Wenhong Fan

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc A class of models for analyzing GeneChip gene expression analysis array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    BMC Genomics 6:16. 2005
  2. pmc A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Theor Biol Med Model 3:19. 2006
  3. pmc Can a metastatic gene expression profile outperform tumor size as a predictor of occult lymph node metastasis in oral cancer patients?
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:2466-73. 2011
  4. pmc Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    Mol Cancer 9:143. 2010
  5. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
  6. pmc Gene expression profiling identifies genes predictive of oral squamous cell carcinoma
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology, 1100 Fairview Avenue North, M5 C800 P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2152-62. 2008
  7. doi request reprint Integrative analysis in oral squamous cell carcinoma reveals DNA copy number-associated miRNAs dysregulating target genes
    Nicholas A Serrano
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98115 7744, USA
    Otolaryngol Head Neck Surg 147:501-8. 2012
  8. pmc Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 120:2796-806. 2012
  9. pmc Polymorphisms in nucleotide excision repair genes and endometrial cancer risk
    Jennifer A Doherty
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:1873-82. 2011
  10. pmc A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98109 1024, USA
    Clin Cancer Res 15:1353-61. 2009

Collaborators

Detail Information

Publications24

  1. pmc A class of models for analyzing GeneChip gene expression analysis array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    BMC Genomics 6:16. 2005
    ....
  2. pmc A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Theor Biol Med Model 3:19. 2006
    ..This additional capacity motivated us to develop a method to predict alternative splicing, taking advance of extensive repositories of GeneChip gene expression array data...
  3. pmc Can a metastatic gene expression profile outperform tumor size as a predictor of occult lymph node metastasis in oral cancer patients?
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:2466-73. 2011
    ..To determine the differential gene expression between oral squamous cell carcinoma (OSCC) with and without metastasis to cervical lymph nodes and to assess prediction of nodal metastasis by using molecular features...
  4. pmc Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    Mol Cancer 9:143. 2010
    ....
  5. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  6. pmc Gene expression profiling identifies genes predictive of oral squamous cell carcinoma
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology, 1100 Fairview Avenue North, M5 C800 P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2152-62. 2008
    ..If confirmed in larger studies, the proposed models may hold promise for monitoring local recurrence at surgical margins and the development of second primary oral cancer in patients with OSCC...
  7. doi request reprint Integrative analysis in oral squamous cell carcinoma reveals DNA copy number-associated miRNAs dysregulating target genes
    Nicholas A Serrano
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98115 7744, USA
    Otolaryngol Head Neck Surg 147:501-8. 2012
    ....
  8. pmc Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 120:2796-806. 2012
    ....
  9. pmc Polymorphisms in nucleotide excision repair genes and endometrial cancer risk
    Jennifer A Doherty
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:1873-82. 2011
    ..Certain estrogen metabolites can form bulky DNA adducts, which are removed via nucleotide excision repair (NER), and the ability to carry out this repair might be related to endometrial cancer risk...
  10. pmc A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98109 1024, USA
    Clin Cancer Res 15:1353-61. 2009
    ..To determine if gene expression signature of invasive oral squamous cell carcinoma (OSCC) can subclassify OSCC based on survival...
  11. pmc Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China
    Chu Chen
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mailstop M5 C800, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3457-66. 2008
    ..Our findings suggest that CYP19A1 variation may enhance breast cancer development in some women, but further confirmation is warranted...
  12. pmc Identification of radiation-induced expression changes in nonimmortalized human T cells
    Era L Pogosova-Agadjanyan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Radiat Res 175:172-84. 2011
    ..These findings suggest that RNA-based expression assays for a small subset of genes can be employed to develop clinical biodosimetry assays to be used in assessments of radiation exposure and toxicity...
  13. pmc Evaluation of published single nucleotide polymorphisms associated with acute GVHD
    Jason W Chien
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 119:5311-9. 2012
    ..These results illustrate the advantages of using imputed single-nucleotide polymorphism data in genetic analyses and demonstrate the importance of validation in genetic association studies...
  14. pmc Simultaneous isolation of DNA and RNA from the same cell population obtained by laser capture microdissection for genome and transcriptome profiling
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
    J Mol Diagn 10:129-34. 2008
    ..Thus, we developed a method to obtain both DNA and RNA material from a single population of LCM-harvested cells and herein discuss the strengths and limitations of this methodology...
  15. ncbi request reprint Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Mutat Res 593:121-42. 2006
    ....
  16. ncbi request reprint Tumor-specific genetic expression profile of metastatic oral squamous cell carcinoma
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    Head Neck 29:803-14. 2007
    ..Metastasis is the most important predictor of survival in patients with oral squamous cell carcinoma (OSCC). We tested the hypothesis that there is a genetic expression profile associated with OSCC metastasis...
  17. ncbi request reprint Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity
    Wen Luo
    Division of Human Biology, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Chem Res Toxicol 18:619-29. 2005
    ..Differences in the transcriptional response of TK6 cells to N-OH-AABP or BPDE exposure may explain the dramatic differences in the toxicity and mutagenicity of these human carcinogens...
  18. pmc Comparison of Two Methods for Detecting Alternative Splice Variants Using GeneChip(®) Exon Arrays
    Wenhong Fan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Int J Biomed Sci 7:172-80. 2011
    ..From our observations, we conclude that MIDAS and Partek(®) GS produce complementary results, and discoveries from both analyses should be considered...
  19. ncbi request reprint Identification of genes with abnormal expression changes in acute myeloid leukemia
    Derek L Stirewalt
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Chromosomes Cancer 47:8-20. 2008
    ..Future studies will determine their potential role in leukemogenesis and their clinical significance...
  20. ncbi request reprint ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth
    Feiyue Fan
    Department of Radiation Oncology, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania PA 15213, USA
    Oncogene 21:7488-96. 2002
    ..Interestingly, over-expression of ATF3 protein is able to slow down progression of cells from G1 to S phase, indicating that ATF3 protein might play a negative role in the control of cell cycle progression...
  21. ncbi request reprint Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling
    Elaine M Ricicki
    The Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
    Anal Chem 78:6422-32. 2006
    ..The results demonstrate the value of anchoring gene expression patterns to phenotypic markers, such as DNA adduct levels, toxicity, and mutagenicity...
  22. ncbi request reprint The cloning and preliminarily functional analysis of the human neurotrimin gene
    Jin Liu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, National Human Genome North Center, Beijing 100005, China
    Sci China C Life Sci 47:158-64. 2004
    ..1+/Zeocin. The pcDNA3.1-HA-NTM is transfected into the Chinese Hamster Ovary (CHO) cells. The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells...
  23. ncbi request reprint GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity
    Shunqian Jin
    Department of Radiation Oncology, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, PA 15213, USA
    Oncogene 21:8696-704. 2002
    ..Therefore, GADD45 inhibition of Cdc2 kinase activity through alteration of cyclin B1 subcellular localization may be an essential step in the GADD45-induced cell cycle G2-M arrest and growth suppression...
  24. ncbi request reprint BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs
    Wenhong Fan
    Department of Radiation Oncology, Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:8061-7. 2002
    ..These findings indicate that BRCA1 can up-regulate its targeted genes through protein-protein interactions and provide a novel mechanism by which BRCA1 participates in transcriptional regulation...