Jonathan A Cooper

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
    Anjali Teckchandani
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 186:99-111. 2009
  2. pmc Cell biology in neuroscience: mechanisms of cell migration in the nervous system
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 202:725-34. 2013
  3. doi A mechanism for inside-out lamination in the neocortex
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Neurosci 31:113-9. 2008
  4. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
  5. pmc A mechanism for SRC kinase-dependent signaling by noncatalytic receptors
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochemistry 47:5681-8. 2008
  6. ncbi Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Traffic 9:267-79. 2008
  7. ncbi Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 117:152-9. 2003
  8. pmc Dual functions of Dab1 during brain development
    Libing Feng
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 29:324-32. 2009
  9. ncbi Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans
    Darren M Kamikura
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Traffic 7:324-36. 2006
  10. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003

Research Grants

  1. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
  2. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2006
  3. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan A Cooper; Fiscal Year: 2010
  4. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2003
  5. PROTEIN PHOSPHORYLATION & CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 1993
  6. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
  7. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 2007
  8. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2004
  9. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2000
  10. Chromosome Metabolism and Cancer Training Grant
    Jonathan Cooper; Fiscal Year: 2007

Collaborators

Detail Information

Publications43

  1. pmc Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
    Anjali Teckchandani
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 186:99-111. 2009
    ....
  2. pmc Cell biology in neuroscience: mechanisms of cell migration in the nervous system
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 202:725-34. 2013
    ..New research is needed to fully understand how migration of such morphologically complicated cells is coordinated over space and time. ..
  3. doi A mechanism for inside-out lamination in the neocortex
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Neurosci 31:113-9. 2008
    ..This 'detach and go' model explains many aspects of inside-out lamination, defects in the Reeler mutant and results of recent genetic and in utero experiments...
  4. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development...
  5. pmc A mechanism for SRC kinase-dependent signaling by noncatalytic receptors
    Jonathan A Cooper
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochemistry 47:5681-8. 2008
    ..Other events that regulate signaling in specific cases may have evolved for fine-tuning of this basic mechanism...
  6. ncbi Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Traffic 9:267-79. 2008
    ....
  7. ncbi Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 117:152-9. 2003
    ....
  8. pmc Dual functions of Dab1 during brain development
    Libing Feng
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 29:324-32. 2009
    ..These results show that Reelin-induced Akt stimulation and Dab1 turnover are not sufficient for normal development and suggest that Dab1 acts both as a kinase switch and as a scaffold for assembling signaling complexes in vivo...
  9. ncbi Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans
    Darren M Kamikura
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Traffic 7:324-36. 2006
    ....
  10. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...
  11. pmc Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
    Lionel Arnaud
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Mol Cell Biol 23:9293-302. 2003
    ..Our data provide the first evidence for how Reelin down-regulates Dab1 protein expression in vivo. Dab1 degradation may be important for ensuring a transient Reelin response and may play a role in normal brain development...
  12. pmc Both the phosphoinositide and receptor binding activities of Dab1 are required for Reelin-stimulated Dab1 tyrosine phosphorylation
    Mei Xu
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 139:300-5. 2005
    ....
  13. pmc Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
    William T Arthur
    Fred Hutchison Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 167:111-22. 2004
    ..These results lead us to propose that Rap1 promotes cell spreading by localizing a subset of Rac GEFs to sites of active lamellipodia extension...
  14. ncbi The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH
    Meghan E Maurer
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    J Cell Sci 119:4235-46. 2006
    ....
  15. ncbi High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons
    Tara M Herrick
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 126:121-8. 2004
    ..The Dab1(F158V) allele adds to a series of Dab1 alleles that demonstrates cell type-specific variation in the Reelin-Dab1 pathway...
  16. pmc Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development
    Libing Feng
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 21:2717-30. 2007
    ..The results implicate Cul5 and SOCS proteins in down-regulation of Dab1 in vivo and show that Cul5 plays an essential role in regulating neuron migrations during cortical development, possibly by opposing a promigratory effect of Dab1...
  17. ncbi Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein
    Meghan E Maurer
    Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Cell Sci 118:5345-55. 2005
    ..These studies suggest that Dab2 p96 mediates endocytosis of megalin in the VE. In addition, rescue of embryonic viability correlates with endocytosis, suggesting that endocytosis mediated by Dab2 is important for normal development...
  18. ncbi Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton
    Shelli M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Traffic 3:331-41. 2002
    ..These results suggest that the myosin VI-Dab2 interaction may be one link between the actin cytoskeleton and receptors undergoing endocytosis...
  19. pmc The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis
    Anjali Teckchandani
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Biol Cell 23:2905-16. 2012
    ..We propose that adaptors may need to be bound to their cargo to regulate EH domain proteins and internalize efficiently...
  20. ncbi ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, WA 98109 1024, USA
    J Leukoc Biol 83:200-11. 2008
    ..Our studies show that restraint of CD33 internalization through the intracellular domain is relieved partly when the ITIMs are phosphorylated and show that Shp1 and Shp2 can modulate this process...
  21. ncbi Absence of Fyn and Src causes a reeler-like phenotype
    Gloria Kuo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 25:8578-86. 2005
    ..This implies that Src and Fyn are needed for Reelin-dependent events during brain development...
  22. ncbi Lipid-dependent recruitment of neuronal Src to lipid rafts in the brain
    Abir Mukherjee
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 278:40806-14. 2003
    ..These findings suggest that NSrc may be involved in signaling from lipid rafts in mouse brain...
  23. pmc Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors
    Sergi Simo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 27:399-411. 2013
    ..Our results suggest that CRL5 adaptor expression is spatiotemporally regulated to modulate Reelin signaling and ensure normal neuron positioning in the developing brain. ..
  24. pmc Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration
    Sergi Simo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 30:5668-76. 2010
    ....
  25. pmc FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis
    Erin E Mulkearns
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Mol Biol Cell 23:1330-42. 2012
    ..These results indicate FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 is needed for LDLR endocytosis under conditions of low AP2...
  26. pmc Restriction of Src activity by Cullin-5
    George S Laszlo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 19:157-62. 2009
    ..These findings demonstrate the importance of a new mechanism that downregulates Src signaling in cells...
  27. pmc Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex
    Yves Jossin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Neurosci 14:697-703. 2011
    ..However, inhibition of Rap1 or NCad had little effect on glia-dependent locomotion. We propose a multistep mechanism in which Reelin activates Rap1, Rap1 upregulates NCad, and NCad is needed to orient cell migration...
  28. ncbi A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development
    Tara M Herrick
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Development 129:787-96. 2002
    ....
  29. pmc SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading
    Leslie A Cary
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:2427-40. 2002
    ..These results indicate that the primary role of Src in integrin signaling is as a kinase. Indirect models for Src function are proposed...
  30. pmc Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport
    Shelli M Morris
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    EMBO J 21:1555-64. 2002
    ..This evidence indicates that Dab2 is pleiotropic and regulates both visceral endoderm function and lipoprotein receptor trafficking in vivo...
  31. ncbi Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, WA 98109 1024, USA
    Blood 105:1295-302. 2005
    ....
  32. pmc Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans
    Darren M Kamikura
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 17:2798-811. 2003
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway...
  33. pmc Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation
    Anjali Teckchandani
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    J Cell Sci 127:509-20. 2014
    ..Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6. ..
  34. ncbi Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog
    Anu Chaudhary
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A2 025, Seattle, WA 98109, USA
    Biochem Biophys Res Commun 294:293-300. 2002
    ..Taken together, these data provide evidence that Src directly phosphorylates Fak and demonstrates the limitations of using this modified ATP strategy for analysis of direct substrates of protein kinases in permeabilized cells...
  35. pmc Regulation of dendritic branching by Cdc42 GAPs
    Sergi Simo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 26:1653-8. 2012
    ..The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching...
  36. doi Temporal cooperativity and sensitivity amplification in biological signal transduction
    Hong Qian
    Department of Applied Mathematics, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 47:2211-20. 2008
    ..The theory is applicable to a wide range of processes in cell signaling including the specificity and sensitivity of T-cell activation...
  37. ncbi Reelin and mDab1 regulate the development of hippocampal connections
    Victor Borrell
    Developmental Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine IRB Barcelona Science Park, Barcelona, E 08028, Spain
    Mol Cell Neurosci 36:158-73. 2007
    ..Altogether these results indicate that Reelin and mDab1 participate in the development and refinement of hippocampal connections by regulating axonal extension, targeting and branching...
  38. ncbi The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations
    Chankyu Park
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genesis 32:32-41. 2002
    ..We suggest that the cdf gene product is required in a subset of Purkinje cells, possibly to respond to Reelin signals...
  39. pmc Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness
    Michael C Brown
    Department of Cell and Developmental Biology, College of Medicine, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Mol Biol Cell 16:4316-28. 2005
    ....
  40. ncbi Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk
    Kevin C Orton
    Department of Biochemistry, University of California, Riverside, Riverside, California 92521, USA
    J Biol Chem 279:38649-57. 2004
    ..These results indicate a role for Pak2 in the down-regulation of translation initiation in apoptosis by phosphorylation of Mnk1...
  41. pmc Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107
    Taku Chibazakura
    Department of Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Proc Natl Acad Sci U S A 101:4465-70. 2004
    ..We concluded that cyclin proteolysis and CDK inhibitors constitute redundant pathways that control cyclin A-CDK activity during mitotic exit in mammalian cells and that loss of these pathways can cause genetic instability...
  42. ncbi Genetic modulation of tau phosphorylation in the mouse
    Jochen Brich
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 23:187-92. 2003
    ..Dab1 mutant mice provide an animal model for studying the relationships between ApoE receptors, tau hyperphosphorylation, and Alzheimer's disease...
  43. ncbi Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL
    Yee Ping Yip
    Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Comp Neurol 502:635-43. 2007
    ..These results suggest a role for CrkL in the Reelin signaling pathway to control neuronal migration...

Research Grants30

  1. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  2. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2006
    ..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
  3. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan A Cooper; Fiscal Year: 2010
    ..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
  4. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2003
    ..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
  5. PROTEIN PHOSPHORYLATION & CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 1993
    ..A search will be made for physiological stimuli that alter the phosphorylation state of the carboxy-terminal tyrosine. The interactions between amino- and carabosy-terminal regulatory domains will be studied...
  6. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  7. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 2007
    ..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
  8. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2004
    ..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
  9. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2000
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  10. Chromosome Metabolism and Cancer Training Grant
    Jonathan Cooper; Fiscal Year: 2007
    ..It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention. ..
  11. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan A Cooper; Fiscal Year: 2010
    ..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
  12. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 1999
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  13. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 2009
    ..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
  14. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2004
    ..These studies will provide insights into the molecular mechanisms of action of Dab2 and into the role of a single gene in receptor trafficking and signal transduction. ..
  15. PROTEIN PHOSPHORYLATION AND CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 1990
    ..A search will be made for physiological stimuli that alter the phosphorylation state of the carboxy-terminal tyrosine. The interactions between amino- and carabosy-terminal regulatory domains will be studied...
  16. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan Cooper; Fiscal Year: 2009
    ..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
  17. PROTEIN PHOSPHORYLATION & CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 1992
    ..A search will be made for physiological stimuli that alter the phosphorylation state of the carboxy-terminal tyrosine. The interactions between amino- and carabosy-terminal regulatory domains will be studied...
  18. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2005
    ..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
  19. PROTEIN PHOSPHORYLATION & CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 1991
    ..A search will be made for physiological stimuli that alter the phosphorylation state of the carboxy-terminal tyrosine. The interactions between amino- and carabosy-terminal regulatory domains will be studied...