Research Topics
Genomes and Genes
| Chu ChenSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
CYP2D6 genotype and the incidence of anal and vulvar cancerC Chen
Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 8:317-21. 1999..6-5.4 with two inactivating alleles. These results provide no support for the hypothesis that cigarette smokers who carry the CYP2D6 alleles that result in a low activity phenotype have a decreased risk of anogenital cancer...- Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulinChu Chen
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer 103:76-84. 2005..To examine this issue further, the authors conducted a nested case-control study within the Cardiovascular Health Study cohort... - Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese womenChu Chen
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Int J Cancer 118:2303-9. 2006..13 (1.50-6.53), 4.57 (2.22-9.39) and 6.30 (3.08-12.89), compared with the lowest fourth. Our results suggest that elevated levels of IGF-I may contribute to the development of FBC... - Endogenous sex hormones and prostate cancer risk: a case-control study nested within the Carotene and Retinol Efficacy TrialChu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 12:1410-6. 2003..The suggestions that intraprostatic androgen activity may increase risk and that serum estrogens may decrease risk, warrant additional study... 
Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, ChinaChu Chen
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mailstop M5 C800, P O Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:3457-66. 2008..Our findings suggest that CYP19A1 variation may enhance breast cancer development in some women, but further confirmation is warranted...- Androgen receptor polymorphisms and the incidence of prostate cancerChu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 11:1033-40. 2002..32-0.98), compared with men with > or =22 CAG repeats and >17 GGC repeats. Our results do not support the hypothesis that a small number of CAG or GGC repeats in the androgen receptor gene increases a man's risk of prostate cancer... - N-Acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer riskC Chen
Program in Epidemiology, Division of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, DE 320, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
Carcinogenesis 22:1993-9. 2001..8-4.9) compared with slow acetylators (1.6%, 95% CI 0.6-2.7) (interaction P = 0.055). These data raise the possibility that NAT2 may be involved in the activation of one or more pro-carcinogens associated with alcohol consumption... - Risk of prostate cancer in relation to polymorphisms of metabolic genesC Chen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, DE320, Seattle, WA 98109, USA
Epidemiol Rev 23:30-5. 2001..Since gene-gene and gene-environment interactions may contribute to cancer risk, it would be desirable to conduct studies in which both biomarkers (or other measures) of exposure and polymorphisms of multiple genes are examined... - Gene expression profiling identifies genes predictive of oral squamous cell carcinomaChu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology, 1100 Fairview Avenue North, M5 C800 P O Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:2152-62. 2008..If confirmed in larger studies, the proposed models may hold promise for monitoring local recurrence at surgical margins and the development of second primary oral cancer in patients with OSCC... - Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in cultureC Chen
Program in Cancer Biology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Carcinogenesis 20:699-703. 1999..Our results suggest that viral infections, through the modulation of cellular xenobiotic-metabolizing enzymes, may play a role in the ability of cells to handle environmental carcinogens... - Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer riskKerryn W Reding
University of Washington, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 18:1461-7. 2009.... - Can a metastatic gene expression profile outperform tumor size as a predictor of occult lymph node metastasis in oral cancer patients?Eduardo Mendez
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
Clin Cancer Res 17:2466-73. 2011..To determine the differential gene expression between oral squamous cell carcinoma (OSCC) with and without metastasis to cervical lymph nodes and to assess prediction of nodal metastasis by using molecular features... - Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer riskKerryn W Reding
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98109, USA
Am J Epidemiol 170:1241-9. 2009..1, 2.2) but not in never users (P(heterogeneity) = 0.02). Interpretation of these subgroup associations must await the results of similar studies conducted in other populations... - Selected estrogen receptor 1 and androgen receptor gene polymorphisms in relation to risk of breast cancer and fibrocystic breast conditions among Chinese womenLori C Sakoda
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol 35:48-55. 2011..Polymorphisms in sex hormone receptor-encoding genes may alter the activity of sex hormone receptors and thereby affect susceptibility to breast cancer and related outcomes... - Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese womenLori C Sakoda
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:1066-73. 2008..Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women... - Ovarian cancer risk and polymorphisms involved in estrogen catabolismSarah K Holt
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 16:481-9. 2007..No association of ovarian cancer risk was observed with any of the other polymorphisms examined, either alone or in combination... - Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survivalChang Xu
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
Mol Cancer 9:143. 2010.... - Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choicesPawadee Lohavanichbutr
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Arch Otolaryngol Head Neck Surg 135:180-8. 2009..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)... - Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factorsBabette S Saltzman
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 167:607-14. 2008..These results support the hypothesis that type 2 diabetes is associated with endometrial cancer irrespective of the presence of other risk factors for this disease, except possibly hypertension and extreme obesity... - Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese womenLori C Sakoda
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Mailstop M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
Breast Cancer Res Treat 109:143-55. 2008..The observed increased risk of breast cancer associated with joint carriage of the GSTM1 null genotype and GSTP1 105-Val allele needs confirmation in other studies... - Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokersLori C Sakoda
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, Mailstop M4 C308, Seattle, WA 98109 1024, USA
Cancer Causes Control 22:449-61. 2011..Studying gene-environment interactions may provide insight about mechanisms underpinning the reported association between chromosome 15q24-25.1 variation and lung cancer susceptibility... - A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survivalEduardo Mendez
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98109 1024, USA
Clin Cancer Res 15:1353-61. 2009..To determine if gene expression signature of invasive oral squamous cell carcinoma (OSCC) can subclassify OSCC based on survival... - Polymorphisms in nucleotide excision repair genes and endometrial cancer riskJennifer A Doherty
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 20:1873-82. 2011..Certain estrogen metabolites can form bulky DNA adducts, which are removed via nucleotide excision repair (NER), and the ability to carry out this repair might be related to endometrial cancer risk... - Pregnancy history and risk of endometrial cancerGaia Pocobelli
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
Epidemiology 22:638-45. 2011..Less clear is whether timing of pregnancies during reproductive life influences risk, and the degree to which incomplete pregnancies are associated with a reduced risk... - Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control studyMary L Biggs
Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Box 354922, Seattle, WA 98195 4922, USA
Cancer Epidemiol Biomarkers Prev 17:2012-8. 2008..Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy... - Tumor-specific genetic expression profile of metastatic oral squamous cell carcinomaEduardo Mendez
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
Head Neck 29:803-14. 2007..Metastasis is the most important predictor of survival in patients with oral squamous cell carcinoma (OSCC). We tested the hypothesis that there is a genetic expression profile associated with OSCC metastasis... - Examination of oral cancer biomarkers by tissue microarray analysisPeter Choi
Department of Otolaryngology Head and Neck Surgery, University ofWashington, Seattle, WA, USA
Arch Otolaryngol Head Neck Surg 134:539-46. 2008.... 
Integrative analysis in oral squamous cell carcinoma reveals DNA copy number-associated miRNAs dysregulating target genesNicholas A Serrano
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98115 7744, USA
Otolaryngol Head Neck Surg 147:501-8. 2012....- Human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectoriesArun Sharma
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
Otolaryngol Head Neck Surg 146:739-45. 2012..Since OSCC that are associated with high-risk HPV have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better QOL trajectories... - Long-term use of continuous-combined estrogen-progestin hormone therapy and risk of endometrial cancerAmanda I Phipps
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Cancer Causes Control 22:1639-46. 2011..19, 95% CI: 0.05-0.68). Associations did not differ according to recency of use. These results suggest that long duration of use of continuous-combined estrogen-progestin therapy is associated with a reduced risk of endometrial cancer... - Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-I, insulin-like growth factor binding protein-3, and insulin-like growth factor-I receptorChu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, USA
Cancer Epidemiol Biomarkers Prev 15:2461-6. 2006..Our observation that men who do not carry two copies of the IGF-IR (AGG)7 allele are at increased risk of prostate cancer merits further investigation... - V89L polymorphism of the 5alpha-reductase Type II gene (SRD5A2), endogenous sex hormones, and prostate cancer riskInbal Boger-Megiddo
Program in Epidemiology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:286-91. 2008..However, the absence of an overall association between V89L genotype and aggressive prostate cancer argues for a cautious interpretation of these observations... - Long-term use of postmenopausal estrogen and progestin hormone therapies and the risk of endometrial cancerJennifer A Doherty
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Obstet Gynecol 197:139.e1-7. 2007.... - Lignan and isoflavone excretion in relation to uterine fibroids: a case-control study of young to middle-aged women in the United StatesCharlotte Atkinson
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Clin Nutr 84:587-93. 2006..No association was found between isoflavone excretion and uterine fibroids; however, the intake of soy foods, the primary source of isoflavones, was low in this population... - Risk factors for the incidence of endometrial cancer according to the aggressiveness of diseaseJocelyn M Weiss
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Epidemiol 164:56-62. 2006..In general, a woman's risk of endometrial cancer appears to be influenced by similar risk factors regardless of disease severity... - Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal womenAnne McTiernan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Breast Cancer Res Treat 108:217-31. 2008..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period... - A log likelihood predictor for genomic classification of oral cancer using principle component analysis for feature selectionMark E Whipple
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98105, USA
Stud Health Technol Inform 107:823-6. 2004..The three most highly positively and three most highly negative predictive genes were all keratins that are known markers of squamous cell carcinoma... - ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium studyJennifer A Doherty
Program in Epidemiology M4 C308, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 19:245-50. 2010..These data provide suggestive evidence that the rs2295190 T allele, or another allele in linkage disequilibrium with it, may be associated with increased risk of invasive ovarian cancer... - Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among Black and White womenKerryn W Reding
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop M4 B874, Seattle, WA 98109 1024, USA
Breast Cancer Res Treat 134:801-9. 2012..These study results suggest that subtle differences in percent African ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics... - Night shift work and hormone levels in womenScott Davis
Program in Epidemiology, Division of Public HealthSciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 21:609-18. 2012..We investigated whether night shift work is associated with decreased levels of urinary 6-sulfatoxymelatonin, the primary metabolite of melatonin, and increased urinary reproductive hormone levels... - Association of marijuana use and the incidence of testicular germ cell tumorsJanet R Daling
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer 115:1215-23. 2009..In this study, the authors tested the hypothesis that marijuana use is a risk factor for TGCT... - Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the associationJocelyn M Weiss
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
Gynecol Oncol 103:891-6. 2006..Certain nucleotide excision repair (NER) genotypes appear to be associated with an altered risk of endometrial cancer. These associations could be modified by characteristics and exposures that themselves influence risk of disease... - Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypesSandi L Navarro
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 18:2974-8. 2009..04) and GSTM1+/GSTT1+ men (by 26%; P = 0.01) but not in women. In summary, cruciferous vegetable supplementation increased GSTA1/2, but the effect was most marked in GSTM1-null/GSTT1-null men... - Simultaneous isolation of DNA and RNA from the same cell population obtained by laser capture microdissection for genome and transcriptome profilingChang Xu
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
J Mol Diagn 10:129-34. 2008..Thus, we developed a method to obtain both DNA and RNA material from a single population of LCM-harvested cells and herein discuss the strengths and limitations of this methodology... - Polymorphic markers in the 5alpha-reductase type II gene and the incidence of prostate cancerNajib Lamharzi
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Int J Cancer 105:480-3. 2003.... - Use of nonsteroidal antiinflammatory drugs and risk of endometrial cancerClara Bodelon
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195 7236, USA
Am J Epidemiol 170:1512-7. 2009..73, 1.53). NSAID use was unrelated to risk of endometrial cancer in both obese and nonobese women. Results from this study suggest that the use of aspirin or other NSAIDs has little or no influence on the risk of endometrial cancer... - Relation of BMI and physical activity to sex hormones in postmenopausal womenAnne McTiernan
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
Obesity (Silver Spring) 14:1662-77. 2006..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones... - The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trialGary E Goodman
The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 12:518-26. 2003..There was no statistically significant association between serum carotenoids and prostate cancer. Our findings provide additional support for the association between physiological levels of dietary micronutrients and cancer incidence... - DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: a reviewYu Chen
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Department of Epidemiology and Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
Head Neck 30:1361-83. 2008..It points out the limitations of some methodologies that were used in the past and discusses the advantages and challenges of using genome-wide SNP arrays... - Transcriptional expression profiles of oral squamous cell carcinomasEduardo Mendez
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
Cancer 95:1482-94. 2002..No system to date has incorporated genetic changes as a factor by which to classify OSCC tumors... - Estrogen-related genes and their contribution to racial differences in breast cancer riskKerryn W Reding
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Causes Control 23:671-81. 2012..02) and with CYP17A1 in Black women (p value = 0.04). This analysis suggests that HT use may modify the effect of variation in estrogen-related genes on breast cancer risk, which may affect Black and White women to a different extent... - Gene expression in uninvolved oral mucosa of OSCC patients facilitates identification of markers predictive of OSCC outcomesPawadee Lohavanichbutr
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 7:e46575. 2012..Dysregulation of 20 of the 71 probe sets was associated with progression-free survival and was validated in an independent dataset... - Tumor and salivary matrix metalloproteinase levels are strong diagnostic markers of oral squamous cell carcinomaMarni Stott-Miller
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 20:2628-36. 2011..The matrix metalloproteinases (MMP) cause degradation of the extracellular matrix and basement membranes, and thus may play a key role in cancer development... - Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent mannerHeather Ann Brauer
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
Nutr J 10:11. 2011..The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo... - Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancerJennifer A Doherty
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 14:357-66. 2005.... - A genomic predictor of oral squamous cell carcinomaMark E Whipple
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
Laryngoscope 114:1346-54. 2004..The objective was to identify a genomic profile that predicts the likelihood of oral squamous cell carcinoma compared with normal oral mucosa in unknown tissue samples... - Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolismJacqueline R Starr
Department of Pediatrics, University of Washington, Seattle, 98105 0371, USA
Cancer Epidemiol Biomarkers Prev 14:2183-90. 2005..0; 95% CI, 1.6-31) or CYP3A5 6986G (RR, 2.4; 95% CI, 1.1-5.6) alleles. These results support the hypothesis that maternal and/or offspring catechol estrogen activity may influence sons' risk of TGCC... - Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagusSid H Siahpush
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 16:2387-95. 2007..IGF-I and its main binding protein, IGF binding protein-3 (IGFBP-3), and their polymorphisms have been investigated in relation to risk of many cancers, but not esophageal adenocarcinoma... - Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trialAndrea Z LaCroix
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, PO 19024, Seattle, WA 98109
JAMA 305:1305-14. 2011..1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported... - Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trialKenneth F Adams
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-800, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 13:644-8. 2004..6% versus 12.8%; P = 0.54). We found no evidence that a 12-month 83 mg/day isoflavone treatment alters serum PSA concentration or velocity in seemingly healthy men aged 50-80 years... - Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese womenS Coosje Dijkstra
Public Health Sciences Division, Fred Hutchinson Research Center, Seattle, WA 98109, USA
J Nutr 140:1302-10. 2010..The inverse associations between plasma isoflavone concentrations and RBC EPA and DPA and fibroadenoma risk suggest that higher intakes of soy foods and fatty fish may lower the risk of fibroadenomas... - Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification TrialAnne McTiernan
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
Am J Clin Nutr 89:1864-76. 2009..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished... - Shift work, hCLOCK T3111C polymorphism, and endometriosis riskJennifer L Marino
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
Epidemiology 19:477-84. 2008..One such exposure may be night shift work, which has been associated with menstrual disruption and increased risk of 2 other estrogen-influenced diseases, breast cancer and adverse coronary events... - Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genesBritton Trabert
University of Washington, Seattle, Washington, USA
Fertil Steril 96:1401-1406.e3. 2011..To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk... - DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patientsThomas J Gal
Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA
Laryngoscope 115:2221-31. 2005.... - Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinomaPeter Choi
Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, 98109, USA
Cancer 104:1113-28. 2005..Further investigation into the genomic, proteomic, and functional consequences of these gene expression alterations may provide insight into the pathophysiology of HNSCC... - Screening for deleterious nonsynonymous single-nucleotide polymorphisms in genes involved in steroid hormone metabolism and responseMelissa M Johnson
Program in Epidemiology, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Mailstop M5-C800, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA
Cancer Epidemiol Biomarkers Prev 14:1326-9. 2005..Of these, 28% were predicted by SIFT and PolyPhen as having a potentially damaging effect on protein function. Investigation into the association of these variant alleles with hormone-related cancers may prove to be fruitful... - Effects of 60-Hz magnetic field exposure on nocturnal 6-sulfatoxymelatonin, estrogens, luteinizing hormone, and follicle-stimulating hormone in healthy reproductive-age women: results of a crossover trialScott Davis
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Ann Epidemiol 16:622-31. 2006.... - Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable dietsJ W Lampe
Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Carcinogenesis 21:1157-62. 2000..This points to a complex association between consumption of a typical diet of various vegetables and biotransformation enzyme activities in humans, an association that may be difficult to interpret in observational studies... - Study of diet, biomarkers and cancer risk in the United States, China and Costa RicaJ A Satia
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Int J Cancer 82:28-32. 1999..9 microg/dl in King County, 585.7 +/- 35.9 microg/dl in Shanghai and 461.1 +/- 33.1 microg/dl in Costa Rica. Plasma trans fatty acids (a biomarker of a diet high in hydrogenated fats) were highest in King County and lowest in Shanghai... - Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulfatoxymelatonin concentration in womenS Davis
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 154:591-600. 2001..These results suggest that exposure to nighttime residential 60-Hz magnetic fields can depress the normal nocturnal rise in melatonin... - Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal womenJ W Lampe
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
J Nutr 131:740-4. 2001..These results suggest that a daily 16 g-fiber dose as wheat bran and the addition of soy protein do not alter significantly the capacity of colonic microflora to produce equol... - Modulation of human glutathione S-transferases by botanically defined vegetable dietsJ W Lampe
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 9:787-93. 2000..GST responses were more pronounced in women than men, but it is not clear from this study whether this is a dose-per-body-weight or a sex-specific effect... - Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypesS M Schwartz
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 10:1137-44. 2001..5-2.6%) and 1.2% (0.0-2.4%) among persons carrying the ADH3*1/*2 and ADH3*1/*1 genotypes, respectively. These data suggest that the ADH3*2 allele confers increased susceptibility to the effect of alcohol on OSCC risk in our population... - Soy isoflavones do not modulate circulating insulin-like growth factor concentrations in an older population in an intervention trialKenneth F Adams
Fred Hutchinson Cancer Research Center, University of Washington, Center for Health Studies, Group Health Cooperative, Seattle, WA, USA
J Nutr 133:1316-9. 2003..A 12 mo, 83 mg/d soy isoflavone intervention did not modulate serum IGF in an older, mostly male population... - Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women... - Inflammation and endometrial cancer: a hypothesisFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Cancer Epidemiol Biomarkers Prev 14:2840-7. 2005..A proinflammatory milieu can also directly increase estrogen production. Hence, inflammation may work in conjunction with or in addition to estrogen exposure in the development of endometrial cancer... - Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intakeCharlotte Atkinson
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 11:253-60. 2002..Measuring isoflavone excretion in one overnight urine collection serves as a biomarker of recent or past isoflavone intake, even in populations whose intake of soy foods is relatively low... - Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemiaC Crump
Department of Epidemiology, University of Washington, Seattle 98195, USA
Cancer Epidemiol Biomarkers Prev 9:457-60. 2000..e., between the GSTT1 gene deletion and trisomy 8, and between the GSTM1 gene deletion and non-8 trisomies or inv(16). These results do not support the hypothesis that the GSTT1 gene deletion is related to the incidence of AML... - Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE reviewPaul Brennan
International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 159:1-16. 2004..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field... - Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsyRowan T Chlebowski
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Arch Intern Med 168:370-7; quiz 345. 2008..The effect of combined hormone therapy on breast cancer detection is not established... - Estrogen plus progestin and colorectal cancer in postmenopausal womenRowan T Chlebowski
Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, Calif 90502, USA
N Engl J Med 350:991-1004. 2004..We analyzed features of the colorectal cancers that developed and their relation to the characteristics of the participants... - Marijuana use and risk of oral squamous cell carcinomaKarin A Rosenblatt
Department of Community Health, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA
Cancer Res 64:4049-54. 2004..Marijuana use was not associated with OSCC risk in this large, population-based study... - Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studiesAndrew W Roddam
Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
Ann Intern Med 149:461-71, W83-8. 2008..Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer... - Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risksYun Ju Chen
Graduate Institute of Occupational Safety and Health, Kaohsiung Medical University, Kaohsiung, Taiwan
Int J Cancer 119:2827-31. 2006..These results suggest that ADH1B and ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed... - The Y deletion gr/gr and susceptibility to testicular germ cell tumorKatherine L Nathanson
Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Hum Genet 77:1034-43. 2005..0; 95% CI 1.6-5.4; P = .0004) than with nonseminoma TGCT (aOR 1.5; 95% CI 0.72-3.0; P = .29). These data indicate that the Y microdeletion gr/gr is a rare, low-penetrance allele that confers susceptibility to TGCT... - Interindividual variation in nucleotide excision repair genes and risk of endometrial cancerJocelyn M Weiss
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8123, MSC 7240, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 14:2524-30. 2005..58; 95% CI, 0.35-0.96). Our data suggest that interindividual variation in XPA and XPC influences a woman's risk of endometrial cancer... - A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Rayjean J Hung
International Agency for Research on Cancer IARC, Lyon 69008, France
Nature 452:633-7. 2008..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets... - Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
J Natl Cancer Inst 99:777-89. 2007.... - Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysisWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005..Consistent findings from three case-control studies suggest that selected DNA repair enzymes may play a role in head and neck carcinogenesis... - Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuitsStephanie De Gois
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurosci 25:7121-33. 2005.... - [Quality estimation on material medica of Rhizoma Paridis from Sichuan & Yunnan province]Hong Xiang Yin
West China College of Pharmacy, Sichuan University, Chengdu 610041, China
Zhong Yao Cai 30:771-4. 2007..To provide valuable reference for comprehensive qualitative estimation and reasonable utilization of material medica Rhizoma Paridis... - Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning... - High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berriesChu Chen
West China School of Pharmacy, Sichuan University, Chengdu 610041, China
J Chromatogr A 1154:250-9. 2007..The established method was considered to be suitable for fingerprint analysis to check the genuine origin and control the quality of sea buckthorn berries and extracts...
Research Grants
- ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMESChu Chen; Fiscal Year: 2010..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
- ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMESChu Chen; Fiscal Year: 2009..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
- Molecular Epidemiology of Endometrial CancerChu Chen; Fiscal Year: 2007..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
- MOLECULAR EPIDEMIOLOGY OF LUNG CANCERChu Chen; Fiscal Year: 2007..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
- ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMESChu Chen; Fiscal Year: 2007..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
- BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMENChu Chen; Fiscal Year: 2003..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
- MOLECULAR EPIDEMIOLOGY OF LUNG CANCERChu Chen; Fiscal Year: 2010..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..