L Hsu

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Powerful cocktail methods for detecting genome-wide gene-environment interaction
    Li Hsu
    Biostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genet Epidemiol 36:183-94. 2012
  2. pmc The contributions of normal variation and genetic background to mammalian gene expression
    Colin Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 7:R26. 2006
  3. pmc Tissue-specific variation in DNA methylation levels along human chromosome 1
    Cecilia De Bustos
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Epigenetics Chromatin 2:7. 2009
  4. pmc Combining multiple family-based association studies
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    BMC Proc 1:S162. 2007
  5. pmc Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Genet 8:63. 2007
  6. pmc Modeling the effect of an associated single-nucleotide polymorphism in linkage studies
    Jeanine J Houwing-Duistermaat
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S46. 2005
  7. pmc Methods to test for association between a disease and a multi-allelic marker applied to a candidate region
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, P O Box 9604, 2300RC Leiden, The Netherlands
    BMC Genet 6:S101. 2005
  8. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
  9. ncbi request reprint Denoising array-based comparative genomic hybridization data using wavelets
    Li Hsu
    Biostatistics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B500, Seattle, WA 98109, USA
    Biostatistics 6:211-26. 2005
  10. ncbi request reprint Multivariate survival analysis for case-control family data
    Li Hsu
    Program in Biostatistics and Biomathematics, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500, PO Box 19024, Seattle, WA 98109 1024, USA
    Biostatistics 7:387-98. 2006

Collaborators

Detail Information

Publications31

  1. pmc Powerful cocktail methods for detecting genome-wide gene-environment interaction
    Li Hsu
    Biostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genet Epidemiol 36:183-94. 2012
    ..It also allows for an easy incorporation of new methods as they are developed. Our work provides a comprehensive and powerful tool for devising effective strategies for genome-wide detection of gene-environment interactions...
  2. pmc The contributions of normal variation and genetic background to mammalian gene expression
    Colin Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 7:R26. 2006
    ..Although potentially important, the relative contributions of genomic versus epigenetic and stochastic factors to variation in gene expression have not been quantified in mammalian species...
  3. pmc Tissue-specific variation in DNA methylation levels along human chromosome 1
    Cecilia De Bustos
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Epigenetics Chromatin 2:7. 2009
    ..CONCLUSION: The varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands...
  4. pmc Combining multiple family-based association studies
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    BMC Proc 1:S162. 2007
    ....
  5. pmc Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Genet 8:63. 2007
    ..As an alternative to the likelihood ratio statistic, we derive a score statistic, which has a tractable expression. For haplotype analysis, we assume that phase is known...
  6. pmc Modeling the effect of an associated single-nucleotide polymorphism in linkage studies
    Jeanine J Houwing-Duistermaat
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Genet 6:S46. 2005
    ..The question to be answered was whether one of the single-nucleotide polymorphisms partly explains these high LOD scores. We did not have the answers when we analyzed the data...
  7. pmc Methods to test for association between a disease and a multi-allelic marker applied to a candidate region
    Rachid El Galta
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, P O Box 9604, 2300RC Leiden, The Netherlands
    BMC Genet 6:S101. 2005
    ..Evidence for association was found for marker D03S0127 (p < 0.01). The analyses were done without any prior knowledge of the answers...
  8. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
    ..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...
  9. ncbi request reprint Denoising array-based comparative genomic hybridization data using wavelets
    Li Hsu
    Biostatistics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B500, Seattle, WA 98109, USA
    Biostatistics 6:211-26. 2005
    ..A simulation study shows that denoising data prior to testing can achieve greater power in detecting the aberrant spot than using the raw data without denoising. Finally, we illustrate the method on two array-CGH data sets...
  10. ncbi request reprint Multivariate survival analysis for case-control family data
    Li Hsu
    Program in Biostatistics and Biomathematics, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500, PO Box 19024, Seattle, WA 98109 1024, USA
    Biostatistics 7:387-98. 2006
    ..We establish a connection with a previously proposed generalized estimating equation-based approach. Simulation studies and an analysis of case-control family data of breast cancer illustrate the methodology's practical utility...
  11. pmc Locally weighted transmission/disequilibrium test for genetic association analysis
    Li Hsu
    Modeling and Methods, Biostatistics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA
    BMC Genet 6:S60. 2005
    ..As an illustration, we applied the method to the simulated Aipotu data...
  12. ncbi request reprint On robustness of marginal regression coefficient estimates and hazard functions in multivariate survival analysis of family data when the frailty distribution is mis-specified
    Li Hsu
    Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, U S A
    Stat Med 26:4657-78. 2007
    ....
  13. pmc On combining triads and unrelated subjects data in candidate gene studies: an application to data on testicular cancer
    Li Hsu
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Wash, USA
    Hum Hered 67:88-103. 2009
    ..Extensive simulation experiments demonstrate that the proposed estimation and inferential methods perform well in realistic settings. We illustrate the method by an application to a study of testicular cancer...
  14. ncbi request reprint Semiparametric estimation of marginal hazard function from case-control family studies
    Li Hsu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biometrics 60:936-44. 2004
    ..The simulation study shows that both methods perform well under finite sample sizes. We illustrate the method with a case-control family study of early onset breast cancer...
  15. ncbi request reprint Genetic association tests with age at onset
    L Hsu
    Division of Public Health Sciences, Biostatistics Modeling and Methods, Fred Hutchinson Cancer Research Center, MP 665, PO Box 19024, Seattle, WA 98109 1024, USA
    Genet Epidemiol 24:118-27. 2003
    ....
  16. ncbi request reprint A method for incorporating ages at onset in affected sibpair linkage studies
    L Hsu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    Hum Hered 54:1-12. 2002
    ..We conduct an analytical study, comparing the combined test with weighted and equal weight with respect to age test. It shows that the combined test retains the most power of the better one of the two tests being combined...
  17. ncbi request reprint Some further results on incorporating risk factor information in assessing the dependence between paired failure times arising from case-control family studies: an application to prostate cancer
    Li Hsu
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, P O Box 19024, Seattle, Washington 98109 1024, U S A
    Stat Med 21:863-76. 2002
    ..Finally we illustrate various analyses using a case-control family study of early onset prostate cancer...
  18. ncbi request reprint A note on a conditional-likelihood approach for family-based association studies of candidate genes
    L Hsu
    Fred Hutchinson Cancer Research Center, Seattle, Wash, USA
    Hum Hered 50:194-200. 2000
    ..Besides being straightforward conceptually and computationally, this approach is robust to ascertainment bias and naturally accommodates genetic heterogeneity across families...
  19. pmc Mapping of complex traits by single-nucleotide polymorphisms
    L P Zhao
    Quantitative Genetic Epidemiology Group, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 63:225-40. 1998
    ..When linkage and linkage-disequilibrium signals were combined, the analysis yielded much stronger and clearer signals for the presence of two major genes than did two separate analyses...
  20. ncbi request reprint Efficient, robust, and unified method for mapping complex traits (I): two-point linkage analysis
    L P Zhao
    Quantitative Genetic Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Med Genet 77:366-83. 1998
    ..The properties of the estimates have been studied in finite samples with a limited simulation study. This method is illustrated with an application to family data contributed to the Breast Cancer Consortium...
  21. ncbi request reprint An efficient, robust and unified method for mapping complex traits (III): combined linkage/linkage-disequilibrium analysis
    L P Zhao
    Quantitative Genetic Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Med Genet 84:433-53. 1999
    ..However, the combined analysis did not provide strong support for any of the findings, implying that linkage and linkage-disequilibrium findings are not consistent...
  22. ncbi request reprint Population-based family study designs: an interdisciplinary research framework for genetic epidemiology
    L P Zhao
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genet Epidemiol 14:365-88. 1997
    ....
  23. ncbi request reprint An efficient, robust, and unified method for mapping complex traits (II): multipoint linkage analysis
    L P Zhao
    Quantitative Genetic Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Med Genet 79:48-61. 1998
    ..Through sensitivity analysis, it appears that the results are robust to misspecification of penetrance and allele frequency...
  24. ncbi request reprint Incorporating age at onset information into the transmission/disequilibrium test
    L Hsu
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, MP-665, Seattle, WA 98109-1024, USA
    Genet Epidemiol 21:S347-52. 2001
    ..Focusing on chromosome 6 where MG6 and MG7 reside, we compared the usual TDT with the newly proposed tests in terms of gene localization...
  25. pmc Gene expression array testing of FFPE archival breast tumor samples: an optimized protocol for WG-DASL sample preparation
    C C Ton
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Breast Cancer Res Treat 125:879-83. 2011
    ..These results indicate that a large fraction of decade-old FFPE samples, of diverse institutional origins and processing histories, can yield RNA suitable for gene expression profiling experiments...
  26. ncbi request reprint Sequence analysis using logic regression
    C Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, MP-1002, Seattle, WA 98109-1024, USA
    Genet Epidemiol 21:S626-31. 2001
    ....
  27. pmc Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span
    E M Wijsman
    Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA
    Am J Hum Genet 67:631-46. 2000
    ..Our study adds to existing studies of the genetic basis of composite phenotypes related to dyslexia, by providing evidence for major-gene modes of inheritance of these single-measure component phenotypes...
  28. pmc Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer
    L W M Loo
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Genes Chromosomes Cancer 47:1049-66. 2008
    ..LOH in chromosomal arms 8p and 5q was common in higher grade IDC tumors, whereas ILC and low-grade IDC grouped together by virtue of LOH in 16q...
  29. ncbi request reprint Polymorphic repeats in the androgen receptor gene in high-risk sibships
    E A Miller
    Department of Urology, University of Washington, Seattle, Washington, USA
    Prostate 48:200-5. 2001
    ..06) compared to men with two long repeats [(CAG)n > or =22 and (GGN)n >16)]. CONCLUSIONS: These results suggest that the (CAG)n and (GGN)n repeats in the AR gene do not play a major role in familial prostate cancer...
  30. pmc On the assessment of statistical significance in disease-gene discovery
    L P Zhao
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98105, USA
    Am J Hum Genet 64:1739-53. 1999
    ..These simulation experiments also identified factors that influence power and reliability, shedding light on the design of genome-scan studies...
  31. pmc Project normal: defining normal variance in mouse gene expression
    C C Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
    Proc Natl Acad Sci U S A 98:13266-71. 2001
    ..These studies help to define the baseline level of variability in mouse gene expression and emphasize the importance of replicate microarray experiments...