Eun Gyung Lee

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Foamy virus assembly with emphasis on pol encapsidation
    Eun Gyung Lee
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Viruses 5:886-900. 2013
  2. pmc A premature termination codon mutation at the C terminus of foamy virus Gag downregulates the levels of spliced pol mRNA
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 82:1656-64. 2008
  3. pmc Mutations in the amino terminus of foamy virus Gag disrupt morphology and infectivity but do not target assembly
    Rachel B Life
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 82:6109-19. 2008
  4. pmc Expression of prototype foamy virus pol as a Gag-Pol fusion protein does not change the timing of reverse transcription
    Dana L Jackson
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Virol 87:1252-4. 2013
  5. pmc Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Virol 86:5992-6001. 2012
  6. pmc The C terminus of foamy retrovirus Gag contains determinants for encapsidation of Pol protein into virions
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 82:10803-10. 2008
  7. pmc Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 85:1655-61. 2011

Collaborators

  • Dana L Jackson
  • Maxine L Linial
  • Rachel B Life
  • Scott W Eastman

Detail Information

Publications7

  1. pmc Foamy virus assembly with emphasis on pol encapsidation
    Eun Gyung Lee
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Viruses 5:886-900. 2013
    ..In addition, a mutant in which Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein is discussed. We also discuss temporal regulation of the protease, reverse transcriptase and integrase activities of WT FV Pol...
  2. pmc A premature termination codon mutation at the C terminus of foamy virus Gag downregulates the levels of spliced pol mRNA
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 82:1656-64. 2008
    ..The results also suggest that normal pol splicing utilizes a suboptimal splice site seen for other spliced mRNAs in most retroviruses, in that introduced exonic enhancer elements can increase splicing efficiency...
  3. pmc Mutations in the amino terminus of foamy virus Gag disrupt morphology and infectivity but do not target assembly
    Rachel B Life
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 82:6109-19. 2008
    ..Our analyses indicate that the amino terminus of Gag contains an Env interaction domain that is critical for bona fide egress of assembled capsids...
  4. pmc Expression of prototype foamy virus pol as a Gag-Pol fusion protein does not change the timing of reverse transcription
    Dana L Jackson
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Virol 87:1252-4. 2013
    ..Thus, timing of reverse transcription is intrinsic to Pol itself...
  5. pmc Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Virol 86:5992-6001. 2012
    ..Our results suggest that enzymes encoded by PFV pol (protease, reverse transcriptase, and integrase) are enzymatically active if they are synthesized as part of a Gag-Pol protein...
  6. pmc The C terminus of foamy retrovirus Gag contains determinants for encapsidation of Pol protein into virions
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 82:10803-10. 2008
    ..Our results suggest that GR1 contains a Pol interaction domain and that a Gag-Pol complex is formed and binds to RNA for incorporation into virions...
  7. pmc Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation
    Eun Gyung Lee
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 85:1655-61. 2011
    ..However, these zip mutants neither cleave Gag nor incorporate Pol into virions. We propose that IN is required for Pol dimerization, which is necessary for the creation of a functional PR active site...