Research Topics
| Ira M LonginiSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Detail Information
Publications
Containing a large bioterrorist smallpox attack: a computer simulation approachIra M Longini
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
Int J Infect Dis 11:98-108. 2007..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries...
Controlling endemic cholera with oral vaccinesIra M Longini
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 4:e336. 2007..We used a large-scale stochastic simulation model to investigate the possibility of controlling endemic cholera with OCVs...- The transmissibility and control of pandemic influenza A (H1N1) virusYang Yang
Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
Science 326:729-33. 2009..If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic... - Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United StatesDennis L Chao
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Epidemiol 173:1121-30. 2011.... - Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United StatesNicole E Basta
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
Am J Epidemiol 170:679-86. 2009..Given the current worldwide threat of novel influenza A (H1N1), with an estimated R of 1.4-1.6, health officials should consider strategies for vaccinating children against novel influenza A (H1N1) as well as seasonal influenza... - Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnosticsLaith J Abu-Raddad
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 106:13980-5. 2009..Elimination will require new delivery strategies, such as mass vaccination campaigns, and new products targeted at latently infected people... - Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2Ramzi A Alsallaq
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Sex Transm Dis 37:290-7. 2010..The continuation of developing Herpes simplex virus type-2 (HSV-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines... - FluTE, a publicly available stochastic influenza epidemic simulation modelDennis L Chao
Center for Statistics and Quantitative Infectious Diseases Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Comput Biol 6:e1000656. 2010..Computer simulation models play an essential role in informing public policy and evaluating pandemic preparedness plans. We have made the source code of this model publicly available to encourage its use and further development... - Estimating influenza vaccine efficacy from challenge and community-based study dataNicole E Basta
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
Am J Epidemiol 168:1343-52. 2008..VE(I) estimates were particularly low for these influenza vaccines. VE(SP) and VE(C) can remain high for both vaccines, even when VE(I) is relatively low, as long as the other 2 measures of vaccine efficacy are relatively high... - Vaccination strategies for epidemic cholera in Haiti with implications for the developing worldDennis L Chao
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 108:7081-5. 2011..For epidemic cholera, we recommend a large mobile stockpile of enough vaccine to cover 30% of a country's population to be reactively targeted to populations at high risk of exposure... 
Critical immune and vaccination thresholds for determining multiple influenza epidemic wavesLaura Matrajt
Department of Medicine, University of Washington, Seattle, WA, USA
Epidemics 4:22-32. 2012..We also used this scheme to accurately predict the second wave of pandemic influenza in London and the West Midlands, UK during the fall of 2009...- The global transmission and control of influenzaEben Kenah
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 6:e19515. 2011..Our open-source, computationally simple model can help public health officials plan for the next pandemic as well as deal with interpandemic influenza... - The global spread of drug-resistant influenzaDennis L Chao
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J R Soc Interface 9:648-56. 2012.... - A Bayesian model for evaluating influenza antiviral efficacy in household studies with asymptomatic infectionsYang Yang
Program of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Biostatistics 10:390-403. 2009..We also found significant therapeutic efficacies in reducing pathogenicity and the risk of infection with disease but no therapeutic efficacy in reducing the risk of viral infection in the contacts... - The effect of age on transmission of 2009 pandemic influenza A (H1N1) in a camp and associated householdsJonathan D Sugimoto
Center for Statistics and Quantitative Infectious Disease, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Epidemiology 22:180-7. 2011..A major portion of influenza disease burden during the 2009 pandemic was observed among young people... - Quantitative assessment of the role of male circumcision in HIV epidemiology at the population levelRamzi A Alsallaq
Vaccine and Infectious Disease Institute, Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Epidemics 1:139-52. 2009.... - No HIV stage is dominant in driving the HIV epidemic in sub-Saharan AfricaLaith J Abu-Raddad
Statistical Center for HIV AIDS Research and Prevention SCHARP, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, LE 400, P O Box 19024, Seattle, WA 98109, USA
AIDS 22:1055-61. 2008..To estimate the role of each of the HIV progression stages in fueling HIV transmission in sub-Saharan Africa by using the recent measurements of HIV transmission probability per coital per HIV stage in the Rakai study... - Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, ThailandMichael G Hudgens
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
Am J Epidemiol 155:159-68. 2002..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype... - A theoretic framework to consider the effect of immunizing schoolchildren against influenza: implications for researchIra M Longini
Program of Biostatistics and Biomathematics, Fred HutchinsonCancer Center, Seattle, Washington, USA
Pediatrics 129:S63-7. 2012.... - Optimizing vaccine allocation at different points in time during an epidemicLaura Matrajt
Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e13767. 2010..To answer this question, we develop a deterministic epidemic model with two age-groups (children and adults) and further subdivide each age group in low and high risk... - School opening dates predict pandemic influenza A(H1N1) outbreaks in the United StatesDennis L Chao
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Infect Dis 202:877-80. 2010..School opening dates can be useful for future pandemic planning, and influenza mitigation strategies should be targeted at school populations before the influenza season... - Detecting human-to-human transmission of avian influenza A (H5N1)Yang Yang
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Emerg Infect Dis 13:1348-53. 2007..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains... - A hybrid EM and Monte Carlo EM algorithm and its application to analysis of transmission of infectious diseasesYang Yang
Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA
Biometrics 68:1238-49. 2012..We use the hybrid EM-MCEM algorithm to analyze two influenza epidemics in the late 1970s to assess the effects of age and preseason antibody levels on the transmissibility and pathogenicity of the viruses... - Controlling dengue with vaccines in ThailandDennis L Chao
Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Negl Trop Dis 6:e1876. 2012.... - Analytic insights into the population level impact of imperfect prophylactic HIV vaccinesLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North LE 400, Seattle, WA 98109, USA
J Acquir Immune Defic Syndr 45:454-67. 2007.... - Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004M Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Vaccine 25:4038-45. 2007..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza... - Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in AfricaLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 3:e2230. 2008..The potential impact of these interventions requires a quantitative assessment of the magnitude of the synergy between HIV and HSV-2 at the population level... - Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trialsM Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 165:212-21. 2007..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies... - Public health. Community studies for vaccinating schoolchildren against influenzaM Elizabeth Halloran
Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 311:615-6. 2006 - Critical factors influencing the occurrence of Vibrio cholerae in the environment of BangladeshAnwar Huq
Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
Appl Environ Microbiol 71:4645-54. 2005..g., plankton population blooms. The new information on the ecology of V. cholerae is proving useful in developing environmental models for the prediction of cholera epidemics... - Containing pandemic influenza at the sourceIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Science 309:1083-7. 2005..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4... - A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of BangladeshR Bradley Sack
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 187:96-101. 2003..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks... - Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challengesRoland R Regoes
Department of Biology, Emory University, Atlanta, Georgia, USA
PLoS Med 2:e249. 2005..The belief that experiments involving realistically low challenge doses require large numbers of animals has so far prevented the development of alternatives to using high challenge doses... - Finding optimal vaccination strategies for pandemic influenza using genetic algorithmsRajan Patel
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
J Theor Biol 234:201-12. 2005..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures... - Population-wide benefits of routine vaccination of children against influenzaDerek Weycker
Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
Vaccine 23:1284-93. 2005..Similar reductions were estimated to occur in influenza-related mortality and economic costs... - Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy childrenManjusha J Gaglani
Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
Arch Pediatr Adolesc Med 158:65-73. 2004.... - Model-based estimation of vaccine effects from community vaccine trialsIra M Longini
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Stat Med 21:481-95. 2002..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions... - Containing pandemic influenza with antiviral agentsIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
Am J Epidemiol 159:623-33. 2004..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available... - Epidemic and endemic cholera trends over a 33-year period in BangladeshIra M Longini
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 186:246-51. 2002..Thus, epidemics of Inaba may selectively confer short-term population-level immunity for a longer period than those of Ogawa. These observations suggest that the Inaba antigen should be maximized in cholera vaccine designs... - Community interventions and the epidemic prevention potentialM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Vaccine 20:3254-62. 2002..The concepts are general and could be applied to other interventions, such as antivirals and quarantine... - The critical vaccination fraction for heterogeneous epidemic modelsAndrew N Hill
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Math Biosci 181:85-106. 2003..Separable or proportionate mixing is also treated. Conditions are conjectured for convexity of the threshold surface and the problem of minimizing the amount of vaccine used while remaining on the threshold surface is discussed... - Containing bioterrorist smallpoxM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Science 298:1428-32. 2002..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox... - Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spreadAndreas Handel
Department of Biology, Emory University, Atlanta, Georgia, United States of America
PLoS Comput Biol 3:e240. 2007..Better knowledge of the quantitative dynamics of the immune response during influenza infections will be crucial to further improve the results... - Safety of cold-adapted live influenza vaccineW Paul Glezen
Pediatr Infect Dis J 23:593-4; author reply 594. 2004 - Strategy for distribution of influenza vaccine to high-risk groups and childrenIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Epidemiol 161:303-6. 2005..The effectiveness of the alternative plan could be assessed through nationwide community studies... - Modeling targeted layered containment of an influenza pandemic in the United StatesM Elizabeth Halloran
Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
Proc Natl Acad Sci U S A 105:4639-44. 2008.... - What is the best control strategy for multiple infectious disease outbreaks?Andreas Handel
Department of Biology, Emory University, Atlanta, GA 30322, USA
Proc Biol Sci 274:833-7. 2007..Here, we identify the best control strategy for such a situation. We further discuss ways in which such a strategy can be implemented to achieve additional public health objectives... - Mitigation strategies for pandemic influenza in the United StatesTimothy C Germann
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Proc Natl Acad Sci U S A 103:5935-40. 2006..For higher R(0), we predict that multiple strategies in combination (involving both social and medical interventions) will be required to achieve similar limits on illness rates... - Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance culturesM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 158:305-11. 2003..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...