cancer in postmenopausal women
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2078-86. 2008
    ..Given the expanding obesity epidemic, the widespread cessation of hormone therapy use, and the poor prognosis of triple-negative tumors, this novel finding merits confirmation...
  32. pmc Reproductive history and risk of three breast cancer subtypes defined by three biomarkers
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Causes Control 22:399-405. 2011
    ..31-2.56). Neither parity nor age at first birth was associated with triple-negative breast cancer. In contrast to ER+ and ER-/PR-/HER2+ subtypes, reproductive history does not appear to be a risk factor for triple-negative breast cancer...
  33. pmc Family history of breast cancer in first-degree relatives and triple-negative breast cancer risk
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, PO Box 19024, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 126:671-8. 2011
    ..Having a first-degree family history of breast cancer was associated with an increased risk of triple-negative breast cancer with a magnitude of association similar to that for the predominant ER+ subtype and ER-/PR-/HER2+ breast cancer...
  34. pmc Relationship between diabetes and risk of second primary contralateral breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 125:545-51. 2011
    ..This is the first study to report this relationship, but if confirmed efforts to insure that diabetic breast cancer survivors are carefully screened for second breast cancers may be warranted...
  35. pmc Relationship between potentially modifiable lifestyle factors and risk of second primary contralateral breast cancer among women diagnosed with estrogen receptor-positive invasive breast cancer
    Christopher I Li
    Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Clin Oncol 27:5312-8. 2009
    ..We evaluated the relationships between obesity, alcohol consumption, and smoking on risk of second primary invasive contralateral breast cancer among breast cancer survivors...
  36. pmc Adjuvant hormonal therapy for breast cancer and risk of hormone receptor-specific subtypes of contralateral breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Res 69:6865-70. 2009
    ..This is of clinical concern given the poorer prognosis of ER- compared with ER+ tumors...
  37. pmc Relationship between migraine history and breast cancer risk among premenopausal and postmenopausal women
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:2030-4. 2009
    ..It extends the prior report in observing that this relationship holds for both premenopausal and postmenopausal women and is independent of exposure to common migraine triggers...
  38. pmc Reproductive factors, age at maximum height, and risk of three histologic types of breast cancer
    Elisabeth F Beaber
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3427-34. 2008
    ..5-0.9) but not lobular or ductal-lobular carcinoma. Further exploration of breast cancer risk by histology is merited to understand differences in the etiology of ductal, lobular, and ductal-lobular carcinoma...
  39. pmc Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 113:1521-6. 2008
    ..Reproductive factors may plausibly be differentially correlated with the risk of different breast cancer subtypes because these factors are presumed to impact exposure to endogenous sex hormones...
  40. ncbi Antidepressant use and breast cancer risk
    Chloe Chien
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 95:131-40. 2006
    ..However, human studies evaluating use of antidepressants in relation to breast cancer risk have yielded inconsistent results...
  41. ncbi The relationship between various measures of cigarette smoking and risk of breast cancer among older women 65-79 years of age (United States)
    Christopher I Li
    Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 16:975-85. 2005
    ..A further understanding of the timing of smoking, and its interaction with other factors, may enhance our knowledge of whether and by what mechanisms smoking alters breast cancer risk...
  42. ncbi Hormonal factors and breast tumor proliferation: do factors that affect cancer risk also affect tumor growth?
    Nina Oestreicher
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
    Breast Cancer Res Treat 85:133-42. 2004
    ..We examined the association between hormone-related breast cancer risk factors and breast tumor proliferation, as reflected in two proliferation measures, Ki-67 and mitotic count...
  43. ncbi Differences in breast cancer stage, treatment, and survival by race and ethnicity
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 381, PO Box 19024, Seattle, WA 98109 1024, USA
    Arch Intern Med 163:49-56. 2003
    ..However, Asians and Pacific Islanders and Hispanic whites are heterogeneous populations, and few studies have evaluated breast cancer stage, treatments, and mortality rates for subgroups of these populations...
  44. ncbi Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 289:3254-63. 2003
    ..Women using combined estrogen and progestin hormone replacement therapy (CHRT) have an increased risk of breast cancer; however, data on use for long durations and on risk associated with patterns of use are lacking...
  45. ncbi Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Clin Oncol 21:28-34. 2003
    ..This is because hormone receptor status may reflect different etiologic pathways and is useful in predicting response to adjuvant therapy and prognosis...
  46. ncbi Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinoma
    Janet R Daling
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 95:2455-64. 2002
    ..However, the use of combined (estrogen and progestin) hormone replacement therapy (CHRT) also has increased during the last decade and may account in part for the increase in invasive lobular breast carcinoma...
  47. ncbi Childbearing and survival after breast carcinoma in young women
    Beth A Mueller
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Cancer 98:1131-40. 2003
    ..The authors measured relative mortality among young patients with breast carcinoma with and without births occurring after diagnosis...
  48. ncbi Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65-79 years
    Christopher I Li
    Public Health Sciences Division, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 98:1504-13. 2003
    ....
  49. ncbi Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA
    Int J Cancer 107:647-51. 2003
    ....
  50. ncbi Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:601-7. 2002
    ..Understanding the factors underlying these differences may provide further insight into breast cancer etiology in different populations...
  51. ncbi A validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use among older women
    Denise M Boudreau
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Am J Epidemiol 159:308-17. 2004
    ..Trivial changes in estimates were observed when health maintenance organization records alone were used as the gold standard. Self-reported use of antihypertensives and statins appears to be relatively accurate among older women...
  52. ncbi The relationship between alcohol use and risk of breast cancer by histology and hormone receptor status among women 65-79 years of age
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:1061-6. 2003
    ..These results are consistent with there being an underlying hormonal basis for the known association between alcohol use and breast cancer incidence...
  53. ncbi Association of regimens of hormone replacement therapy to prognostic factors among women diagnosed with breast cancer aged 50-64 years
    Janet R Daling
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:1175-81. 2003
    ....
  54. ncbi Age-specific incidence rates of in situ breast carcinomas by histologic type, 1980 to 2001
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1008-11. 2005
    ..These trends present important public health and clinical challenges...
  55. ncbi Allergy and risk of breast cancer among young women (United States)
    Monique M Hedderson
    Fred Hutchinson Center Research Program, Division of Public Health Sciences, Seattle, WA, USA
    Cancer Causes Control 14:619-26. 2003
    ..To investigate the relationship between allergy and risk of breast cancer in women 45 years of age and younger...
  56. pmc Effect of prediagnostic alcohol consumption on survival after breast cancer in young women
    Kerryn W Reding
    Fred Hutchinson Cancer Research Center, M4 C308, Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1988-96. 2008
    ..Alcohol consumption has been comprehensively investigated as an etiologic risk factor for breast cancer but has received little attention in terms of its effect on prognosis after breast cancer, particularly for young women...
  57. ncbi The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study
    Denise M Boudreau
    Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101, USA
    Cancer 100:2308-16. 2004
    ..However, statins have been found to be carcinogenic in rodents and one clinical trial found an excess of breast carcinoma cases in the treatment group...
  58. pmc Epidemiologic and molecular risk factors for contralateral breast cancer among young women
    C I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Avenue North, MP 381, PO Box 19024, Seattle, WA 98109 1024, USA
    Br J Cancer 89:513-8. 2003
    ..Further observational studies are needed to confirm these findings and to evaluate whether testing for c-erbB-2 in this population may help identify those at high risk for CBC...
  59. pmc Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer
    L W M Loo
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Genes Chromosomes Cancer 47:1049-66. 2008
    ..LOH in chromosomal arms 8p and 5q was common in higher grade IDC tumors, whereas ILC and low-grade IDC grouped together by virtue of LOH in 16q...
  60. pmc Case-control study of fetal microchimerism and breast cancer
    Vijayakrishna K Gadi
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 3:e1706. 2008
    ..We asked whether presence of FMc, routinely acquired during pregnancy, is a protective factor for breast cancer...
  61. ncbi Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes
    Lenora W M Loo
    Division of Human Biology, Division of Public Health Sciences, and Genomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:8541-9. 2004
    ..These results indicate that array comparative genomic hybridization can identify significant differences in the genomic alterations between subtypes of breast cancer...
  62. pmc Psychometric evaluation of the Brief Cancer Impact Assessment among breast cancer survivors
    Catherine M Alfano
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Oncology 70:190-202. 2006
    ..This study evaluated the psychometric properties of the 16-item Brief Cancer Impact Assessment (BCIA)...
  63. ncbi The NICHD Women's Contraceptive and Reproductive Experiences Study: methods and operational results
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann Epidemiol 12:213-21. 2002
    ..This paper presents methods and operational results of a population-based case-control study examining the effects of oral contraceptive use on breast cancer risk among white and black women aged 35-64 years in five U.S. locations...
  64. ncbi Projecting individualized absolute invasive breast cancer risk in African American women
    Mitchell H Gail
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South Rm 8032, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 99:1782-92. 2007
    ..We developed a model for projecting absolute risk of invasive breast cancer in African American women and compared its projections with those from the Breast Cancer Risk Assessment Tool...
  65. ncbi Oral contraceptives and the risk of breast cancer
    Polly A Marchbanks
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 346:2025-32. 2002
    ..We conducted a population-based, case-control study to determine the risk of breast cancer among former and current users of oral contraceptives...
  66. ncbi Occupation and breast cancer in women 20-44 years of age (United States)
    Susan L Teitelbaum
    Division of Environmental Health Science, Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Causes Control 14:627-37. 2003
    ..To examine the relation between breast cancer risk and job history among women 20-44 years of age who participated in a multi-center, population-based, case-control study...
  67. ncbi Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences Study
    Ronald T Burkman
    National Cancer Institute Surveillance, Epidemiology, and End Results Registry, Department of Obstetrics and Gynecology, Henry Ford Health System, Detroit, Michigan, USA
    Fertil Steril 79:844-51. 2003
    ..To determine the association between infertility drug use and invasive breast cancer in a population-based case-control study...
  68. ncbi Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of age
    Julie A Britton
    Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Epidemiol 156:507-16. 2002
    ..These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER-PR- tumors among younger women...
  69. ncbi Hormone replacement therapy regimens and breast cancer risk(1)
    Linda K Weiss
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA
    Obstet Gynecol 100:1148-58. 2002
    ..Progestin administered in an uninterrupted regimen may be a contributing factor. Risk dissipates once use is discontinued...
  70. ncbi Breast cancer risk estimates for relatives of white and African American women with breast cancer in the Women's Contraceptive and Reproductive Experiences Study
    Michael S Simon
    Division of Hematology and Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI 48201, USA
    J Clin Oncol 24:2498-504. 2006
    ..The purpose of this report is to update breast cancer risk estimates associated with a family history of breast cancer for white and AA women...
  71. ncbi Breast cancers among very young premenopausal women (United States)
    Michelle D Althuis
    National Cancer Institute, Rockville, MD, USA
    Cancer Causes Control 14:151-60. 2003
    ..To assess risk factors for breast cancer among very young compared to older premenopausal women...
  72. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
  73. pmc Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis
    Catherine M Alfano
    Comprehensive Cancer Center and School of Public Health, The Ohio State University, Columbus, OH, USA
    J Cancer Surviv 1:116-28. 2007
    ..This prospective study investigated physical activity (PA), occurrence of physical symptoms, and HRQOL in a large, ethnically-diverse cohort of breast cancer survivors...
  74. ncbi Reproductive history and risk of second primary breast cancer: the WECARE study
    Joan A Largent
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:906-11. 2007
    ..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results...
  75. ncbi Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report
    Kathleen Meeske
    Department of Preventive Medicine, Keck School of Medicine of University of Southern California, USC Norris Comprehensive Cancer Center, 1444 Eastlake Avenue, Room 4449, Los Angeles, CA 90033, USA
    Qual Life Res 16:947-60. 2007
    ....
  76. ncbi Lifetime recreational exercise activity and breast cancer risk among black women and white women
    Leslie Bernstein
    Department of Preventive Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 97:1671-9. 2005
    ....
  77. ncbi Risk of breast cancer associated with short-term use of oral contraceptives
    Suzanne G Folger
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Cancer Causes Control 18:189-98. 2007
    ..To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history...
  78. ncbi Perinatal factors and mortality from breast cancer
    Maureen Sanderson
    Division of Epidemiology, University of Texas Houston School of Public Health at Brownsville, 80 Fort Brown, Brownsville, TX 78520, USA
    Cancer Epidemiol Biomarkers Prev 15:1984-7. 2006
    ..1) and twin membership (HR, 2.5; 95% CI, 1.0-6.2). The protective effect of being born second or higher in the birth order against breast cancer mortality regardless of maternal age is striking and needs to be confirmed in future studies...
  79. ncbi Benefit of screening mammography in reducing the rate of late-stage breast cancer diagnoses (United States)
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 17:921-9. 2006
    ..We studied the benefit of modern mammography screening in community settings, evaluating age-related differences in rates of late-stage breast cancer detection...
  80. ncbi Reproductive factors and risk of breast carcinoma in a study of white and African-American women
    Giske Ursin
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 101:353-62. 2004
    ....
  81. ncbi Alcohol exposure and breast cancer: results of the women's contraceptive and reproductive experiences study
    Jill A McDonald
    National Center for Chronic Disease Prevention and Health Promotion, Division of Reproductive Health, 4770 Buford Highway Northeast, MS K22, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 13:2106-16. 2004
    ..To explore associated biological outcomes and clarify the role of timing of exposure in the alcohol-breast cancer relationship...
  82. ncbi Protection of mammography screening against death from breast cancer in women aged 40-64 years
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 18:909-18. 2007
    ..This study assessed the efficacy of community-based screening mammography in protecting against breast cancer death, asking whether age differences in efficacy persisted in the 1990s...
  83. pmc Validity of models for predicting BRCA1 and BRCA2 mutations
    Giovanni Parmigiani
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
    Ann Intern Med 147:441-50. 2007
    ..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...
  84. doi Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Oncol 26:1411-8. 2008
    ..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...
  85. ncbi Combined effect of oral contraceptive use and hormone replacement therapy on breast cancer risk in postmenopausal women
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 14:933-43. 2003
    ..We examined breast cancer risk related to lifetime exposure to oral contraceptives (OCs) and hormone replacement therapy (HRT) in postmenopausal women...
  86. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
    ..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers...
  87. ncbi Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Natl Cancer Inst 100:32-40. 2008
    ..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...
  88. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
    ..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated...
  89. ncbi Absence of an effect of injectable and implantable progestin-only contraceptives on subsequent risk of breast cancer
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, 824 Blockley Hall, 423 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Contraception 69:353-60. 2004
    ..This study does not support an increased risk of breast cancer associated with the use of injectable or implantable progestin-only contraceptives in women aged 35 to 64...
  90. ncbi The association between oral contraceptive use and lobular and ductal breast cancer in young women
    Sarah J Nyante
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Int J Cancer 122:936-41. 2008
    ..These results are similar to previous studies that report little difference in the effect of oral contraceptive use on breast cancer by histology...
  91. ncbi Racial differences in the familial aggregation of breast cancer and other female cancers
    Michael S Simon
    Division of Haematology and Oncology, Barbara Ann Karmanos Cancer Institute, 4100 John R, 4221 Hudson, Weber Cancer Research Building, Detroit, M1 48201, USA
    Breast Cancer Res Treat 89:227-35. 2005
    ..17 (1.22-3.85). In conclusion, these racially distinct aggregation patterns may reflect different modes of inheritance and/or environmental factors that impact cancer risk...
  92. ncbi Validation of self-reported screening mammography histories among women with and without breast cancer
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia 19104 6021, USA
    Am J Epidemiol 158:264-71. 2003
    ..Therefore, odds ratios will likely be biased toward the null, underestimating screening efficacy...

Research Grants13

  1. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
    ..abstract_text> ..
  2. Adiposity Related Biomarkers and Breast Tumor Size
    Kathleen Malone; Fiscal Year: 2002
    ..Findings from this study could begin to clarify a mechanism by which adiposity affects prognosis from breast cancer. ..
  3. FACTORS AFFECTING SURVIVAL OF YOUNG CANCER PATIENTS
    Kathleen Malone; Fiscal Year: 2002
    ....
  4. Breast cancer prognostic factors/pathobiology
    Kathleen Malone; Fiscal Year: 2009
    ....