Affiliation: Fred Hutchinson Cancer Research Center
- n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and womenMario Kratz
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Nutr 143:1340-7. 2013..We conclude that a relatively high dose of n3 PUFAs from plant and marine sources did not significantly lower adipose tissue or systemic inflammation in overweight to moderately obese healthy men and women over 14 wk. ..
- The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic diseaseMario Kratz
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mail Stop M4 B402, Seattle, WA, 98109, USA
Eur J Nutr 52:1-24. 2013..To comprehensively review the data on the relationship between the consumption of dairy fat and high-fat dairy foods, obesity, and cardiometabolic disease...
- Exchanging carbohydrate or protein for fat improves lipid-related cardiovascular risk profile in overweight men and women when consumed ad libitumMario Kratz
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Investig Med 58:711-9. 2010..The impact of low-fat diets on the plasma lipoprotein profile is incompletely understood...
- Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophyMario Kratz
Department of Medicine, University of Washington, Seattle, Washington 98109, USA
J Clin Endocrinol Metab 93:959-66. 2008..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
- Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and womenMario Kratz
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
Am J Clin Nutr 87:347-53. 2008..Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents...
- Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trialMario Kratz
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Nutr Metab (Lond) 6:24. 2009..abstract:..
- Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese childrenChristian L Roth
Seattle Children s Hospital Research Institute, University of Washington, Seattle, WA 98101, USA
Metabolism 60:445-52. 2011....
- Comparison and validation of 2 analytical methods for measurement of urinary sucrose and fructose excretionXiaoling Song
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Electronic address
Nutr Res 33:696-703. 2013..7% of the sum of urinary fructose and sucrose. Therefore, we caution using these biomarkers to predict sugars consumption before other factors that determine urinary sugars excretion are understood. ..
- Lifestyle factors and inflammation: associations by body mass indexElizabeth D Kantor
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 8:e67833. 2013..These results suggest that posited anti-inflammatory drugs and behaviors may be less strongly associated with inflammation among the obese than among lower weight persons. ..
- Inflammation and oxidative stress markers and esophageal adenocarcinoma incidence in a Barrett's esophagus cohortSheetal Hardikar
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Epidemiology, University of Washington, Seattle, Washington
Cancer Epidemiol Biomarkers Prev 23:2393-403. 2014..Persons with Barrett's esophagus experience increased risk of esophageal adenocarcinoma. Prediagnostic inflammation markers predict several cancers, but their role in predicting esophageal adenocarcinoma is unknown...
- Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adultsSandi L Navarro
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA
J Nutr 144:1850-7. 2014..Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response...
- Effects of a high-protein diet on regulation of phosphorus homeostasisRobin A Kremsdorf
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA
J Clin Endocrinol Metab 98:1207-13. 2013..High-protein diets, which are popular for weight loss, contain large quantities of phosphorus. Phosphorus excess and consequent changes in phosphorus regulatory hormones are implicated in vascular calcification and cardiovascular disease...
- Reliability of serum biomarkers of inflammation from repeated measures in healthy individualsSandi L Navarro
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 21:1167-70. 2012..Biomarkers of low-grade systemic inflammation are used to study the associations of inflammation with chronic diseases, including cancer. However, relatively little is known about the intraindividual variability of most of these measures...
- Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humansMario Kratz
From the Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Program MK and XS and Biostatistics Program CD, Seattle, WA the Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA MK and KMU the Departments of Epidemiology MK and Pathology MMY, University of Washington, Seattle, WA the University of Washington Northwest Lipid Research Laboratories, Seattle, WA SM Benaroya Research Institute, Virginia Mason Medical Center, Seattle, WA JEN and KVK the University of Washington Institute of Translational Health Sciences, Seattle, WA HSC and the VA Puget Sound Health Care System, Department of Medicine, Division of Endocrinology, Seattle, WA KMU
Am J Clin Nutr 99:1385-96. 2014..Plasma phospholipid concentrations of trans-palmitoleic acid (trans-16:1n-7), a biomarker of dairy fat intake, are inversely associated with incident type 2 diabetes in 2 US cohorts...
- Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthaseJung Ting Lee
Departments of Medicine J T L, n p, N C L, M M A, L B, K E F S, B V Y, K E B, R C L, M K, J W H, Pathology K E B, and Epidemiology E A K, M K, University of Washington, Seattle, Washington 98105 and Fred Hutchinson Cancer Research Center D K H, M K, Public Health Sciences, Seattle, Washington 98103
Endocrinology 155:3409-20. 2014..We propose that MMP12 acts as a double-edged sword by promoting insulin resistance while combatting adipose tissue expansion...
- Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processingDerek K Hagman
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Immunol Methods 386:50-9. 2012....
- Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophagesMario Kratz
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Department of Epidemiology, University of Washington, Seattle, WA 98195, USA Department of Medicine, University of Washington, Seattle, WA 98195, USA
Cell Metab 20:614-25. 2014..Collectively, our data provide important mechanistic insights into pathways that drive the metabolic-disease-specific phenotype of macrophages. ..
- Effects of dietary fat and saturated fat content on liver fat and markers of oxidative stress in overweight/obese men and women under weight-stable conditionsAnna Marina
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Nutrients 6:4678-90. 2014..On the other hand, a diet very high in fat and saturated fat had no effect on hepatic triglyceride or markers of metabolism, inflammation and oxidative stress. ..
- Intraindividual variability over time in plasma biomarkers of inflammation and effects of long-term storageSheetal Hardikar
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Causes Control 25:969-76. 2014..However, more information is needed on the measurement error in these markers due to laboratory error, within-person variation over time, and long-term storage...
- A pilot study of sampling subcutaneous adipose tissue to examine biomarkers of cancer riskKristin L Campbell
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
Cancer Prev Res (Phila) 2:37-42. 2009..Subcutaneous adipose tissue biopsies from healthy, overweight individuals provide adequate amounts for RNA extraction, gene expression, and other assays of relevance to cancer prevention research...
- Biomarkers of systemic inflammation and risk of incident, symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trialJeannette M Schenk
Schenk, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 171:571-82. 2010..82; interleukin 6: OR = 1.79, 95% CI: 1.32, 2.42); these associations were only in men aged <65 years. Results suggest that systemic inflammation or lower levels of soluble receptors that bind inflammatory cytokines increase BPH risk...
- Increased risk of orofacial clefts associated with maternal obesity: case-control study and Monte Carlo-based bias analysisMarni Stott-Miller
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
Paediatr Perinat Epidemiol 24:502-12. 2010..However, it is also possible that these results represent a stronger underlying association. More precise exposure measurement could help distinguish between these two possibilities...
- Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokinesChristian L Roth
Division of Endocrinology, Seattle Children s Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
J Obes 2011:495101. 2011..Furthermore, 25(OH)D correlated significantly with adiponectin, but not with resistin. Our results suggest that hypovitaminosis D is a risk factor for developing insulin resistance independent of adiposity...
- Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemiaBirgitta Jacobs
Institute of Arteriosclerosis Research, University of Muenster, Muenster, Germany
J Nutr 134:1400-5. 2004..5 mmol/L). However, a lower-fat diet is more suitable for some subjects with more distinctly elevated triglyceride concentrations...
- Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptorsAndrea Cignarella
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Atherosclerosis 179:229-36. 2005....
- The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and womenMario Kratz
Institute of Arteriosclerosis Research, University of Muenster, Domagkstrasse 3, 48149 Muenster, Germany
J Clin Endocrinol Metab 87:5008-14. 2002..Thus, it is proposed that serum leptin levels were affected by the high amount of alpha-linolenic acid in rapeseed oil. However, questions remain as to why this diet differently affected serum leptin in men and women...
- Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and womenMario Kratz
Institute of Arteriosclerosis Research at the University of Münster, Domagkstrasse 3, 48149 Munster, Germany
J Nutr 132:715-8. 2002..However, the small magnitude of this reduction also suggests that the composition of dietary fat is not a major factor affecting LDL size...