Research Topics
| David HockenberySummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
Research Grants
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Detail Information
Publications
Oral beclomethasone dipropionate in gastrointestinal graft-versus-host diseaseDavid M Hockenbery
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2 190, Seattle, WA 98109 1024, USA
Expert Rev Clin Immunol 3:695-700. 2007....
MMPs in unusual placesDavid M Hockenbery
Fred Hutchinson Cancer Research Center, Division of Clinical Research and Human Biology, 1100 Fairview Avenue North, C3-168, Seattle, WA 98109-1024, USA
Am J Pathol 169:1101-3. 2006
Targeting mitochondria for cancer therapyDavid M Hockenbery
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Environ Mol Mutagen 51:476-89. 2010....- A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host diseaseDavid M Hockenbery
Fred Hutchinson Cancer Research Center, University of Washington, School of Medicine, Seattle, WA 98109 1024, USA
Blood 109:4557-63. 2007..02). The survival benefit was durable to 1 year after randomization. Oral BDP prevents relapses of gastrointestinal GVHD following tapering of prednisone; survival is statistically significantly better among patients receiving BDP... - Mitochondria and apoptosis: new therapeutic targetsDavid M Hockenbery
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Adv Cancer Res 85:203-42. 2002 - Bcl-2-related proteins as drug targetsDavid M Hockenbery
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Curr Med Chem 10:1553-62. 2003..There has been substantial progress in this task using molecular modeling and drug leads. The prospects are also good for development of chemical tools for functional analysis of the Bcl-2 proteins... - Identification of genes with abnormal expression changes in acute myeloid leukemiaDerek L Stirewalt
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genes Chromosomes Cancer 47:8-20. 2008..Future studies will determine their potential role in leukemogenesis and their clinical significance... - Gastrointestinal graft-versus-host disease in recipients of autologous hematopoietic stem cells: incidence, risk factors, and outcomeLeona Holmberg
Medical Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, Washington 98109, USA
Biol Blood Marrow Transplant 12:226-34. 2006..We conclude that women with breast cancer or hematologic malignancy are more likely to develop GI GVHD after autologous transplantation, and that treatment with prednisone was effective... - Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomasJohn M Pagel
Fred Hutchinson Cancer Research Center Department of Medicine, University of Washington, Seattle, Washington 98109, USA
Clin Cancer Res 11:4857-66. 2005..Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction... - Prevention of Fas-mediated hepatic failure by transferrinVladimir A Lesnikov
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Lab Invest 84:342-52. 2004..In conclusion, the data suggest that Tf has broader functions than previously recognized and may serve as a cytoprotective agent... - Targeting BCL-2-related proteins in cancer therapyMichael K Manion
Hockenbery Lab, Fred Hutchinson Cancer Research Center Seattle, Washington 98109, USA
Cancer Biol Ther 2:S105-14. 2003..Initial efforts have been centered on disrupting protein-protein interactions within the BCL-2 homology (BH) family. Substantial progress in this task has been made using molecular modeling and drug leads... - Nailing down a link between tuberin and renal cystsDavid M Hockenbery
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
Am J Pathol 162:369-71. 2003 - Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapyMichael Manion
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2-190, PO Box 19024, Seattle, Washington 98109-1024, USA
Biochim Biophys Acta 1705:43-51. 2004.... - Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNAFionnuala Morrish
Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
Mitochondrion 6:143-8. 2006..Thus, TRalpha isoforms may directly regulate T(3) responses at mtDNA in the heart... - Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entryFionnuala Morrish
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Biol Chem 285:36267-74. 2010..These data point to a key role for Myc in directing the interconnection of -omic networks, and in particular, epigenetic modification of proteins in response to proliferative signals... - Breaking down tumor defensesDavid Hockenbery
Fred Hutchinson Cancer Research Center, University of Washington, Box 358080, 1100 Fairview Avenue North, C3-155, Seattle, WA 98104, USA
Chem Biol 11:417-8. 2004 - Bcl-2 family proteins as regulators of oxidative stressNathan Susnow
Department of Medicine, University of Washington, Seattle, 98195 6424, United States
Semin Cancer Biol 19:42-9. 2009..In this review, we consider the role of reactive oxygen species, a metabolic by-product, in the mitochondrial pathway of apoptosis, and the relationships between Bcl-2 functions and oxidative stress... - BCL-XL dimerization by three-dimensional domain swappingJason W O'Neill
Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Mol Biol 356:367-81. 2006..Chemical crosslinking studies of Cys-substituted BCL-X(L) proteins demonstrate that 3DDS dimers form in synthetic lipid vesicles... - Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signalsSudeshna Seal
Fred Hutchinson Cancer Research Center, Department of Chemistry, University of Washington School of Medicine, Seattle, WA 98109 1024, USA
Exp Hematol 36:1660-72. 2008..Therefore, we aimed at characterizing potential differential effects of FLIPL and FLIPS, on TRAIL and TNF-alpha-induced apoptosis in model leukemic cell lines... - Hsp90 inhibition decreases mitochondrial protein turnoverDaciana H Margineantu
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 2:e1066. 2007.... - A mitochondrial Achilles' heel in cancer?David M Hockenbery
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Cell 2:1-2. 2002..A new paper demonstrates the therapeutic potential of directly engaging these apoptotic pathways by identifying a mitochondrial toxin selective for tumor cells... - Small-molecule inhibitors of Bcl-2Michael K Manion
Fred Hutchinson Cancer Research Center, Division of Clinical Research and Human Biology, 1100 Fairview Avenue North, C3-168, Seattle, WA 98109-1024, USA
Curr Opin Investig Drugs 7:1077-84. 2006..Ongoing studies with these investigational drugs should provide new insights into optimal strategies to disrupt Bcl-2 survival functions to selectively kill cancer cells... - Targeted therapies for epithelial cancers: in vivo efficacy of the BCL-2/BCL-XL inhibitor 2-MeAAPamela S Schwartz
Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Biol Ther 6:465-6. 2007 - BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell deathHan K Ho
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
Biochem Pharmacol 69:147-57. 2005..Hence, TFEC-induced necrotic cell death in the TAMH cell line is mediated by BAX and antagonized by the anti-apoptotic BCL-2 family member, BCL-xL... - BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiationLoralee Haughn
Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Biol Chem 278:25158-65. 2003..These effects are associated with differential regulation of Raf-1 expression, perhaps involving the previously identified interaction between BCL-2-BH4 and the catalytic domain of Raf-1... - Bcl-XL mutations suppress cellular sensitivity to antimycin AMichael K Manion
Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Biol Chem 279:2159-65. 2004..The LD(50) of AA for cells expressing BCL-X(L) mutants directly correlates with the measured in vitro dissociation constants for AA binding. These results indicate that BCL-X(L) is a principal target mediating AA cytotoxicity... - Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activationEzekiel Maloney
Department of Medicine, University of Washington, Seattle, WA 98109, USA
Arterioscler Thromb Vasc Biol 29:1370-5. 2009..We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate... - Identification of androgen-coregulated protein networks from the microsomes of human prostate cancer cellsMichael E Wright
Institute for Systems Biology, Seattle, WA 98103, USA
Genome Biol 5:R4. 2003.... - The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entryFionnuala Morrish
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cell Cycle 7:1054-66. 2008..This function of Myc may underlie the pervasive presence of Myc in many human cancers... - A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve systemHolger A Erxleben
Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA
Analyst 129:205-12. 2004.... - 2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibitionPamela S Schwartz
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue D2 190, Seattle, WA 98109, USA
Mol Cancer Ther 6:2073-80. 2007..These results provide an example of the intersection of bioenergetic metabolism and Bcl-x(L) functions and suggest a metabolic basis for the gain-of-function mechanism of Bcl-x(L) inhibitors... - Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA cross-linkingRandall A Phelps
Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA
Exp Cell Res 313:2283-92. 2007..In contrast, normal responses to ionizing radiation were observed in FANCC-deficient cells. Absence of this late S-phase response in FANCC-deficient cells leads to activation of secondary checkpoint responses... - Differential effects of bexarotene on intrinsic and extrinsic pathways in TRAIL-induced apoptosis in two myeloid leukemia cell linesShao Xu Ying
Shanghai Sixth Hospital, Shanghai Jiaotong University, Shanghai, China
Leuk Lymphoma 48:1003-14. 2007..These studies add further information to the regulation of programmed cell death in leukemic cells that have to be considered when designing therapeutic strategies...
Research Grants
- Regulation of substrate-linked mitochondrial ROS generationDavid Hockenbery; Fiscal Year: 2007....
- Cell Metabolism and Myc induced growth, death, and neoplasiaDavid Hockenbery; Fiscal Year: 2007....
- Small Molecule Inhibitors of BcI xL Survival ProteinDavid Hockenbery; Fiscal Year: 2004..3. Determine the role of endogenous pro-apoptotic dimer partners of Eel-if in the cytotoxic mechanism of antimycin A. ..
- Cell Metabolism and Myc induced growth, death, and neoplasiaDavid Hockenbery; Fiscal Year: 2009....