Wendy M Leisenring

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
  2. pmc Pediatric cancer survivorship research: experience of the Childhood Cancer Survivor Study
    Wendy M Leisenring
    Cancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 27:2319-27. 2009
  3. ncbi request reprint Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation
    Wendy Leisenring
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 24:1119-26. 2006
  4. pmc HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, Washington 98115, USA
    Biol Blood Marrow Transplant 18:1700-8. 2012
  5. pmc Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States
    Mellissa Yong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Steroid Biochem Mol Biol 124:10-8. 2011
  6. pmc CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia
    Margaret L Green
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 122:1316-24. 2013
  7. pmc Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients
    Filippo Milano
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 118:5689-96. 2011
  8. pmc Outcome of allogeneic hematopoietic cell transplantation from HLA-identical siblings for severe aplastic anemia in patients over 40 years of age
    Dario Sangiolo
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 16:1411-8. 2010
  9. ncbi request reprint Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation
    Marco Mielcarek
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, Seattle, WA, 98109 1024, USA
    Blood 102:756-62. 2003
  10. pmc Outcome of respiratory syncytial virus lower respiratory tract disease in hematopoietic cell transplant recipients receiving aerosolized ribavirin: significance of stem cell source and oxygen requirement
    Sachiko Seo
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 19:589-96. 2013

Detail Information

Publications69

  1. pmc Modifiable risk factors associated with bone deficits in childhood cancer survivors
    Lynda E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    BMC Pediatr 12:40. 2012
    ..To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS...
  2. pmc Pediatric cancer survivorship research: experience of the Childhood Cancer Survivor Study
    Wendy M Leisenring
    Cancer Prevention and Clinical Statistics Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 27:2319-27. 2009
    ..Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship...
  3. ncbi request reprint Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation
    Wendy Leisenring
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 24:1119-26. 2006
    ..To evaluate the incidence of and risk factors for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in survivors of hematopoietic cell transplantation (HCT)...
  4. pmc HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, Washington 98115, USA
    Biol Blood Marrow Transplant 18:1700-8. 2012
    ..A randomized antiviral trial is warranted to establish causality between HHV-6 and these endpoints and to determine if reducing HHV-6 reactivation will improve outcome after HCT...
  5. pmc Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States
    Mellissa Yong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Steroid Biochem Mol Biol 124:10-8. 2011
    ..Further study of UGT and SULT polymorphisms and circulating sex steroid measures in larger populations of premenopausal women is warranted...
  6. pmc CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia
    Margaret L Green
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 122:1316-24. 2013
    ..05; 95% CI, 0.9-1.3). This report demonstrates a modest reduction in early relapse risk after HCT associated with CMV reactivation in a large cohort of patients without a benefit in overall survival. ..
  7. pmc Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients
    Filippo Milano
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 118:5689-96. 2011
    ..001). Use of an intensive CMV prevention strategy in high-risk CMVseropositive UCBT recipients results in a significant decrease in CMV reactivation and disease...
  8. pmc Outcome of allogeneic hematopoietic cell transplantation from HLA-identical siblings for severe aplastic anemia in patients over 40 years of age
    Dario Sangiolo
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 16:1411-8. 2010
    ..5 and 15 years after HCT. Our data favor a practice of extending HLA-identical sibling HCT for treatment of SAA in patients older than 40 years of age who are without significant medical comorbidities...
  9. ncbi request reprint Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation
    Marco Mielcarek
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, Seattle, WA, 98109 1024, USA
    Blood 102:756-62. 2003
    ..This "late-onset acute GVHD" should be taken into consideration in the design of prospective studies comparing GVHD resulting from the two types of transplantation procedures...
  10. pmc Outcome of respiratory syncytial virus lower respiratory tract disease in hematopoietic cell transplant recipients receiving aerosolized ribavirin: significance of stem cell source and oxygen requirement
    Sachiko Seo
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 19:589-96. 2013
    ..These results may explain differences in outcomes reported from RSV infection over time and may guide the design of future interventional trials...
  11. ncbi request reprint Weight characteristics and height in relation to risk of gestational diabetes mellitus
    Carole B Rudra
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA
    Am J Epidemiol 165:302-8. 2007
    ..zero cycles: RR = 2.04, 95% CI: 0.83, 5.02). Efforts to prevent obesity and weight gain among young women may reduce gestational diabetes risk...
  12. ncbi request reprint Maternal plasma ascorbic Acid (vitamin C) and risk of gestational diabetes mellitus
    Cuilin Zhang
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington, USA
    Epidemiology 15:597-604. 2004
    ..Antioxidants, particularly vitamin C (ascorbic acid), have the capacity to influence glucose tolerance. Modification of diet could reduce the likelihood of developing gestational diabetes mellitus...
  13. pmc Validation of a flow cytometric scoring system as a prognostic indicator for posttransplantation outcome in patients with myelodysplastic syndrome
    Bart L Scott
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 112:2681-6. 2008
    ..7; P = .02). This analysis confirmed that FCSS scores are predictive of posttransplantation outcomes in patients with MDS even after adjusting for risk factors such as marrow myeloblast percentage and IPSS score...
  14. pmc Salvage allogeneic hematopoietic cell transplantation with fludarabine and low-dose total body irradiation after rejection of first allografts
    Boglarka Gyurkocza
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 15:1314-22. 2009
    ..We concluded that graft rejection after allogeneic HCT could be overcome by salvage transplantation using conditioning with Flu and low-dose TBI...
  15. ncbi request reprint Maternal birth weight in relation to plasma lipid concentrations in early pregnancy
    Jennifer C Dempsey
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Obstet Gynecol 190:1359-68. 2004
    ..The purpose of this study was to determine the extent to which, if at all, maternal weight at birth is related to dyslipidemia during early pregnancy, which is a risk factor for preeclampsia...
  16. pmc Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 359:1766-77. 2008
    ..We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants...
  17. pmc Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation
    Jeffrey L Schwartz
    Department of Radiation Oncology, The University of Washington Medical Center, Seattle, Washington 98195 6069, USA
    Radiat Res 171:155-63. 2009
    ....
  18. pmc Late cardiovascular complications after hematopoietic cell transplantation
    Eric J Chow
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Pediatrics, Seattle Children s Hospital, University of Washington, Seattle, Washington Electronic address
    Biol Blood Marrow Transplant 20:794-800. 2014
    ..These survivors should receive appropriate follow-up and be considered for primary intervention...
  19. pmc Factors associated with adherence to preventive care practices among hematopoietic cell transplantation survivors
    Nandita Khera
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 17:995-1003. 2011
    ..Future efforts to improve adherence should address concerns about medical costs and lack of knowledge, two major modifiable predictors of lower adherence to preventive care practices in HCT survivors...
  20. pmc An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens
    Wendy M Leisenring
    Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, 98109, USA
    Blood 108:749-55. 2006
    ..These results demonstrate that clinical manifestations of GVHD severity can be used to accurately predict the risk of NRM in real time...
  21. ncbi request reprint Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone
    Sibel Koc
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 100:48-51. 2002
    ....
  22. pmc Fluconazole coadministration concurrent with cyclophosphamide conditioning may reduce regimen-related toxicity postmyeloablative hematopoietic cell transplantation
    Arlo Upton
    Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington, USA
    Biol Blood Marrow Transplant 13:760-4. 2007
    ..No difference in relapsed malignancy was apparent. These data support the hypothesis that fluconazole, when coadministered with CY, decreases CY-related toxicities by inhibiting cytochrome P450 2C9 metabolism...
  23. pmc Differential effects of radiotherapy on growth and endocrine function among acute leukemia survivors: a childhood cancer survivor study report
    Eric J Chow
    Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, WA, USA
    Pediatr Blood Cancer 60:110-5. 2013
    ..The differential effects of cranial radiotherapy (CRT), spinal radiotherapy (SRT), and total body irradiation (TBI) on growth and endocrine outcomes have rarely been examined in combination among childhood acute leukemia survivors...
  24. ncbi request reprint Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsia
    Ihunnaya O Frederick
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
    J Reprod Med 50:332-44. 2005
    ..To explore the relation between preeclampsia risk and maternal intake of dietary fiber, potassium, magnesium and calcium...
  25. pmc HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
    Danielle M Zerr
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Blood 117:5243-9. 2011
    ..These data provide the basis to conduct a randomized clinical trial to determine whether prevention of HHV-6 reactivation will reduce neurocognitive morbidity in HCT recipients...
  26. pmc Pregnancy, microchimerism, and the maternal grandmother
    Hilary S Gammill
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e24101. 2011
    ..An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the next generation (grandchildren)...
  27. ncbi request reprint Survival after second hematopoietic stem cell transplantation for recurrent pediatric acute myeloid leukemia
    Soheil Meshinchi
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 9:706-13. 2003
    ..Because a higher tumor burden at the time of second HSCT was associated with a higher risk of subsequent relapse, patients might benefit from reinduction therapy before the second HSCT...
  28. pmc Behaviors associated with ultraviolet radiation exposure in a cohort of adult survivors of childhood and adolescent cancer: a report from the Childhood Cancer Survivor Study
    Natasha Buchanan
    Aflac Cancer Center and Blood Disorders Service, Children s Healthcare of Atlanta Emory University, Department of Cancer Prevention, Fred Hutchinson Cancer Research Center, Atlanta, GA 30322, USA
    Cancer 115:4374-84. 2009
    ..The potential role of ultraviolet radiation exposure in survivors has not been described...
  29. pmc Longitudinal assessment of morbidity and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation: retrospective analysis of a multicenter phase III study
    Fabrizio Carnevale-Schianca
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Biol Blood Marrow Transplant 15:749-56. 2009
    ..The difficulty of demonstrating clinical benefits from objective parameters, such as survival and morbidity, and the subjectivity of grading acute GVHD emphasize the need for blinded assessments in clinical trials of GVHD prevention...
  30. pmc Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women
    Mellissa Yong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 20:1039-53. 2009
    ....
  31. pmc Prospective predictors of return to work in the 5 years after hematopoietic cell transplantation
    Anne C Kirchhoff
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N D5 220, Seattle, WA 98109, USA
    J Cancer Surviv 4:33-44. 2010
    ..Work return is an indicator of recovery and functional status for cancer survivors. We investigated whether demographic, medical and functional factors predicted full-time work return following hematopoietic cell transplantation (HCT)...
  32. pmc Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study
    Anne C Kirchhoff
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Care 48:1015-25. 2010
    ..Adult childhood cancer survivors report high levels of unemployment, although it is unknown whether this is because of health or employability limitations...
  33. pmc Low relapse without excessive transplant-related mortality following myeloablative cord blood transplantation for acute leukemia in complete remission: a matched cohort analysis
    Jonathan A Gutman
    Fred Hutchinson Cancer Research Center, Seattle, Washington Medicine and Pediatrics, University of Washington, Seattle, Washington, USA
    Biol Blood Marrow Transplant 15:1122-9. 2009
    ..These data support increased investigation of the use of CBT...
  34. pmc Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study
    Parveen Bhatti
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, UA
    Radiat Res 174:741-52. 2010
    ....
  35. pmc Increased risk of breast cancer among survivors of allogeneic hematopoietic cell transplantation: a report from the FHCRC and the EBMT-Late Effect Working Party
    Debra L Friedman
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98109, USA
    Blood 111:939-44. 2008
    ..Hazard for death associated with breast cancer was 2.5 (95% CI: 1.1-5.8). We conclude that female survivors of allogeneic HCT are at increased risk of breast cancer and should be educated about the need for regular screening...
  36. pmc Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Benjamin Musher
    University of Washington, Seattle, WA, USA
    J Clin Microbiol 42:5517-22. 2004
    ..GM EIA and qPCR assay add to the sensitivity of BAL for diagnosing IPA in high-risk patients, with excellent specificity. Adjunctive use of these tests may reduce dependence on invasive diagnostic procedures...
  37. ncbi request reprint What role is there for antithymocyte globulin in allogeneic nonmyeloablative canine hematopoietic cell transplantation?
    Razvan Diaconescu
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 11:335-44. 2005
    ..82 (P = .09). We concluded that administering ATG before an otherwise suboptimal conditioning dose of 1 Gy of TBI failed to secure uniform stable hematopoietic engraftment...
  38. ncbi request reprint Design issues in studies evaluating diagnostic tests for aspergillosis
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
    Clin Infect Dis 41:S381-6. 2005
    ..The widespread availability of a standardized assay may now allow us to address the multiple sources of variability and bias via large, cooperative studies...
  39. ncbi request reprint Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long-term follow-up
    Christoph Kahl
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Br J Haematol 130:747-51. 2005
    ..Six patients developed cancer: one fatal lymphoma and five carcinomas (all five patients are now free of cancer). Survival was 88%. The regimen appeared well tolerated and effective in heavily pretreated patients with aplastic anaemia...
  40. ncbi request reprint Prognostic relevance of 'early-onset' graft-versus-host disease following non-myeloablative haematopoietic cell transplantation
    Marco Mielcarek
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Br J Haematol 129:381-91. 2005
    ..Patients with early-onset GVHD after non-myeloablative HCT from HLA-identical related donors might benefit from intensified primary immunosuppressive treatment...
  41. ncbi request reprint Extending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
    Lauri Burroughs
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Transplantation 81:818-25. 2006
    ....
  42. ncbi request reprint Liver biopsies from human females contain male hepatocytes in the absence of transplantation
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lab Invest 84:1603-9. 2004
    ..Whether fetal cells play a role in autoimmune diseases like PBC merits further investigation...
  43. ncbi request reprint Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease
    Terry Furlong
    Fred Hutchinson Cancer Research Center, and the Department of Medicine, University of Washington, Seattle 98109 1024, USA
    Biol Blood Marrow Transplant 8:206-12. 2002
    ..Fifty-three patients (51%) remain alive at 129-1883 days after transplantation. These results suggest that PUVA can be an effective therapy for steroid-resistant acute GVHD of the skin...
  44. ncbi request reprint Cyclophosphamide metabolism is affected by azole antifungals
    Kieren A Marr
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
    Blood 103:1557-9. 2004
    ..These data suggest that azole antifungals, through differential inhibition of hepatic cytochrome P-450 isoenzymes, affect CY metabolism and conditioning-related toxicities...
  45. ncbi request reprint Predictive factors for outcome of allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia
    Kristine Doney
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D5 280, P O Box 19024, Seattle, WA 98109 1024, USA
    Biol Blood Marrow Transplant 9:472-81. 2003
    ..Patients with Philadelphia chromosome-positive ALL had survival and relapse rates similar to patients with normal cytogenetics...
  46. ncbi request reprint Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity
    Michael Boeckh
    Program in Infectious Diseases Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Blood 101:407-14. 2003
    ..Prevention strategies should be targeted at patients in whom CMV reactivated during the first 3 months and those with poor CMV-specific immunity or low CD4 counts...
  47. ncbi request reprint Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants
    Kieren A Marr
    Program of Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 103:1527-33. 2004
    ..69). There was no difference in overall or fungal-free survival. Itraconazole appears to prevent IMI in the subset of patients who tolerate the drug; however, toxicities and poor tolerability limit its success as prophylactic therapy...
  48. ncbi request reprint Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay
    Kieren A Marr
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Infect Dis 40:1762-9. 2005
    ..Reported sensitivity of the galactomannan enzyme immunoassay as an early diagnostic test for invasive aspergillosis (IA) has been widely variable, ranging from 29% to 100% in earlier clinical studies...
  49. ncbi request reprint Relation between maternal recreational physical activity and plasma lipids in early pregnancy
    Carole L Butler
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA
    Am J Epidemiol 160:350-9. 2004
    ..No association was found between physical activity and high density lipoprotein cholesterol. These data suggest that habitual physical activity may attenuate pregnancy-associated dyslipidemia...
  50. pmc The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation
    Zejing Wang
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    Br J Haematol 149:101-10. 2010
    ..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
  51. doi request reprint Intensified postgrafting immunosuppression failed to assure long-term engraftment of dog leukocyte antigen-identical canine marrow grafts after 1 gray total body irradiation
    Mohamed L Sorror
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Transplantation 85:1023-9. 2008
    ..Late graft rejection after conditioning with 1 Gy of total body irradiation (TBI) was consistently seen in historical dogs given two postgrafting immunosuppressive drugs...
  52. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  53. pmc Impact of treatment exposures on cardiovascular risk and insulin resistance in childhood cancer survivors
    K Scott Baker
    Authors Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington University of California San Diego and Rady Children s Hospital, San Diego, California Children s Hospitals and Clinics of Minnesota and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Cancer Epidemiol Biomarkers Prev 22:1954-63. 2013
    ..This study examines specific treatment exposures associated with cardiovascular risk factors and insulin resistance...
  54. pmc Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States
    Mellissa Yong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 19:537-46. 2010
    ..We assessed relationships between functional polymorphisms in the UGT and SULT genes and breast density in premenopausal women...
  55. pmc Reproducibility of low galactomannan enzyme immunoassay index values tested in multiple laboratories
    Arlo Upton
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Microbiol 43:4796-800. 2005
    ..However, changes in GMI levels when different kit lots are used, and single samples with low-positive (GMI of 0.5 to 0.7) indices, should be interpreted with caution...
  56. ncbi request reprint Second malignant neoplasms following hematopoietic stem cell transplantation
    Debra L Friedman
    University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Int J Hematol 79:229-34. 2004
    ..We review the incidence and spectrum of posttransplantation malignancies and discuss risk factors and future directions for research...
  57. ncbi request reprint Myeloid and monocytic dyspoiesis as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation
    Denise A Wells
    HematoLogics, Inc, 113 1st Avenue N, Seattle, WA 98109, USA
    Blood 102:394-403. 2003
    ..01, P =.02, and P =.03, respectively). These data suggest that FCSS is useful in assessing marrows for diagnosis of MDS and in determining the prognostic outcome in patients with this disorder...
  58. ncbi request reprint Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 196:266-70. 2007
    ..2% [95% CI, 0%-0.8%]; P=.006), and in 0 patients in cohort 3 (cohort 2 vs. cohort 3, P=.3). Long-term use of suppressive prophylactic ACV appears to prevent the emergence of drug-resistant HSV disease in HCT...
  59. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
    ..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...
  60. ncbi request reprint A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia
    Chunfang Qiu
    Center for Perinatal Studies, Swedish Medical Center, 747 Broadway, Suite 449 North, Seattle, WA 98122, USA
    Am J Hypertens 17:154-60. 2004
    ..We measured C-reactive protein (CRP), a clinical marker of systemic inflammation, in maternal serum collected at 13 weeks gestation on average, to determine whether elevations precede the clinical manifestation of preeclampsia...
  61. ncbi request reprint Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 19024, USA
    Blood 104:1894-7. 2004
    ..01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation...
  62. ncbi request reprint Maternal second-trimester serum ferritin concentrations and subsequent risk of preterm delivery
    Rong Xiao
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
    Paediatr Perinat Epidemiol 16:297-304. 2002
    ..0 ng/mL. These results are consistent with some previous reports, and further underline the potential for heterogeneity in the aetiology of preterm delivery...
  63. ncbi request reprint Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker
    Margaret Sullivan Pepe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 159:882-90. 2004
    ..In addition, the serious pitfalls of using more traditional methods based on parameters in logistic regression models are illustrated...
  64. pmc Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Rajen Mody
    Department of Pediatrics, University of Michigan, Ann Arbor, USA
    Blood 111:5515-23. 2008
    ..001). Long-term survivors of childhood ALL exhibit excess mortality and morbidity. Survivors who received radiation therapy as part of their treatment or had a leukemia relapse are at greatest risk for adverse outcomes...
  65. ncbi request reprint Chronic health conditions in adult survivors of childhood cancer
    Kevin C Oeffinger
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    N Engl J Med 355:1572-82. 2006
    ..Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors...
  66. ncbi request reprint Twenty-year follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyclosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-identical marrow grafts for leukemia
    Mohamed L Sorror
    Biol Blood Marrow Transplant 11:814-5. 2005
  67. ncbi request reprint Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study
    Daniel C Bowers
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, TX 75390 9063, USA
    J Clin Oncol 24:5277-82. 2006
    ..This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors...
  68. ncbi request reprint Prediction of second malignant neoplasm incidence in a large cohort of long-term survivors of childhood cancers
    Irina Dinu
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Blood Cancer 50:1026-31. 2008
    ..The ability to predict adverse-event occurrences accurately in long-term survivors of childhood cancer is of high importance in late effects research, both clinically and methodologically...
  69. ncbi request reprint Re: Twenty-year follow-up in patients with aplastic anemia given marrow grafts from HLA-identical siblings and randomized to receive methotrexate/cyclosporine or methotrexate alone for prevention of graft-versus-host disease
    Mohamed L Sorror
    Biol Blood Marrow Transplant 11:567-8. 2005