Timothy J King

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Carcinog 35:29-41. 2002
  2. ncbi request reprint Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Carcinogenesis 25:669-80. 2004
  3. ncbi request reprint The gap junction protein connexin32 is a mouse lung tumor suppressor
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, and Department of Pathobiology, University of Washington, Seattle, Washington, USA
    Cancer Res 64:7191-6. 2004
  4. ncbi request reprint Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Oncogene 24:1718-26. 2005
  5. pmc Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1-deficient mice
    Timothy J King
    Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cell Commun Adhes 12:293-305. 2005
  6. pmc Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart
    Paul D Lampe
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Department of Pathobiology, University of Washington, 1100 Fairview Avenue N, M5C800, PO Box 19024, Seattle, WA 98109, USA
    J Cell Sci 119:3435-42. 2006
  7. pmc Temporal regulation of connexin phosphorylation in embryonic and adult tissues
    Timothy J King
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, USA
    Biochim Biophys Acta 1719:24-35. 2005
  8. ncbi request reprint Connexins as targets for cancer chemoprevention and chemotherapy
    Timothy J King
    Hawaii Biotech, Inc, Aiea, HI 96701, USA
    Biochim Biophys Acta 1719:146-60. 2005
  9. pmc Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation
    Jose F Ek-Vitorin
    Department of Physiology, University of Arizona, Tucson 85724, USA
    Circ Res 98:1498-505. 2006

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Carcinog 35:29-41. 2002
    ..This study also further supports the hypothesis that loss of Cx43/GJIC in human tumors may play an important role in the dysregulation of normal growth control...
  2. ncbi request reprint Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Carcinogenesis 25:669-80. 2004
    ....
  3. ncbi request reprint The gap junction protein connexin32 is a mouse lung tumor suppressor
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, and Department of Pathobiology, University of Washington, Seattle, Washington, USA
    Cancer Res 64:7191-6. 2004
    ..001) compared with wild-type tumors, implicating this signaling pathway in Cx32/gap junction intercellular communication-associated lung tumorigenesis...
  4. ncbi request reprint Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner
    Timothy J King
    Cancer Prevention Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Oncogene 24:1718-26. 2005
    ..This study demonstrates that tissues dependent on Cx32 tumor suppression, such as the liver and lung, exhibit altered tumorigenesis and tumor biology (MAPK pathway activation) related to p27 status...
  5. pmc Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1-deficient mice
    Timothy J King
    Molecular Diagnostics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cell Commun Adhes 12:293-305. 2005
    ..Furthermore, these studies demonstrate that different carcinogens interact disparately with Cx32/p27Kip1 genotypic backgrounds in situ resulting in varied tumorigenic response...
  6. pmc Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart
    Paul D Lampe
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Department of Pathobiology, University of Washington, 1100 Fairview Avenue N, M5C800, PO Box 19024, Seattle, WA 98109, USA
    J Cell Sci 119:3435-42. 2006
    ..These data suggest that phosphorylation of Cx43 at serine residues 325, 328 and/or 330 influences channel permselectivity and regulates the efficiency of gap junction assembly...
  7. pmc Temporal regulation of connexin phosphorylation in embryonic and adult tissues
    Timothy J King
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5C800, Box 19024, Seattle, WA 98109, USA
    Biochim Biophys Acta 1719:24-35. 2005
    ..These new antibody tools and those under development will allow us to correlate specific phosphorylation events with changes in connexin function...
  8. ncbi request reprint Connexins as targets for cancer chemoprevention and chemotherapy
    Timothy J King
    Hawaii Biotech, Inc, Aiea, HI 96701, USA
    Biochim Biophys Acta 1719:146-60. 2005
    ..Here, we discuss the important role of connexins and GJC in tumorigenesis and suggest the possibility of connexins as potential anti-oncogenic targets for chemoprevention and/or chemotherapy...
  9. pmc Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation
    Jose F Ek-Vitorin
    Department of Physiology, University of Arizona, Tucson 85724, USA
    Circ Res 98:1498-505. 2006
    ..Our data suggest that the selectivity of gap junction channels at intercalated disks is increased early in ischemia...