Alan Kristal

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Associations of serum sex steroid hormone and 5α-androstane-3α,17β-diol glucuronide concentrations with prostate cancer risk among men treated with finasteride
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1823-32. 2012
  2. ncbi request reprint Differences in fat-related dietary patterns between black, Hispanic and White women: results from the Women's Health Trial Feasibility Study in Minority Populations
    A R Kristal
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Public Health Nutr 2:253-62. 1999
  3. ncbi request reprint Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence
    Alan R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nutr Cancer 42:1-9. 2002
  4. ncbi request reprint Obesity and prostate cancer mortality
    Alan R Kristal
    Fred Hutchinson Cancer Research Center and University of Washington, Cancer Association Program, 1100 Fairview Avenue N, M4 B402 PO Box 19024, Seattle, WA 98109 1024, USA
    Future Oncol 3:557-67. 2007
  5. ncbi request reprint Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Urol 177:1395-400; quiz 1591. 2007
  6. ncbi request reprint Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 106:320-8. 2006
  7. ncbi request reprint Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, M4 B402, P O Box 19024, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 14:2377-83. 2005
  8. ncbi request reprint Directions for future epidemiological research in lycopene and prostate cancer risk
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4686, USA
    J Nutr 135:2037S-9S. 2005
  9. ncbi request reprint Centralized blood processing for the selenium and vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte vi
    Alan R Kristal
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:727-30. 2005
  10. doi request reprint Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:925-34. 2008

Research Grants

Detail Information

Publications91

  1. pmc Associations of serum sex steroid hormone and 5α-androstane-3α,17β-diol glucuronide concentrations with prostate cancer risk among men treated with finasteride
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1823-32. 2012
    ..It also modestly increases serum testosterone (T), estrone (E(1)), and estradiol (E(2)). In this altered hormonal milieu, it is unknown whether serum concentrations of these hormones are associated with prostate cancer risk...
  2. ncbi request reprint Differences in fat-related dietary patterns between black, Hispanic and White women: results from the Women's Health Trial Feasibility Study in Minority Populations
    A R Kristal
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Public Health Nutr 2:253-62. 1999
    ..This report examines how sources of fat and patterns of fat-related dietary habits differed between black, Hispanic and white women participating in a randomized trial of a low-fat diet intervention...
  3. ncbi request reprint Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence
    Alan R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nutr Cancer 42:1-9. 2002
    ..06) with high Brassica vegetable consumption. The epidemiological literature provides modest support for the hypothesis that high intakes of Brassica vegetables reduce prostate cancer risk...
  4. ncbi request reprint Obesity and prostate cancer mortality
    Alan R Kristal
    Fred Hutchinson Cancer Research Center and University of Washington, Cancer Association Program, 1100 Fairview Avenue N, M4 B402 PO Box 19024, Seattle, WA 98109 1024, USA
    Future Oncol 3:557-67. 2007
    ....
  5. ncbi request reprint Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Urol 177:1395-400; quiz 1591. 2007
    ..We examined risk factors for incident symptomatic benign prostate hyperplasia in 5,667 Prostate Cancer Prevention Trial placebo arm participants who were free of benign prostatic hyperplasia at baseline...
  6. ncbi request reprint Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 106:320-8. 2006
    ..The objective of this study was to examine whether demographic and lifestyle characteristics are associated with prostate-specific antigen (PSA) levels and the rate of PSA increase (PSA velocity)...
  7. ncbi request reprint Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, M4 B402, P O Box 19024, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 14:2377-83. 2005
    ..We conclude that substantial dietary change has no short-term effects on biomarkers of cellular proliferation in Barrett esophagus or on clinical observations of the Barrrett segment...
  8. ncbi request reprint Directions for future epidemiological research in lycopene and prostate cancer risk
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4686, USA
    J Nutr 135:2037S-9S. 2005
  9. ncbi request reprint Centralized blood processing for the selenium and vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte vi
    Alan R Kristal
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:727-30. 2005
    ..Longer processing delays, however, have small but statistically significant effects on many analytes and substantially decrease lymphocyte viability...
  10. doi request reprint Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:925-34. 2008
    ..A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH...
  11. ncbi request reprint Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer
    Alan R Kristal
    Cnacer Prevention Program, Fred Hutchinson Cancer Research Program, Seattle, Washington 98109 1024, USA
    J Urol 171:S54-8; discussion S58. 2004
    ..Evidence is examined for the use of vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer...
  12. ncbi request reprint Mediating factors in dietary change: understanding the impact of a worksite nutrition intervention
    A R Kristal
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Health Educ Behav 27:112-25. 2000
    ....
  13. ncbi request reprint A randomized trial of a tailored, self-help dietary intervention: the Puget Sound Eating Patterns study
    A R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prev Med 31:380-9. 2000
    ..This study evaluated a tailored, multiple-component self-help intervention designed to promote lower fat and higher fruit and vegetable consumption...
  14. ncbi request reprint Precision and bias of food frequency-based measures of fruit and vegetable intakes
    A R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:939-44. 2000
    ..24-0.32). These results, which were consistent across diverse participant samples, suggest that the 5 A Day method yields both biased and imprecise measures of vegetable intake and that research to improve this measure is needed...
  15. pmc Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Alan R Kristal
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:638-46. 2011
    ..Lycopene has been promoted for prostate cancer prevention, despite the inconsistency of scientific evidence...
  16. pmc Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Epidemiol 172:566-77. 2010
    ..High intake of n-6 fatty acids, through their effects on inflammation and oxidative stress, may increase prostate cancer risk...
  17. pmc Serum steroid and sex hormone-binding globulin concentrations and the risk of incident benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, PO Box 19024, Seattle, WA 98109 1024, USA
    Am J Epidemiol 168:1416-24. 2008
    ..Genetic or environmental factors that affect the activity of 5-alpha-reductase may be important in the development of symptomatic BPH...
  18. doi request reprint Androgen receptor CAG repeat length is not associated with the risk of incident symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Washington 98109 1024, USA
    Prostate 70:584-90. 2010
    ..To examine whether androgen receptor (AR) CAG repeat length was associated with the risk of incident benign prostatic hyperplasia (BPH)...
  19. ncbi request reprint Steroid hormones and hormone-related genetic and lifestyle characteristics as risk factors for benign prostatic hyperplasia: review of epidemiologic literature
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Urology 64:201-11. 2004
  20. pmc Insulin-like growth factors and insulin-like growth factor-binding proteins and prostate cancer risk: results from the prostate cancer prevention trial
    Marian L Neuhouser
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA
    Cancer Prev Res (Phila) 6:91-9. 2013
    ..Further research is needed to understand better the risk incurred by high IGFBP2 and whether androgen-suppressing agents such as finasteride influence aspects of IGFBP2 physiology relevant to prostate carcinogenesis...
  21. pmc Finasteride modifies the relation between serum C-peptide and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Prev Res (Phila) 3:279-89. 2010
    ..Our novel finding is that the C-peptide-associated risk was attenuated by use of finasteride...
  22. ncbi request reprint Demographic and health-related correlates of herbal and specialty supplement use
    Susan Gunther
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 104:27-34. 2004
    ....
  23. ncbi request reprint A comprehensive examination of health conditions associated with obesity in older adults
    Ruth E Patterson
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Prev Med 27:385-90. 2004
    ....
  24. pmc Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study
    Linda M Dong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Nutr Cancer 60:39-48. 2008
    ..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus...
  25. ncbi request reprint Energy from fat is associated with obesity in U.S. men: results from the Prostate Cancer Prevention Trial
    Jessie Satia-Abouta
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, 1100 Fairview Avenue N, MP 702, Seattle, Washington, 98109, USA
    Prev Med 34:493-501. 2002
    ..However, the literature on fat consumption and human obesity is inconclusive. This research examines associations between dietary fat intake and obesity in men participating in the Prostate Cancer Prevention Trial...
  26. ncbi request reprint Diet and lifestyle correlates of lutein in the blood and diet
    Cheryl L Rock
    Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093 0901, USA
    J Nutr 132:525S-530S. 2002
    ..4% increase in serum lutein concentration. Notably, however, the amount of variance in serum concentration that is explained by demographic characteristics, health-related behaviors and lifestyle factors remains substantial...
  27. ncbi request reprint Changes in food sources of dietary fat in response to an intensive low-fat dietary intervention: early results from the Women's Health Initiative
    Ruth E Patterson
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Am Diet Assoc 103:454-60. 2003
    ..To evaluate changes in food sources of dietary fat made by participants in the Women's Health Initiative Low-Fat Dietary Modification Trial...
  28. ncbi request reprint Nonsteroidal anti-inflammatory drug use, body mass index, and anthropometry in relation to genetic and flow cytometric abnormalities in Barrett's esophagus
    Thomas L Vaughan
    Program in Epidemiology T L V, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:745-52. 2002
    ..We also conclude that NSAID use may reduce the risk of progression to cancer in this population. Prospective studies are needed to confirm these results...
  29. ncbi request reprint Associations of energy, fat, calcium, and vitamin D with prostate cancer risk
    Alan R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 981091024, USA
    Cancer Epidemiol Biomarkers Prev 11:719-25. 2002
    ..These results are consistent with general dietary guidelines to moderate consumption of total energy and fat, and they motivate further research to consider the potential benefits and risks of high calcium intake...
  30. pmc Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality
    Gaia Pocobelli
    Department of Epidemiology, University of Washington, Seattle, USA
    Am J Epidemiol 170:472-83. 2009
    ..Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users...
  31. ncbi request reprint Supplement use among cancer survivors in the Vitamins and Lifestyle (VITAL) study cohort
    Heather Greenlee
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Altern Complement Med 10:660-6. 2004
    ..These analyses describe the use of specific supplements by 10,857 cancer survivors in comparison to cancer-free controls (n = 64,226)...
  32. ncbi request reprint Is olestra consumption associated with changes in dietary intake, serum lipids, and body weight?
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nutrition 19:754-9. 2003
    ..This report gives associations of olestra consumption (in savory snacks) with changes in nutrient intake, serum lipid concentrations, and body weight 1 y after these snacks became available nationally in the United States...
  33. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  34. ncbi request reprint Alcohol use and the risk of prostate cancer: results from the VITAL cohort study
    Christine M Velicer
    Department of Epidemiology, and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98195, USA
    Nutr Cancer 56:50-6. 2006
    ..Associations of alcohol use with prostate cancer are modest and complex. More detailed assessment of specific alcoholic beverages is warranted in future studies...
  35. ncbi request reprint Calcium intake and 10-year weight change in middle-aged adults
    Alejandro J Gonzalez
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 474, PO Box 19024, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 106:1066-73; quiz 1082. 2006
    ..The goal of this study was to examine the purported effects of calcium on modulating body weight...
  36. ncbi request reprint Yoga practice is associated with attenuated weight gain in healthy, middle-aged men and women
    Alan R Kristal
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash, USA
    Altern Ther Health Med 11:28-33. 2005
    ..Yoga is promoted or weight maintenance, but there is little evidence of its efficacy...
  37. ncbi request reprint Estimated impact of the prostate cancer prevention trial on population mortality
    Steven B Zeliadt
    Cancer 104:1556-7; author reply 1557. 2005
  38. ncbi request reprint Psychosocial predictors of diet and acculturation in Chinese American and Chinese Canadian women
    Jessie Satia-Abouta
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, USA
    Ethn Health 7:21-39. 2002
    ..To examine the influence of diet-related psychosocial constructs on the dietary practices of Chinese populations living in North America...
  39. pmc A dietary intervention to elicit rapid and complex dietary changes for studies investigating the effects of diet on tissues collected during invasive surgical procedures
    Jeannette M Schenk
    Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, USA
    J Am Diet Assoc 109:459-63. 2009
    ..Further studies in larger and more diverse populations are needed to fully understand the potential of this novel intervention approach...
  40. pmc Effect of population trends in body mass index on prostate cancer incidence and mortality in the United States
    Megan Dann Fesinmeyer
    Fred Hutchinson Cancer Research Center, Department of Veterans Affairs Puget Sound Health Care System, Fairview Avenue North, M2 B230, PO Box 19024, Seattle WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:808-15. 2009
    ..0% (under different survival for obese and nonobese cases) in 2002. We conclude that increasing obesity prevalence since 1980 has partially obscured declines in prostate cancer mortality...
  41. ncbi request reprint Not the time to abandon the food frequency questionnaire: counterpoint
    Alan R Kristal
    Cancer Prevention Program, Fred Hutchinson Canser Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:1759-60. 2006
  42. ncbi request reprint Dietary supplement use and medical conditions: the VITAL study
    Jessie Satia-Abouta
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Prev Med 24:43-51. 2003
    ....
  43. ncbi request reprint First International Conference on Chemoprevention of Prostate Cancer. Overview consensus statement
    Ian M Thompson
    University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Urol 171:S3-4. 2004
  44. ncbi request reprint Cruciferous vegetables and prostate cancer risk: confounding by PSA screening
    Alan R Kristal
    Cancer Epidemiol Biomarkers Prev 13:1265. 2004
  45. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
    ..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...
  46. pmc Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial
    Andrea Z LaCroix
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, PO 19024, Seattle, WA 98109
    JAMA 305:1305-14. 2011
    ..1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported...
  47. pmc Evaluation of the branched-chain DNA assay for measurement of RNA in formalin-fixed tissues
    Beatrice S Knudsen
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seatle, Washington, USA
    J Mol Diagn 10:169-76. 2008
    ..It also appears to be well suited for the clinical analysis of FFPE tissues with diagnostic or prognostic gene expression biomarker panels for use in patient treatment and management...
  48. doi request reprint Finasteride, prostate cancer, and weight gain: evidence for genetic or environmental factors that affect cancer outcomes during finasteride treatment
    Yoonju Song
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 68:281-6. 2008
    ..Finasteride affects both prostate cancer risk and body weight. We examined whether, during 7 years of finasteride treatment, the magnitude of weight change was associated with the diagnosis of no, low-, or high-grade cancer...
  49. pmc Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and risk of benign prostate hyperplasia in the prostate cancer prevention trial
    Marian L Neuhouser
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Prostate 68:1477-86. 2008
    ....
  50. pmc Dietary supplement use and prostate cancer risk in the Carotene and Retinol Efficacy Trial
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:2202-6. 2009
    ..CARET only included smokers, so findings reported here may not apply to nonsmokers. Our results are consistent with other studies suggesting that dietary supplements may influence prostate cancer risk...
  51. ncbi request reprint Dietary determinants of plasma enterolactone
    Neilann K Horner
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:121-6. 2002
    ....
  52. pmc Transition of a clinical trial into translational research: the prostate cancer prevention trial experience
    Phyllis J Goodman
    Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Cancer Prev Res (Phila) 3:1523-33. 2010
    ..We provide a framework for doing collaborative research in an international setting structured around a common theme of a clinical trial...
  53. pmc Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:3185-8. 2010
    ..Several epidemiologic studies have reported inverse associations between nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only...
  54. ncbi request reprint Psychosocial factors and dietary habits associated with vegetable consumption
    Jessie A Satia
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109 1024, USA
    Nutrition 18:247-54. 2002
    ..We assessed scales of psychosocial factors and dietary habits related to vegetable consumption and examined associations of these scales with vegetable intake...
  55. pmc Serum adiponectin, C-peptide and leptin and risk of symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial
    Jeannette M Schenk
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Washington 98109 1024, USA
    Prostate 69:1303-11. 2009
    ..We examined whether adiponectin, leptin, and C-peptide were associated with incident, symptomatic BPH and whether these factors mediate the relationship between obesity and BPH risk...
  56. pmc Biomarkers of systemic inflammation and risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial
    Jeannette M Schenk
    Schenk, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 171:571-82. 2010
    ..82; interleukin 6: OR = 1.79, 95% CI: 1.32, 2.42); these associations were only in men aged <65 years. Results suggest that systemic inflammation or lower levels of soluble receptors that bind inflammatory cytokines increase BPH risk...
  57. pmc Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among Yup'ik Eskimos
    Zeina Makhoul
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Nutr 91:777-85. 2010
    ..Few studies have examined the associations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with biomarkers of chronic disease risk in populations with high intakes...
  58. ncbi request reprint Reliability and validity of 2 single-item measures of psychosocial stress
    Alyson J Littman
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Epidemiology 17:398-403. 2006
    ..The objective of this study was to evaluate the measurement characteristics of 2 single-item measures on the amount of stress and the ability to handle stress...
  59. ncbi request reprint Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:75-87. 2008
    ..We aimed to investigate the association of vitamin E and selenium supplementation with prostate cancer in the VITamins And Lifestyle (VITAL) study, a cohort study specifically designed to examine supplement use and future cancer risk...
  60. ncbi request reprint Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations
    Marian L Neuhouser
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 83:624-31. 2006
    ....
  61. pmc Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagus
    Rebecca E Rudolph
    Cancer Prevention and Trials Program, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
    J Natl Cancer Inst 95:750-7. 2003
    ..We used a cross-sectional study to investigate the relationship between serum selenium levels and markers of neoplastic progression among persons with Barrett's esophagus...
  62. ncbi request reprint A practical method for collecting 3-day food records in a large cohort
    Ann Shattuck Kolar
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Epidemiology 16:579-83. 2005
    ..However, food records are considered unsuitable for large studies due to the need to train participants and to review and correct completed records...
  63. ncbi request reprint Serum trans-fatty acids are associated with risk of prostate cancer in beta-Carotene and Retinol Efficacy Trial
    Irena B King
    Cancer Prevention Program, Division of Public Health Sciences, Public Health Sciences Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Suite M 5A864, Seattle WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:988-92. 2005
    ..Additional studies are needed to confirm these findings and better control for factors, such as use of prostate-specific antigen screening, which may confound this association...
  64. ncbi request reprint Recreational physical activity and prostate cancer risk (United States)
    Alyson J Littman
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, 19024, Seattle, WA 98109 1024, USA
    Cancer Causes Control 17:831-41. 2006
    ..To examine recreational physical activity (PA) and prostate cancer risk in a large cohort of men living in Washington State, focusing on frequency and type of physical activity at various times throughout life...
  65. ncbi request reprint Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1977-83. 2006
    ..Obesity increases the risk of high-grade but decreases the risk of low-grade prostate cancer, and this relationship is independent of the lower risk for prostate cancer among men with diabetes...
  66. ncbi request reprint (n-6) PUFA increase and dairy foods decrease prostate cancer risk in heavy smokers
    Marian L Neuhouser
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 137:1821-7. 2007
    ..42, 95% CI = 0.25-0.70). Our findings suggest that associations of dietary fat with prostate cancer risk may vary by type of fat or fat-containing food, and that risk may vary by host factors, including family history and smoking...
  67. ncbi request reprint VITamins And Lifestyle cohort study: study design and characteristics of supplement users
    Emily White
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 159:83-93. 2004
    ..These methods may be useful to other researchers implementing a large cohort study or designing a passive follow-up system...
  68. ncbi request reprint Anthropometrics and prostate cancer risk
    Alyson J Littman
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98101, USA
    Am J Epidemiol 165:1271-9. 2007
    ..Results from this study demonstrate the complexity of prostate cancer epidemiology and the importance of examining risk factors by tumor characteristics...
  69. ncbi request reprint Melanoma and lifetime UV radiation
    Cam C Solomon
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Cancer Causes Control 15:893-902. 2004
    ..The goal of this case-control study was to quantify the risks of melanoma associated with UV exposure at different periods of life...
  70. ncbi request reprint Assessment of a one-page questionnaire on long-term recreational physical activity
    Alyson J Littman
    Fred Hutchinson Cancer Research Center, Public Health Sciences, Seattle, Washington 98109 1024, USA
    Epidemiology 15:105-13. 2004
    ..Although there is considerable published research on methods to assess current or recent recreational physical activity, there are few short, self-administered questionnaires designed to assess long-term physical activity...
  71. ncbi request reprint Diet and exercise habits of patients with diabetes, dyslipidemia, cardiovascular disease or hypertension
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Coll Nutr 21:394-401. 2002
    ....
  72. doi request reprint Coffee, tea, colas, and risk of epithelial ovarian cancer
    Yoon Ju Song
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 99109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:712-6. 2008
    ..Green tea, which is commonly consumed in countries with low ovarian cancer incidence, should be further investigated for its cancer prevention properties...
  73. ncbi request reprint Reliability and validity of self-report of vitamin and mineral supplement use in the vitamins and lifestyle study
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Epidemiol 157:944-54. 2003
    ..07). This self-administered questionnaire demonstrated high reproducibility and validity for collecting detailed information on supplement use...
  74. ncbi request reprint Localized prostate cancer: quality of life meets Whitmore's legacy
    Carlos Bermejo
    J Natl Cancer Inst 96:1348-9. 2004
  75. pmc Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:964-70. 2008
    ..These findings suggest that higher iron intake may be associated with risk of clinically aggressive prostate cancer, and that endogenous antioxidant capabilities may modify these associations...
  76. ncbi request reprint Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 97:94-102. 2005
    ....
  77. ncbi request reprint Influence of surgical manipulation on prostate gene expression: implications for molecular correlates of treatment effects and disease prognosis
    Daniel W Lin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Clin Oncol 24:3763-70. 2006
    ..This study examines whether there are transcript alterations associated with surgical resection of the prostate gland by radical retropubic prostatectomy...
  78. pmc Correlation between selenium concentrations and glutathione peroxidase activity in serum and human prostate tissue
    Yumie Takata
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 69:1635-42. 2009
    ..Hence, we investigated the correlation between serum and prostate tissue selenium concentrations and prostate tissue activity of glutathione peroxidase (GPX), a major selenoenzyme with antioxidant properties...
  79. ncbi request reprint Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle-aged men
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 109:1192-202. 2007
    ..The objective of this study was to examine associations between obesity and the risks of developing metastasis or prostate cancer-specific mortality in a population-based cohort of men with prostate cancer...
  80. ncbi request reprint Diet and trend in prostate-specific antigen: inferences for prostate cancer risk
    Alan R Kristal
    J Clin Oncol 20:3570-1. 2002
  81. ncbi request reprint The association of body mass index and prostate-specific antigen in a population-based study
    Jacques Baillargeon
    Center for Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas 78284 7802, USA
    Cancer 103:1092-5. 2005
    ..One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma...
  82. doi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  83. ncbi request reprint Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues
    Daniel W Lin
    Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 16:2150-4. 2007
    ..We examined the feasibility of using gene expression changes in human prostate epithelium as a measure of response to a dietary intervention...
  84. ncbi request reprint Psychological distress is associated with unhealthful dietary practices
    Jennifer H Cohen
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 102:699-703. 2002
  85. pmc Total mortality risk in relation to use of less-common dietary supplements
    Gaia Pocobelli
    Department of Epidemiology, University of Washington, Seattle, USA
    Am J Clin Nutr 91:1791-800. 2010
    ..Dietary supplement use is common in older US adults; however, data on health risks and benefits are lacking for a number of supplements...
  86. pmc Prostate-specific antigen: a misused and maligned prostate cancer biomarker
    Ian M Thompson
    J Natl Cancer Inst 100:1487-8. 2008
  87. ncbi request reprint Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1115-20. 2007
    ....
  88. pmc Development and validation of the mindful eating questionnaire
    Celia Framson
    Interdisciplinary Program in Nutritional Sciences, University of Washington, Seattle, USA
    J Am Diet Assoc 109:1439-44. 2009
    ..Its negative association with body mass index and positive association with yoga provide evidence of construct validity. Further evaluation in more diverse populations is warranted...
  89. ncbi request reprint Buccal cell DNA yield, quality, and collection costs: comparison of methods for large-scale studies
    Irena B King
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1130-3. 2002
    ..We conclude that the collection of DNA with cytobrushes using simple instructions is cost effective in large-scale studies, and yields sufficient quantity and quality of DNA for genotyping...
  90. ncbi request reprint Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:25-31. 2008
    ..The aim of this study was to examine associations of smoking at the time of diagnosis with the risk of prostate cancer death in a population-based cohort of men with prostate cancer...
  91. ncbi request reprint Is it time to abandon the food frequency questionnaire?
    Alan R Kristal
    Cancer Epidemiol Biomarkers Prev 14:2826-8. 2005

Research Grants3

  1. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2003
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  2. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2004
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  3. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..