Z Feng

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008
  2. ncbi A new family-based association test via a least-squares method
    Song Yang
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    BMC Genet 6:S110. 2005
  3. ncbi Research issues and strategies for genomic and proteomic biomarker discovery and validation: a statistical perspective
    Ziding Feng
    Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Pharmacogenomics 5:709-19. 2004
  4. ncbi Selected statistical issues in group randomized trials
    Z Feng
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 702, Seattle, Washington 98109 1024, USA
    Annu Rev Public Health 22:167-87. 2001
  5. ncbi Some design issues in a community intervention trial
    Ziding Feng
    Cancer Prevention Research Program, Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Control Clin Trials 23:431-49. 2002
  6. ncbi Classification versus association models: should the same methods apply?
    Ziding Feng
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Scand J Clin Lab Invest Suppl 242:53-8. 2010
  7. ncbi Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
  8. ncbi Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Carcinogenesis 21:1157-62. 2000
  9. ncbi CYP17 polymorphisms and prostate cancer outcomes
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 70:1094-101. 2010
  10. ncbi Association of caveolin-1 and -2 genetic variants and post-treatment serum caveolin-1 with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 70:1020-35. 2010

Research Grants

  1. STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALS
    Ziding Feng; Fiscal Year: 2003
  2. EDRN:Data Management and Coordinating Center
    Ziding Feng; Fiscal Year: 2007

Detail Information

Publications94

  1. ncbi Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008
    ..Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women...
  2. ncbi A new family-based association test via a least-squares method
    Song Yang
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    BMC Genet 6:S110. 2005
    ..When applied to the data from Collaborative Study on the Genetics of Alcoholism, this new method shows a significant association between the marker rs1037475 and alcoholism...
  3. ncbi Research issues and strategies for genomic and proteomic biomarker discovery and validation: a statistical perspective
    Ziding Feng
    Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Pharmacogenomics 5:709-19. 2004
    ..Model assessment and cross-validation are critical components of data analysis. Having an independent test set is a vital feature of study design...
  4. ncbi Selected statistical issues in group randomized trials
    Z Feng
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 702, Seattle, Washington 98109 1024, USA
    Annu Rev Public Health 22:167-87. 2001
    ..Also discussed are various design issues, along with guidelines for choosing among them. A real data example illustrates these issues and methods...
  5. ncbi Some design issues in a community intervention trial
    Ziding Feng
    Cancer Prevention Research Program, Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Control Clin Trials 23:431-49. 2002
    ..These include collecting information in baseline and follow-up surveys on intervention dose and conducting surveys in three similar communities in another part of the state...
  6. ncbi Classification versus association models: should the same methods apply?
    Ziding Feng
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Scand J Clin Lab Invest Suppl 242:53-8. 2010
    ..We suggest that developing classification models by focusing on the region of receiver operating characteristic (ROC) curve relevant to the intended clinical application optimizes the model for the intended application setting...
  7. ncbi Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
    ..We examine the association between endotoxin exposure and lung cancer risk in a cohort of female textile workers...
  8. ncbi Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Carcinogenesis 21:1157-62. 2000
    ..This points to a complex association between consumption of a typical diet of various vegetables and biotransformation enzyme activities in humans, an association that may be difficult to interpret in observational studies...
  9. ncbi CYP17 polymorphisms and prostate cancer outcomes
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 70:1094-101. 2010
    ..However, studies relating prostate cancer outcomes with CYP17 gene variants have conflicting results. In this study we analyzed Single Nucleotide Polymorphisms (SNPs) spanning the CYP17 gene for association with PCa survival...
  10. ncbi Association of caveolin-1 and -2 genetic variants and post-treatment serum caveolin-1 with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 70:1020-35. 2010
    ..This study evaluated the relationship between post-treatment serum cav-1 levels and single nucleotide polymorphisms (SNPs) in the cav-1 and -2 genes with risk of PC, aggressive PC, PC recurrence or death...
  11. ncbi Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1203-13. 2008
    ....
  12. ncbi Clinical utility of five genetic variants for predicting prostate cancer risk and mortality
    Claudia A Salinas
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 69:363-72. 2009
    ..3 and a family history of the disease may predict risk of prostate cancer. The present study tests the performance of these factors in prediction models for prostate cancer risk and prostate cancer-specific mortality...
  13. ncbi A randomized trial of a tailored, self-help dietary intervention: the Puget Sound Eating Patterns study
    A R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prev Med 31:380-9. 2000
    ..This study evaluated a tailored, multiple-component self-help intervention designed to promote lower fat and higher fruit and vegetable consumption...
  14. ncbi Occupational risk factors for nasopharyngeal cancer among female textile workers in Shanghai, China
    W Li
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Occup Environ Med 63:39-44. 2006
    ..6-fold excess risk of NPC (95% CI 1.0 to 12.1). CONCLUSIONS: Occupational exposure to cotton dust, acids, and caustics, and work in dyeing and printing jobs in the textile industry may have increased risk of NPC in this cohort...
  15. ncbi Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias
    Dale McLerran
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 54:44-52. 2008
    ..Details of this 3-stage process have been described. This report describes the development of the algorithm and results of the blinded test for stage 1...
  16. ncbi Vitamin D receptor gene polymorphisms and prostate cancer risk
    Mahesh B Keitheri Cheteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:409-18. 2004
    ..To further evaluate this relationship, we conducted a population-based case-control study of the VDR BsmI, FokI, and Poly-A polymorphisms, and prostate cancer...
  17. ncbi Evaluation of community-intervention trials via generalized linear mixed models
    Yutaka Yasui
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 60:1043-52. 2004
    ..This work is motivated by a series of large randomized trials that test community interventions for promoting cancer preventive lifestyles and behaviors...
  18. ncbi Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Mailstop M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 109:143-55. 2008
    ..The observed increased risk of breast cancer associated with joint carriage of the GSTM1 null genotype and GSTP1 105-Val allele needs confirmation in other studies...
  19. ncbi Evaluating the predictiveness of a continuous marker
    Ying Huang
    University of Washington Biostatistics Department, F 600 Health Sciences Building, Box 357232, Seattle, Washington 98195 7232, USA
    Biometrics 63:1181-8. 2007
    ..Applications to risk prediction markers in cancer and cystic fibrosis are discussed...
  20. ncbi Modeling, estimation and validation of cotton dust and endotoxin exposures in Chinese textile operations
    George Astrakianakis
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Ann Occup Hyg 50:573-82. 2006
    ....
  21. ncbi Polymorphisms in the glutathione S-transferase M1, T1, and P1 genes and prostate cancer prognosis
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 66:1535-41. 2006
    ..The aim of this study was to examine associations between GSTM1, T1, or P1 genetic variants and prostate cancer outcomes...
  22. ncbi Conditional estimation of sensitivity and specificity from a phase 2 biomarker study allowing early termination for futility
    Margaret Sullivan Pepe
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B500, Seattle, WA 98109, U S A
    Stat Med 28:762-79. 2009
    ..The conditional-UMVUE appears to be a very good choice...
  23. ncbi Integrating the predictiveness of a marker with its performance as a classifier
    Margaret S Pepe
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Epidemiol 167:362-8. 2008
    ..The methods are demonstrated with data on prostate-specific antigen and risk factors from the Prostate Cancer Prevention Trial, 1993-2003...
  24. ncbi Recruiting women into a smoking cessation program: who might quit?
    D J Bowen
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Women Health 31:41-58. 2000
    ..However, level of stress, cognitive restraint, and weight gain concerns did predict self-efficacy. These data indicate strong interest in quitting among women and highlight the role of affect and weight concerns in quitting confidence...
  25. ncbi Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109 1024, USA
    JAMA 283:354-60. 2000
    ..Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients...
  26. ncbi Occupational risk factors for pancreatic cancer among female textile workers in Shanghai, China
    W Li
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Occup Environ Med 63:788-93. 2006
    ..To investigate whether occupational exposures to dusts and chemicals in the Shanghai textile industry are associated with risk of pancreatic cancer...
  27. ncbi Occupational exposures and breast cancer among women textile workers in Shanghai
    Roberta M Ray
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Epidemiology 18:383-92. 2007
    ..Breast cancer incidence rates have been increasing in China over the past 2 decades. Most studies have focused on reproductive, dietary, and genetic risk factors. Little is known about the contribution of occupational exposures...
  28. ncbi Occupational risk factors for esophageal and stomach cancers among female textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 163:717-25. 2006
    ..01) and stomach cancer (p-trend < 0.001) when exposures were lagged 20 years. Endotoxin has not been previously reported to be a protective factor for either stomach cancer or esophageal cancer and therefore warrants further study...
  29. ncbi Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China
    Laura S Gold
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N. PO Box 19024 Seattle, WA 98109, USA
    Scand J Work Environ Health 32:178-84. 2006
    ..CONCLUSIONS: These results provide some preliminary suggestion that employment in textile industry maintenance jobs and exposure to wool products may be associated with an increased risk of brain tumors...
  30. ncbi FDR-controlling testing procedures and sample size determination for microarrays
    Shuying S Li
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stat Med 24:2267-80. 2005
    ..Thus, these existing procedures can overestimate the power and underestimate the sample size. Accordingly, we developed a simulation-based method to provide more accurate estimates for power and sample size...
  31. ncbi Telomere length in the colon declines with age: a relation to colorectal cancer?
    Jacintha O'Sullivan
    Department of Pathology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:573-7. 2006
    ..We suggest that the positive association between telomere length and age in the oldest patients is a consequence of selective survival of elderly patients with long colonocyte telomeres...
  32. ncbi Occupational exposures and ovarian cancer in textile workers
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Epidemiology 19:244-50. 2008
    ..Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry...
  33. ncbi SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer
    Dale McLerran
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 54:53-60. 2008
    ..This report is the 2nd of 2 companion articles describing a validation study of a SELDI-TOF MS approach with IMAC surface sample processing to identify prostatic adenocarcinoma...
  34. ncbi Quantifying peptide signal in MALDI-TOF mass spectrometry data
    Timothy W Randolph
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Mol Cell Proteomics 4:1990-9. 2005
    ....
  35. ncbi Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 62:279-87. 2006
    ..Our results indicate the proposed methods are both flexible and efficient. We contrast these methods with an application concerning the prognostic accuracies of expression levels of six genes...
  36. ncbi Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women
    Chu Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 118:2303-9. 2006
    ..13 (1.50-6.53), 4.57 (2.22-9.39) and 6.30 (3.08-12.89), compared with the lowest fourth. Our results suggest that elevated levels of IGF-I may contribute to the development of FBC...
  37. ncbi Data reduction using a discrete wavelet transform in discriminant analysis of very high dimensionality data
    Yinsheng Qu
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 702 Seattle, Washington, USA
    Biometrics 59:143-51. 2003
    ..The linear classifier with the 11 wavelet coefficients detected prostate cancer in a separate test set with a sensitivity of 97% and specificity of 100%...
  38. ncbi Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 172:578-90. 2010
    ..These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research...
  39. ncbi Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  40. ncbi A polymorphism in the CYP17 gene and risk of prostate cancer
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:243-7. 2002
    ..It is also possible that CYP17 interacts with other genes that influence risk of familial prostate cancer...
  41. ncbi A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection
    Yutaka Yasui
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Biostatistics 4:449-63. 2003
    ..We discuss practical issues associated with our proposed approach to the analysis of SELDI output and its application in cancer biomarker discovery...
  42. ncbi Effect of c-mpl ligands after total body irradiation (TBI) with and without allogeneic hematopoietic stem cell transplantation: low-dose TBI does not prevent sensitization
    Richard A Nash
    Biol Blood Marrow Transplant 8:360-7. 2002
    ..The significant effect that rhTPO-specific antibodies had on the platelet counts may limit the clinical role of recombinant c-mpl ligands unless sensitization can be prevented...
  43. ncbi Cancer prevention behaviors and socioeconomic status among Hispanics and non-Hispanic whites in a rural population in the United States
    Beti Thompson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 13:719-28. 2002
    ..Socioeconomic status is explored as a predictor of differences between Hispanics and non-Hispanic Whites in cancer prevention behavior...
  44. ncbi Boosting with missing predictors
    C Y Wang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Biostatistics 11:195-212. 2010
    ..Simulation results indicate that the proposed methods are superior than other naive methods. We apply the methods to a pancreatic cancer study in which serum protein microarrays are used for classification...
  45. ncbi Semiparametric models of time-dependent predictive values of prognostic biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 66:50-60. 2010
    ..We illustrate our approach with numerical studies and a dataset from a prostate cancer study...
  46. ncbi Development of common data elements: the experience of and recommendations from the early detection research network
    Marcy D Winget
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 859, Seattle, WA 98109, USA
    Int J Med Inform 70:41-8. 2003
    ..There are currently CDEs in the development or pilot phase for eight different organ sites and 13 different types of specimen procurements and plans to develop CDEs for 12 or more additional types of specimens...
  47. ncbi Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China
    Chu Chen
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mailstop M5 C800, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3457-66. 2008
    ..Our findings suggest that CYP19A1 variation may enhance breast cancer development in some women, but further confirmation is warranted...
  48. ncbi Baseline data and design for a randomized intervention study of dietary change in religious organizations
    Deborah J Bowen
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Prev Med 39:602-11. 2004
    ..Several studies have identified methods of changing dietary fat consumption in small, intensive intervention settings. Fewer studies have examined how to improve dietary habits of individuals in the general public...
  49. ncbi Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 9810, USA
    Am J Ind Med 51:673-9. 2008
    ..A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China...
  50. ncbi Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera
    Ji Qiu
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 26:5060-6. 2008
    ....
  51. ncbi Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design
    Margaret S Pepe
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 100:1432-8. 2008
    ..Common biases that pervade the biomarker research literature would be eliminated if these rigorous standards were followed...
  52. ncbi Partially supervised learning using an EM-boosting algorithm
    Yutaka Yasui
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biometrics 60:199-206. 2004
    ..Notable improvements in misclassification rates are observed with EM-Boost...
  53. ncbi Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
    ..We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men <age 65 years...
  54. ncbi Durability and diffusion of the nutrition intervention in the Working Well Trial
    R E Patterson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Prev Med 27:668-73. 1998
    ..We used data from 107 worksites in the WWT to test whether the nutrition intervention activities were maintained after the research program (i.e., durability) or were adopted by control sites (i.e., diffusion)...
  55. ncbi Reproductive history, occupational exposures, and thyroid cancer risk among women textile workers in Shanghai, China
    E Y Wong
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Int Arch Occup Environ Health 79:251-8. 2006
    ..CONCLUSIONS: Despite statistically imprecise risk estimates, the findings suggest potential associations with some occupational chemical exposures in this cohort of textile workers...
  56. ncbi Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients
    Yinsheng Qu
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Clin Chem 48:1835-43. 2002
    ..CONCLUSIONS: The high sensitivity and specificity achieved in this study provides support of the potential for SELDI, coupled with a bioinformatics learning algorithm, to improve the early detection/diagnosis of PCA...
  57. ncbi Modulation of human glutathione S-transferases by botanically defined vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:787-93. 2000
    ..GST responses were more pronounced in women than men, but it is not clear from this study whether this is a dose-per-body-weight or a sex-specific effect...
  58. ncbi Seattle 5 a Day worksite program to increase fruit and vegetable consumption
    S A Beresford
    Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
    Prev Med 32:230-8. 2001
    ..The Seattle 5 a Day worksite investigators designed and evaluated an intervention, organized on stages of behavioral change, to increase worksitewide fruit and vegetable consumption...
  59. ncbi Lactose metabolism and time to pregnancy
    L J Herrinton
    University of Washington, Fred Hutchinson Cancer Research Center, Seattle, USA
    Fertil Steril 66:384-8. 1996
    ..To investigate whether, in the absence of galactosemia, relatively high intestinal lactase activity or low activity of an enzyme involved in galactose catabolism reduces fertility, as it does in the presence of galactosemia...
  60. ncbi Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Gastroenterology 135:410-8. 2008
    ..We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory disease that predisposes to colorectal cancer and in which shorter telomeres have been associated with chromosomal instability and tumor progression...
  61. ncbi Statistical considerations in combining biomarkers for disease classification
    Ziding Feng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dis Markers 20:45-51. 2004
  62. ncbi Reliability, effect size, and responsiveness of health status measures in the design of randomized and cluster-randomized trials
    Paula Diehr
    Department of Biostatistics University of Washington, Box 357232, Seattle, WA 98195, USA
    Contemp Clin Trials 26:45-58. 2005
    ..Studies using better instruments can be performed with smaller sample sizes, but better instruments may be more expensive in terms of dollars, opportunity cost, or poorer data quality due to the response burden of longer instruments...
  63. ncbi The role of participation in the women's health trial: feasibility study in minority populations
    D Bowen
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prev Med 31:474-80. 2000
    ....
  64. ncbi Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929)
    M S Pepe
    Fred Hutchinson Cancer Research Center, Biostatistics and Biomathematics, Seattle, WA 98109, USA
    Stat Med 27:173-81. 2008
  65. ncbi Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China
    H Checkoway
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Occup Environ Med 68:425-9. 2011
    ....
  66. ncbi A baseline study of importance of bovines for human Schistosoma japonicum infections around Poyang Lake, China: villages studied and snail sampling strategy
    George M Davis
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, District of Columbia 20037, USA
    Am J Trop Med Hyg 66:359-71. 2002
    ..Hypothetically, treating bovines should reduce infection rates in snails to below the critical number necessary to maintain infections in man and bovines...
  67. ncbi Effects of a multilevel dietary intervention in religious organizations
    Deborah J Bowen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Health Promot 24:15-22. 2009
    ..This study examined how to improve dietary habits of individuals from the general public...
  68. ncbi Canary Prostate Active Surveillance Study: design of a multi-institutional active surveillance cohort and biorepository
    Lisa F Newcomb
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Urology 75:407-13. 2010
    ..The Canary Prostate Active Surveillance Study is a multicenter study and a biorepository that will discover and confirm biomarkers of aggressive disease as defined by histologic, prostate-specific antigen, or clinical criteria...
  69. ncbi Prostate cancer specific mortality and Gleason 7 disease differences in prostate cancer outcomes between cases with Gleason 4 + 3 and Gleason 3 + 4 tumors in a population based cohort
    Jonathan L Wright
    Department of Urology, University of Washington School of Public Health, Seattle, Washington 98195, USA
    J Urol 182:2702-7. 2009
    ..In this population based cohort we determined prostate cancer outcomes at different Gleason scores, particularly the different Gleason 7 patterns...
  70. ncbi A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy
    Yingye Zheng
    The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin Cancer Res 13:6984-92. 2007
    ....
  71. ncbi Immunohistochemical validation of expression microarray results
    Lawrence True
    Department of Pathology, Room EE110, 1959 NE Pacific St, Box 356100, University of Washington, Seattle, WA 98195, USA
    J Mol Diagn 7:149-51. 2005
  72. ncbi Signal detection in high-resolution mass spectrometry data
    Dale F McLerran
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Proteome Res 7:276-85. 2008
    ..Defining signal peaks as outliers with respect to these distributions leads to more precision in detecting the isotopic envelope of peaks from low-abundance peptides in high-resolution spectra...
  73. ncbi General quality of life 2 years following treatment for prostate cancer: what influences outcomes? Results from the prostate cancer outcomes study
    David F Penson
    Section of Urology, VA Puget Sound Health Care System and the Department of Urology, University of Washington, Seattle, WA 98108, USA
    J Clin Oncol 21:1147-54. 2003
    ..The goal of this study was to determine the relationship between primary treatment, urinary dysfunction, sexual dysfunction, and general health-related quality of life (HRQOL) in prostate cancer...
  74. ncbi Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas TX 75390-8593, USA
    Int J Cancer 103:153-60. 2003
    ..Our findings demonstrate important smoke exposure, histologic type and geography-related differences in the methylation profiles of NSCLC tumors...
  75. ncbi Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men
    Bao-Ling Adam
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Cancer Res 62:3609-14. 2002
    ..This high-throughput proteomic classification system will provide a highly accurate and innovative approach for the early detection/diagnosis of PCA...
  76. ncbi An intervention study on screening for breast cancer among single African-American women aged 65 and older
    Kangmin Zhu
    Pennsylvania State University College of Medicine, Hershey 17033, USA
    Prev Med 34:536-45. 2002
    ..Older African-American women with single marital status are least likely to use screening procedures. This study aimed to evaluate a breast screening intervention program conducted in this population...
  77. ncbi Syndecan-1 expression in locally invasive and metastatic prostate cancer
    David Chen
    Department of Urology, New York Presbyterian Hospital, New York, New York, USA
    Urology 63:402-7. 2004
    ..To determine the significance of syndecan-1 expression, a cell-surface heparan sulfate proteoglycan in localized and metastatic prostate cancer...
  78. ncbi DNA methylation profiles of lymphoid and hematopoietic malignancies
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 10:2928-35. 2004
    ..CONCLUSIONS: The three major forms of lymphoid/hematopoietic malignancies show overlapping but individual patterns of methylation...
  79. ncbi Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer
    William E Grizzle
    University of Alabama at Birmingham, Birmingham, AL 35233 0007, USA
    Dis Markers 19:185-95. 2003
    ..At the end of this validation study, the usefulness of the general SELDI-TOF-MS approach to identifying patients with PCA will be demonstrated and how it compares with PCA diagnosis by measuring prostate specific antigen...
  80. ncbi The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology
    William E Grizzle
    University of Alabama at Birmingham, Birmingham, AL, USA
    Urol Oncol 22:337-43. 2004
    ..The methodologies used for this evaluation will prove useful for guiding future biomarker studies in this challenging disease...
  81. ncbi Optimized normalization for antibody microarrays and application to serum-protein profiling
    Darren Hamelinck
    The Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Cell Proteomics 4:773-84. 2005
    ....
  82. ncbi Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Natl Cancer Inst 98:529-34. 2006
    ..We used prostate biopsy data from men who participated in the Prostate Cancer Prevention Trial (PCPT) to develop a predictive model of prostate cancer...
  83. ncbi Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
    Masaharu Nomura
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 4:e125. 2007
    ..The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers...
  84. ncbi Antibody microarray profiling reveals individual and combined serum proteins associated with pancreatic cancer
    Randal Orchekowski
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 65:11193-202. 2005
    ....
  85. ncbi Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
    Karsten Schulmann
    Division of Gastroenterology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 24:4138-48. 2005
    ..These findings have implications regarding risk stratification, early EAC detection, and the appropriate endoscopic surveillance interval for patients with BE...
  86. ncbi Diagnostic markers for early detection of ovarian cancer
    Irene Visintin
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Clin Cancer Res 14:1065-72. 2008
    ..In this study, we characterize and validate the combination of six serum biomarkers that discriminate between disease-free and ovarian cancer patients with high efficiency...
  87. ncbi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
    ..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
  88. ncbi Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
    ..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...
  89. ncbi Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
    ..This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer...
  90. ncbi Application of a methylation gene panel by quantitative PCR for lung cancers
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Lett 247:56-71. 2007
    ..Our preliminary data on the analysis of sputum DNA specimens from cancer patients further support these observations...
  91. ncbi [-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study
    Lori J Sokoll
    Departments of Pathology and Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 180:539-43; discussion 543. 2008
    ..This study evaluated the [-2]proenzyme prostate specific antigen serum marker using a blinded reference specimen set from 3 National Cancer Institute Early Detection Research Network centers from men with an indication for prostate biopsy...
  92. ncbi Mediation of adult fruit and vegetable consumption in the National 5 A Day for Better Health community studies
    Marci Kramish Campbell
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Ann Behav Med 35:49-60. 2008
    ..The 5 A Day for Better Health community studies demonstrated in randomized trials the efficacy of population-based strategies to increase fruit and vegetable consumption in diverse geographic areas and settings...
  93. ncbi 5-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study
    David F Penson
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Urol 173:1701-5. 2005
    ..In this study we assessed temporal changes in urinary and sexual function up to 5 years following radical prostatectomy in a population based cohort...
  94. ncbi Knowledge, attitudes, and behaviors of hepatitis B screening and vaccination and liver cancer risks among Vietnamese Americans
    Grace Xueqin Ma
    Department of Public Health and Center for Asian Health, College of Health Professions, at Temple University, USA
    J Health Care Poor Underserved 18:62-73. 2007
    ..5%) while 7.5% were ever screened and 6.3% had been vaccinated. Community-based, culturally appropriate interventions for Vietnamese Americans and health care providers should increase screening and vaccination rates...

Research Grants6

  1. STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALS
    Ziding Feng; Fiscal Year: 2003
    ..The bias and efficiency of this method compared to competing procedures will be examined analytically and via simulation. ..
  2. EDRN:Data Management and Coordinating Center
    Ziding Feng; Fiscal Year: 2007
    ....