Research Topics
Genomes and Genes | Anneclaire J De RoosSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrationsAnneclaire J De Roos
Epidemiology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Expo Sci Environ Epidemiol 22:617-24. 2012..Our finding of increased organochlorine concentrations with past weight loss episodes may have public health significance; however, this association requires confirmation in longitudinal studies...
Markers of B-cell activation in relation to risk of non-Hodgkin lymphomaAnneclaire J De Roos
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Res 72:4733-43. 2012..Taken together, our findings indicate a prominent role for B-cell activation among postmenopausal women in the etiology of B-cell NHL and/or in processes reflective of early disease development as early as 9 years before diagnosis...
Persistent organochlorine chemicals in plasma and risk of non-Hodgkin's lymphomaAnneclaire J De Roos
Fred Hutchinson Cancer Research Center and University of Washington Department of Epidemiology, Seattle, Washington 98109 1024, USA
Cancer Res 65:11214-26. 2005..02-1.79). Our results add to existing literature, which suggests that exposure to organochlorines contributes to non-Hodgkin's lymphoma risk; these risks were most apparent for certain PCBs and furans...- A population-based study of survival in patients with secondary myelodysplastic syndromes (MDS): impact of type and treatment of primary cancersAnneclaire J De Roos
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA 98109 1024, USA
Cancer Causes Control 18:1199-208. 2007..Clinical observations suggest a worse prognosis for secondary than for primary MDS, but differences in survival have not been studied in a general population sample... - Incidence of myelodysplastic syndromes within a nonprofit healthcare system in western Washington state, 2005-2006Anneclaire J De Roos
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
Am J Hematol 85:765-70. 2010.... - Intentional weight loss and risk of lymphohematopoietic cancersAnneclaire J De Roos
Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Causes Control 21:223-36. 2010..We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies... - Nitrate in public water supplies and the risk of colon and rectum cancersAnneclaire J De Roos
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Epidemiology 14:640-9. 2003..N-nitroso compound formation is inhibited by certain nutrients, such as vitamin C, and increased by meat intake... - Integrative assessment of multiple pesticides as risk factors for non-Hodgkin's lymphoma among menA J De Roos
Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, Bethesda, MD, USA
Occup Environ Med 60:E11. 2003..An increased rate of non-Hodgkin's lymphoma (NHL) has been repeatedly observed among farmers, but identification of specific exposures that explain this observation has proven difficult... - Metabolic gene variants and risk of non-Hodgkin's lymphomaAnneclaire J De Roos
Fred Hutchinson Cancer Research Center and University of Washington, 1100 Fairview Avenue North, M4 B874, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 15:1647-53. 2006..There was no overall association with non-Hodgkin's lymphoma for the other gene variants we examined. The modest effects we observed may reflect the context of exposures within the general population represented in our study... - Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myelomaLaura S Gold
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Epidemiol 33:276-80. 2009.... - The relationship between multiple myeloma and occupational exposure to six chlorinated solventsLaura S Gold
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Occup Environ Med 68:391-9. 2011..We evaluated associations between multiple myeloma and occupational exposure to six chlorinated solvents: 1,1,1-trichloroethane, trichloroethylene (TCE), methylene chloride (DCM), perchloroethylene, carbon tetrachloride and chloroform... - Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington StateJonathan N Hofmann
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Occup Environ Med 67:375-86. 2010..To identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides... - Occupational risk factors for endometrial cancer among textile workers in Shanghai, ChinaKaren J Wernli
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 9810, USA
Am J Ind Med 51:673-9. 2008..A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China... - Occupation and multiple myeloma: an occupation and industry analysisLaura S Gold
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Ind Med 53:768-79. 2010..Multiple myeloma (MM) is an incurable plasma cell malignancy with a poorly understood etiology. The purpose of our research was to examine the relationships between lifetime occupations and MM in a relatively large case-control study... - Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphomaJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Blood 113:1899-905. 2009..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL... - Biomarkers of sensitivity and exposure in Washington state pesticide handlersJonathan N Hofmann
Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA
Adv Exp Med Biol 660:19-27. 2010..Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter... - Etiologic heterogeneity among non-Hodgkin lymphoma subtypesLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Rockville, MD, USA
Blood 112:5150-60. 2008.... - Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, ChinaEva Y Wong
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
Am J Ind Med 53:497-505. 2010..Strenuous occupational physical activity and physical demands may be risk factors for adverse reproductive outcomes... - Fine particulate matter (PM₂.₅) air pollution and immune status among women in the Seattle areaLori Williams
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
Arch Environ Occup Health 66:155-65. 2011..If additional studies confirm our findings, then future health effect assessments for PM₂.₅ should consider changes in cellular immunity as an endpoint that may lead to overt clinical disease... - Occupational exposures and ovarian cancer in textile workersKaren J Wernli
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Epidemiology 19:244-50. 2008..Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry... - Personal and family medical history correlates of rheumatoid arthritisAnneclaire J De Roos
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Ann Epidemiol 18:433-9. 2008..We studied personal and family medical history correlates of incident and prevalent RA in women... - Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control studyDavid C Wheeler
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
Environ Health 10:63. 2011..Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL... - A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Environ Health Perspect 119:232-8. 2011..Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL)... - Exposure to atrazine and selected non-persistent pesticides among corn farmers during a growing seasonBerit Bakke
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852 7240, USA
J Expo Sci Environ Epidemiol 19:544-54. 2009..Elevated background levels of non-persistent pesticides, especially 2,4-D, indicate importance in epidemiologic studies of capturing pesticide exposures that might not be directly related to the actual application... - Occupational exposure to pesticides and risk of adult brain tumorsClaudine M Samanic
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Am J Epidemiol 167:976-85. 2008..01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations... - A case-control study of occupational exposure to trichloroethylene and non-hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Environ Health Perspect 119:232-8. 2010..However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated... - Newborn screening archives as a specimen source for epidemiologic studies: feasibility and potential for biasSusan Searles Nielsen
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109 1024, USA
Ann Epidemiol 18:58-64. 2008..To evaluate the feasibility of obtaining dried blood spots (DBS) from newborn screening archives for subjects in epidemiologic studies and using these specimens for genotyping, and to evaluate the potential for bias in their use... - Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlersJonathan N Hofmann
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Environ Health Perspect 117:1402-8. 2009..However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals... - Diet and risk of endometriosis in a population-based case-control studyBritton Trabert
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
Br J Nutr 105:459-67. 2011..1: OR 0·6, >2 servings/d v. ≤ 1: OR 0·7), but this association was not statistically significant for the highest tertile. The present study suggests that specific dietary components may be associated with endometriosis risk... - Rheumatoid arthritis among women in the Agricultural Health Study: risk associated with farming activities and exposuresAnneclaire J De Roos
University of Washington Department of Epidemiology and Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Ann Epidemiol 15:762-70. 2005..We studied risk factors for RA in the Agricultural Health Study, a cohort of over 57,000 licensed pesticide applicators and their spouses... - Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genesBritton Trabert
University of Washington, Seattle, Washington, USA
Fertil Steril 96:1401-1406.e3. 2011..To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk... - Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, ChinaLaura S Gold
Program in Epidemiology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N. PO Box 19024 Seattle, WA 98109, USA
Scand J Work Environ Health 32:178-84. 2006..CONCLUSIONS: These results provide some preliminary suggestion that employment in textile industry maintenance jobs and exposure to wool products may be associated with an increased risk of brain tumors... - Census and geographic differences between respondents and nonrespondents in a case-control study of non-Hodgkin lymphomaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Am J Epidemiol 167:350-61. 2008..The bias was 8%, indicating that the socioeconomic and demographic differences between respondents and nonrespondents did not result in a large bias in the risk estimate for education... - Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: a case-control studyAnjoeka Pronk
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
Environ Health 12:20. 2013..The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States... - Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese womenKaren J Wernli
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Causes Control 17:949-55. 2006..50, 95% CI 0.23-1.07). This prospective study confirms findings from previous case-control studies relating menstrual, reproductive, and contraceptive factors and endometrial carcinoma... - Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel WorkshopFrederick W Miller
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health Clinical Research Center, Bethesda, MD 20892 1301, USA
J Autoimmun 39:259-71. 2012.... - Proximity to traffic, inflammation, and immune function among women in the Seattle, Washington, areaLori A Williams
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
Environ Health Perspect 117:373-8. 2009..Traffic-related air pollution has been associated with adverse health outcomes, and the immune system may be a biologic mediator of health effects... - Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumorsAnneclaire J De Roos
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 12:14-22. 2003..5; 95% CL, 1.0, 2.3). These findings may provide clues to both genetic and environmental determinants of brain tumors... - The impact of the First Steps prenatal care program on birth outcomes among women receiving Medicaid in Washington StateYuzo Arima
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA, 98195, United States
Health Policy 92:49-54. 2009.... - Systematic literature review of uses and levels of occupational exposure to tetrachloroethyleneLaura S Gold
Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
J Occup Environ Hyg 5:807-39. 2008..Researchers conducting these types of studies will be able to use results of the measurements to quantify tetrachloroethylene exposure levels for various jobs... - Spatial clustering of myelodysplastic syndromes (MDS) in the Seattle-Puget Sound region of Washington StateMichelle E Ross
Department of Biostatistics, University of Washington, Seattle, WA, USA
Cancer Causes Control 21:829-38. 2010..In this investigation, we described small-scale incidence patterns of MDS within the Seattle-Puget Sound region from 2002 to 2006 and identified potential spatial clusters to inform planning of future studies of MDS etiology... - Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumorsAnneclaire J De Roos
Fred Hutchinson Cancer Research Center and University of Washington Department of Epidemiology, Seattle, WA 98109, USA
Neuro Oncol 8:145-55. 2006..The association with the GSTM3 *B allele, while intriguing, requires replication, and additional research is needed to clarify the function of the GSTM3 alleles studied here... - Non-dioxin-like polychlorinated biphenyls and risk of endometriosisBritton Trabert
University of Washington, Seattle, Washington, USA
Environ Health Perspect 118:1280-5. 2010..Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones... - Differences in survival by histologic type of pancreatic cancerMegan Dann Fesinmeyer
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, HSB F-363, Box 357236, 1959 Northeast Pacific Avenue, Seattle, WA 98195-7236, USA
Cancer Epidemiol Biomarkers Prev 14:1766-73. 2005..A better understanding of these differences could contribute to identifying the underlying causes of pancreatic cancer and to improving survival rates across all histologic types... - Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1)Susan Searles Nielsen
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Environ Health Perspect 113:909-13. 2005..Larger studies that measure plasma PON1 levels and incorporate more accurate estimates of pesticide exposure will be required to confirm these observations... - Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health StudyAnneclaire J De Roos
Program in Epidemiology, Fred Hutchinson Cancer Research Center and the Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
Environ Health Perspect 113:49-54. 2005..Given the widespread use of glyphosate, future analyses of the AHS will allow further examination of long-term health effects, including less common cancers... - Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008Gregory S Calip
Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Br J Haematol 160:343-50. 2013..There is growing evidence of seasonality in AML diagnosis, particularly among older persons and men. Investigation of specific seasonal risk factors would be informative in explaining the aetiology behind the observed variation... - Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortiumTodd M Gibson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Bethesda, MD 20892, USA
Cancer Causes Control 24:125-34. 2013.... - Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancersKatrina F Trivers
Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, Chapel Hill, North Carolina 27599 7435, USA
Clin Gastroenterol Hepatol 3:225-30. 2005..Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown... - Occupation and risk of meningioma and acoustic neuroma in the United StatesPreetha Rajaraman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7238, USA
Am J Ind Med 45:395-407. 2004..Workplace exposures may be related to the development of brain tumors. In this case-control study, we examine occupation as a risk factor for meningioma and acoustic neuroma... - Drinking water and cancerAnneclaire J De Roos
Epidemiology 15:378-80. 2004 - Asthma history, occupational exposure to pesticides and the risk of non-Hodgkin's lymphomaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul
Int J Cancer 118:3174-6. 2006..2-29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics... - A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis ProjectJoanne M Jordan
Thurston Arthritis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, 27599 7330, USA
Am J Epidemiol 159:968-77. 2004..Associations between radiographic knee osteoarthritis and tocopherol isoforms are complex and may vary by ethnicity and sex... - Cancer incidence of dry cleaning, laundry and ironing workers in SwedenNoomie Travier
Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, Lyon, France
Scand J Work Environ Health 28:341-8. 2002..The results are limited by the use of job and industry titles as proxies for occupational exposures...
Research Grants
- Industrial Pollutants and Risk of Non-Hodgkins LymphomaAnneclaire De Roos; Fiscal Year: 2006..abstract_text> ..
- Energy Balance, Organochlorine Exposure, and Possible Toxicologic EffectsAnneclaire De Roos; Fiscal Year: 2007..Understanding possible toxicologic effects of organochlorine exposure following weight loss may provide clues about certain detrimental effects of energy imbalance. ..