Debra L Friedman

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Late effects of treatment for Hodgkin lymphoma
    Debra L Friedman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Natl Compr Canc Netw 4:249-57. 2006
  2. ncbi request reprint Increased risk of cancer among siblings of long-term childhood cancer survivors: a report from the childhood cancer survivor study
    Debra L Friedman
    University of Washington and Fred Hutchinson Cancer Research Center, Suite D5 280, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1922-7. 2005
  3. pmc Increased risk of breast cancer among survivors of allogeneic hematopoietic cell transplantation: a report from the FHCRC and the EBMT-Late Effect Working Party
    Debra L Friedman
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98109, USA
    Blood 111:939-44. 2008
  4. ncbi request reprint Models of care for survivors of childhood cancer
    Debra L Friedman
    University of Washington, Seattle, Washington 98109 024, USA
    Pediatr Blood Cancer 46:159-68. 2006
  5. ncbi request reprint Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 50:854-8. 2008
  6. pmc Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study
    Anne C Kirchhoff
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Care 48:1015-25. 2010
  7. ncbi request reprint A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancers
    Yutaka Yasui
    Cancer Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 158:1108-13. 2003
  8. doi request reprint Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation
    Eric J Chow
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Ann Intern Med 155:21-32. 2011
  9. ncbi request reprint Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation
    Wendy Leisenring
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 24:1119-26. 2006
  10. pmc Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study
    Parveen Bhatti
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, UA
    Radiat Res 174:741-52. 2010

Research Grants

Detail Information

Publications36

  1. ncbi request reprint Late effects of treatment for Hodgkin lymphoma
    Debra L Friedman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Natl Compr Canc Netw 4:249-57. 2006
    ..Primary and secondary prevention strategies can be developed as knowledge of delayed effects of therapy increases...
  2. ncbi request reprint Increased risk of cancer among siblings of long-term childhood cancer survivors: a report from the childhood cancer survivor study
    Debra L Friedman
    University of Washington and Fred Hutchinson Cancer Research Center, Suite D5 280, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1922-7. 2005
    ..9-1.0). Seventy percent of siblings' cancers developed in adulthood. These findings suggest that familial cancer syndromes may be revealed as this cohort and family members age and with accrual of more offspring and subjects with SMNs...
  3. pmc Increased risk of breast cancer among survivors of allogeneic hematopoietic cell transplantation: a report from the FHCRC and the EBMT-Late Effect Working Party
    Debra L Friedman
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98109, USA
    Blood 111:939-44. 2008
    ..Hazard for death associated with breast cancer was 2.5 (95% CI: 1.1-5.8). We conclude that female survivors of allogeneic HCT are at increased risk of breast cancer and should be educated about the need for regular screening...
  4. ncbi request reprint Models of care for survivors of childhood cancer
    Debra L Friedman
    University of Washington, Seattle, Washington 98109 024, USA
    Pediatr Blood Cancer 46:159-68. 2006
    ..As outcome research progresses for childhood cancer survivors, methodological issues of optimal health care delivery for this population deserve to be the subject of such research...
  5. ncbi request reprint Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 50:854-8. 2008
    ..The objective of this study was to determine risk factors associated with abnormal timing of menarche among survivors of childhood acute lymphoblastic leukemia (ALL)...
  6. pmc Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study
    Anne C Kirchhoff
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Care 48:1015-25. 2010
    ..Adult childhood cancer survivors report high levels of unemployment, although it is unknown whether this is because of health or employability limitations...
  7. ncbi request reprint A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancers
    Yutaka Yasui
    Cancer Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 158:1108-13. 2003
    ..These showed appreciable differences in the analytical results by not accounting for the natural age-associated increase of risk, illustrating a significant impact of this methodological issue on study conclusions...
  8. doi request reprint Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation
    Eric J Chow
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Ann Intern Med 155:21-32. 2011
    ..Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat multiple malignant and nonmalignant conditions. The risk for cardiovascular disease after the procedure has not been well-described...
  9. ncbi request reprint Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation
    Wendy Leisenring
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 24:1119-26. 2006
    ..To evaluate the incidence of and risk factors for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in survivors of hematopoietic cell transplantation (HCT)...
  10. pmc Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study
    Parveen Bhatti
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, UA
    Radiat Res 174:741-52. 2010
    ....
  11. pmc Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    J Pediatr 150:370-5, 375.e1. 2007
    ..To determine risk factors associated with reduced adult height in survivors of childhood acute lymphoblastic leukemia (ALL)...
  12. pmc Glucocorticoids and insulin resistance in children with acute lymphoblastic leukemia
    Eric J Chow
    Department of Pediatrics, Seattle Children s Hospital, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 60:621-6. 2013
    ..Children treated for acute lymphoblastic leukemia (ALL) are more likely to become overweight. Prolonged exposure to high-dose glucocorticoids may cause insulin resistance and facilitate development of this phenotype...
  13. ncbi request reprint Employment status among adult survivors in the Childhood Cancer Survivor Study
    Jenny W Y Pang
    University of Washington School of Public Health and Community Medicine, Department of Epidemiology, Seattle, Washington, USA
    Pediatr Blood Cancer 50:104-10. 2008
    ..With increased cure, childhood cancer survivors are reaching adulthood and seeking employment. Host, disease and treatment risk factors may contribute to inability to attain or maintain employment...
  14. pmc Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation
    Jeffrey L Schwartz
    Department of Radiation Oncology, The University of Washington Medical Center, Seattle, Washington 98195 6069, USA
    Radiat Res 171:155-63. 2009
    ....
  15. pmc Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 53:432-7. 2009
    ..To determine the risk of thyroid dysfunction and subsequent thyroid cancer among childhood acute lymphoblastic leukemia (ALL) survivors...
  16. ncbi request reprint Second malignant neoplasms following hematopoietic stem cell transplantation
    Debra L Friedman
    University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Int J Hematol 79:229-34. 2004
    ..We review the incidence and spectrum of posttransplantation malignancies and discuss risk factors and future directions for research...
  17. pmc Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation
    Eric J Chow
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 16:1674-81. 2010
    ..In summary, pediatric ALL survivors exposed to TBI-based HCT as well as to any cranial radiation may manifest cardiometabolic traits at an early age and should be screened accordingly...
  18. ncbi request reprint Issues and challenges in palliative care for children with cancer
    Debra L Friedman
    Division of Hematology Oncology, University of Washington, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Curr Pain Headache Rep 9:249-55. 2005
    ..Hypothesis-driven research must be developed to help us learn more about how best to deliver end-of-life care to children and their families...
  19. pmc Secondary malignant neoplasms after Wilms tumor: an international collaborative study
    Norman E Breslow
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Int J Cancer 127:657-66. 2010
    ..003). These trends may reflect the decreasing use of radiation therapy and increasing intensity of chemotherapy in modern protocols for treatment of WT...
  20. ncbi request reprint Obesity and hypertension among children after treatment for acute lymphoblastic leukemia
    Eric J Chow
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 110:2313-20. 2007
    ..The purpose was to determine the prevalence and treatment-related risk factors for obesity and hypertension among childhood acute lymphoblastic leukemia (ALL) survivors treated with contemporary therapy...
  21. doi request reprint Tp53 codon-72 polymorphisms identify different radiation sensitivities to g2-chromosome breakage in human lymphoblast cells
    Jeffrey L Schwartz
    Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
    Environ Mol Mutagen 52:77-80. 2011
    ..Distinguishing the effect of TP53 codon-72 variations from other modifiers of G2-chromosome radiosensitivity might aid in identifying new markers of cancer risk...
  22. ncbi request reprint Ciprofloxacin and amoxicillin as continuation treatment of febrile neutropenia in pediatric cancer patients
    Julie R Park
    Pediatric Hematology Oncology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington, USA
    Med Pediatr Oncol 40:93-8. 2003
    ..Outpatient empiric antibiotic therapy can be safely administered to a subset of febrile neutropenic patients at low risk for clinical complications...
  23. ncbi request reprint Issues and challenges in palliative care for children with cancer
    Debra L Friedman
    Division of Hematology Oncology, University of Washington, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Curr Oncol Rep 6:431-7. 2004
    ..Hypothesis-driven research must be developed to help us learn more about how best to deliver end-of-life care to children and their families...
  24. ncbi request reprint Influence of age upon Ifosfamide-induced nephrotoxicity
    Jeannine S McCune
    University of Washington Medical Center, Seattle, Washington, USA
    Pediatr Blood Cancer 42:427-32. 2004
    ..Ifosfamide-induced nephrotoxicity is well recognized in children, although it has also been reported in adults. Whether ifosfamide nephrotoxicity is more common in children than in adults is not known...
  25. ncbi request reprint The risk of cancer in twins: a report from the childhood cancer survivor study
    Nina S Kadan-Lottick
    Yale University, New Haven, Connecticut 06520, USA
    Pediatr Blood Cancer 46:476-81. 2006
    ....
  26. ncbi request reprint Long-term effects of treatments for childhood cancers
    Jorge A Alvarez
    Department of Pediatrics, University of Miami Jackson Memorial Medical Center, Miami, Florida, USA
    Curr Opin Pediatr 19:23-31. 2007
    ..We selectively review the negative late cardiac, endocrine, and neurological effects of childhood cancer and its treatments and comment on current research and recommendations for the care of long-term survivors of childhood cancer...
  27. ncbi request reprint Chronic health conditions in adult survivors of childhood cancer
    Kevin C Oeffinger
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    N Engl J Med 355:1572-82. 2006
    ..Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors...
  28. ncbi request reprint Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study
    Mylène Bassal
    Division of Pediatric Hematology Oncology BMT, University of Colorado Health Sciences Center, Denver, CO, USA
    J Clin Oncol 24:476-83. 2006
    ..To determine the risk of subsequent carcinomas other than breast, thyroid, and skin, and to identify factors that influence the risk among survivors of childhood cancer...
  29. ncbi request reprint The Minneapolis-Manchester Quality of Life instrument: Reliability and validity of the Youth Form
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, California, USA
    J Pediatr 145:39-46. 2004
    ..We developed the Minneapolis-Manchester Quality of Life-Youth Form (MMQL-YF) as a standardized patient self-report instrument designed to assess HRQoL in childhood cancer survivors between the ages of 8 and 12 years...
  30. ncbi request reprint The Minneapolis-Manchester Quality of Life instrument: reliability and validity of the Adolescent Form
    Smita Bhatia
    Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA, USA
    J Clin Oncol 20:4692-8. 2002
    ..This report focuses on the development and testing of the MMQL-Adolescent Form...
  31. ncbi request reprint Self-reported family history of cancer: the utility of probing questions
    Nina S Kadan-Lottick
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Epidemiology 14:737-40. 2003
    ..Self-reported data might be nonspecific and prone to errors, although of high quality for certain cancers. We evaluated the utility of a brief follow-up survey to elicit further details regarding uncertain cancer conditions...
  32. ncbi request reprint Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline
    Wendy Landier
    Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    J Clin Oncol 22:4979-90. 2004
    ..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org...
  33. ncbi request reprint Monitoring diagnostic accuracy and complications. A report from the Children's Oncology Group Hodgkin lymphoma study
    Peter F Ehrlich
    Department of Pediatric Surgery and University of Michigan Medical Center, Ann Arbor, MI 48104, USA
    J Pediatr Surg 42:788-91. 2007
    ..A surgical quality assurance program was embedded as part of the of the Hodgkin lymphoma study (AHODOOO31) to assess diagnostic accuracy and complications...
  34. ncbi request reprint Complementary and alternative medicine in pediatric oncology: availability and institutional policies in Canada--a report from the Children's Oncology Group
    Donna L Johnston
    Division of Hematology Oncology, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Pediatr Blood Cancer 47:955-8. 2006
    ..Despite published widespread use of CAM therapies, our study demonstrates that institutional CAM resources and policies on CAM are present in much lower proportions...
  35. doi request reprint Availability and use of palliative care and end-of-life services for pediatric oncology patients
    Donna L Johnston
    Division of Hematology Oncology, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
    J Clin Oncol 26:4646-50. 2008
    ..We sought to investigate the current practices and resources surrounding palliative and end-of-life care among participating institutions of the Children's Oncology Group (COG)...
  36. ncbi request reprint Late effects of childhood cancer therapy
    Debra L Friedman
    Division of Pediatric Hematology Oncology, Children s Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle 98117, USA
    Pediatr Clin North Am 49:1083-106, x. 2002
    ..It discusses the clinical and research challenges posed by such late effects. The authors address related topics of late effects research and clinical care, methodological issues, barriers and directions for the future...

Research Grants3

  1. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..The findings of this research can be applied to the development of preventive strategies of second malignant neoplasms and other adverse long-term health-related outcomes for cancer survivors. ..
  2. Exercise and Fitness in Childhood Cancer Survivors
    Debra Friedman; Fiscal Year: 2005
    ..Ultimately, this research will provide vital information regarding the long-term physical sequelae of childhood cancer, and will direct interventions to mitigate these outcomes and enhance quality of life. ..
  3. Social & Physical Activity of Childhood Cancer Survivors
    Debra Friedman; Fiscal Year: 2006
    ..Subjects in the 1C will be compared to an equal number of subjects enrolled in a standard care CC on identical outcome measures. ..