Affiliation: Fred Hutchinson Cancer Research Center
Grandori C, Wu K, Fernandez P, Ngouenet C, Grim J, Clurman B, et al. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 2003;17:1569-74 pubmed
..We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence. ..
Grandori C, Gomez Roman N, Felton Edkins Z, Ngouenet C, Galloway D, Eisenman R, et al. c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol. 2005;7:311-8 pubmed
..We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis. ..