J W Lampe

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations
    Johanna W Lampe
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Proc Nutr Soc 72:207-18. 2013
  2. pmc Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner
    Heather Ann Brauer
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Nutr J 10:11. 2011
  3. ncbi request reprint UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Pharmacogenetics 9:341-9. 1999
  4. pmc Interindividual differences in response to plant-based diets: implications for cancer risk
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 89:1553S-1557S. 2009
  5. pmc Is equol the key to the efficacy of soy foods?
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 89:1664S-1667S. 2009
  6. ncbi request reprint Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables
    Johanna W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 132:2991-4. 2002
  7. ncbi request reprint Isoflavonoid and lignan phytoestrogens as dietary biomarkers
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 133:956S-964S. 2003
  8. pmc Emerging research on equol and cancer
    Johanna W Lampe
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 140:1369S-72S. 2010
  9. ncbi request reprint Dairy products and cancer
    Johanna W Lampe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Coll Nutr 30:464S-70S. 2011
  10. ncbi request reprint Serum beta-glucuronidase activity is inversely associated with plant-food intakes in humans
    Johanna W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 132:1341-4. 2002

Collaborators

Detail Information

Publications99

  1. pmc Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations
    Johanna W Lampe
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Proc Nutr Soc 72:207-18. 2013
    ....
  2. pmc Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner
    Heather Ann Brauer
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Nutr J 10:11. 2011
    ..The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo...
  3. ncbi request reprint UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Pharmacogenetics 9:341-9. 1999
    ..These highly prevalent polymorphisms, which result in modified expression and activity of UGTs, may influence susceptibility to cancers associated with altered metabolism of endogenous and xenobiotic compounds...
  4. pmc Interindividual differences in response to plant-based diets: implications for cancer risk
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 89:1553S-1557S. 2009
    ....
  5. pmc Is equol the key to the efficacy of soy foods?
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 89:1664S-1667S. 2009
    ..The extent to which isoflavone metabolism is key to the efficacy of soy foods remains to be established...
  6. ncbi request reprint Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables
    Johanna W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 132:2991-4. 2002
    ....
  7. ncbi request reprint Isoflavonoid and lignan phytoestrogens as dietary biomarkers
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 133:956S-964S. 2003
    ..Understanding these sources of variation is important to be able to use these measures effectively as dietary biomarkers...
  8. pmc Emerging research on equol and cancer
    Johanna W Lampe
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 140:1369S-72S. 2010
    ..With the availability of R- and S-equol, animal studies of carcinogenesis and human intervention studies addressing effects of the equol enantiomers on intermediate biomarkers may help to ascertain the role of equol in cancer risk...
  9. ncbi request reprint Dairy products and cancer
    Johanna W Lampe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Coll Nutr 30:464S-70S. 2011
    ..The influence of live microbes in fermented dairy products and certain cheeses on the human gut microbiome and immune function is a growing area of study...
  10. ncbi request reprint Serum beta-glucuronidase activity is inversely associated with plant-food intakes in humans
    Johanna W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 132:1341-4. 2002
    ..Although these associations are modest, the data suggest that plant foods, particularly constituents of fruits and fiber-containing foods, may influence human beta-glucuronidase activity in a potentially favorable direction...
  11. ncbi request reprint Assessing exposure to lignans and their metabolites in humans
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109, USA
    J AOAC Int 89:1174-81. 2006
    ....
  12. ncbi request reprint Spicing up a vegetarian diet: chemopreventive effects of phytochemicals
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Am J Clin Nutr 78:579S-583S. 2003
    ..Embracing a cuisine rich in spice, as well as in fruit and vegetables, may further enhance the chemopreventive capacity of one's diet...
  13. ncbi request reprint Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies
    J W Lampe
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 70:475S-490S. 1999
    ..Rigorously conducted experimental dietary studies in humans are an important link between population- and laboratory-based research...
  14. ncbi request reprint Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:329-33. 2000
    ..This warrants evaluation both in larger, multiethnic cohorts and in relation to known ecological differences in risk of sex hormone-dependent cancers...
  15. ncbi request reprint Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Carcinogenesis 21:1157-62. 2000
    ..This points to a complex association between consumption of a typical diet of various vegetables and biotransformation enzyme activities in humans, an association that may be difficult to interpret in observational studies...
  16. ncbi request reprint Modulation of human glutathione S-transferases by botanically defined vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:787-93. 2000
    ..GST responses were more pronounced in women than men, but it is not clear from this study whether this is a dose-per-body-weight or a sex-specific effect...
  17. ncbi request reprint Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women
    Cara L Frankenfeld
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1156-62. 2004
    ....
  18. ncbi request reprint Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
    J Nutr 131:740-4. 2001
    ..These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol...
  19. ncbi request reprint Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China
    Johanna W Lampe
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 16:2579-86. 2007
    ..Soy isoflavone exposure may influence breast cancer risk, but little is known of its association with benign conditions...
  20. pmc Interindividual differences in phytochemical metabolism and disposition
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center and Nutritional Sciences Program, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Semin Cancer Biol 17:347-53. 2007
    ....
  21. ncbi request reprint Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women
    Cara L Frankenfeld
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program and the Department of Epidemiology, University of Washington, Seattle, 98109 1024, USA
    Am J Clin Nutr 77:674-80. 2003
    ..Soy foods may have various health benefits, but little is known about the patterns and correlates of soy consumption among postmenopausal women in the United States...
  22. pmc Dietary and demographic correlates of serum beta-glucuronidase activity
    Sonia S Maruti
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nutr Cancer 62:208-19. 2010
    ..In conclusion, several dietary and nondietary factors were associated with beta -glucuronidase activity; however, confirmation of these associations are needed...
  23. ncbi request reprint Glutathione S-transferase M1, T1, and P1 polymorphisms and prostate cancer risk in middle-aged men
    Ilir Agalliu
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 66:146-56. 2006
    ..The glutathione S-transferase (GST) enzymes detoxify several carcinogens. Genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been associated with prostate cancer, however, results have been inconsistent across studies...
  24. ncbi request reprint Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States
    Charlotte Atkinson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Clin Nutr 87:679-87. 2008
    ..Studies suggest beneficial health effects associated with daidzein-metabolizing phenotypes; thus, assessing their determinants is an important goal...
  25. ncbi request reprint Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes
    Cara L Frankenfeld
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, PO Box 19024, Seattle, WA 98109 1024, USA
    Maturitas 53:315-24. 2006
    ..The aim of this study was to evaluate bone mineral density (BMD) in relation to presence of these urinary metabolites...
  26. ncbi request reprint CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk
    J Bigler
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 61:3566-9. 2001
    ..73). The variants of these enzymes did not influence the association between nonaspirin NSAIDs and adenoma risk. These data indicate that the effectiveness of chemopreventive drugs can be modulated by the genotype of metabolizing enzymes...
  27. ncbi request reprint A case-control study of risk factors for fibrocystic breast conditions: Shanghai Nutrition and Breast Disease Study, China, 1995-2000
    Chunyuan Wu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Epidemiol 160:945-60. 2004
    ..A diet rich in fruits and vegetables may reduce cellular proliferation in the mammary epithelium; this is one mechanism by which such a diet could reduce risk of breast cancer...
  28. ncbi request reprint Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  29. ncbi request reprint Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case-control study in Shanghai, China
    Wenjin Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 115:981-93. 2005
    ....
  30. ncbi request reprint Serum steroid hormones, sex hormone-binding globulin concentrations, and urinary hydroxylated estrogen metabolites in post-menopausal women in relation to daidzein-metabolizing phenotypes
    Cara L Frankenfeld
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave N, PO Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    J Steroid Biochem Mol Biol 88:399-408. 2004
    ..These results suggest that interindividual variability in intestinal bacteria may be related to differences in products of hormone metabolism in post-menopausal women...
  31. pmc Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism
    Misty R Saracino
    Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    J Nutr 139:555-60. 2009
    ..006 and 0.03, respectively). These results suggest that citrus consumption may increase UGT1A1 activity among women with the 7/7 genotype...
  32. ncbi request reprint Diet, genetic polymorphisms, detoxification, and health risks
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, USA
    Altern Ther Health Med 13:S108-11. 2007
    ....
  33. doi request reprint Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States
    Charlotte Atkinson
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 116:587-94. 2009
    ....
  34. ncbi request reprint Urinary 3-(3,5-dihydroxyphenyl)-1-propanoic acid, an alkylresorcinol metabolite, is a potential biomarker of whole-grain intake in a U.S. population
    Laura A Guyman
    Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle, WA 98195 3410, USA
    J Nutr 138:1957-62. 2008
    ..67 (1.28, 2.17); P < 0.0001]. This study supports the potential utility of urinary DHPPA as a biomarker of whole-grain intake in a U.S. population...
  35. ncbi request reprint Participant characteristics associated with errors in self-reported energy intake from the Women's Health Initiative food-frequency questionnaire
    Neilann K Horner
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 76:766-73. 2002
    ..Errors in self-reported dietary intake threaten inferences from studies relying on instruments such as food-frequency questionnaires (FFQs), food records, and food recalls...
  36. pmc Serum beta-glucuronidase activity in response to fruit and vegetable supplementation: a controlled feeding study
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1808-12. 2008
    ..One hypothesized, but understudied, chemopreventive mechanism is that plant food constituents inhibit beta-glucuronidase, an acid hydrolase that deconjugates glucuronides...
  37. doi request reprint Daidzein-metabolizing phenotypes in relation to serum hormones and sex hormone binding globulin, and urinary estrogen metabolites in premenopausal women in the United States
    Charlotte Atkinson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 19:1085-93. 2008
    ..We evaluated relationships between daidzein-metabolizing phenotypes and follicular phase concentrations of estrogens, androgens, sex hormone binding globulin (SHBG), and urinary estrogen metabolites in premenopausal women...
  38. ncbi request reprint High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart
    Cara L Frankenfeld
    Department of Epidemiology, University of Washington, Seattle, WA 98109 1024, USA
    Br J Nutr 94:873-6. 2005
    ....
  39. ncbi request reprint Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults
    Cara L Frankenfeld
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Diet Assoc 102:1407-13. 2002
    ..To validate assessment of soy intake using food frequency questionnaires (FFQs) compared with plasma isoflavone (genistein and daidzein) concentrations...
  40. ncbi request reprint Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health
    Charlotte Atkinson
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, P O Box 19024, Seattle, WA 98109 1024, USA
    Exp Biol Med (Maywood) 230:155-70. 2005
    ..In this review, we discuss the available evidence for a relationship between daidzeinmetabolizing phenotypes and human health, and suggest potential mechanisms for some of the reported relationships...
  41. ncbi request reprint Dietary determinants of plasma enterolactone
    Neilann K Horner
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:121-6. 2002
    ....
  42. pmc Brief telephone intervention increases soy intake in peri- and postmenopausal US women: the Herbal Alternatives Trial (HALT)
    Jeannette M Beasley
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N M3 A410, PO Box 19024, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 110:1189-97. 2010
    ..The purpose of this study was to describe and evaluate the effectiveness of a telephone-based soy intervention...
  43. ncbi request reprint Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  44. ncbi request reprint Dietary soy isoflavone intake in older Japanese American women
    M M Rice
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Public Health Nutr 4:943-52. 2001
    ....
  45. pmc Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women
    Mellissa Yong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 20:1039-53. 2009
    ....
  46. pmc Zinc intake from supplements and diet and prostate cancer
    Alejandro Gonzalez
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Interdisciplinary Degree Program, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Nutr Cancer 61:206-15. 2009
    ..Because few other epidemiologic studies have investigated the association between zinc and prostate cancer, and these have not yielded consistent findings, further research is needed...
  47. ncbi request reprint UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial
    Jyh Lurn Chang
    Interdisciplinary Graduate Program in Nutritional Sciences, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Nutr 137:890-7. 2007
    ..002). These results suggest that serum bilirubin glucuronidation is modulated by dietary intervention, but factors such as UGT1A1 genotype and sex may affect the response to diet...
  48. ncbi request reprint Exercise effect on weight and body fat in men and women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Obesity (Silver Spring) 15:1496-512. 2007
    ..The effect of national exercise recommendations on adiposity is unknown and may differ by sex. We examined long-term effects of aerobic exercise on adiposity in women and men...
  49. ncbi request reprint Frequency of soy food consumption and serum isoflavone concentrations among Chinese women in Shanghai
    Cara L Frankenfeld
    Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Public Health Nutr 7:765-72. 2004
    ..The objective of this study was to validate the assessment of soy and isoflavone (daidzein and genistein) intakes, measured by an FFQ, by comparing intakes with serum isoflavone concentrations...
  50. ncbi request reprint Boron intake and prostate cancer risk
    Alejandro Gonzalez
    Cancer Prevention Pragram, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 18:1131-40. 2007
    ..Only one small epidemiological study has been conducted of boron, which found that those in the highest quartile of boron intake had less than half the risk of prostate cancer versus those in the lowest quartile...
  51. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  52. ncbi request reprint Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention
    Misty R Saracino
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nutr Cancer 59:121-41. 2007
    ..In this review, we summarize the knowledge of dietary modulation of UGTs, particularly by phytochemicals, and discuss the potential mechanisms by which phytochemicals regulate UGT transcription...
  53. ncbi request reprint Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence
    Alan R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nutr Cancer 42:1-9. 2002
    ..06) with high Brassica vegetable consumption. The epidemiological literature provides modest support for the hypothesis that high intakes of Brassica vegetables reduce prostate cancer risk...
  54. ncbi request reprint Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007
    ..There were no associations of leptin receptor genotypes or haplotypes and adenoma risk. The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas...
  55. ncbi request reprint Lignan and isoflavone excretion in relation to uterine fibroids: a case-control study of young to middle-aged women in the United States
    Charlotte Atkinson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Clin Nutr 84:587-93. 2006
    ..Phytoestrogens, including isoflavones and lignans, can act as weak estrogens or antiestrogens...
  56. ncbi request reprint Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1588-97. 2006
    ..A hypothesized mechanism for exercise-induced colon cancer risk reduction might be through alterations in colon crypt cell architecture and proliferation...
  57. ncbi request reprint Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake
    Charlotte Atkinson
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:253-60. 2002
    ..Measuring isoflavone excretion in one overnight urine collection serves as a biomarker of recent or past isoflavone intake, even in populations whose intake of soy foods is relatively low...
  58. ncbi request reprint FDR-controlling testing procedures and sample size determination for microarrays
    Shuying S Li
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stat Med 24:2267-80. 2005
    ..Thus, these existing procedures can overestimate the power and underestimate the sample size. Accordingly, we developed a simulation-based method to provide more accurate estimates for power and sample size...
  59. pmc Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States
    Mellissa Yong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 19:537-46. 2010
    ..We assessed relationships between functional polymorphisms in the UGT and SULT genes and breast density in premenopausal women...
  60. ncbi request reprint Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Nutr 82:620-6. 2005
    ..Colorectal epithelial cell proliferation has been used extensively as an intermediate endpoint biomarker for colorectal neoplasia...
  61. ncbi request reprint Risk factors for colorectal cancer in relation to number and size of aberrant crypt foci in humans
    Rebecca E Rudolph
    Veterans Affairs Puget Sound Health Care System, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:605-8. 2005
    ..Future research should be directed toward developing techniques to identify ACF that are likely to progress to cancer and the modifiable factors that promote or inhibit such progression...
  62. ncbi request reprint Selected nutritional biomarkers predict diet quality
    Marian L Neuhouser
    Cancer Prevention, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, POB 19024, MP 702, Seattle, WA 98109 1024, USA
    Public Health Nutr 6:703-9. 2003
    ..To examine associations of biomarkers of nutrient intake with overall diet quality...
  63. pmc Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet
    Fei Li
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 and 5Interdisplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle, WA 98195, USA
    J Nutr 139:1685-91. 2009
    ..In conclusion, human gut bacterial community composition was altered by cruciferous vegetable consumption, which could ultimately influence gut metabolism of bioactive food components and host exposure to these compounds...
  64. pmc Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:1696-708. 2010
    ..However, there have been no prospective studies of the association between the long-term use of these supplements and breast cancer risk...
  65. pmc Sources of cadmium exposure among healthy premenopausal women
    Scott V Adams
    Fred Hutchinson Cancer Research Center, PO Box 19024, M4 B402, Seattle, WA 98109, USA
    Sci Total Environ 409:1632-7. 2011
    ..Cigarettes are the dominant source of cadmium exposure among smokers; the primary source of cadmium in non-smokers is food. We investigated sources of cadmium exposure in a sample of healthy women...
  66. ncbi request reprint Familial correlations, segregation analysis, and nongenetic correlates of soy isoflavone-metabolizing phenotypes
    C L Frankenfeld
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, P O Box 19024, Seattle, WA 98109 1024, USA
    Exp Biol Med (Maywood) 229:902-13. 2004
    ..These results provide a foundation for further work to refine our understanding of heritable and environmental determinants of daidzein-metabolizing phenotypes...
  67. pmc Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study
    S S Runchey
    Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Eur J Clin Nutr 66:1146-52. 2012
    ..We aimed to assess the impact of GL on concentrations of IGF-1 and IGF-binding protein-3 (IGFBP-3)...
  68. ncbi request reprint Soy protein and bone mineral density in older men and women: a randomized trial
    K M Newton
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Maturitas 55:270-7. 2006
    ..Test the hypothesis that soy isoflavone supplementation preserves bone mineral density (BMD) in men and women...
  69. pmc Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial
    Sandi L Navarro
    Bastyr University, Kenmore, WA, USA
    Cancer Prev Res (Phila) 2:345-52. 2009
    ..These results may have implications for altering carcinogen metabolism through dietary intervention, particularly among UGT1A1*28/*28 individuals...
  70. ncbi request reprint Cruciferae interact with the UGT1A1*28 polymorphism to determine serum bilirubin levels in humans
    Sabrina Peterson
    Interdisciplinary Graduate Program in Nutritional Sciences, Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Nutr 135:1051-5. 2005
    ....
  71. pmc Correlates of toenail zinc in a free-living U.S. population
    Alejandro Gonzalez
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Program, University of Washington, Seattle, WA 98109 1024, USA
    Ann Epidemiol 18:74-7. 2008
    ..The study aim was to identify dietary and other factors that influence toenail zinc in a healthy population, in order to understand the usefulness of this biomarker in public health studies...
  72. pmc Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese women
    S Coosje Dijkstra
    Public Health Sciences Division, Fred Hutchinson Research Center, Seattle, WA 98109, USA
    J Nutr 140:1302-10. 2010
    ..The inverse associations between plasma isoflavone concentrations and RBC EPA and DPA and fibroadenoma risk suggest that higher intakes of soy foods and fatty fish may lower the risk of fibroadenomas...
  73. ncbi request reprint Indirect calorimetry protocol development for measuring resting metabolic rate as a component of total energy expenditure in free-living postmenopausal women
    N K Horner
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA 98109-1024, USA
    J Nutr 131:2215-8. 2001
    ....
  74. ncbi request reprint Evaluation of matrix-assisted laser desorption/ionization-time of flight mass spectrometry proteomic profiling: identification of alpha 2-HS glycoprotein B-chain as a biomarker of diet
    Breeana L Mitchell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, 98109, USA
    Proteomics 5:2238-46. 2005
    ..cruciferous) with 76% accuracy. The 2740 m/z peak was identified as the B-chain of alpha 2-HS glycoprotein, a serum protein previously found to vary with diet and be involved in insulin resistance and immune function...
  75. pmc DNA damage and repair: fruit and vegetable effects in a feeding trial
    Jyh Lurn Chang
    University of Washington, Seattle, Washington, USA
    Nutr Cancer 62:329-35. 2010
    ..With inconsistent findings in the literature, additional dietary intervention studies on the effect of F&V on DNA damage and repair are needed...
  76. ncbi request reprint Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 13:445-53. 2004
    ..These findings suggest that expression patterns can be used to identify a complex environmental exposure in humans...
  77. ncbi request reprint Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1
    Sabrina Peterson
    Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, WA 98195 4695, USA
    Food Chem Toxicol 44:1474-84. 2006
    ..These results suggest that in vivo CYP1A2 inhibition by apiaceous vegetables may be due to the phytochemicals present and imply that apiaceous vegetable intake may be chemopreventive by inhibiting CYP1A2-mediated carcinogen activation...
  78. doi request reprint Self-reported menopausal symptoms in a racially diverse population and soy food consumption
    S D Reed
    University of Washington, USA
    Maturitas 75:152-8. 2013
    ..Evaluate the association of self-reported vasomotor symptom (VMS) frequency with race/ethnicity among a diverse midlife US population and explore menopause symptom differences by dietary soy isoflavone (genistein+daidzein) consumption...
  79. pmc Mechanisms of action of isothiocyanates in cancer chemoprevention: an update
    Sandi L Navarro
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave, N M4 B402, Seattle, WA 98109, USA
    Food Funct 2:579-87. 2011
    ..In addition, the effects of dose, duration of exposure, and specificity of different ITC should be considered...
  80. pmc UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables
    Sandi L Navarro
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Drug Metab Dispos 39:1650-7. 2011
    ..Selected F&V known to affect UGT activity led to greater glucuronidation and less sulfation...
  81. ncbi request reprint Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    JAMA 292:65-74. 2004
    ..Isoflavones, estrogenlike compounds naturally occurring in plant foods, might confer positive effects with fewer adverse effects...
  82. ncbi request reprint Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 800, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:644-8. 2004
    ..6% versus 12.8%; P = 0.54). We found no evidence that a 12-month 83 mg/day isoflavone treatment alters serum PSA concentration or velocity in seemingly healthy men aged 50-80 years...
  83. ncbi request reprint Antibiotic use in relation to the risk of breast cancer
    Christine M Velicer
    Department of Epidemiology, University of Washington, Seattle, USA
    JAMA 291:827-35. 2004
    ....
  84. ncbi request reprint Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women
    Sanne Kreijkamp-Kaspers
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands
    Am J Clin Nutr 81:189-95. 2005
    ..The incidence of cardiovascular disease increases after menopause, possibly because of the decline in estrogen. Soy protein, a rich source of estrogen-like isoflavones, is hypothesized to improve vascular function...
  85. ncbi request reprint A randomized, placebo-controlled trial on the effects of soy protein containing isoflavones on quality of life in postmenopausal women
    Linda Kok
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Menopause 12:56-62. 2005
    ..However, because of known or suspected serious side-effects of conventional hormone therapy there is a need for alternatives...
  86. ncbi request reprint Soy protein isolates of varying isoflavone content exert minor effects on serum reproductive hormones in healthy young men
    Barbara L Dillingham
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Nutr 135:584-91. 2005
    ..The relevance of the magnitude of these effects to future prostate cancer risk requires further investigation...
  87. ncbi request reprint Nutrition and cancer prevention: small-scale human studies for the 21st century
    Johanna W Lampe
    Cancer Epidemiol Biomarkers Prev 13:1987-8. 2004
  88. ncbi request reprint Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls
    Kyung Bin Song
    Department of Food Science and Technology, Chungnam National University, Daejeon, Korea
    J Nutr 136:1347-51. 2006
    ..The additional observation that the prevalence of the ODMA-producer phenotype is lower in KAs suggests that daidzein-metabolizing patterns in general may differ between KAs and CAs...
  89. ncbi request reprint Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial
    Kristin L Campbell
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:1767-74. 2007
    ..The objective of this study is to examine the effects of a 12-month aerobic exercise program on expression of proteins that promote (Bax) or inhibit (Bcl-2) apoptosis in colon crypts...
  90. ncbi request reprint A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women
    Heather Greenlee
    Mailman School of Public Health, Columbia University, 7th Floor, 722 West 168th Street, New York, NY 10028, USA
    Cancer Epidemiol Biomarkers Prev 16:1601-9. 2007
    ..Overall, in this pilot study, the naturopathic interventions had no substantial effects on estrogen measures. Early-follicular phase androgens decreased with the botanical supplement...
  91. ncbi request reprint Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China
    Jackilen Shannon
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR, USA
    Am J Clin Nutr 85:1090-7. 2007
    ..The SI reflects the activity of several genes involved in lipid metabolism, including fatty acid synthase and steroyl coenzyme-A desaturase, that have been shown to be overexpressed in breast cancer...
  92. ncbi request reprint Soy protein isolates of varied isoflavone content do not influence serum thyroid hormones in healthy young men
    Barbara L Dillingham
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Thyroid 17:131-7. 2007
    ..The purpose of this study was to determine the effects of soy protein isolates of varied isoflavone content on circulating thyroid hormones in healthy young men...
  93. ncbi request reprint Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk
    Alina Vrieling
    Division of Experimental Therapy, Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Nutr 137:379-83. 2007
    ..This underlines the importance of taking into account equol status in future isoflavone intervention studies...
  94. ncbi request reprint Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings
    Mark Messina
    Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA, USA
    J Natl Cancer Inst 98:1275-84. 2006
    ..This paper summarizes the workshop findings and recommendations. The primary research recommendation is that the impact of isoflavones on breast tissue needs to be evaluated at the cellular level in women at high risk for breast cancer...
  95. ncbi request reprint An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels
    Mark Messina
    Loma Linda University, School of Public Health, Department of Nutrition, Loma Linda, CA 92350, USA
    J AOAC Int 89:1121-34. 2006
    ....
  96. ncbi request reprint Association between antibiotic use prior to breast cancer diagnosis and breast tumour characteristics (United States)
    Christine M Velicer
    Department of Epidemiology, University of Washington, Seattle, 98195, USA
    Cancer Causes Control 17:307-13. 2006
    ..To determine if breast tumour characteristics varied by antibiotic use prior to diagnosis in 2,266 women with primary, invasive breast cancer...
  97. ncbi request reprint Soy isoflavones, body composition, and physical performance
    Linda Kok
    The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Maturitas 52:102-10. 2005
    ..Decline in estradiol levels after menopause is hypothesized to contribute to this risk. Thus, hormone therapy (HT) might prevent or delay those changes. However, HT has serious side effects and alternative approaches are needed...
  98. ncbi request reprint Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy
    Sheila G West
    Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Womens Health (Larchmt) 14:253-62. 2005
    ..However, it is not clear whether adding soy to a low-fat diet has additional lipid-lowering benefits, and few previous studies have examined these effects in women using hormone replacement therapy (HRT+)...
  99. doi request reprint Reproducibility of serum leptin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 measurements
    Victoria M Chia
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Horm Res 69:295-300. 2008
    ....

Research Grants22

  1. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  2. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  3. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  4. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  5. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2007
    ..Resulting data will be used to guide future, larger, population-based studies of genetic differences in steroid hormone metabolism and may ultimately be used to identify women who are more susceptible to hormone-related conditions. ..
  6. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2007
    ..Furthermore, the additional data collected will add to the wealth of information available on this study population and will help guide further research on the impact of the gut microbiota on disease risk. ..
  7. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  8. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  9. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  10. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  11. Cruciferous vegetable feeding and inflammation: effect of GST genotypes
    Johanna W Lampe; Fiscal Year: 2010
    ..Moreover, it is important to test if particular genetic characteristics augment or decrease the effect of these vegetables. ..