Linda N Geng

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Immunodetection of human double homeobox 4
    Linda N Geng
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Hybridoma (Larchmt) 30:125-30. 2011
  2. pmc DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003947. 2013
  3. pmc DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy
    Linda N Geng
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 22:38-51. 2012
  4. pmc Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 6:e1001181. 2010
  5. pmc RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:2414-30. 2009
  6. pmc DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences
    Scott J Diede
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 107:234-9. 2010

Collaborators

Detail Information

Publications6

  1. pmc Immunodetection of human double homeobox 4
    Linda N Geng
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Hybridoma (Larchmt) 30:125-30. 2011
    ..Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis...
  2. pmc DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003947. 2013
    ..Our findings demonstrate a role for DUX4 and repetitive elements in mammalian germline evolution and in FSHD muscular dystrophy. ..
  3. pmc DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy
    Linda N Geng
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 22:38-51. 2012
    ..These findings suggest specific mechanisms of FSHD pathology and identify candidate biomarkers for disease diagnosis and progression...
  4. pmc Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 6:e1001181. 2010
    ..Therefore, FSHD represents the first human disease to be associated with the incomplete developmental silencing of a retrogene array normally expressed early in development...
  5. pmc RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:2414-30. 2009
    ..Together, we have identified new sense and anti-sense RNA transcripts, novel mRNAs and mi/siRNA-sized RNA fragments generated from the D4Z4 units that are new candidates for the pathophysiology of FSHD...
  6. pmc DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences
    Scott J Diede
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 107:234-9. 2010
    ..This finding warrants strong consideration for DNA demethylating agents in future clinical trials for children with this disease...