David Hockenbery

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Hsp90 inhibition decreases mitochondrial protein turnover
    Daciana H Margineantu
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 2:e1066. 2007
  2. pmc MMPs in unusual places
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, Division of Clinical Research and Human Biology, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 1024, USA
    Am J Pathol 169:1101-3. 2006
  3. ncbi request reprint A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle, WA 98109 1024, USA
    Blood 109:4557-63. 2007
  4. ncbi request reprint Targeting mitochondria for cancer therapy
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Environ Mol Mutagen 51:476-89. 2010
  5. ncbi request reprint Oral beclomethasone dipropionate in gastrointestinal graft-versus-host disease
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2 190, Seattle, WA 98109 1024, USA
    Expert Rev Clin Immunol 3:695-700. 2007
  6. ncbi request reprint Bcl-2-related proteins as drug targets
    Jason W O'Neill
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Med Chem 10:1553-62. 2003
  7. ncbi request reprint Mitochondria and apoptosis: new therapeutic targets
    David M Hockenbery
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Adv Cancer Res 85:203-42. 2002
  8. ncbi request reprint Identification of genes with abnormal expression changes in acute myeloid leukemia
    Derek L Stirewalt
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Chromosomes Cancer 47:8-20. 2008
  9. ncbi request reprint Targeting BCL-2-related proteins in cancer therapy
    Michael K Manion
    Hockenbery Lab, Fred Hutchinson Cancer Research Center Seattle, Washington 98109, USA
    Cancer Biol Ther 2:S105-14. 2003
  10. ncbi request reprint Prevention of Fas-mediated hepatic failure by transferrin
    Vladimir A Lesnikov
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Lab Invest 84:342-52. 2004

Collaborators

Detail Information

Publications35

  1. pmc Hsp90 inhibition decreases mitochondrial protein turnover
    Daciana H Margineantu
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 2:e1066. 2007
    ....
  2. pmc MMPs in unusual places
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, Division of Clinical Research and Human Biology, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 1024, USA
    Am J Pathol 169:1101-3. 2006
  3. ncbi request reprint A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle, WA 98109 1024, USA
    Blood 109:4557-63. 2007
    ..02). The survival benefit was durable to 1 year after randomization. Oral BDP prevents relapses of gastrointestinal GVHD following tapering of prednisone; survival is statistically significantly better among patients receiving BDP...
  4. ncbi request reprint Targeting mitochondria for cancer therapy
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Environ Mol Mutagen 51:476-89. 2010
    ....
  5. ncbi request reprint Oral beclomethasone dipropionate in gastrointestinal graft-versus-host disease
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2 190, Seattle, WA 98109 1024, USA
    Expert Rev Clin Immunol 3:695-700. 2007
    ....
  6. ncbi request reprint Bcl-2-related proteins as drug targets
    Jason W O'Neill
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Med Chem 10:1553-62. 2003
    ..There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins...
  7. ncbi request reprint Mitochondria and apoptosis: new therapeutic targets
    David M Hockenbery
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Adv Cancer Res 85:203-42. 2002
  8. ncbi request reprint Identification of genes with abnormal expression changes in acute myeloid leukemia
    Derek L Stirewalt
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Chromosomes Cancer 47:8-20. 2008
    ..Future studies will determine their potential role in leukemogenesis and their clinical significance...
  9. ncbi request reprint Targeting BCL-2-related proteins in cancer therapy
    Michael K Manion
    Hockenbery Lab, Fred Hutchinson Cancer Research Center Seattle, Washington 98109, USA
    Cancer Biol Ther 2:S105-14. 2003
    ..Initial efforts have been centered on disrupting protein-protein interactions within the BCL-2 homology (BH) family. Substantial progress in this task has been made using molecular modeling and drug leads...
  10. ncbi request reprint Prevention of Fas-mediated hepatic failure by transferrin
    Vladimir A Lesnikov
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Lab Invest 84:342-52. 2004
    ..In conclusion, the data suggest that Tf has broader functions than previously recognized and may serve as a cytoprotective agent...
  11. ncbi request reprint Gastrointestinal graft-versus-host disease in recipients of autologous hematopoietic stem cells: incidence, risk factors, and outcome
    Leona Holmberg
    Medical Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 12:226-34. 2006
    ..We conclude that women with breast cancer or hematologic malignancy are more likely to develop GI GVHD after autologous transplantation, and that treatment with prednisone was effective...
  12. pmc Nailing down a link between tuberin and renal cysts
    David M Hockenbery
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Pathol 162:369-71. 2003
  13. ncbi request reprint Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas
    John M Pagel
    Fred Hutchinson Cancer Research Center Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Clin Cancer Res 11:4857-66. 2005
    ..Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction...
  14. ncbi request reprint Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy
    Jason O'Neill
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2 190, PO Box 19024, Seattle, Washington 98109 1024, USA
    Biochim Biophys Acta 1705:43-51. 2004
    ....
  15. ncbi request reprint Breaking down tumor defenses
    David Hockenbery
    Fred Hutchinson Cancer Research Center, University of Washington, Box 358080, 1100 Fairview Avenue North, C3 155, Seattle, WA 98104, USA
    Chem Biol 11:417-8. 2004
  16. pmc Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry
    Fionnuala Morrish
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 285:36267-74. 2010
    ..These data point to a key role for Myc in directing the interconnection of -omic networks, and in particular, epigenetic modification of proteins in response to proliferative signals...
  17. ncbi request reprint Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA
    Fionnuala Morrish
    Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Mitochondrion 6:143-8. 2006
    ..Thus, TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart...
  18. ncbi request reprint Bcl-2 family proteins as regulators of oxidative stress
    Nathan Susnow
    Department of Medicine, University of Washington, Seattle, 98195 6424, United States
    Semin Cancer Biol 19:42-9. 2009
    ..In this review, we consider the role of reactive oxygen species, a metabolic by-product, in the mitochondrial pathway of apoptosis, and the relationships between Bcl-2 functions and oxidative stress...
  19. pmc Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
    Paul T Brinkkoetter
    Division of Nephrology, University of Washington, Seattle, Washington 98195 6521, USA
    J Clin Invest 119:3089-101. 2009
    ..Taken together, these data suggest that a cyclin I-Cdk5 complex forms a critical antiapoptotic factor in terminally differentiated cells that functions via MAPK signaling to modulate levels of the prosurvival proteins Bcl-2 and Bcl-XL...
  20. pmc Warburg and Crabtree effects in premalignant Barrett's esophagus cell lines with active mitochondria
    Martin T Suchorolski
    Molecular and Cellular Biology Department, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e56884. 2013
    ..Periodic ischemia occurs in the premalignant condition Barrett's esophagus (BE) due to tissue damage from chronic acid-bile reflux and may select for early adaptations to hypoxia, including upregulation of glycolysis...
  21. ncbi request reprint Small-molecule inhibitors of Bcl-2
    Michael K Manion
    Fred Hutchinson Cancer Research Center, Division of Clinical Research and Human Biology, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 1024, USA
    Curr Opin Investig Drugs 7:1077-84. 2006
    ..Ongoing studies with these investigational drugs should provide new insights into optimal strategies to disrupt Bcl-2 survival functions to selectively kill cancer cells...
  22. ncbi request reprint BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death
    Han K Ho
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Pharmacol 69:147-57. 2005
    ..Hence, TFEC-induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti-apoptotic BCL-2 family member, BCL-xL...
  23. pmc Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals
    Sudeshna Seal
    Fred Hutchinson Cancer Research Center, Department of Chemistry, University of Washington School of Medicine, Seattle, WA 98109 1024, USA
    Exp Hematol 36:1660-72. 2008
    ..Therefore, we aimed at characterizing potential differential effects of FLIPL and FLIPS, on TRAIL and TNF-alpha-induced apoptosis in model leukemic cell lines...
  24. ncbi request reprint BCL-XL dimerization by three-dimensional domain swapping
    Jason W O'Neill
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Mol Biol 356:367-81. 2006
    ..Chemical crosslinking studies of Cys-substituted BCL-X(L) proteins demonstrate that 3DDS dimers form in synthetic lipid vesicles...
  25. ncbi request reprint A mitochondrial Achilles' heel in cancer?
    David M Hockenbery
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Cell 2:1-2. 2002
    ..A new paper demonstrates the therapeutic potential of directly engaging these apoptotic pathways by identifying a mitochondrial toxin selective for tumor cells...
  26. ncbi request reprint Targeted therapies for epithelial cancers: in vivo efficacy of the BCL-2/BCL-XL inhibitor 2-MeAA
    Pamela S Schwartz
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Biol Ther 6:465-6. 2007
  27. ncbi request reprint BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation
    Loralee Haughn
    Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 278:25158-65. 2003
    ..These effects are associated with differential regulation of Raf-1 expression, perhaps involving the previously identified interaction between BCL-2-BH4 and the catalytic domain of Raf-1...
  28. ncbi request reprint Bcl-XL mutations suppress cellular sensitivity to antimycin A
    Michael K Manion
    Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Biol Chem 279:2159-65. 2004
    ..The LD(50) of AA for cells expressing BCL-X(L) mutants directly correlates with the measured in vitro dissociation constants for AA binding. These results indicate that BCL-X(L) is a principal target mediating AA cytotoxicity...
  29. pmc Identification of androgen-coregulated protein networks from the microsomes of human prostate cancer cells
    Michael E Wright
    Institute for Systems Biology, Seattle, WA 98103, USA
    Genome Biol 5:R4. 2003
    ..To this end, we have applied a large-scale proteomic approach to define cellular processes that are responsive to androgen treatment in LNCaP prostate cancer cells...
  30. ncbi request reprint A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system
    Holger A Erxleben
    Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195 1700, USA
    Analyst 129:205-12. 2004
    ....
  31. pmc Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation
    Ezekiel Maloney
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 29:1370-5. 2009
    ..We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate...
  32. pmc The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    Fionnuala Morrish
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cell Cycle 7:1054-66. 2008
    ..This function of Myc may underlie the pervasive presence of Myc in many human cancers...
  33. ncbi request reprint Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA cross-linking
    Randall A Phelps
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA
    Exp Cell Res 313:2283-92. 2007
    ..In contrast, normal responses to ionizing radiation were observed in FANCC-deficient cells. Absence of this late S-phase response in FANCC-deficient cells leads to activation of secondary checkpoint responses...
  34. ncbi request reprint 2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition
    Pamela S Schwartz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue D2 190, Seattle, WA 98109, USA
    Mol Cancer Ther 6:2073-80. 2007
    ..These results provide an example of the intersection of bioenergetic metabolism and Bcl-x(L) functions and suggest a metabolic basis for the gain-of-function mechanism of Bcl-x(L) inhibitors...
  35. ncbi request reprint Differential effects of bexarotene on intrinsic and extrinsic pathways in TRAIL-induced apoptosis in two myeloid leukemia cell lines
    Shao Xu Ying
    Shanghai Sixth Hospital, Shanghai Jiaotong University, Shanghai, China
    Leuk Lymphoma 48:1003-14. 2007
    ..These studies add further information to the regulation of programmed cell death in leukemic cells that have to be considered when designing therapeutic strategies...

Research Grants12

  1. Small Molecule Inhibitors of BcI xL Survival Protein
    David Hockenbery; Fiscal Year: 2004
    ..3. Determine the role of endogenous pro-apoptotic dimer partners of Eel-if in the cytotoxic mechanism of antimycin A. ..
  2. Regulation of substrate-linked mitochondrial ROS generation
    David Hockenbery; Fiscal Year: 2007
    ....
  3. Cell Metabolism & Myc induced growth death, & neoplasia
    David Hockenbery; Fiscal Year: 2006
    ....
  4. Cell Metabolism and Myc induced growth, death, and neoplasia
    David Hockenbery; Fiscal Year: 2007
    ....
  5. Cell Metabolism and Myc induced growth, death, and neoplasia
    David Hockenbery; Fiscal Year: 2009
    ....