Chu Chen

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Gene expression in uninvolved oral mucosa of OSCC patients facilitates identification of markers predictive of OSCC outcomes
    Pawadee Lohavanichbutr
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e46575. 2012
  2. ncbi request reprint CYP2D6 genotype and the incidence of anal and vulvar cancer
    C Chen
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 8:317-21. 1999
  3. pmc Gene expression profiling identifies genes predictive of oral squamous cell carcinoma
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology, 1100 Fairview Avenue North, M5 C800 P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2152-62. 2008
  4. pmc Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China
    Chu Chen
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mailstop M5 C800, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3457-66. 2008
  5. ncbi request reprint Endogenous sex hormones and prostate cancer risk: a case-control study nested within the Carotene and Retinol Efficacy Trial
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:1410-6. 2003
  6. ncbi request reprint Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women
    Chu Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 118:2303-9. 2006
  7. ncbi request reprint Androgen receptor polymorphisms and the incidence of prostate cancer
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1033-40. 2002
  8. ncbi request reprint Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulin
    Chu Chen
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 103:76-84. 2005
  9. ncbi request reprint N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk
    C Chen
    Program in Epidemiology, Division of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, DE 320, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
    Carcinogenesis 22:1993-9. 2001
  10. ncbi request reprint Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture
    C Chen
    Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Carcinogenesis 20:699-703. 1999

Detail Information

Publications96

  1. pmc Gene expression in uninvolved oral mucosa of OSCC patients facilitates identification of markers predictive of OSCC outcomes
    Pawadee Lohavanichbutr
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e46575. 2012
    ..Dysregulation of 20 of the 71 probe sets was associated with progression-free survival and was validated in an independent dataset...
  2. ncbi request reprint CYP2D6 genotype and the incidence of anal and vulvar cancer
    C Chen
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 8:317-21. 1999
    ..6-5.4 with two inactivating alleles. These results provide no support for the hypothesis that cigarette smokers who carry the CYP2D6 alleles that result in a low activity phenotype have a decreased risk of anogenital cancer...
  3. pmc Gene expression profiling identifies genes predictive of oral squamous cell carcinoma
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology, 1100 Fairview Avenue North, M5 C800 P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2152-62. 2008
    ..If confirmed in larger studies, the proposed models may hold promise for monitoring local recurrence at surgical margins and the development of second primary oral cancer in patients with OSCC...
  4. pmc Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China
    Chu Chen
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mailstop M5 C800, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3457-66. 2008
    ..Our findings suggest that CYP19A1 variation may enhance breast cancer development in some women, but further confirmation is warranted...
  5. ncbi request reprint Endogenous sex hormones and prostate cancer risk: a case-control study nested within the Carotene and Retinol Efficacy Trial
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:1410-6. 2003
    ..The suggestions that intraprostatic androgen activity may increase risk and that serum estrogens may decrease risk, warrant additional study...
  6. ncbi request reprint Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women
    Chu Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 118:2303-9. 2006
    ..13 (1.50-6.53), 4.57 (2.22-9.39) and 6.30 (3.08-12.89), compared with the lowest fourth. Our results suggest that elevated levels of IGF-I may contribute to the development of FBC...
  7. ncbi request reprint Androgen receptor polymorphisms and the incidence of prostate cancer
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1033-40. 2002
    ..32-0.98), compared with men with > or =22 CAG repeats and >17 GGC repeats. Our results do not support the hypothesis that a small number of CAG or GGC repeats in the androgen receptor gene increases a man's risk of prostate cancer...
  8. ncbi request reprint Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulin
    Chu Chen
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 103:76-84. 2005
    ..To examine this issue further, the authors conducted a nested case-control study within the Cardiovascular Health Study cohort...
  9. ncbi request reprint N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk
    C Chen
    Program in Epidemiology, Division of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, DE 320, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
    Carcinogenesis 22:1993-9. 2001
    ..8-4.9) compared with slow acetylators (1.6%, 95% CI 0.6-2.7) (interaction P = 0.055). These data raise the possibility that NAT2 may be involved in the activation of one or more pro-carcinogens associated with alcohol consumption...
  10. ncbi request reprint Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture
    C Chen
    Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Carcinogenesis 20:699-703. 1999
    ..Our results suggest that viral infections, through the modulation of cellular xenobiotic-metabolizing enzymes, may play a role in the ability of cells to handle environmental carcinogens...
  11. ncbi request reprint Risk of prostate cancer in relation to polymorphisms of metabolic genes
    C Chen
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, DE320, Seattle, WA 98109, USA
    Epidemiol Rev 23:30-5. 2001
    ..Since gene-gene and gene-environment interactions may contribute to cancer risk, it would be desirable to conduct studies in which both biomarkers (or other measures) of exposure and polymorphisms of multiple genes are examined...
  12. pmc Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk
    Kerryn W Reding
    University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1461-7. 2009
    ....
  13. pmc Can a metastatic gene expression profile outperform tumor size as a predictor of occult lymph node metastasis in oral cancer patients?
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:2466-73. 2011
    ..To determine the differential gene expression between oral squamous cell carcinoma (OSCC) with and without metastasis to cervical lymph nodes and to assess prediction of nodal metastasis by using molecular features...
  14. pmc Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk
    Kerryn W Reding
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98109, USA
    Am J Epidemiol 170:1241-9. 2009
    ..1, 2.2) but not in never users (P(heterogeneity) = 0.02). Interpretation of these subgroup associations must await the results of similar studies conducted in other populations...
  15. pmc A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation
    Pawadee Lohavanichbutr
    Program in Epidemiology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Cancer Res 19:1197-203. 2013
    ..To identify a prognostic gene signature for patients with human papilloma virus (HPV)-negative oral squamous cell carcinomas (OSCC)...
  16. pmc Selected estrogen receptor 1 and androgen receptor gene polymorphisms in relation to risk of breast cancer and fibrocystic breast conditions among Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol 35:48-55. 2011
    ..Polymorphisms in sex hormone receptor-encoding genes may alter the activity of sex hormone receptors and thereby affect susceptibility to breast cancer and related outcomes...
  17. ncbi request reprint Ovarian cancer risk and polymorphisms involved in estrogen catabolism
    Sarah K Holt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:481-9. 2007
    ..No association of ovarian cancer risk was observed with any of the other polymorphisms examined, either alone or in combination...
  18. pmc Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008
    ..Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women...
  19. pmc A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98109 1024, USA
    Clin Cancer Res 15:1353-61. 2009
    ..To determine if gene expression signature of invasive oral squamous cell carcinoma (OSCC) can subclassify OSCC based on survival...
  20. pmc Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    Mol Cancer 9:143. 2010
    ....
  21. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  22. ncbi request reprint Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors
    Babette S Saltzman
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:607-14. 2008
    ..These results support the hypothesis that type 2 diabetes is associated with endometrial cancer irrespective of the presence of other risk factors for this disease, except possibly hypertension and extreme obesity...
  23. pmc Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Mailstop M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 109:143-55. 2008
    ..The observed increased risk of breast cancer associated with joint carriage of the GSTM1 null genotype and GSTP1 105-Val allele needs confirmation in other studies...
  24. pmc Examination of oral cancer biomarkers by tissue microarray analysis
    Peter Choi
    Department of Otolaryngology Head and Neck Surgery, University ofWashington, Seattle, WA, USA
    Arch Otolaryngol Head Neck Surg 134:539-46. 2008
    ....
  25. ncbi request reprint Tumor-specific genetic expression profile of metastatic oral squamous cell carcinoma
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    Head Neck 29:803-14. 2007
    ..Metastasis is the most important predictor of survival in patients with oral squamous cell carcinoma (OSCC). We tested the hypothesis that there is a genetic expression profile associated with OSCC metastasis...
  26. pmc Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers
    Lori C Sakoda
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, Mailstop M4 C308, Seattle, WA 98109 1024, USA
    Cancer Causes Control 22:449-61. 2011
    ..Studying gene-environment interactions may provide insight about mechanisms underpinning the reported association between chromosome 15q24-25.1 variation and lung cancer susceptibility...
  27. ncbi request reprint Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  28. ncbi request reprint Lignan and isoflavone excretion in relation to uterine fibroids: a case-control study of young to middle-aged women in the United States
    Charlotte Atkinson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Clin Nutr 84:587-93. 2006
    ..Phytoestrogens, including isoflavones and lignans, can act as weak estrogens or antiestrogens...
  29. pmc Integrative genomics in combination with RNA interference identifies prognostic and functionally relevant gene targets for oral squamous cell carcinoma
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 9:e1003169. 2013
    ..Further investigation is warranted to examine the biological role of these genes in OSCC progression and their therapeutic potentials...
  30. pmc Polymorphisms in nucleotide excision repair genes and endometrial cancer risk
    Jennifer A Doherty
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:1873-82. 2011
    ..Certain estrogen metabolites can form bulky DNA adducts, which are removed via nucleotide excision repair (NER), and the ability to carry out this repair might be related to endometrial cancer risk...
  31. pmc Pregnancy history and risk of endometrial cancer
    Gaia Pocobelli
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
    Epidemiology 22:638-45. 2011
    ..Less clear is whether timing of pregnancies during reproductive life influences risk, and the degree to which incomplete pregnancies are associated with a reduced risk...
  32. pmc Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Box 354922, Seattle, WA 98195 4922, USA
    Cancer Epidemiol Biomarkers Prev 17:2012-8. 2008
    ..Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy...
  33. pmc Simultaneous isolation of DNA and RNA from the same cell population obtained by laser capture microdissection for genome and transcriptome profiling
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
    J Mol Diagn 10:129-34. 2008
    ..Thus, we developed a method to obtain both DNA and RNA material from a single population of LCM-harvested cells and herein discuss the strengths and limitations of this methodology...
  34. ncbi request reprint Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association
    Jocelyn M Weiss
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Gynecol Oncol 103:891-6. 2006
    ..Certain nucleotide excision repair (NER) genotypes appear to be associated with an altered risk of endometrial cancer. These associations could be modified by characteristics and exposures that themselves influence risk of disease...
  35. ncbi request reprint Integrative analysis in oral squamous cell carcinoma reveals DNA copy number-associated miRNAs dysregulating target genes
    Nicholas A Serrano
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98115 7744, USA
    Otolaryngol Head Neck Surg 147:501-8. 2012
    ....
  36. pmc Human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories
    Arun Sharma
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Otolaryngol Head Neck Surg 146:739-45. 2012
    ..Since OSCC that are associated with high-risk HPV have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better QOL trajectories...
  37. pmc Long-term use of continuous-combined estrogen-progestin hormone therapy and risk of endometrial cancer
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Causes Control 22:1639-46. 2011
    ..19, 95% CI: 0.05-0.68). Associations did not differ according to recency of use. These results suggest that long duration of use of continuous-combined estrogen-progestin therapy is associated with a reduced risk of endometrial cancer...
  38. ncbi request reprint Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-I, insulin-like growth factor binding protein-3, and insulin-like growth factor-I receptor
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:2461-6. 2006
    ..Our observation that men who do not carry two copies of the IGF-IR (AGG)7 allele are at increased risk of prostate cancer merits further investigation...
  39. pmc ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study
    Jennifer A Doherty
    Program in Epidemiology M4 C308, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:245-50. 2010
    ..These data provide suggestive evidence that the rs2295190 T allele, or another allele in linkage disequilibrium with it, may be associated with increased risk of invasive ovarian cancer...
  40. ncbi request reprint Risk factors for the incidence of endometrial cancer according to the aggressiveness of disease
    Jocelyn M Weiss
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 164:56-62. 2006
    ..In general, a woman's risk of endometrial cancer appears to be influenced by similar risk factors regardless of disease severity...
  41. ncbi request reprint Long-term use of postmenopausal estrogen and progestin hormone therapies and the risk of endometrial cancer
    Jennifer A Doherty
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Obstet Gynecol 197:139.e1-7. 2007
    ....
  42. ncbi request reprint A log likelihood predictor for genomic classification of oral cancer using principle component analysis for feature selection
    Mark E Whipple
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98105, USA
    Stud Health Technol Inform 107:823-6. 2004
    ..The three most highly positively and three most highly negative predictive genes were all keratins that are known markers of squamous cell carcinoma...
  43. doi request reprint V89L polymorphism of the 5alpha-reductase Type II gene (SRD5A2), endogenous sex hormones, and prostate cancer risk
    Inbal Boger-Megiddo
    Program in Epidemiology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:286-91. 2008
    ..However, the absence of an overall association between V89L genotype and aggressive prostate cancer argues for a cautious interpretation of these observations...
  44. ncbi request reprint Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
    ..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones...
  45. ncbi request reprint Transcriptional expression profiles of oral squamous cell carcinomas
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Cancer 95:1482-94. 2002
    ..No system to date has incorporated genetic changes as a factor by which to classify OSCC tumors...
  46. ncbi request reprint Polymorphic markers in the 5alpha-reductase type II gene and the incidence of prostate cancer
    Najib Lamharzi
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 105:480-3. 2003
    ....
  47. pmc Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among Black and White women
    Kerryn W Reding
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop M4 B874, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 134:801-9. 2012
    ..These study results suggest that subtle differences in percent African ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics...
  48. doi request reprint Night shift work and hormone levels in women
    Scott Davis
    Program in Epidemiology, Division of Public HealthSciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:609-18. 2012
    ..We investigated whether night shift work is associated with decreased levels of urinary 6-sulfatoxymelatonin, the primary metabolite of melatonin, and increased urinary reproductive hormone levels...
  49. pmc Association of marijuana use and the incidence of testicular germ cell tumors
    Janet R Daling
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 115:1215-23. 2009
    ..In this study, the authors tested the hypothesis that marijuana use is a risk factor for TGCT...
  50. pmc Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes
    Sandi L Navarro
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:2974-8. 2009
    ..04) and GSTM1+/GSTT1+ men (by 26%; P = 0.01) but not in women. In summary, cruciferous vegetable supplementation increased GSTA1/2, but the effect was most marked in GSTM1-null/GSTT1-null men...
  51. ncbi request reprint A genomic predictor of oral squamous cell carcinoma
    Mark E Whipple
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Laryngoscope 114:1346-54. 2004
    ..The objective was to identify a genomic profile that predicts the likelihood of oral squamous cell carcinoma compared with normal oral mucosa in unknown tissue samples...
  52. ncbi request reprint Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism
    Jacqueline R Starr
    Department of Pediatrics, University of Washington, Seattle, 98105 0371, USA
    Cancer Epidemiol Biomarkers Prev 14:2183-90. 2005
    ..0; 95% CI, 1.6-31) or CYP3A5 6986G (RR, 2.4; 95% CI, 1.1-5.6) alleles. These results support the hypothesis that maternal and/or offspring catechol estrogen activity may influence sons' risk of TGCC...
  53. pmc Use of nonsteroidal antiinflammatory drugs and risk of endometrial cancer
    Clara Bodelon
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195 7236, USA
    Am J Epidemiol 170:1512-7. 2009
    ..73, 1.53). NSAID use was unrelated to risk of endometrial cancer in both obese and nonobese women. Results from this study suggest that the use of aspirin or other NSAIDs has little or no influence on the risk of endometrial cancer...
  54. ncbi request reprint The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial
    Gary E Goodman
    The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 12:518-26. 2003
    ..There was no statistically significant association between serum carotenoids and prostate cancer. Our findings provide additional support for the association between physiological levels of dietary micronutrients and cancer incidence...
  55. pmc DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: a review
    Yu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology and Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Head Neck 30:1361-83. 2008
    ..It points out the limitations of some methodologies that were used in the past and discusses the advantages and challenges of using genome-wide SNP arrays...
  56. pmc Estrogen-related genes and their contribution to racial differences in breast cancer risk
    Kerryn W Reding
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 23:671-81. 2012
    ..02) and with CYP17A1 in Black women (p value = 0.04). This analysis suggests that HT use may modify the effect of variation in estrogen-related genes on breast cancer risk, which may affect Black and White women to a different extent...
  57. pmc Tumor and salivary matrix metalloproteinase levels are strong diagnostic markers of oral squamous cell carcinoma
    Marni Stott-Miller
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:2628-36. 2011
    ..The matrix metalloproteinases (MMP) cause degradation of the extracellular matrix and basement membranes, and thus may play a key role in cancer development...
  58. pmc Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner
    Heather Ann Brauer
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Nutr J 10:11. 2011
    ..The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo...
  59. ncbi request reprint Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer
    Jennifer A Doherty
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:357-66. 2005
    ....
  60. pmc Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese women
    S Coosje Dijkstra
    Public Health Sciences Division, Fred Hutchinson Research Center, Seattle, WA 98109, USA
    J Nutr 140:1302-10. 2010
    ..The inverse associations between plasma isoflavone concentrations and RBC EPA and DPA and fibroadenoma risk suggest that higher intakes of soy foods and fatty fish may lower the risk of fibroadenomas...
  61. pmc Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial
    Andrea Z LaCroix
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, PO 19024, Seattle, WA 98109
    JAMA 305:1305-14. 2011
    ..1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported...
  62. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
    ..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...
  63. ncbi request reprint Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 800, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:644-8. 2004
    ..6% versus 12.8%; P = 0.54). We found no evidence that a 12-month 83 mg/day isoflavone treatment alters serum PSA concentration or velocity in seemingly healthy men aged 50-80 years...
  64. ncbi request reprint Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus
    Sid H Siahpush
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 16:2387-95. 2007
    ..IGF-I and its main binding protein, IGF binding protein-3 (IGFBP-3), and their polymorphisms have been investigated in relation to risk of many cancers, but not esophageal adenocarcinoma...
  65. pmc Shift work, hCLOCK T3111C polymorphism, and endometriosis risk
    Jennifer L Marino
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Epidemiology 19:477-84. 2008
    ..One such exposure may be night shift work, which has been associated with menstrual disruption and increased risk of 2 other estrogen-influenced diseases, breast cancer and adverse coronary events...
  66. pmc Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes
    Britton Trabert
    University of Washington, Seattle, Washington, USA
    Fertil Steril 96:1401-1406.e3. 2011
    ..To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk...
  67. ncbi request reprint DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients
    Thomas J Gal
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Laryngoscope 115:2221-31. 2005
    ....
  68. ncbi request reprint Screening for deleterious nonsynonymous single-nucleotide polymorphisms in genes involved in steroid hormone metabolism and response
    Melissa M Johnson
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, P O Box 19024, Mailstop M5 C800, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1326-9. 2005
    ..Of these, 28% were predicted by SIFT and PolyPhen as having a potentially damaging effect on protein function. Investigation into the association of these variant alleles with hormone-related cancers may prove to be fruitful...
  69. ncbi request reprint Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma
    Peter Choi
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, 98109, USA
    Cancer 104:1113-28. 2005
    ..Further investigation into the genomic, proteomic, and functional consequences of these gene expression alterations may provide insight into the pathophysiology of HNSCC...
  70. ncbi request reprint Effects of 60-Hz magnetic field exposure on nocturnal 6-sulfatoxymelatonin, estrogens, luteinizing hormone, and follicle-stimulating hormone in healthy reproductive-age women: results of a crossover trial
    Scott Davis
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Ann Epidemiol 16:622-31. 2006
    ....
  71. ncbi request reprint Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
    J Nutr 131:740-4. 2001
    ..These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol...
  72. ncbi request reprint Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulfatoxymelatonin concentration in women
    S Davis
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 154:591-600. 2001
    ..These results suggest that exposure to nighttime residential 60-Hz magnetic fields can depress the normal nocturnal rise in melatonin...
  73. ncbi request reprint Modulation of human glutathione S-transferases by botanically defined vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:787-93. 2000
    ..GST responses were more pronounced in women than men, but it is not clear from this study whether this is a dose-per-body-weight or a sex-specific effect...
  74. ncbi request reprint Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Carcinogenesis 21:1157-62. 2000
    ..This points to a complex association between consumption of a typical diet of various vegetables and biotransformation enzyme activities in humans, an association that may be difficult to interpret in observational studies...
  75. ncbi request reprint Study of diet, biomarkers and cancer risk in the United States, China and Costa Rica
    J A Satia
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 82:28-32. 1999
    ..9 microg/dl in King County, 585.7 +/- 35.9 microg/dl in Shanghai and 461.1 +/- 33.1 microg/dl in Costa Rica. Plasma trans fatty acids (a biomarker of a diet high in hydrogenated fats) were highest in King County and lowest in Shanghai...
  76. ncbi request reprint Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes
    S M Schwartz
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:1137-44. 2001
    ..5-2.6%) and 1.2% (0.0-2.4%) among persons carrying the ADH3*1/*2 and ADH3*1/*1 genotypes, respectively. These data suggest that the ADH3*2 allele confers increased susceptibility to the effect of alcohol on OSCC risk in our population...
  77. ncbi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  78. ncbi request reprint Soy isoflavones do not modulate circulating insulin-like growth factor concentrations in an older population in an intervention trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, University of Washington, Center for Health Studies, Group Health Cooperative, Seattle, WA, USA
    J Nutr 133:1316-9. 2003
    ..A 12 mo, 83 mg/d soy isoflavone intervention did not modulate serum IGF in an older, mostly male population...
  79. ncbi request reprint Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake
    Charlotte Atkinson
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:253-60. 2002
    ..Measuring isoflavone excretion in one overnight urine collection serves as a biomarker of recent or past isoflavone intake, even in populations whose intake of soy foods is relatively low...
  80. ncbi request reprint Inflammation and endometrial cancer: a hypothesis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 14:2840-7. 2005
    ..A proinflammatory milieu can also directly increase estrogen production. Hence, inflammation may work in conjunction with or in addition to estrogen exposure in the development of endometrial cancer...
  81. ncbi request reprint Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia
    C Crump
    Department of Epidemiology, University of Washington, Seattle 98195, USA
    Cancer Epidemiol Biomarkers Prev 9:457-60. 2000
    ..e., between the GSTT1 gene deletion and trisomy 8, and between the GSTM1 gene deletion and non-8 trisomies or inv(16). These results do not support the hypothesis that the GSTT1 gene deletion is related to the incidence of AML...
  82. ncbi request reprint Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8123, MSC 7240, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:2524-30. 2005
    ..58; 95% CI, 0.35-0.96). Our data suggest that interindividual variation in XPA and XPC influences a woman's risk of endometrial cancer...
  83. ncbi request reprint Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks
    Yun Ju Chen
    Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Cancer 119:2827-31. 2006
    ..These results suggest that ADH1B and ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed...
  84. pmc The Y deletion gr/gr and susceptibility to testicular germ cell tumor
    Katherine L Nathanson
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 77:1034-43. 2005
    ..0; 95% CI 1.6-5.4; P = .0004) than with nonseminoma TGCT (aOR 1.5; 95% CI 0.72-3.0; P = .29). These data indicate that the Y microdeletion gr/gr is a rare, low-penetrance allele that confers susceptibility to TGCT...
  85. ncbi request reprint Estrogen plus progestin and colorectal cancer in postmenopausal women
    Rowan T Chlebowski
    Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, Calif 90502, USA
    N Engl J Med 350:991-1004. 2004
    ..We analyzed features of the colorectal cancers that developed and their relation to the characteristics of the participants...
  86. pmc Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
    Andrew W Roddam
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Ann Intern Med 149:461-71, W83-8. 2008
    ..Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer...
  87. ncbi request reprint Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...
  88. ncbi request reprint Marijuana use and risk of oral squamous cell carcinoma
    Karin A Rosenblatt
    Department of Community Health, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
    Cancer Res 64:4049-54. 2004
    ..Marijuana use was not associated with OSCC risk in this large, population-based study...
  89. ncbi request reprint Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    ....
  90. ncbi request reprint Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsy
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Arch Intern Med 168:370-7; quiz 345. 2008
    ..The effect of combined hormone therapy on breast cancer detection is not established...
  91. ncbi request reprint Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
    ..Consistent findings from three case-control studies suggest that selected DNA repair enzymes may play a role in head and neck carcinogenesis...
  92. doi request reprint A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  93. ncbi request reprint Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits
    Stephanie De Gois
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:7121-33. 2005
    ....
  94. ncbi request reprint High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries
    Chu Chen
    West China School of Pharmacy, Sichuan University, Chengdu 610041, China
    J Chromatogr A 1154:250-9. 2007
    ..The established method was considered to be suitable for fingerprint analysis to check the genuine origin and control the quality of sea buckthorn berries and extracts...
  95. pmc Calcium, vitamin D supplementation, and physical function in the Women's Health Initiative
    Robert L Brunner
    University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
    J Am Diet Assoc 108:1472-9. 2008
    ..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning...
  96. ncbi request reprint [Quality estimation on material medica of Rhizoma Paridis from Sichuan & Yunnan province]
    Hong Xiang Yin
    West China College of Pharmacy, Sichuan University, Chengdu 610041, China
    Zhong Yao Cai 30:771-4. 2007
    ..To provide valuable reference for comprehensive qualitative estimation and reasonable utilization of material medica Rhizoma Paridis...

Research Grants19

  1. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2009
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  2. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  3. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  4. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2004
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  5. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  6. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2003
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  7. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2005
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  8. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2005
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  9. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  10. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2006
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  11. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2006
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  12. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2004
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  13. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2007
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  14. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2007
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  15. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2006
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  16. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2009
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  17. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2002
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  18. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2001
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..