KEITH JEROME

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Herpes simplex virus genes Us3, Us5, and Us12 differentially regulate cytotoxic T lymphocyte-induced cytotoxicity
    Martine Aubert
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 94109, USA
    Viral Immunol 19:391-408. 2006
  2. pmc Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome
    Keith R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98105, USA
    Diagn Microbiol Infect Dis 71:66-71. 2011
  3. ncbi request reprint HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 167:3928-35. 2001
  4. ncbi request reprint Measurement of CTL-induced cytotoxicity: the caspase 3 assay
    K R Jerome
    Fred Hutchinson Cancer Research Center, Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    Apoptosis 8:563-71. 2003
  5. pmc Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 73:8950-7. 1999
  6. ncbi request reprint Inhibition of apoptosis by primary isolates of herpes simplex virus
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Arch Virol 146:2219-25. 2001
  7. pmc Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1-specific CD8(+) cytotoxic T lymphocytes
    L Musey
    Departments of Medicine, University of Washington, Seattle 98109, USA
    J Virol 77:291-300. 2003
  8. ncbi request reprint A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease
    Paul A Carpenter
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, Mailstop D5 290, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 11:465-71. 2005
  9. ncbi request reprint Measuring T-cell-mediated cytotoxicity using antibody to activated caspase 3
    Keith R Jerome
    Nat Med 9:4-5. 2003
  10. ncbi request reprint The danger within
    Keith R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    N Engl J Med 350:411-2. 2004

Research Grants

  1. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
  2. Inactivation of CTL by HSV-infected cells
    KEITH JEROME; Fiscal Year: 2005
  3. Mechanisms of Inactivation of T Cells by HSV
    KEITH JEROME; Fiscal Year: 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Herpes simplex virus genes Us3, Us5, and Us12 differentially regulate cytotoxic T lymphocyte-induced cytotoxicity
    Martine Aubert
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 94109, USA
    Viral Immunol 19:391-408. 2006
    ..Taken together, these results suggest that HSV evasion of cellular immunity is multifacterial and complex, and relies on the partially redundant activities of various individual HSV proteins...
  2. pmc Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome
    Keith R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98105, USA
    Diagn Microbiol Infect Dis 71:66-71. 2011
    ..However, serum from the same day was negative, as was a follow-up plasma sample obtained 2 days after the positive specimen. These data do not support an association of XMRV with CFS...
  3. ncbi request reprint HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 167:3928-35. 2001
    ....
  4. ncbi request reprint Measurement of CTL-induced cytotoxicity: the caspase 3 assay
    K R Jerome
    Fred Hutchinson Cancer Research Center, Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    Apoptosis 8:563-71. 2003
    ..Our assay is convenient and more sensitive than the (51)Cr release assay. The use of this assay should allow mechanistic studies of the intracellular events resulting from CTL attack...
  5. pmc Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 73:8950-7. 1999
    ..The Us11 and Us12 genes were not necessary for protection from apoptosis induced by either stimulus. The differences between HSV-1 and HSV-2 in the ability to inhibit apoptosis may be factors in the immunobiology of HSV infections...
  6. ncbi request reprint Inhibition of apoptosis by primary isolates of herpes simplex virus
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Arch Virol 146:2219-25. 2001
    ..These findings suggest fundamental differences between HSV-1 and HSV-2 in their manipulation of host cell apoptosis...
  7. pmc Ontogeny and specificities of mucosal and blood human immunodeficiency virus type 1-specific CD8(+) cytotoxic T lymphocytes
    L Musey
    Departments of Medicine, University of Washington, Seattle 98109, USA
    J Virol 77:291-300. 2003
    ..Thus, these effectors can provide immune surveillance at the mucosa, where rapid responses are needed to contain HIV-1 infection...
  8. ncbi request reprint A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease
    Paul A Carpenter
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, Mailstop D5 290, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 11:465-71. 2005
    ..Survival at 180 days was 32% (95% confidence interval, 18%-46%). The administration of visilizumab as used in this study seems to be sufficiently safe and effective to warrant further assessment for treatment or prevention of GVHD...
  9. ncbi request reprint Measuring T-cell-mediated cytotoxicity using antibody to activated caspase 3
    Keith R Jerome
    Nat Med 9:4-5. 2003
  10. ncbi request reprint The danger within
    Keith R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    N Engl J Med 350:411-2. 2004
  11. ncbi request reprint Immune surveillance in multiple sclerosis patients treated with natalizumab
    Olaf Stuve
    Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, USA
    Ann Neurol 59:743-7. 2006
    ....
  12. ncbi request reprint Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    Olaf Stuve
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, USA
    Arch Neurol 63:1383-7. 2006
    ....
  13. ncbi request reprint CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase
    Derek D Sloan
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 171:6733-41. 2003
    ..HSV-infected cells require the expression of U(S)3, a viral protein kinase, to transmit the inactivating signal. Elucidation of the molecular nature of this signaling pathway may allow targeted manipulation of CTL function...

Research Grants7

  1. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
    ....
  2. Inactivation of CTL by HSV-infected cells
    KEITH JEROME; Fiscal Year: 2005
    ..The understanding of this pathway may also suggest rational targets for pharmacological manipulation of CTL function. ..
  3. Mechanisms of Inactivation of T Cells by HSV
    KEITH JEROME; Fiscal Year: 2006
    ..The elucidaton of the mechanism by which HSV inactivates T cells will provide new insight into the regulation of T cells, and may suggest targets for pharmacologic manipulation. ..