Affiliation: Fred Hutchinson Cancer Research Center
- Towards prediction of degenerate CTL epitope recognitionFusheng Li
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Hum Vaccin 4:115-21. 2008..As the data cumulates, we anticipate that eventually EPSSMs will be available for prediction of degenerate T-cell epitope recognition...
- Identification of cross-neutralization determinants by GAP analysis: a mutational behavior approachFusheng Li
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Curr HIV Res 5:87-96. 2007..Correlated mutation analysis and structure mapping further refine the cross-neutralization determinants. The usability of this approach is confirmed by analysis of an Influenza H3N2 cross-reactive dataset...
- HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response featuresFusheng Li
Statistical Center for HIV Aids Research and Prevention, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Curr HIV Res 5:97-107. 2007..Based on these analyses, several approaches are proposed to enhance the breadth of vaccine responses and, hence, the potential protective efficacy...
- Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluationFusheng Li
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Vaccine 24:6893-904. 2006..The usability of PTE peptide set was manifested by detection of Nef-specific CTL responses in HIV-1 subtype B infections...
- Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infectionNatalie N Zheng
Department of Pathology, University of Washington, Seattle, WA 98195, USA
J Virol 81:9061-71. 2007..In conclusion, the T-cell memory responses associated with containment of single HIV-1 and HIV-2 infection play a similar significant role in the immune control of dual HIV-1 and HIV-2 infection...
- Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step studyFusheng Li
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 6:e20479. 2011..Trial registration: ClinicalTrials.gov NCT00849680, A Study of Safety, Tolerability, and Immunogenicity of the MRKAd5 Gag/Pol/Nef Vaccine in Healthy Adults...
- Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infectionUma Malhotra
Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
J Virol 81:5225-37. 2007..Our findings suggest that Nef responses induced by a given vaccine strain before HIV-1 exposure may be sufficiently broad to recognize most variants within subtype B HIV-1...
- Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trialMorgane Rolland
Department of Microbiology, University of Washington, Seattle, Washington, USA
Nat Med 17:366-71. 2011..These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans...
- Dual HIV-1 infection associated with rapid disease progressionGeoffrey S Gottlieb
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
Lancet 363:619-22. 2004..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level...
- The G protein-coupled receptor repertoires of human and mouseDemetrios K Vassilatis
Primal, Incorporated, 1124 Columbia Street, Seattle, WA 98104, USA
Proc Natl Acad Sci U S A 100:4903-8. 2003..Over 90% of GPCRs are expressed in the brain. Strikingly, however, the profiles of most GPCRs are unique, yielding thousands of tissue- and cell-specific receptor combinations for the modulation of physiological processes...