Research Topics
Genomes and GenesSpecies | Deborah DonnellSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
Correlation between pill counts and biologic effects in an HIV-1 prevention clinical trial: implications for measuring adherenceDEBORAH J DONNELL
Department of Global Health, University of Washington, Seattle, USA
AIDS Behav 17:632-9. 2013..e., fewer pills returned than expected) and when pill counts were missing because bottles were not returned, plasma HIV-1 RNA and GUD effects were diminished, likely indicating periods of non-adherence...
HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)Estelle Piwowar-Manning
Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
BMC Infect Dis 11:251. 2011..We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study...
Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trialDeborah Donnell
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Ctr, Seattle, WA 98109, USA
AIDS Behav 14:1182-9. 2010....
Challenges in the design of HIV prevention trials in the United StatesDeborah Donnell
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Acquir Immune Defic Syndr 55:S136-40. 2010..However, for interventions where efficacy is already established, conducting trials that test different implementation strategies in these populations could provide definitive evidence about how to achieve high levels of coverage...
Antiretroviral prophylaxis for HIV prevention in heterosexual men and womenJared M Baeten
Department of Global Health, University of Washington, Seattle, WA 98104, USA
N Engl J Med 367:399-410. 2012..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1Romel D Mackelprang
Department of Global Health, University of Washington, WA, USA
J Infect Dis 206:1299-308. 2012..We developed a novel approach for quantifying HIV-1 exposure to identify individuals remaining HIV-1 uninfected despite persistent high exposure...
Outside sexual partnerships and risk of HIV acquisition for HIV uninfected partners in African HIV serodiscordant partnershipsPatrick Ndase
Department of Global Health, University of Washington, Seattle, 98104, USA
J Acquir Immune Defic Syndr 59:65-71. 2012..As African countries scale-up couples HIV testing, little is known about sexual behaviors and HIV risk for HIV-uninfected partners in known HIV-serodiscordant relationships...
Hormonal contraceptive use and risk of HIV-1 disease progressionRenee Heffron
Department of Epidemiology, University of Washington, Seattle, Washington 98104, USA
AIDS 27:261-7. 2013..For HIV-1-infected women, hormonal contraception prevents unintended pregnancy, excess maternal morbidity, and vertical HIV-1 transmission. Hormonal contraceptives are widely used but their effects on HIV-1 disease progression are unclear...
Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysisDeborah Donnell
Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 375:2092-8. 2010..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 preventionAndrew Mujugira
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e25828. 2011..We describe the trial design and characteristics of the study cohort...
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposureJairam R Lingappa
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e28632. 2011..To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use...
Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort studyRenee Heffron
Department of Epidemiology, University of Washington, Seattle, WA, USA
Lancet Infect Dis 12:19-26. 2012..We aimed to assess the association between hormonal contraceptive use and risk of HIV-1 acquisition by women and HIV-1 transmission from HIV-1-infected women to their male partners...
Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission riskJairam R Lingappa
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e12598. 2010....
Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmissionJared M Baeten
Department of Global Health, University of Washington, Seattle, WA 98195, USA
Sci Transl Med 3:77ra29. 2011..These data suggest that HIV-1 RNA in genital secretions could be used as a marker of HIV-1 sexual transmission risk...
Statistical considerations for the HPTN 052 Study to evaluate the effectiveness of early versus delayed antiretroviral strategies to prevent the sexual transmission of HIV-1 in serodiscordant couplesYing Qing Chen
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Contemp Clin Trials 33:1280-6. 2012..Nevertheless, the durability of its long-term effectiveness is yet to be assessed. The HPTN 052 Study is still ongoing and will not complete till 2015...
Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couplesJared M Baeten
University of Washington, WA, USA
AIDS 24:737-44. 2010....
