Carolyn M Hutter

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Characterization of gene-environment interactions for colorectal cancer susceptibility loci
    Carolyn M Hutter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Res 72:2036-44. 2012
  2. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
  3. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
  4. pmc Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease
    Carolyn M Hutter
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Eur J Neurol 15:134-9. 2008
  5. pmc Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease
    Cyrus P Zabetian
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Ann Neurol 62:137-44. 2007
  6. pmc Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 73:767-75. 2013
  7. pmc Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain
    Ignacio F Mata
    Geriatric Research Education and Clinical Center S 182, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Neurogenetics 10:347-53. 2009
  8. doi Association mapping of the PARK10 region for Parkinson's disease susceptibility genes
    Jia Y Wan
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
    Parkinsonism Relat Disord 20:93-8. 2014
  9. pmc Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis
    Jonathan D Kocarnik
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 19:3131-9. 2010
  10. pmc Common variation in the LRRK2 gene is a risk factor for Parkinson's disease
    Ignacio F Mata
    Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Mov Disord 27:1822-5. 2012

Collaborators

Detail Information

Publications34

  1. pmc Characterization of gene-environment interactions for colorectal cancer susceptibility loci
    Carolyn M Hutter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Res 72:2036-44. 2012
    ....
  2. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
    ..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...
  3. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
    ..Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis...
  4. pmc Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease
    Carolyn M Hutter
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Eur J Neurol 15:134-9. 2008
    ..Our results suggest that UCHL1 S18Y is not a major susceptibility factor for PD in white populations although we cannot exclude the possibility that the S18Y variant exerts weak effects on risk, particularly in early-onset disease...
  5. pmc Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease
    Cyrus P Zabetian
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Ann Neurol 62:137-44. 2007
    ..We sought to replicate these findings...
  6. pmc Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 73:767-75. 2013
    ..79; CI, 0.64-0.98 in replication]. No associations were noted for SNPs of AR, ESR1, or PGR. SNPs in the promoter of ESR2 may be important to pathways related to the association between ERβ and tumor progression and metastasis...
  7. pmc Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain
    Ignacio F Mata
    Geriatric Research Education and Clinical Center S 182, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Neurogenetics 10:347-53. 2009
    ..We hypothesize that R1441G originated in the Basque population and that dispersion of the mutation then occurred through short-range gene flow that was largely limited to nearby regions in Spain...
  8. doi Association mapping of the PARK10 region for Parkinson's disease susceptibility genes
    Jia Y Wan
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
    Parkinsonism Relat Disord 20:93-8. 2014
    ..Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD)...
  9. pmc Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis
    Jonathan D Kocarnik
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 19:3131-9. 2010
    ..A potential susceptibility locus for colorectal cancer on chromosome 9p24 (rs719725) was initially identified through a genome-wide association study, though replication attempts have been inconclusive...
  10. pmc Common variation in the LRRK2 gene is a risk factor for Parkinson's disease
    Ignacio F Mata
    Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Mov Disord 27:1822-5. 2012
    ..Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear...
  11. doi Multivariate linkage scan for metabolic syndrome traits in families with type 2 diabetes
    Karen L Edwards
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Obesity (Silver Spring) 19:1235-43. 2011
    ..2, 8q23.3, 14q23.2, 14q32.11, and 20p11.21). The results from this study indicate that several correlated traits of the MetS are influenced by the same gene(s) that account for some of the clustering of the MetS features...
  12. ncbi Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview
    Carolyn M Hutter
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:430-5. 2004
    ....
  13. doi No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    From the 1Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 2Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 3Division of General Medical Disciplines, Stanford University School of Medicine, Stanford, CA 4SRI International, Menlo Park, CA 5Department of Biostatistics, University of Washington School of Public Health, Seattle, WA 6Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ 7Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA and 8Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Menopause 21:415-20. 2014
    ..Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival...
  14. pmc Meta-analysis of new genome-wide association studies of colorectal cancer risk
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
    Hum Genet 131:217-34. 2012
    ..03; combined p value 1.9 × 10(-4)). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer...
  15. ncbi Measuring dietary acculturation in Japanese Americans with the use of confirmatory factor analysis of food-frequency data
    Brandon L Pierce
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Clin Nutr 86:496-503. 2007
    ..Epidemiologic evidence suggests that dietary changes associated with acculturation to a Western diet may increase the risk of type 2 diabetes in Japanese Americans...
  16. pmc Genetic variation in inflammatory pathways is related to colorectal cancer survival
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:7139-47. 2011
    ..Genetic variation in proinflammatory pathways can affect an individual's CRC risk. However, few studies have investigated the prognostic importance of this genetic variation in CRC patients...
  17. pmc LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease
    Cyrus P Zabetian
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    Mov Disord 24:1034-41. 2009
    ..However, LRRK2 mutations appear to be rare among Japanese patients with PD...
  18. pmc Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: the Collaborative Study on the Genetics of Alcoholism
    Helen Kim
    Department of Epidemiology, University of Washington, School of Public Health and Community Medicine, Seattle, WA, USA
    BMC Genet 6:S5. 2005
    ..78 cM (SNP1), and 0.31 cM (SNP2) were used to identify quantitative trait loci (QTLs) affecting maximum number of alcoholic drinks consumed in a 24-hour period (Inmaxalc)...
  19. doi Genome-wide linkage scan for the metabolic syndrome: the GENNID study
    Karen L Edwards
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Obesity (Silver Spring) 16:1596-601. 2008
    ..1-2q13) in the white sample and on chromosome 3 (3q26.1-3q29) in the Mexican-American sample. In conclusion, the results suggest that several regions harbor MetS susceptibility genes and that heterogeneity may exist across groups...
  20. pmc DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease
    Lani S Chun
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98108, USA
    Ann Neurol 62:99-101. 2007
    ..Furthermore, we found no evidence for an effect of genotype on age at onset among patients. Our findings argue against DBH -1021C-->T as a risk factor or age at onset modifier in PD...
  21. pmc Genome-wide search for gene-gene interactions in colorectal cancer
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e52535. 2012
    ..1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC...
  22. pmc Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)
    Cara L Carty
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 21:711-20. 2012
    ..Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations...
  23. pmc Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer
    Amanda I Phipps
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 143:51-4.e4. 2012
    ..05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC...
  24. pmc Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:1950-9. 2011
    ..These studies have primarily been conducted in populations of European descent. To fully understand the impact of these loci, it is important to study groups with other genetic ancestries, including African American women...
  25. pmc Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis
    Yumie Takata
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:1822-30. 2011
    ..Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk...
  26. pmc Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data
    Lin S Chen
    Biostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Hum Genet 86:860-71. 2010
    ..Elucidating the role of variation in these pathways may enhance our understanding of colon cancer etiology...
  27. pmc A population-based study of the risk of repeat clinical chorioamnionitis in Washington State, 1989-2008
    Hannah N Cohen-Cline
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 207:473.e1-7. 2012
    ..Chorioamnionitis can cause severe complications for the infant; therefore, characterization of the risk of recurrence and identification of the factors that modify it are clinically relevant to pregnant women and their providers...
  28. pmc The use of imputed values in the meta-analysis of genome-wide association studies
    Shuo Jiao
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Genet Epidemiol 35:597-605. 2011
    ..Our results show that the performance of the inverse variance weight is always indistinguishable from the optimal weight and similar to or better than the other two methods...
  29. pmc CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290
    Nicholas T Gorden
    Division of Genetics and Developmental Medicine, Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 83:559-71. 2008
    ..These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies...
  30. ncbi Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
    ..In conclusion, this community-based family study of Japanese Americans demonstrates that LIPG variants are associated with HDL related risk factors, and may play a role in susceptibility to cardiovascular disease in this population...
  31. pmc Tri-county comprehensive assessment of risk factors for sporadic reportable bacterial enteric infection in children
    Donna M Denno
    Department of Pediatrics and Global Health, University of Washington, Public Health Seattle and King County, Seattle, Washington, USA
    J Infect Dis 199:467-76. 2009
    ..The aim of this study was to determine risk factors for childhood sporadic reportable enteric infection (REI) caused by bacteria, specifically Campylobacter, Salmonella, Escherichia coli O157, or Shigella (REI-B)...
  32. pmc Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Genes Chromosomes Cancer 50:875-86. 2011
    ..33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94). SMAD7 variants known to be important for CRC risk were associated with disease-specific survival among prediagnostic NSAID users...
  33. pmc LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago
    Cyrus P Zabetian
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Hum Genet 79:752-8. 2006
    ..Our data suggest two separate founding events for G2019S in these populations, beginning at a time that coincides with the Jewish Diasporas...
  34. ncbi Familial hypercholesterolemia and coronary heart disease: a HuGE association review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:421-9. 2004
    ..Preliminary research indicates that the FH phenotype is influenced by other genetic and environmental factors; however, it is not clear if these are synergistic interactions or simply additive effects...