Affiliation: Fred Hutchinson Cancer Research Center
- The Women's Health Initiative recruitment methods and resultsJennifer Hays
From the WHI Clinical Center, Baylor College of Medicine, Houston, TX 77030, USA
Ann Epidemiol 13:S18-77. 2003
- Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)Libby M Morimoto
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Causes Control 13:741-51. 2002..Lifetime weight gain is also a strong predictor of breast cancer. Waist to hip ratio, a measure of weight distribution, does not appear to be related to postmenopausal breast cancer risk...
- Calcium plus vitamin D supplementation and the risk of colorectal cancerJean Wactawski-Wende
Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
N Engl J Med 354:684-96. 2006..However, randomized-trial evidence that calcium with vitamin D supplementation is beneficial in the primary prevention of colorectal cancer is lacking...
- Predictors of dietary change and maintenance in the Women's Health Initiative Dietary Modification TrialLesley F Tinker
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Am Diet Assoc 107:1155-66. 2007..Candidate predictors included intrapersonal, interpersonal, intervention program characteristics, and clinical center...
- Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal womenAnne McTiernan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Breast Cancer Res Treat 108:217-31. 2008..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
- Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsyRowan T Chlebowski
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Arch Intern Med 168:370-7; quiz 345. 2008..The effect of combined hormone therapy on breast cancer detection is not established...
- Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary eventsPaul F Bray
Cardeza Foundation for Hematologic Research and Jefferson Medical College, Philadelphia, Pennsylvania, USA
Am J Cardiol 101:1599-1605. 2008..However, women with favorable lipid levels, especially LDL/HDL cholesterol ratio <2.5, did not have increased risk of coronary heart disease with CEE with or without MPA irrespective of hs-CRP...
- A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory StudyKaren C Johnson
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
J Am Geriatr Soc 56:1449-58. 2008..To examine the relationship between baseline hypertension, blood pressure, and the development of cognitive decline in participants in the Women's Health Initiative Memory Study (WHIMS)...
- Cystatin-C, renal function, and incidence of hip fracture in postmenopausal womenAndrea Z LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Am Geriatr Soc 56:1434-41. 2008..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
- Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
- Hip bone density predicts breast cancer risk independently of Gail score: results from the Women's Health InitiativeZhao Chen
Division of Epidemiology and Biostatistics, University of Arizona College of Public Health, Tucson, Arizona 85724 5211, USA
Cancer 113:907-15. 2008..The objective of the current study was to investigate whether hip BMD predicts postmenopausal breast cancer risk independently of the Gail score...
- Calcium plus vitamin D supplementation and the risk of fracturesRebecca D Jackson
Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
N Engl J Med 354:669-83. 2006..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
- Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification TrialBarbara V Howard
MedStar Research Institute Howard University, Washington, DC, USA
JAMA 295:655-66. 2006..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed...
- Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trialGarnet L Anderson
Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
JAMA 291:1701-12. 2004..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
- Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory StudyMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 291:2959-68. 2004..The effect of estrogen-alone therapy, also evaluated in WHIMS, on cognition has not been established for this population...
- Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialStephen R Rapp
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 289:2663-72. 2003..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women...
- Effects of estrogen plus progestin on health-related quality of lifeJennifer Hays
Center for Women s Health, Department of Medicine, Baylor College of Medicine, Houston 77025, USA
N Engl J Med 348:1839-54. 2003..The Women's Health Initiative (WHI) and other clinical trials indicate that significant health risks are associated with combination hormone use. Less is known about the effect of hormone therapy on health-related quality of life...
- Symptom experience after discontinuing use of estrogen plus progestinJudith K Ockene
Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester 01655, USA
JAMA 294:183-93. 2005..Little is known about women's experiences after stopping menopausal hormone therapy...
- Effects of conjugated equine estrogen on health-related quality of life in postmenopausal women with hysterectomy: results from the Women's Health Initiative Randomized Clinical TrialRobert L Brunner
Department of Family and Community Medicine, University of Nevada School of Medicine, Reno 89557, USA
Arch Intern Med 165:1976-86. 2005..Because CEE is still prescribed for treatment of menopausal symptoms and prevention of osteoporosis, it is important to understand the overall impact of this therapy on health-related quality of life (HRQOL)...
- Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
JAMA 295:629-42. 2006..The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial...
- Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialShirley A A Beresford
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
JAMA 295:643-54. 2006..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial...
- Behavioral variables and education are predictors of dietary change in the Women's Health Trial: Feasibility Study in Minority PopulationsAlok Bhargava
Department of Economics, University of Houston, Houston, TX 77204 5019, USA
Prev Med 38:442-51. 2004....
- Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium studyMatthew A Allison
University of California San Diego, La Jolla, CA, USA
Menopause 15:639-47. 2008..In this study, we aimed to determine the associations between coronary artery calcium (CAC) and hysterectomy, oophorectomy, and hormone therapy use with a focus on the duration of menopause for which there was no hormone therapy use...
- Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestinGerardo Heiss
University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, NC 27514 3628, USA
JAMA 299:1036-45. 2008..The Women's Health Initiative (WHI) trial of estrogen plus progestin vs placebo was stopped early, after a mean 5.6 years of follow-up, because the overall health risks of hormone therapy exceeded its benefits...
- Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning...