Edward Giniger

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics
    Edward Giniger
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109 1024, USA
    Differentiation 70:385-96. 2002
  2. ncbi request reprint Lola regulates midline crossing of CNS axons in Drosophila
    Daniel Crowner
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    Development 129:1317-25. 2002
  3. ncbi request reprint Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway
    Daniel Crowner
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, Seattle, WA 98109, USA
    Curr Biol 13:967-72. 2003
  4. ncbi request reprint Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila
    Scott Goeke
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109 1024, USA
    Nat Neurosci 6:917-24. 2003
  5. pmc Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan
    Lisa Connell-Crowley
    Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke NINDS, National Human Genome Research Institute NHGRI, National Institutes of Health Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 124:341-9. 2007
  6. pmc Molecular separation of two signaling pathways for the receptor, Notch
    Maude Le Gall
    Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health, Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Dev Biol 313:556-67. 2008
  7. pmc The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 37 Room 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 125:247-56. 2008

Collaborators

  • Daniel Crowner
  • Maude Le Gall
  • Scott Goeke
  • Jeong K Song
  • Lisa Connell-Crowley
  • Michael A Gates
  • Cordell De Mattei
  • Chand J Desai
  • Lori Luke
  • Duc Vo
  • Paul K Grant
  • Elizabeth A Greene
  • Toshiro Aigaki
  • Knut Madden

Detail Information

Publications7

  1. ncbi request reprint How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics
    Edward Giniger
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109 1024, USA
    Differentiation 70:385-96. 2002
    ..This review will intentionally be highly selective in its treatment of this subject in order to synthesize a simplified view that may be of value in directing further thinking and experiments...
  2. ncbi request reprint Lola regulates midline crossing of CNS axons in Drosophila
    Daniel Crowner
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    Development 129:1317-25. 2002
    ....
  3. ncbi request reprint Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway
    Daniel Crowner
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, Seattle, WA 98109, USA
    Curr Biol 13:967-72. 2003
    ..We suggest that the Notch/Abl interaction promotes the turning of ISNb axons by attenuating the Abl-dependent adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attraction from target muscles...
  4. ncbi request reprint Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila
    Scott Goeke
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109 1024, USA
    Nat Neurosci 6:917-24. 2003
    ..Thus, in this system, the alternative splicing of a key transcription factor helps to explain how a small genome encodes all the information that is necessary to specify the enormous diversity of axonal trajectories...
  5. pmc Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan
    Lisa Connell-Crowley
    Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke NINDS, National Human Genome Research Institute NHGRI, National Institutes of Health Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 124:341-9. 2007
    ..We further show that, while viable and fertile, p35 mutant adults display progressive, age-dependent loss of motor function and have a significantly shortened lifespan...
  6. pmc Molecular separation of two signaling pathways for the receptor, Notch
    Maude Le Gall
    Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health, Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Dev Biol 313:556-67. 2008
    ..Together, these data provide evidence for an alternate Notch signaling pathway that mediates a postmitotic, morphogenetic function of the receptor...
  7. pmc The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 37 Room 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 125:247-56. 2008
    ....