Deborah Donnell

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Correlation between pill counts and biologic effects in an HIV-1 prevention clinical trial: implications for measuring adherence
    DEBORAH J DONNELL
    Department of Global Health, University of Washington, Seattle, USA
    AIDS Behav 17:632-9. 2013
  2. pmc HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)
    Estelle Piwowar-Manning
    Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
    BMC Infect Dis 11:251. 2011
  3. pmc Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial
    Deborah Donnell
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Ctr, Seattle, WA 98109, USA
    AIDS Behav 14:1182-9. 2010
  4. pmc Challenges in the design of HIV prevention trials in the United States
    Deborah Donnell
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 55:S136-40. 2010
  5. pmc Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    N Engl J Med 367:399-410. 2012
  6. pmc Hormonal contraceptive use and risk of HIV-1 disease progression
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
    AIDS 27:261-7. 2013
  7. doi request reprint Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis
    Kenneth K Mugwanya
    Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Disease Control and Environmental Health, Makerere University, Kampala, Uganda
    Lancet Infect Dis 13:1021-8. 2013
  8. pmc Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1
    Romel D Mackelprang
    Department of Global Health, University of Washington, WA, USA
    J Infect Dis 206:1299-308. 2012
  9. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
  10. pmc Efficacy of preexposure prophylaxis for HIV-1 prevention among high-risk heterosexuals: subgroup analyses from a randomized trial
    Pamela M Murnane
    aDepartment of Epidemiology bDepartment of Global Health cDepartment of Medicine, University of Washington, Seattle, Washington, USA dDepartment of Obstetrics and Gynaecology, University of Nairobi eDepartment of Obstetrics and Gynaecology, Kenyatta National Hospital, Nairobi, Kenya fDivision of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, CDC Uganda, Entebbe, Uganda gDivision of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland hStatistical Center for HIV AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA iCenters for Disease Control and Prevention, Atlanta, Georgia, USA Members of the Partners PrEP Study Team listed at end of paper
    AIDS 27:2155-60. 2013

Collaborators

Detail Information

Publications24

  1. pmc Correlation between pill counts and biologic effects in an HIV-1 prevention clinical trial: implications for measuring adherence
    DEBORAH J DONNELL
    Department of Global Health, University of Washington, Seattle, USA
    AIDS Behav 17:632-9. 2013
    ..e., fewer pills returned than expected) and when pill counts were missing because bottles were not returned, plasma HIV-1 RNA and GUD effects were diminished, likely indicating periods of non-adherence...
  2. pmc HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)
    Estelle Piwowar-Manning
    Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
    BMC Infect Dis 11:251. 2011
    ..We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study...
  3. pmc Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial
    Deborah Donnell
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Ctr, Seattle, WA 98109, USA
    AIDS Behav 14:1182-9. 2010
    ....
  4. pmc Challenges in the design of HIV prevention trials in the United States
    Deborah Donnell
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 55:S136-40. 2010
    ..However, for interventions where efficacy is already established, conducting trials that test different implementation strategies in these populations could provide definitive evidence about how to achieve high levels of coverage...
  5. pmc Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    N Engl J Med 367:399-410. 2012
    ..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
  6. pmc Hormonal contraceptive use and risk of HIV-1 disease progression
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
    AIDS 27:261-7. 2013
    ..For HIV-1-infected women, hormonal contraception prevents unintended pregnancy, excess maternal morbidity, and vertical HIV-1 transmission. Hormonal contraceptives are widely used but their effects on HIV-1 disease progression are unclear...
  7. doi request reprint Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis
    Kenneth K Mugwanya
    Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Disease Control and Environmental Health, Makerere University, Kampala, Uganda
    Lancet Infect Dis 13:1021-8. 2013
    ..We studied whether the use of pre-exposure prophylaxis in HIV-uninfected men and women in HIV-serodiscordant couples was associated with increased sexual risk behaviour...
  8. pmc Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1
    Romel D Mackelprang
    Department of Global Health, University of Washington, WA, USA
    J Infect Dis 206:1299-308. 2012
    ..We developed a novel approach for quantifying HIV-1 exposure to identify individuals remaining HIV-1 uninfected despite persistent high exposure...
  9. pmc Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  10. pmc Efficacy of preexposure prophylaxis for HIV-1 prevention among high-risk heterosexuals: subgroup analyses from a randomized trial
    Pamela M Murnane
    aDepartment of Epidemiology bDepartment of Global Health cDepartment of Medicine, University of Washington, Seattle, Washington, USA dDepartment of Obstetrics and Gynaecology, University of Nairobi eDepartment of Obstetrics and Gynaecology, Kenyatta National Hospital, Nairobi, Kenya fDivision of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, CDC Uganda, Entebbe, Uganda gDivision of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland hStatistical Center for HIV AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA iCenters for Disease Control and Prevention, Atlanta, Georgia, USA Members of the Partners PrEP Study Team listed at end of paper
    AIDS 27:2155-60. 2013
    ..One hypothesis proposed for these divergent results is that PrEP efficacy may be reduced in populations with higher HIV-1 incidence...
  11. doi request reprint A Prospective Study of the Effect of Pregnancy on CD4 Counts and Plasma HIV-1 RNA Concentrations of Antiretroviral-Naive HIV-1-Infected Women
    Renee Heffron
    Department of Global Health, University of Washington, Seattle, WA Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya Wits Reproductive Health and HIV Institute WRHI, University of the Witwatersrand, Johannesburg, South Africa Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya Kenya Medical Research Institute, Nairobi, Kenya Department of Reproductive Health, Moi University, Eldoret, Kenya and Departments of Epidemiology and Medicine, University of Washington, Seattle, WA
    J Acquir Immune Defic Syndr 65:231-6. 2014
    ....
  12. pmc Study design considerations for evaluating efficacy of systemic preexposure prophylaxis interventions
    Deborah Donnell
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 63:S130-4. 2013
    ..This development is particularly complex because of inconsistency of efficacy results of FTC/TDF PrEP trials for HIV prevention...
  13. pmc Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e28632. 2011
    ..To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use...
  14. pmc Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e12598. 2010
    ....
  15. pmc Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention
    Andrew Mujugira
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e25828. 2011
    ..We describe the trial design and characteristics of the study cohort...
  16. pmc Outside sexual partnerships and risk of HIV acquisition for HIV uninfected partners in African HIV serodiscordant partnerships
    Patrick Ndase
    Department of Global Health, University of Washington, Seattle, 98104, USA
    J Acquir Immune Defic Syndr 59:65-71. 2012
    ..As African countries scale-up couples HIV testing, little is known about sexual behaviors and HIV risk for HIV-uninfected partners in known HIV-serodiscordant relationships...
  17. pmc Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study
    Renee Heffron
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Lancet Infect Dis 12:19-26. 2012
    ..We aimed to assess the association between hormonal contraceptive use and risk of HIV-1 acquisition by women and HIV-1 transmission from HIV-1-infected women to their male partners...
  18. pmc Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98195, USA
    Sci Transl Med 3:77ra29. 2011
    ..These data suggest that HIV-1 RNA in genital secretions could be used as a marker of HIV-1 sexual transmission risk...
  19. pmc Daily short message service surveys to measure sexual behavior and pre-exposure prophylaxis use among Kenyan men and women
    Kathryn Curran
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    AIDS Behav 17:2977-85. 2013
    ..87). PrEP adherence was high, missed doses were correlated with sexual abstinence, and unprotected sex was not associated with decreased PrEP adherence...
  20. doi request reprint HIV-1 subtype C is not associated with higher risk of heterosexual HIV-1 transmission: a multinational study among HIV-1 serodiscordant couples
    Erin Kahle
    aDepartment of Epidemiology bDepartment of Global Health cDepartment of Medicine dDepartment of Pediatrics eDepartment of Microbiology fDepartment of Laboratory Medicine, University of Washington gVaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA hKenya Medical Research Institute, Kisumu, Kenya iDepartment of Medicine, Indiana University, Indianapolis, Indiana, USA jDepartment of Obstetrics and Gynecology, University of Nairobi and Kenyatta National Hospital, Nairobi, Kenya kLondon School of Hygiene and Tropical Medicine, London, UK
    AIDS 28:235-43. 2014
    ..We compared the risk of HIV-1 transmission for subtype C versus non-C subtypes (A, D, G and recombinant forms) among heterosexual African HIV-1 serodiscordant couples...
  21. pmc Differential regulatory T cell activity in HIV type 1-exposed seronegative individuals
    Laura Pattacini
    1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    AIDS Res Hum Retroviruses 29:1321-9. 2013
    ....
  22. pmc Statistical considerations for the HPTN 052 Study to evaluate the effectiveness of early versus delayed antiretroviral strategies to prevent the sexual transmission of HIV-1 in serodiscordant couples
    Ying Qing Chen
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Contemp Clin Trials 33:1280-6. 2012
    ..Nevertheless, the durability of its long-term effectiveness is yet to be assessed. The HPTN 052 Study is still ongoing and will not complete till 2015...
  23. pmc Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  24. doi request reprint Long-term follow-up of children in the HIVNET 012 perinatal HIV prevention trial: five-year growth and survival
    Maxensia Owor
    Clinical Division, Makerere University Johns Hopkins University Research Collaboration, Kampala, Uganda Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda Science Facilitation Department, Family Health International, Durham, NC Department of Pathology, Johns Hopkins University, Baltimore, MD and Department of Epidemiology and Biostatistics, George Washington University School of Public Health and Health Services, Washington, DC
    J Acquir Immune Defic Syndr 64:464-71. 2013
    ..To describe 5-year growth, survival, and long-term safety among children exposed to nevirapine or zidovudine in an African perinatal prevention trial, HIVNET 012...