Research Topics
Genomes and Genes
Species | Tobias M HohlSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Detail Information
Publications
Selective expansion of the monocytic lineage directed by bacterial infectionNatalya V Serbina
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
J Immunol 183:1900-10. 2009..Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection...- In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosisOumaima Ibrahim-Granet
Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
BMC Microbiol 10:105. 2010..Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminescent A. fumigatus strain... - Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infectionTobias M Hohl
Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell Host Microbe 6:470-81. 2009.... - Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiationAmariliz Rivera
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Exp Med 208:369-81. 2011..fumigatus-specific CD4 T cells and enabling Th17 differentiation... - Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligandsChao Shi
Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 34:590-601. 2011..Our findings suggest that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses... - Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan displayTobias M Hohl
Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
PLoS Pathog 1:e30. 2005..Selective responsiveness to germinating conidia provides the innate immune system with a mechanism to restrict inflammatory responses to metabolically active, potentially invasive fungal spores... - Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infectionChao Shi
Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Immunol 187:5293-8. 2011..In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection... - Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infectionMonica M Mircescu
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
J Infect Dis 200:647-56. 2009..Our studies suggest that neutrophils, but not alveolar macrophages, provide essential anticonidial defense and that a brief period of influx into the respiratory tree is sufficient to prevent conidial germination and invasive disease... - Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expressionChao Shi
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Immunol 184:6266-74. 2010..monocytogenes-infected liver does not require chemokine receptor-mediated signals but instead is principally dependent on integrin- and extracellular matrix-mediated monocyte adhesion... - Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defenseMelissa A Kinnebrew
Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 36:276-87. 2012..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria... - Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidiaAmariliz Rivera
Memorial Sloan-Kettering Cancer Center, Infectious Diseases Service, Immunology Program, Department of Medicine, New York, NY 10021, USA
Infect Immun 73:7170-9. 2005..How the adaptive immune system distinguishes between metabolically active and inactive fungal spores remains an important question... - Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironmentAlexander M Lesokhin
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cancer Res 72:876-86. 2012..Our results argue that therapeutic targeting of monocytic MDSCs would enhance outcomes in immunotherapy... - Monocyte-mediated defense against microbial pathogensNatalya V Serbina
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Immunol 26:421-52. 2008..The in vivo mechanisms that promote chemokine secretion, monocyte differentiation and trafficking, and finally monocyte-mediated microbial killing remain active and important areas of investigation... - Aspergillus fumigatus: principles of pathogenesis and host defenseTobias M Hohl
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Eukaryot Cell 6:1953-63. 2007 
Immunity to fungiTobias M Hohl
Infectious Diseases Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Curr Opin Immunol 18:465-72. 2006..Greater understanding of the molecular mechanisms that underlie antifungal defense has provided a framework for the investigation of protective vaccines and strategies for therapeutic adoptive cell transfer...