Ira M Longini

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States
    Nicole E Basta
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 170:679-86. 2009
  2. pmc Detecting human-to-human transmission of avian influenza A (H5N1)
    Yang Yang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Emerg Infect Dis 13:1348-53. 2007
  3. ncbi request reprint Containing a large bioterrorist smallpox attack: a computer simulation approach
    Ira M Longini
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
    Int J Infect Dis 11:98-108. 2007
  4. pmc Controlling endemic cholera with oral vaccines
    Ira M Longini
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e336. 2007
  5. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
  6. pmc Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Epidemiol 173:1121-30. 2011
  7. pmc Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics
    Laith J Abu-Raddad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:13980-5. 2009
  8. pmc Estimating influenza vaccine efficacy from challenge and community-based study data
    Nicole E Basta
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 168:1343-52. 2008
  9. pmc FluTE, a publicly available stochastic influenza epidemic simulation model
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 6:e1000656. 2010
  10. pmc Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2
    Ramzi A Alsallaq
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Sex Transm Dis 37:290-7. 2010

Detail Information

Publications52

  1. pmc Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States
    Nicole E Basta
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 170:679-86. 2009
    ..Given the current worldwide threat of novel influenza A (H1N1), with an estimated R of 1.4-1.6, health officials should consider strategies for vaccinating children against novel influenza A (H1N1) as well as seasonal influenza...
  2. pmc Detecting human-to-human transmission of avian influenza A (H5N1)
    Yang Yang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Emerg Infect Dis 13:1348-53. 2007
    ..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains...
  3. ncbi request reprint Containing a large bioterrorist smallpox attack: a computer simulation approach
    Ira M Longini
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
    Int J Infect Dis 11:98-108. 2007
    ..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries...
  4. pmc Controlling endemic cholera with oral vaccines
    Ira M Longini
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e336. 2007
    ..We used a large-scale stochastic simulation model to investigate the possibility of controlling endemic cholera with OCVs...
  5. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
    ..If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic...
  6. pmc Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Epidemiol 173:1121-30. 2011
    ....
  7. pmc Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics
    Laith J Abu-Raddad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:13980-5. 2009
    ..Elimination will require new delivery strategies, such as mass vaccination campaigns, and new products targeted at latently infected people...
  8. pmc Estimating influenza vaccine efficacy from challenge and community-based study data
    Nicole E Basta
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 168:1343-52. 2008
    ..VE(I) estimates were particularly low for these influenza vaccines. VE(SP) and VE(C) can remain high for both vaccines, even when VE(I) is relatively low, as long as the other 2 measures of vaccine efficacy are relatively high...
  9. pmc FluTE, a publicly available stochastic influenza epidemic simulation model
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 6:e1000656. 2010
    ..Computer simulation models play an essential role in informing public policy and evaluating pandemic preparedness plans. We have made the source code of this model publicly available to encourage its use and further development...
  10. pmc Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2
    Ramzi A Alsallaq
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Sex Transm Dis 37:290-7. 2010
    ..The continuation of developing Herpes simplex virus type-2 (HSV-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines...
  11. pmc Vaccination strategies for epidemic cholera in Haiti with implications for the developing world
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:7081-5. 2011
    ..For epidemic cholera, we recommend a large mobile stockpile of enough vaccine to cover 30% of a country's population to be reactively targeted to populations at high risk of exposure...
  12. pmc Critical immune and vaccination thresholds for determining multiple influenza epidemic waves
    Laura Matrajt
    Department of Medicine, University of Washington, Seattle, WA, USA
    Epidemics 4:22-32. 2012
    ..We also used this scheme to accurately predict the second wave of pandemic influenza in London and the West Midlands, UK during the fall of 2009...
  13. pmc The global transmission and control of influenza
    Eben Kenah
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e19515. 2011
    ..Our open-source, computationally simple model can help public health officials plan for the next pandemic as well as deal with interpandemic influenza...
  14. pmc Controlling dengue with vaccines in Thailand
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Negl Trop Dis 6:e1876. 2012
    ....
  15. pmc The global spread of drug-resistant influenza
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J R Soc Interface 9:648-56. 2012
    ....
  16. pmc A Bayesian model for evaluating influenza antiviral efficacy in household studies with asymptomatic infections
    Yang Yang
    Program of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biostatistics 10:390-403. 2009
    ..We also found significant therapeutic efficacies in reducing pathogenicity and the risk of infection with disease but no therapeutic efficacy in reducing the risk of viral infection in the contacts...
  17. pmc The effect of age on transmission of 2009 pandemic influenza A (H1N1) in a camp and associated households
    Jonathan D Sugimoto
    Center for Statistics and Quantitative Infectious Disease, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Epidemiology 22:180-7. 2011
    ..A major portion of influenza disease burden during the 2009 pandemic was observed among young people...
  18. doi request reprint Quantitative assessment of the role of male circumcision in HIV epidemiology at the population level
    Ramzi A Alsallaq
    Vaccine and Infectious Disease Institute, Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Epidemics 1:139-52. 2009
    ....
  19. doi request reprint No HIV stage is dominant in driving the HIV epidemic in sub-Saharan Africa
    Laith J Abu-Raddad
    Statistical Center for HIV AIDS Research and Prevention SCHARP, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, LE 400, P O Box 19024, Seattle, WA 98109, USA
    AIDS 22:1055-61. 2008
    ..To estimate the role of each of the HIV progression stages in fueling HIV transmission in sub-Saharan Africa by using the recent measurements of HIV transmission probability per coital per HIV stage in the Rakai study...
  20. ncbi request reprint Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand
    Michael G Hudgens
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
    Am J Epidemiol 155:159-68. 2002
    ..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype...
  21. pmc Optimizing vaccine allocation at different points in time during an epidemic
    Laura Matrajt
    Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e13767. 2010
    ..To answer this question, we develop a deterministic epidemic model with two age-groups (children and adults) and further subdivide each age group in low and high risk...
  22. ncbi request reprint Analytic insights into the population level impact of imperfect prophylactic HIV vaccines
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North LE 400, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 45:454-67. 2007
    ....
  23. pmc Optimal vaccine allocation for the early mitigation of pandemic influenza
    Laura Matrajt
    Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America
    PLoS Comput Biol 9:e1002964. 2013
    ..We show that it is possible to significantly mitigate a more global epidemic with limited quantities of vaccine, provided that the vaccination campaign is extremely fast and it occurs within the first weeks of transmission...
  24. doi request reprint A theoretic framework to consider the effect of immunizing schoolchildren against influenza: implications for research
    Ira M Longini
    Program of Biostatistics and Biomathematics, Fred HutchinsonCancer Center, Seattle, Washington, USA
    Pediatrics 129:S63-7. 2012
    ....
  25. pmc School opening dates predict pandemic influenza A(H1N1) outbreaks in the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Infect Dis 202:877-80. 2010
    ..School opening dates can be useful for future pandemic planning, and influenza mitigation strategies should be targeted at school populations before the influenza season...
  26. ncbi request reprint Public health. Community studies for vaccinating schoolchildren against influenza
    M Elizabeth Halloran
    Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:615-6. 2006
  27. pmc The effects of vector movement and distribution in a mathematical model of dengue transmission
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e76044. 2013
    ..Two assumptions usually incorporated by mathematical models of vector-borne disease transmission is homogeneous mixing among the hosts and vectors and homogeneous distribution of the vectors...
  28. pmc A hybrid EM and Monte Carlo EM algorithm and its application to analysis of transmission of infectious diseases
    Yang Yang
    Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA
    Biometrics 68:1238-49. 2012
    ..We use the hybrid EM-MCEM algorithm to analyze two influenza epidemics in the late 1970s to assess the effects of age and preseason antibody levels on the transmissibility and pathogenicity of the viruses...
  29. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
    ..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza...
  30. ncbi request reprint Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 165:212-21. 2007
    ..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...
  31. pmc Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
    Laith J Abu-Raddad
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e2230. 2008
    ..The potential impact of these interventions requires a quantitative assessment of the magnitude of the synergy between HIV and HSV-2 at the population level...
  32. ncbi request reprint Modeling cholera outbreaks
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Curr Top Microbiol Immunol 379:195-209. 2014
    ..Major challenges to cholera modeling are insufficient data for calibrating models and the need to tailor models for different outbreak scenarios. ..
  33. ncbi request reprint Model-based estimation of vaccine effects from community vaccine trials
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Stat Med 21:481-95. 2002
    ..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions...
  34. ncbi request reprint Epidemic and endemic cholera trends over a 33-year period in Bangladesh
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 186:246-51. 2002
    ..Thus, epidemics of Inaba may selectively confer short-term population-level immunity for a longer period than those of Ogawa. These observations suggest that the Inaba antigen should be maximized in cholera vaccine designs...
  35. ncbi request reprint A 4-year study of the epidemiology of Vibrio cholerae in four rural areas of Bangladesh
    R Bradley Sack
    Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 187:96-101. 2003
    ..These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks...
  36. ncbi request reprint Community interventions and the epidemic prevention potential
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 20:3254-62. 2002
    ..The concepts are general and could be applied to other interventions, such as antivirals and quarantine...
  37. ncbi request reprint The critical vaccination fraction for heterogeneous epidemic models
    Andrew N Hill
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Math Biosci 181:85-106. 2003
    ..Separable or proportionate mixing is also treated. Conditions are conjectured for convexity of the threshold surface and the problem of minimizing the amount of vaccine used while remaining on the threshold surface is discussed...
  38. ncbi request reprint Containing bioterrorist smallpox
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Science 298:1428-32. 2002
    ..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox...
  39. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  40. pmc Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh
    Anwar Huq
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA
    Appl Environ Microbiol 71:4645-54. 2005
    ..g., plankton population blooms. The new information on the ecology of V. cholerae is proving useful in developing environmental models for the prediction of cholera epidemics...
  41. pmc Neuraminidase inhibitor resistance in influenza: assessing the danger of its generation and spread
    Andreas Handel
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Comput Biol 3:e240. 2007
    ..Better knowledge of the quantitative dynamics of the immune response during influenza infections will be crucial to further improve the results...
  42. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
    ..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4...
  43. pmc Preclinical assessment of HIV vaccines and microbicides by repeated low-dose virus challenges
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, Georgia, USA
    PLoS Med 2:e249. 2005
    ..The belief that experiments involving realistically low challenge doses require large numbers of animals has so far prevented the development of alternatives to using high challenge doses...
  44. ncbi request reprint Finding optimal vaccination strategies for pandemic influenza using genetic algorithms
    Rajan Patel
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    J Theor Biol 234:201-12. 2005
    ..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures...
  45. ncbi request reprint Population-wide benefits of routine vaccination of children against influenza
    Derek Weycker
    Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
    Vaccine 23:1284-93. 2005
    ..Similar reductions were estimated to occur in influenza-related mortality and economic costs...
  46. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
    ..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available...
  47. ncbi request reprint Strategy for distribution of influenza vaccine to high-risk groups and children
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 161:303-6. 2005
    ..The effectiveness of the alternative plan could be assessed through nationwide community studies...
  48. pmc Modeling targeted layered containment of an influenza pandemic in the United States
    M Elizabeth Halloran
    Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4639-44. 2008
    ....
  49. ncbi request reprint Safety of cold-adapted live influenza vaccine
    W Paul Glezen
    Pediatr Infect Dis J 23:593-4; author reply 594. 2004
  50. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  51. pmc What is the best control strategy for multiple infectious disease outbreaks?
    Andreas Handel
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Biol Sci 274:833-7. 2007
    ..Here, we identify the best control strategy for such a situation. We further discuss ways in which such a strategy can be implemented to achieve additional public health objectives...
  52. pmc Mitigation strategies for pandemic influenza in the United States
    Timothy C Germann
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Proc Natl Acad Sci U S A 103:5935-40. 2006
    ..For higher R(0), we predict that multiple strategies in combination (involving both social and medical interventions) will be required to achieve similar limits on illness rates...