Fusheng Li

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Towards prediction of degenerate CTL epitope recognition
    Fusheng Li
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Hum Vaccin 4:115-21. 2008
  2. ncbi request reprint Identification of cross-neutralization determinants by GAP analysis: a mutational behavior approach
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Curr HIV Res 5:87-96. 2007
  3. ncbi request reprint HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Curr HIV Res 5:97-107. 2007
  4. ncbi request reprint Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Vaccine 24:6893-904. 2006
  5. pmc Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection
    Natalie N Zheng
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Virol 81:9061-71. 2007
  6. pmc Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study
    Fusheng Li
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e20479. 2011
  7. pmc Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection
    Uma Malhotra
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
    J Virol 81:5225-37. 2007
  8. pmc Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
  9. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
  10. pmc The G protein-coupled receptor repertoires of human and mouse
    Demetrios K Vassilatis
    Primal, Incorporated, 1124 Columbia Street, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 100:4903-8. 2003

Detail Information

Publications10

  1. ncbi request reprint Towards prediction of degenerate CTL epitope recognition
    Fusheng Li
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Hum Vaccin 4:115-21. 2008
    ..As the data cumulates, we anticipate that eventually EPSSMs will be available for prediction of degenerate T-cell epitope recognition...
  2. ncbi request reprint Identification of cross-neutralization determinants by GAP analysis: a mutational behavior approach
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Curr HIV Res 5:87-96. 2007
    ..Correlated mutation analysis and structure mapping further refine the cross-neutralization determinants. The usability of this approach is confirmed by analysis of an Influenza H3N2 cross-reactive dataset...
  3. ncbi request reprint HIV-1 CTL-based vaccine immunogen selection: antigen diversity and cellular response features
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Curr HIV Res 5:97-107. 2007
    ..Based on these analyses, several approaches are proposed to enhance the breadth of vaccine responses and, hence, the potential protective efficacy...
  4. ncbi request reprint Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation
    Fusheng Li
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Vaccine 24:6893-904. 2006
    ..The usability of PTE peptide set was manifested by detection of Nef-specific CTL responses in HIV-1 subtype B infections...
  5. pmc Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection
    Natalie N Zheng
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Virol 81:9061-71. 2007
    ..In conclusion, the T-cell memory responses associated with containment of single HIV-1 and HIV-2 infection play a similar significant role in the immune control of dual HIV-1 and HIV-2 infection...
  6. pmc Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study
    Fusheng Li
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e20479. 2011
    ..Trial registration: ClinicalTrials.gov NCT00849680, A Study of Safety, Tolerability, and Immunogenicity of the MRKAd5 Gag/Pol/Nef Vaccine in Healthy Adults...
  7. pmc Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection
    Uma Malhotra
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
    J Virol 81:5225-37. 2007
    ..Our findings suggest that Nef responses induced by a given vaccine strain before HIV-1 exposure may be sufficiently broad to recognize most variants within subtype B HIV-1...
  8. pmc Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
    ..These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans...
  9. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
    ..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level...
  10. pmc The G protein-coupled receptor repertoires of human and mouse
    Demetrios K Vassilatis
    Primal, Incorporated, 1124 Columbia Street, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 100:4903-8. 2003
    ..Over 90% of GPCRs are expressed in the brain. Strikingly, however, the profiles of most GPCRs are unique, yielding thousands of tissue- and cell-specific receptor combinations for the modulation of physiological processes...