Florian Hladik

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Atopic dermatitis with increased severity along a line of Blaschko
    Florian Hladik
    Division of Immunology, Department of Dermatology, Allergy and Infectious Diseases, University of Vienna Medical School, Vienna, Austria
    J Am Acad Dermatol 53:S221-4. 2005
  2. ncbi request reprint HIV infection of the genital mucosa in women
    Florian Hladik
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3 100, Seattle, WA 98109 1024, USA
    Curr HIV/AIDS Rep 6:20-8. 2009
  3. pmc Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities
    Florian Hladik
    Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Antiviral Res 88:S3-9. 2010
  4. ncbi request reprint Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
  5. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
  6. pmc Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells
    M Juliana McElrath
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Antimicrob Agents Chemother 54:763-72. 2010
  7. pmc Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells
    Lamar Ballweber
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109 1024, USA
    J Virol 85:13443-7. 2011
  8. pmc Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission
    Florian Hladik
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Infectious Diseases, 1100 Fairview Ave N, P O Box 19024, D3 100, Seattle, WA 98109 1024, USA
    J Virol 79:11677-84. 2005
  9. pmc Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunity 26:257-70. 2007
  10. pmc Impaired viral entry cannot explain reduced CD4+ T cell susceptibility to HIV type 1 in certain highly exposed individuals
    Emily C Speelmon
    Medical Scientist Training Program, University of Washington, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 24:1415-27. 2008

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Atopic dermatitis with increased severity along a line of Blaschko
    Florian Hladik
    Division of Immunology, Department of Dermatology, Allergy and Infectious Diseases, University of Vienna Medical School, Vienna, Austria
    J Am Acad Dermatol 53:S221-4. 2005
    ..Individuals such as our patient offer an opportunity to identify intraindividual genetic variations marking loci involved in the pathogenesis of atopy and atopic eczema...
  2. ncbi request reprint HIV infection of the genital mucosa in women
    Florian Hladik
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3 100, Seattle, WA 98109 1024, USA
    Curr HIV/AIDS Rep 6:20-8. 2009
    ..Studies using human explant tissues and in vivo animal studies have improved our understanding of the cellular and molecular pathways of infection; this information could be harnessed to design effective HIV vaccines and microbicides...
  3. pmc Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities
    Florian Hladik
    Department of Obstetrics and Gynecology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Antiviral Res 88:S3-9. 2010
    ..This article forms part of a special supplement on presentations covering HIV transmission and microbicides, based on the symposium "Trends in Microbicide Formulations", held on 25 and 26 January 2010, Arlington, VA...
  4. ncbi request reprint Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...
  5. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  6. pmc Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells
    M Juliana McElrath
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Antimicrob Agents Chemother 54:763-72. 2010
    ..8 microg/ml). These results highlight the merit of our model for screening the mucosal efficacies of novel microbicides and their formulations and potentially rank ordering candidates for clinical evaluation...
  7. pmc Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells
    Lamar Ballweber
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109 1024, USA
    J Virol 85:13443-7. 2011
    ..Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle...
  8. pmc Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission
    Florian Hladik
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Infectious Diseases, 1100 Fairview Ave N, P O Box 19024, D3 100, Seattle, WA 98109 1024, USA
    J Virol 79:11677-84. 2005
    ..We conclude that the CCR5 ORF delta32/wt-CCR5 -2459 A/G genotype combination offers an advantage in resisting sexual HIV-1 transmission and that this effect is mediated by a relative paucity of CCR5 on potential target cells of HIV-1...
  9. pmc Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunity 26:257-70. 2007
    ..Our findings shed light on the very earliest steps of mucosal HIV infection in vivo and may guide the design of effective strategies to block local transmission and prevent HIV-1 spread...
  10. pmc Impaired viral entry cannot explain reduced CD4+ T cell susceptibility to HIV type 1 in certain highly exposed individuals
    Emily C Speelmon
    Medical Scientist Training Program, University of Washington, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 24:1415-27. 2008
    ..Identifying the host-virus interactions responsible for diminished in vitro susceptibility may contribute to the development of novel therapeutic strategies...
  11. pmc Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:595-603. 2007
    ..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
  12. ncbi request reprint Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Eur J Hum Genet 13:707-15. 2005
    ..Soluble isoforms, in particular, may modulate the efficiency of viral transmission and dissemination...
  13. pmc Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus
    M J McElrath
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Acquir Immune Defic Syndr 63:263-71. 2013
    ..Yet, little is known about the specific target-cell milieu in the human rectum other than inferences made from the colon...
  14. pmc Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells
    Brian P Doehle
    University of Washington School of Medicine, Department of Immunology, Seattle, Washington, USA
    J Virol 86:8499-506. 2012
    ..These observations show that HIV-1 can indeed be recognized as a pathogen in infected cells and provide a novel and effective platform for defining the native innate immune programs of target cells of HIV-1 infection...
  15. pmc Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells
    Brian P Doehle
    University of Washington School of Medicine, Department of Immunology, Seattle, WA 98195, USA
    J Virol 83:10395-405. 2009
    ..IRF-3 may direct an innate antiviral response that regulates HIV-1 replication and viral set point while governing susceptibility to opportunistic virus coinfections...
  16. pmc Setting the stage: host invasion by HIV
    Florian Hladik
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Rev Immunol 8:447-57. 2008
    ..Furthermore, we discuss the gaps in our knowledge that are relevant to future studies, which will shape strategies for effective HIV prevention...
  17. ncbi request reprint Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3 100, Seattle, WA 98109, USA
    J Immunol 171:2671-83. 2003
    ..HIV-1-specific, IFN-gamma-secreting T cells are thus unlikely to substantially contribute to resistance against infection in most exposed seronegative men having sex with men...

Research Grants5

  1. Mechanisms of Sexual HIV-1 Transmission
    Florian Hladik; Fiscal Year: 2006
    ..These studies will improve our knowledge of the human genital immune system and shed light on the mechanisms of HIV-l targeting and strain selection in the female genital tract. ..
  2. Mechanisms of HIV-1 Transmission in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2007
    ..In this proposal, we will use a novel organ culture model of human vaginal tissue obtained from surgeries to characterize the entry pathways of HIV during the earliest stages of sexual transmission. ..
  3. Mechanisms of HIV-1 Transmission in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2007
    ..In this proposal, we will use a novel organ culture model of human vaginal tissue obtained from surgeries to characterize the entry pathways of HIV during the earliest stages of sexual transmission. ..