BRUCE EDGAR

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease
    Tao Wang
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 186:703-11. 2009
  2. pmc Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    Dayna J Hall
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    BMC Biol 5:10. 2007
  3. ncbi How flies get their size: genetics meets physiology
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, B 2152, Seattle, Washington 98109, USA
    Nat Rev Genet 7:907-16. 2006
  4. ncbi From cell structure to transcription: Hippo forges a new path
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Cell 124:267-73. 2006
  5. ncbi Endoreplication cell cycles: more for less
    B A Edgar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
    Cell 105:297-306. 2001
  6. ncbi Developmental control of cell cycle regulators: a fly's perspective
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 274:1646-52. 1996
  7. ncbi Coordination of growth and cell division in the Drosophila wing
    T P Neufeld
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 93:1183-93. 1998
  8. pmc The Drosophila cyclin D-Cdk4 complex promotes cellular growth
    S A Datar
    Program in Molecular and Cellular Biology and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 19:4543-54. 2000
  9. ncbi Drosophila myc regulates cellular growth during development
    L A Johnston
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109, USA
    Cell 98:779-90. 1999
  10. ncbi Ras1 promotes cellular growth in the Drosophila wing
    D A Prober
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 100:435-46. 2000

Collaborators

Detail Information

Publications48

  1. pmc TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease
    Tao Wang
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 186:703-11. 2009
    ..Thus, our data indicate that TOR induces cell death by suppressing autophagy and provide direct genetic evidence that autophagy alleviates cell death in several common types of neurodegenerative disease...
  2. pmc Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    Dayna J Hall
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    BMC Biol 5:10. 2007
    ..TOR activity is regulated by nutritional cues, suggesting that Rheb might either control, or respond to, nutrient availability...
  3. ncbi How flies get their size: genetics meets physiology
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, B 2152, Seattle, Washington 98109, USA
    Nat Rev Genet 7:907-16. 2006
    ..However, we still understand little about how size is actually sensed, or how organ-intrinsic size controls interface with whole-body physiology...
  4. ncbi From cell structure to transcription: Hippo forges a new path
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Cell 124:267-73. 2006
    ..This conserved signaling pathway contains several tumor-suppressor genes and regulates the contact inhibition of proliferation in cultured cells...
  5. ncbi Endoreplication cell cycles: more for less
    B A Edgar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
    Cell 105:297-306. 2001
  6. ncbi Developmental control of cell cycle regulators: a fly's perspective
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 274:1646-52. 1996
    ....
  7. ncbi Coordination of growth and cell division in the Drosophila wing
    T P Neufeld
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 93:1183-93. 1998
    ..We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth...
  8. pmc The Drosophila cyclin D-Cdk4 complex promotes cellular growth
    S A Datar
    Program in Molecular and Cellular Biology and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 19:4543-54. 2000
    ..Interaction tests with a Drosophila Rb homolog, RBF, indicate that CycD-Cdk4 can counteract the cell cycle suppressive effects of RBF, but that its growth promoting activity is mediated at least in part via other targets...
  9. ncbi Drosophila myc regulates cellular growth during development
    L A Johnston
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109, USA
    Cell 98:779-90. 1999
    ..Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism...
  10. ncbi Ras1 promotes cellular growth in the Drosophila wing
    D A Prober
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 100:435-46. 2000
    ..We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit...
  11. ncbi Pattern- and growth-linked cell cycles in Drosophila development
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Novartis Found Symp 237:3-12; discussion 12-8, 36-42. 2001
    ..The dual control mechanism used by imaginal disc cells allows integration of diverse inputs which operate in both cell specification and cell metabolism...
  12. ncbi Cell cycle. Cell-cycle control in a developmental context
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Curr Biol 4:522-4. 1994
    ..Down-regulation of a cyclin specific to the G1 phase of the cell cycle, cyclin E, terminates the initial period of cell proliferation in developing Drosophila embryos...
  13. ncbi Cis-regulatory elements of the mitotic regulator, string/Cdc25
    D A Lehman
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 126:1793-803. 1999
    ..We suggest that, during evolution, cell-type-specific control elements were acquired by a simple growth-regulated promoter as a means of coordinating cell division with developmental processes, particularly neurogenesis...
  14. ncbi Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms
    J S Britton
    Molecular and Cellular Biology Program and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Development 125:2149-58. 1998
    ..These results demonstrate a fundamental difference in the control of cell cycle activation and maintenance in these two cell types, and imply the existence of a novel mitogen generated by the larval fat body in response to nutrition...
  15. ncbi Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program
    B A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genes Dev 10:1966-77. 1996
    ..Unlike timing or counting mechanisms, this mechanism can compensate for losses or additions of nuclei by altering the timing and number of the maternal cycles and thus will always generate the correct cell density at the MZT...
  16. ncbi Connections between growth and the cell cycle
    T P Neufeld
    Fred Hutchinson Cancer Research Center Basic Sciences Division 1100 Fairview Avenue North Seattle WA 98109 USA
    Curr Opin Cell Biol 10:784-90. 1998
    ..Recent work has identified several mechanisms which couple cell division to growth. Different mechanisms are used at different times during development to coordinate growth, cell division, and patterning...
  17. pmc Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth
    J C Migeon
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Biol Cell 10:1733-44. 1999
    ..Overexpression of the wild-type gene causes cell death and disrupts the normal development of adult structures. The ppan gene family appears to have an essential and evolutionarily conserved role in cell growth...
  18. ncbi Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster
    M Galloni
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, B2 152, Seattle, Washington, USA
    Development 126:2365-75. 1999
    ..The isolation of non-cell-autonomous larval growth-defective mutants suggests that specialized organs coordinate growth throughout the animal and provides new tools for studies of organismal growth regulation...
  19. ncbi Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing
    L A Johnston
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 394:82-4. 1998
    ..Notch activity creates a third domain by preventing arrest at G2 in wg-expressing cells, resulting in their arrest in G1...
  20. ncbi Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors
    A Orian
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cold Spring Harb Symp Quant Biol 70:299-307. 2005
    ..We further show that the dMyc antagonist dMnt inhibits rRNA transcription in the wing disc. Our results support the view that the Myc/Max/Mad network influences transcription on a global scale...
  21. ncbi Growth regulation by oncogenes--new insights from model organisms
    D A Prober
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 11:19-26. 2001
    ..These studies have also suggested how growth and cell-cycle progression may be coupled...
  22. ncbi Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila
    Sanjeev A Datar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, USA
    Cell Cycle 5:647-52. 2006
    ..Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals...
  23. ncbi A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila
    Laura A Buttitta
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 12:631-43. 2007
    ..In other cell types, however (e.g., wing epithelial cells), unknown mechanisms inhibit E2F and Cyclin/Cdk activity in parallel to enforce permanent cell cycle exit upon terminal differentiation...
  24. pmc Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression
    Efrat Oron
    Department of Plant Sciences, Tel Aviv University, Tel Aviv, Israel
    Mol Syst Biol 3:108. 2007
    ..A null mutation in CSN subunit 4 and hypomorphic mutations in csn5 lead to more severe defects than seen in the csn5-null mutants strain, suggesting that CSN5 carries only some of the CSN function...
  25. ncbi Filling out the Hippo pathway
    Leslie J Saucedo
    Department of Biology, University of Puget Sound, 1500 North Warner Street, Tacoma, Washington 98416, USA
    Nat Rev Mol Cell Biol 8:613-21. 2007
    ..Although poorly characterized in mammals, several components of the Hippo pathway seem to be tumour suppressors in humans...
  26. ncbi Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    Yong Zhang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 5:578-81. 2003
    ..Point mutations in the GAP domain of Tsc2 disrupted its ability to regulate Rheb without affecting the ability of Tsc2 to form a complex with Tsc1. Our studies identify Rheb as a molecular target of the TSC tumour suppressors...
  27. pmc Mechanisms controlling cell cycle exit upon terminal differentiation
    Laura A Buttitta
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Opin Cell Biol 19:697-704. 2007
    ..This review focuses on describing recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated...
  28. pmc Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 179:1105-13. 2007
    ..Stimulation of rRNA synthesis by TIF-IA may therefore provide a feed-forward mechanism to coregulate the levels of other ribosome components...
  29. doi Yorkie and Scalloped: partners in growth activation
    Jennifer L Bandura
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 14:315-6. 2008
    ..The TEAD/TEF factor Scalloped (Sd) has been identified as the first known transcription factor to partner with Yki as a downstream target of Hpo signaling...
  30. doi Flow cytometric analysis of Drosophila cells
    Aida Flor A de la Cruz
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods Mol Biol 420:373-89. 2008
    ..In addition, we present protocols for performing flow cytometry on fixed or live-cultured Drosophila S2 cells...
  31. pmc The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster
    Lenora W M Loo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Mol Cell Biol 25:7078-91. 2005
    ..Our results demonstrate that dMnt is a transcriptional repressor that regulates D. melanogaster body size...
  32. ncbi How size is controlled: from Hippos to Yorkies
    Laura A Buttitta
    Nat Cell Biol 9:1225-7. 2007
  33. ncbi The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis
    Deborah J Frank
    Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 129:399-407. 2002
    ..Furthermore, brat overexpressing cells contain less ribosomal RNA than control cells. These results suggest that the tumorous phenotype of brat mutants may be due to excess cell growth and ribosome synthesis...
  34. ncbi Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    Jessica S Britton
    Molecular and Cellular Biology Program, Seattle, WA 98109, USA
    Dev Cell 2:239-49. 2002
    ..Hence we surmise that an essential function of insulin/PI3K signaling in Drosophila is to coordinate cellular metabolism with nutritional conditions...
  35. ncbi A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing
    Cristina Martín-Castellanos
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 129:1003-13. 2002
    ..The growth response to altering Dpp signaling varied regionally and temporally in the wing disc, indicating that other patterned factors modify the response...
  36. ncbi Why size matters: altering cell size
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 12:565-71. 2002
    ..Several physiological repercussions of altering cell size have been identified...
  37. pmc Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
    David A Prober
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 16:2286-99. 2002
    ....
  38. pmc Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network
    Amir Orian
    Division of Basic Sciences and Divison of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:1101-14. 2003
    ..These results suggest that a fundamental aspect of Max network function involves widespread binding and regulation of gene expression...
  39. pmc Controlling cell division in yeast and animals: does size matter?
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Biol 2:5. 2003
    ..Now, evidence has been provided that such checkpoints probably do not exist in mammalian cells. These findings highlight an important difference between how yeast and animal cells proliferate in response to extracellular cues...
  40. ncbi Rheb promotes cell growth as a component of the insulin/TOR signalling network
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Nat Cell Biol 5:566-71. 2003
    ..Levels of rheb mRNA are rapidly induced in response to protein starvation, and overexpressed Rheb can drive cell growth in starved animals, suggesting a role for Rheb in the nutritional control of cell growth...
  41. ncbi Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Cell 6:241-51. 2004
    ..Our data suggest that Hph, in addition to its function in hypoxic response, is a regulator of cellular growth and that it is a key mediator for CycD/Cdk4...
  42. ncbi Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
    Tânia Reis
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 117:253-64. 2004
    ..g., by ectopic Dacapo, dWee1, dMyc, or Rheb). Without dE2F1, the compensatory mechanism fails, and treatments that alter Cdk activity cause aberrant cell cycle timing and cell death...
  43. ncbi dMyc is required for larval growth and endoreplication in Drosophila
    Sarah B Pierce
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109 1024, USA
    Development 131:2317-27. 2004
    ..Our results indicate that larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt...
  44. pmc Cyclin D does not provide essential Cdk4-independent functions in Drosophila
    Jan Emmerich
    Bayreuther Zentrum für Molekulare Biowissenschaften, Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Genetics 168:867-75. 2004
    ..The reduced cellular and organismal growth rates observed in both mutants indicate that Cyclin D-Cdk4 acts as a growth driver...
  45. pmc The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 24:623-34. 2005
    ..Both functions depend on mRpL12 dosage, suggesting that CycD/Cdk4, mRpL12 and Hph function together in a common pathway that controls cell growth via affecting mitochondrial activity...
  46. pmc Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 311:25-39. 2007
    ..Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology...
  47. ncbi Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development
    Pazit Oren-Giladi
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel
    Genes Cells 13:221-31. 2008
    ..CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin deneddylation is impaired in the csn8(null) mutants...
  48. ncbi Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Cell Biol 7:295-302. 2005
    ..In addition, the growth effects of dMyc in larval wing imaginal discs require de novo rRNA synthesis. We suggest that during animal development, the control of rRNA synthesis and ribosome biogenesis is an essential Myc function...

Research Grants33

  1. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2006
    ..It has relevance to medical conditions involving cell and tissue growth including cancer diagnosis and therapy, regeneration, wound healing, diabetes and other metabolic diseases. ..
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2004
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. ..
  3. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2005
    ..It has relevance to medical conditions involving cell and tissue growth including cancer diagnosis and therapy, regeneration, wound healing, diabetes and other metabolic diseases. ..
  4. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2005
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. ..
  5. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2006
    ....
  6. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2006
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. ..
  7. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2006
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..
  8. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
    ....
  9. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. ..
  10. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2007
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..
  11. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
    ..abstract_text> ..
  12. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2004
    ..It has relevance to medical conditions involving cell and tissue growth including cancer diagnosis and therapy, regeneration, wound healing, diabetes and other metabolic diseases. ..
  13. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  14. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2003
    ..It has relevance to medical conditions involving cell and tissue growth including cancer diagnosis and therapy, regeneration, wound healing, diabetes and other metabolic diseases. ..
  15. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 1999
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  16. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2000
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  17. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2000
    ..The identification of growth regulatory genes in flies should also provide entry points for studies of cell growth control in humans during both normal and neoplastic development. ..
  18. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2001
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  19. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2001
    ..The identification of growth regulatory genes in flies should also provide entry points for studies of cell growth control in humans during both normal and neoplastic development. ..
  20. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2001
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  21. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2002
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  22. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2002
    ..The identification of growth regulatory genes in flies should also provide entry points for studies of cell growth control in humans during both normal and neoplastic development. ..
  23. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2003
    ..The identification of growth regulatory genes in flies should also provide entry points for studies of cell growth control in humans during both normal and neoplastic development. ..
  24. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2009
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..