Steven T Kosak

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Coordinate gene regulation during hematopoiesis is related to genomic organization
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Biol 5:e309. 2007
  2. pmc Networking the nucleus
    Indika Rajapakse
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Syst Biol 6:395. 2010
  3. ncbi request reprint A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements
    Tobias Ragoczy
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Chromosome Res 11:513-25. 2003
  4. ncbi request reprint Gene order and dynamic domains
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 306:644-7. 2004
  5. ncbi request reprint Form follows function: The genomic organization of cellular differentiation
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:1371-84. 2004
  6. pmc The emergence of lineage-specific chromosomal topologies from coordinate gene regulation
    Indika Rajapakse
    Division of Basic Sciences and Department of Biostatistics and Biomathematics, Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:6679-84. 2009
  7. ncbi request reprint The undiscovered country: chromosome territories and the organization of transcription
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:690-2. 2002
  8. ncbi request reprint Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    Steven T Kosak
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Science 296:158-62. 2002

Collaborators

Detail Information

Publications8

  1. pmc Coordinate gene regulation during hematopoiesis is related to genomic organization
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Biol 5:e309. 2007
    ..We suggest that proximity in the form of chromosomal gene distribution and homolog association may be the basis for organizing the genome for coordinate gene regulation during cellular differentiation...
  2. pmc Networking the nucleus
    Indika Rajapakse
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Syst Biol 6:395. 2010
    ..Studying the interaction within and among networks provides a useful framework for investigating the complex organization and dynamic function of the nucleus...
  3. ncbi request reprint A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements
    Tobias Ragoczy
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Chromosome Res 11:513-25. 2003
    ..We therefore suggest that the looping of gene loci from their CTs may reflect poised and repressed states, as well as the previously documented transcriptionally active state...
  4. ncbi request reprint Gene order and dynamic domains
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 306:644-7. 2004
    ..Contrary to prevailing notions in this postgenomic era, the bacteriophage lambda, a paragon of simplicity, may still have a few things to teach us with respect to these facets of nonrandom genomes...
  5. ncbi request reprint Form follows function: The genomic organization of cellular differentiation
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:1371-84. 2004
    ..Current network theories may provide a useful framework for modeling the inherent complexity the functional organization of the nucleus...
  6. pmc The emergence of lineage-specific chromosomal topologies from coordinate gene regulation
    Indika Rajapakse
    Division of Basic Sciences and Department of Biostatistics and Biomathematics, Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:6679-84. 2009
    ..We discuss how these observations may be generally relevant to cell fate decisions encountered by progenitor/stem cells...
  7. ncbi request reprint The undiscovered country: chromosome territories and the organization of transcription
    Steven T Kosak
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:690-2. 2002
    ..A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model...
  8. ncbi request reprint Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    Steven T Kosak
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
    Science 296:158-62. 2002
    ..We suggest that subnuclear positioning represents a novel means of regulating transcription and recombination of IgH and Igkappa loci during lymphocyte development...