Affiliation: Fred Hutchinson Cancer Research Center
King T, Lampe P. Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation. Carcinogenesis. 2004;25:669-80 pubmed
King T, Lampe P. The gap junction protein connexin32 is a mouse lung tumor suppressor. Cancer Res. 2004;64:7191-6 pubmed
..001) compared with wild-type tumors, implicating this signaling pathway in Cx32/gap junction intercellular communication-associated lung tumorigenesis. ..
King T, Gurley K, Prunty J, Shin J, Kemp C, Lampe P. Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene. 2005;24:1718-26 pubmed
..This study demonstrates that tissues dependent on Cx32 tumor suppression, such as the liver and lung, exhibit altered tumorigenesis and tumor biology (MAPK pathway activation) related to p27 status. ..