M Elizabeth Halloran

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 165:212-21. 2007
  2. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
  3. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
  4. pmc Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Epidemiol 173:1121-30. 2011
  5. pmc Estimating influenza vaccine efficacy from challenge and community-based study data
    Nicole E Basta
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 168:1343-52. 2008
  6. pmc The effects of vector movement and distribution in a mathematical model of dengue transmission
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e76044. 2013
  7. pmc Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States
    Nicole E Basta
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 170:679-86. 2009
  8. pmc The global transmission and control of influenza
    Eben Kenah
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e19515. 2011
  9. pmc The effect of age on transmission of 2009 pandemic influenza A (H1N1) in a camp and associated households
    Jonathan D Sugimoto
    Center for Statistics and Quantitative Infectious Disease, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Epidemiology 22:180-7. 2011
  10. pmc Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics
    Laith J Abu-Raddad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:13980-5. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 165:212-21. 2007
    ..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...
  2. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
    ..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza...
  3. pmc The transmissibility and control of pandemic influenza A (H1N1) virus
    Yang Yang
    Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA
    Science 326:729-33. 2009
    ..If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic...
  4. pmc Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Epidemiol 173:1121-30. 2011
    ....
  5. pmc Estimating influenza vaccine efficacy from challenge and community-based study data
    Nicole E Basta
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 168:1343-52. 2008
    ..VE(I) estimates were particularly low for these influenza vaccines. VE(SP) and VE(C) can remain high for both vaccines, even when VE(I) is relatively low, as long as the other 2 measures of vaccine efficacy are relatively high...
  6. pmc The effects of vector movement and distribution in a mathematical model of dengue transmission
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e76044. 2013
    ..Two assumptions usually incorporated by mathematical models of vector-borne disease transmission is homogeneous mixing among the hosts and vectors and homogeneous distribution of the vectors...
  7. pmc Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States
    Nicole E Basta
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 170:679-86. 2009
    ..Given the current worldwide threat of novel influenza A (H1N1), with an estimated R of 1.4-1.6, health officials should consider strategies for vaccinating children against novel influenza A (H1N1) as well as seasonal influenza...
  8. pmc The global transmission and control of influenza
    Eben Kenah
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e19515. 2011
    ..Our open-source, computationally simple model can help public health officials plan for the next pandemic as well as deal with interpandemic influenza...
  9. pmc The effect of age on transmission of 2009 pandemic influenza A (H1N1) in a camp and associated households
    Jonathan D Sugimoto
    Center for Statistics and Quantitative Infectious Disease, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Epidemiology 22:180-7. 2011
    ..A major portion of influenza disease burden during the 2009 pandemic was observed among young people...
  10. pmc Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics
    Laith J Abu-Raddad
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 106:13980-5. 2009
    ..Elimination will require new delivery strategies, such as mass vaccination campaigns, and new products targeted at latently infected people...
  11. pmc A Bayesian model for evaluating influenza antiviral efficacy in household studies with asymptomatic infections
    Yang Yang
    Program of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biostatistics 10:390-403. 2009
    ..We also found significant therapeutic efficacies in reducing pathogenicity and the risk of infection with disease but no therapeutic efficacy in reducing the risk of viral infection in the contacts...
  12. pmc FluTE, a publicly available stochastic influenza epidemic simulation model
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 6:e1000656. 2010
    ..Computer simulation models play an essential role in informing public policy and evaluating pandemic preparedness plans. We have made the source code of this model publicly available to encourage its use and further development...
  13. pmc Controlling dengue with vaccines in Thailand
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Negl Trop Dis 6:e1876. 2012
    ....
  14. pmc Detecting human-to-human transmission of avian influenza A (H5N1)
    Yang Yang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Emerg Infect Dis 13:1348-53. 2007
    ..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains...
  15. ncbi request reprint Containing a large bioterrorist smallpox attack: a computer simulation approach
    Ira M Longini
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
    Int J Infect Dis 11:98-108. 2007
    ..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries...
  16. pmc School opening dates predict pandemic influenza A(H1N1) outbreaks in the United States
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Infect Dis 202:877-80. 2010
    ..School opening dates can be useful for future pandemic planning, and influenza mitigation strategies should be targeted at school populations before the influenza season...
  17. pmc Vaccination strategies for epidemic cholera in Haiti with implications for the developing world
    Dennis L Chao
    Center for Statistics and Quantitative Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:7081-5. 2011
    ..For epidemic cholera, we recommend a large mobile stockpile of enough vaccine to cover 30% of a country's population to be reactively targeted to populations at high risk of exposure...
  18. pmc A hybrid EM and Monte Carlo EM algorithm and its application to analysis of transmission of infectious diseases
    Yang Yang
    Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA
    Biometrics 68:1238-49. 2012
    ..We use the hybrid EM-MCEM algorithm to analyze two influenza epidemics in the late 1970s to assess the effects of age and preseason antibody levels on the transmissibility and pathogenicity of the viruses...
  19. pmc Invited commentary: Evaluating vaccination programs using genetic sequence data
    M Elizabeth Halloran
    Statistics and Quantitative Infectious Diseases, Seattle, WA 98109, USA
    Am J Epidemiol 170:1464-6; discussion 1467-8. 2009
    ..Second, data need to reflect sufficiently fine-grained temporal sampling. Third, other processes that can potentially influence genetic diversity and confuse demographic inferences should be considered...
  20. ncbi request reprint Invited commentary: Challenges of using contact data to understand acute respiratory disease transmission
    M Elizabeth Halloran
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, MS LE 400, Seattle, WA 98109, USA
    Am J Epidemiol 164:945-6. 2006
  21. ncbi request reprint Public health. Community studies for vaccinating schoolchildren against influenza
    M Elizabeth Halloran
    Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:615-6. 2006
  22. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  23. ncbi request reprint Containing bioterrorist smallpox
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Science 298:1428-32. 2002
    ..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox...
  24. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
    ..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available...
  25. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  26. ncbi request reprint Estimating heterogeneous transmission with multiple infectives using MCMC methods
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:35-49. 2004
    ..Parameters are estimated using Markov chain Monte Carlo methods...
  27. ncbi request reprint Safety of cold-adapted live influenza vaccine
    W Paul Glezen
    Pediatr Infect Dis J 23:593-4; author reply 594. 2004
  28. ncbi request reprint Estimating vaccine efficacy using auxiliary outcome data and a small validation sample
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:2697-711. 2004
    ..Comparing the performance of these approaches using data from a field study of influenza vaccine and simulations, we recommend to use the Bayesian method in this situation...
  29. ncbi request reprint Population-wide benefits of routine vaccination of children against influenza
    Derek Weycker
    Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
    Vaccine 23:1284-93. 2005
    ..Similar reductions were estimated to occur in influenza-related mortality and economic costs...
  30. ncbi request reprint Strategy for distribution of influenza vaccine to high-risk groups and children
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 161:303-6. 2005
    ..The effectiveness of the alternative plan could be assessed through nationwide community studies...
  31. ncbi request reprint Finding optimal vaccination strategies for pandemic influenza using genetic algorithms
    Rajan Patel
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    J Theor Biol 234:201-12. 2005
    ..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures...
  32. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
    ..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4...
  33. pmc On estimation of vaccine efficacy using validation samples with selection bias
    Daniel O Scharfstein
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biostatistics 7:615-29. 2006
    ..Our approach is generally applicable to studies with missing binary outcomes with categorical covariates...
  34. ncbi request reprint A family study of lymphedema of the leg in a lymphatic filariasis-endemic area
    Karen T Cuenco
    Departments of Epidemiology and Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Am J Trop Med Hyg 70:180-4. 2004
    ..This family study will be useful to investigate the role of genes and environment in the development of filarial-related lymphedema...
  35. ncbi request reprint Community interventions and the epidemic prevention potential
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 20:3254-62. 2002
    ..The concepts are general and could be applied to other interventions, such as antivirals and quarantine...