Timothy J King
Affiliation: Fred Hutchinson Cancer Research Center
- King T, Lampe P. Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation. Carcinogenesis. 2004;25:669-80 pubmed....
- King T, Lampe P. The gap junction protein connexin32 is a mouse lung tumor suppressor. Cancer Res. 2004;64:7191-6 pubmed..001) compared with wild-type tumors, implicating this signaling pathway in Cx32/gap junction intercellular communication-associated lung tumorigenesis. ..
- King T, Gurley K, Prunty J, Shin J, Kemp C, Lampe P. Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene. 2005;24:1718-26 pubmed..This study demonstrates that tissues dependent on Cx32 tumor suppression, such as the liver and lung, exhibit altered tumorigenesis and tumor biology (MAPK pathway activation) related to p27 status. ..