Affiliation: Fred Hutchinson Cancer Research Center
- The Myc/Max/Mad network and the transcriptional control of cell behaviorC Grandori
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Annu Rev Cell Dev Biol 16:653-99. 2000..Because Myc and Mad proteins are expressed in response to diverse signaling pathways, the network can be viewed as a functional module which acts to convert environmental signals into specific gene-regulatory programs...
- Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivoC Grandori
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
EMBO J 15:4344-57. 1996..Therefore, Myc may exert its effects on cell behavior through proteins that affect RNA structure and metabolism...
- Regulation of telomerase by human papillomavirusesD A Galloway
Program in Cancer Biology, Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
Cold Spring Harb Symp Quant Biol 70:209-15. 2005..The NFX1-123 isoform has the opposite activity, increasing hTERT transcription or translation. This is the first example of viral oncoproteins disrupting regulation of telomerase, a critical event in tumorigenesis...
- Direct activation of TERT transcription by c-MYCK J Wu
Department of Pathology, Columbia University, New York, New York 10027, USA
Nat Genet 21:220-4. 1999..Our results indicate that TERT is a target of c-MYC activity and identify a pathway linking cell proliferation and chromosome integrity in normal and neoplastic cells...