- DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclassesAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Epigenetics 6:1403-12. 2011..Additional validation of those CpG sites that distinguished BE from BE + HGD and EAC may lead to the discovery of useful biomarkers with potential clinical applications in the diagnosis and prognosis of BE and EAC...
- Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinomaAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genes Chromosomes Cancer 51:384-93. 2012..Thus, PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of BE to EAC in a subset of patients via decreased desmosome assembly and increased cell motility...
- Epigenetic biomarkers in esophageal cancerAndrew M Kaz
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States Research and Development Service, VA Puget Sound Health Care System, Seattle, WA, United States Electronic address
Cancer Lett 342:193-9. 2014..Finally, special attention will be paid to some of the challenges that must be overcome in order to develop clinically useful esophageal cancer biomarkers...