Carla Grandori

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Non-transcriptional control of DNA replication by c-Myc
    David Dominguez-Sola
    Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Nature 448:445-51. 2007
  2. pmc NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes
    Mei Xu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 28:4819-28. 2008
  3. ncbi request reprint c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Nat Cell Biol 7:311-8. 2005
  4. pmc Werner syndrome protein limits MYC-induced cellular senescence
    Carla Grandori
    Basic Sciences, Human Biology and Clinical Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:1569-74. 2003
  5. ncbi request reprint Functional link between Myc and the Werner gene in tumorigenesis
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell Cycle 3:22-5. 2004
  6. pmc An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes
    Mei Xu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Virology 446:17-24. 2013
  7. pmc c-Myc accelerates S-phase and requires WRN to avoid replication stress
    Kristin Robinson
    Program in Cancer Biology and Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e5951. 2009
  8. pmc Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ
    Myra L Wang
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cell Cycle 10:2540-8. 2011
  9. pmc NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity
    Mei Xu
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, C1 015, Seattle, WA 98109 1024, USA
    J Virol 84:11461-9. 2010
  10. pmc MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency
    Russell Moser
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cancer Res 10:535-45. 2012

Research Grants

  1. DIRECT TARGET GENES OF THE MYC ONCOPROTEIN
    Carla Grandori; Fiscal Year: 2002
  2. Role of RecQ Helicases to Prevent Senescence By c-Myc
    Carla Grandori; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Non-transcriptional control of DNA replication by c-Myc
    David Dominguez-Sola
    Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Nature 448:445-51. 2007
    ..These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions...
  2. pmc NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes
    Mei Xu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 28:4819-28. 2008
    ..These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription...
  3. ncbi request reprint c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Nat Cell Biol 7:311-8. 2005
    ..We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis...
  4. pmc Werner syndrome protein limits MYC-induced cellular senescence
    Carla Grandori
    Basic Sciences, Human Biology and Clinical Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:1569-74. 2003
    ..We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence...
  5. ncbi request reprint Functional link between Myc and the Werner gene in tumorigenesis
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell Cycle 3:22-5. 2004
    ..In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers...
  6. pmc An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes
    Mei Xu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Virology 446:17-24. 2013
    ..These data also highlight multiple factors that normally regulate hTERT repression in HFKs, and therefore are targeted by E6 for hTERT expression. ..
  7. pmc c-Myc accelerates S-phase and requires WRN to avoid replication stress
    Kristin Robinson
    Program in Cancer Biology and Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e5951. 2009
    ..This work provides an additional mechanistic explanation for c-Myc-induced DNA damage and senescence, and reveals a vulnerability of c-Myc overexpressing cells that could potentially be exploited in cancer therapy...
  8. pmc Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ
    Myra L Wang
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cell Cycle 10:2540-8. 2011
    ..These findings highlight the potential to reveal key pathways contributing to the self-renewal of cancer cells through functional mining of the unique gene expression signature of cells immortalized by c-MYC...
  9. pmc NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity
    Mei Xu
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, C1 015, Seattle, WA 98109 1024, USA
    J Virol 84:11461-9. 2010
    ..Also, it provides evidence that NFX1-91 can function as a dual regulator, not only a transcriptional repressor, but also a transcriptional activator, when bound to DNA...
  10. pmc MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency
    Russell Moser
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cancer Res 10:535-45. 2012
    ..This leads to inhibition of tumor growth and prolonged tumor-free survival. Targeting WRN or its enzymatic function could prove to be an effective strategy in the treatment of MYC-associated cancers...
  11. pmc Functional genomics identifies therapeutic targets for MYC-driven cancer
    Masafumi Toyoshima
    Department of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:9545-50. 2012
    ..In summary, through a functional genomics approach, pathways essential in the context of oncogenic MYC but not to normal cells were identified, thus revealing a rich therapeutic space linked to a previously "undruggable" oncogene...
  12. ncbi request reprint Epigenetic down-regulation of ARF expression is a selection step in immortalization of human fibroblasts by c-Myc
    Jennifer A Benanti
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 015, P O Box 19024, Seattle, WA 98109 1024, USA
    Mol Cancer Res 5:1181-9. 2007
    ..Our findings predict that epigenetic events play a significant role in human tumors that express high levels of c-Myc...
  13. ncbi request reprint MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
    Zhan Zhang
    Rosetta Inpharmatics LLC, Seattle, WA, USA
    Cell Cycle 8:2756-68. 2009
    ..Thus, miR-210 influences the hypoxia response in tumor cells through targeting a key transcriptional repressor of the MYC-MAX network...
  14. pmc Functional kinomics identifies candidate therapeutic targets in head and neck cancer
    Russell Moser
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Clin Cancer Res 20:4274-88. 2014
    ..To identify novel therapeutic drug targets for p53-mutant head and neck squamous cell carcinoma (HNSCC)...
  15. pmc PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality
    Eric G Bluemn
    School of Medicine, University of Washington, Seattle, Washington, USA
    Mol Cancer Res 11:568-78. 2013
    ..These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes or the growth pathway(s) activated by PPP2R2C as a therapeutic strategy...
  16. pmc Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1
    Brian M Iritani
    Division of Basic Sciences and DNA Array Facility, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, PO Box 19024, Seattle, WA 98109 1024, USA
    EMBO J 21:4820-30. 2002
    ..These results suggest that a balance between Myc and Mad levels may normally modulate lymphocyte proliferation and development in part by controlling expression of growth-regulating genes...
  17. doi request reprint A high-throughput siRNA screening platform to identify MYC-synthetic lethal genes as candidate therapeutic targets
    Carla Grandori
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods Mol Biol 1012:187-200. 2013
    ..This flexible platform can be readily applied to other oncogenes or tumor suppressor genes. ..
  18. ncbi request reprint Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest
    Cayetano Von Kobbe
    Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    FASEB J 18:1970-2. 2004
    ..We propose a role for WRN in the detection and/or processing of oxidative DNA lesions and in cellular responses to H2O2 as they relate to some of the phenotypical aspects of WS cells...
  19. ncbi request reprint Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc
    Zoe A Felton-Edkins
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Cell Cycle 2:181-4. 2003
    ..Availability of pol III products may be an important determinant of a cell's capacity to grow. The ability to regulate pol III output may therefore be integral to the growth control functions of RB, p53 and c-Myc...
  20. ncbi request reprint Direct activation of RNA polymerase III transcription by c-Myc
    Natividad Gomez-Roman
    Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK
    Nature 421:290-4. 2003
    ..These results suggest that activation of pol III may have a role in the ability of c-Myc to stimulate cell growth...

Research Grants2

  1. DIRECT TARGET GENES OF THE MYC ONCOPROTEIN
    Carla Grandori; Fiscal Year: 2002
    ..These studies will provide several pieces of the puzzle necessary to understand how Myc functions as an oncogene. ..
  2. Role of RecQ Helicases to Prevent Senescence By c-Myc
    Carla Grandori; Fiscal Year: 2010
    ..If so, drug inhibitors of WRN function could be proposed for the treatment of cancer. ..