Tobias M Hohl

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Selective expansion of the monocytic lineage directed by bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Immunol 183:1900-10. 2009
  2. pmc In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis
    Oumaima Ibrahim-Granet
    Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
    BMC Microbiol 10:105. 2010
  3. pmc Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection
    Tobias M Hohl
    Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell Host Microbe 6:470-81. 2009
  4. pmc Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation
    Amariliz Rivera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 208:369-81. 2011
  5. pmc Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:590-601. 2011
  6. pmc Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Pathog 1:e30. 2005
  7. pmc Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 187:5293-8. 2011
  8. pmc Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection
    Monica M Mircescu
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    J Infect Dis 200:647-56. 2009
  9. pmc Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression
    Chao Shi
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 184:6266-74. 2010
  10. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012

Collaborators

Detail Information

Publications17

  1. pmc Selective expansion of the monocytic lineage directed by bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Immunol 183:1900-10. 2009
    ..Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection...
  2. pmc In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis
    Oumaima Ibrahim-Granet
    Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
    BMC Microbiol 10:105. 2010
    ..Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminescent A. fumigatus strain...
  3. pmc Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection
    Tobias M Hohl
    Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell Host Microbe 6:470-81. 2009
    ....
  4. pmc Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation
    Amariliz Rivera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 208:369-81. 2011
    ..fumigatus-specific CD4 T cells and enabling Th17 differentiation...
  5. pmc Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:590-601. 2011
    ..Our findings suggest that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses...
  6. pmc Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Pathog 1:e30. 2005
    ..Selective responsiveness to germinating conidia provides the innate immune system with a mechanism to restrict inflammatory responses to metabolically active, potentially invasive fungal spores...
  7. pmc Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 187:5293-8. 2011
    ..In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection...
  8. pmc Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection
    Monica M Mircescu
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    J Infect Dis 200:647-56. 2009
    ..Our studies suggest that neutrophils, but not alveolar macrophages, provide essential anticonidial defense and that a brief period of influx into the respiratory tree is sufficient to prevent conidial germination and invasive disease...
  9. pmc Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression
    Chao Shi
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 184:6266-74. 2010
    ..monocytogenes-infected liver does not require chemokine receptor-mediated signals but instead is principally dependent on integrin- and extracellular matrix-mediated monocyte adhesion...
  10. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012
    ..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria...
  11. pmc Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice
    Melissa J Grimm
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 190:4175-84. 2013
    ..Taken together, our studies identify a central role for monocyte/macrophage NADPH oxidase in controlling fungal infection and in limiting acute lung inflammation...
  12. pmc Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia
    Amariliz Rivera
    Memorial Sloan Kettering Cancer Center, Infectious Diseases Service, Immunology Program, Department of Medicine, New York, NY 10021, USA
    Infect Immun 73:7170-9. 2005
    ..How the adaptive immune system distinguishes between metabolically active and inactive fungal spores remains an important question...
  13. pmc Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment
    Alexander M Lesokhin
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Res 72:876-86. 2012
    ..Our results argue that therapeutic targeting of monocytic MDSCs would enhance outcomes in immunotherapy...
  14. pmc Monocyte-mediated defense against microbial pathogens
    Natalya V Serbina
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Immunol 26:421-52. 2008
    ..The in vivo mechanisms that promote chemokine secretion, monocyte differentiation and trafficking, and finally monocyte-mediated microbial killing remain active and important areas of investigation...
  15. pmc Aspergillus fumigatus: principles of pathogenesis and host defense
    Tobias M Hohl
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Eukaryot Cell 6:1953-63. 2007
  16. ncbi request reprint Immunity to fungi
    Tobias M Hohl
    Infectious Diseases Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Immunol 18:465-72. 2006
    ..Greater understanding of the molecular mechanisms that underlie antifungal defense has provided a framework for the investigation of protective vaccines and strategies for therapeutic adoptive cell transfer...
  17. pmc Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression
    Mabel Ryder
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 8:e54302. 2013
    ..Our data demonstrate that TAMs are pro-tumorigenic in advanced PTCs and that they can be targeted pharmacologically, which may be potentially useful for patients with advanced thyroid cancers...