Genomes and Genes
Cara L Carty
Affiliation: Fred Hutchinson Cancer Research Center
- Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology studyKira C Taylor
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Genet 14:33. 2013..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
- Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification TrialCara L Carty
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Clin Nutr 93:516-24. 2011..The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (≤20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women...
- A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averagingBenjamin A Logsdon
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109, Seattle, WA 98195, USA
Bioinformatics 28:1738-44. 2012....
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)Cara L Carty
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Hum Mol Genet 21:711-20. 2012..Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations...
- Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African AmericansCara L Carty
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA C L C, C K, A R Center for Health Disparities, East Carolina University, Greenville, NC K L K Baltimore Veterans Administration Medical Center, MD Y C C, S J K University of Maryland School of Medicine, Baltimore Y C C, S J K, B D M Mayo Clinic Florida, Jacksonville, FL J F M Public Health Sciences, University of Virginia, Charlottesville W M C, S S R, M M S, B B W National Institute of Aging, NIH, Bethesda, MD M N, S T, A B Z, M K E University of Washington, Seattle J C B, W T L, B M P, A R Wake Forest University, Winston Salem, NC C D L, Y L Division of Cerebrovascular Neurology, Johns Hopkins University School of Medicine, Baltimore, MD R G Department of Neurology, Department of Medicine
Stroke 46:2063-8. 2015..The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations...
- Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence ProjectPaul L Auer
Joseph J Zilber School of Public Health, University of Wisconsin, Milwaukee2Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
JAMA Neurol 72:781-8. 2015..These variants often have small effects without obvious biological significance. Exome sequencing may discover predicted protein-altering variants with a potentially large effect on ischemic stroke risk...
- Evidence of heterogeneity by race/ethnicity in genetic determinants of QT intervalAmanda A Seyerle
From the aDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC bDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA cCharles Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY dCentre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Australia eDepartment of Biostatistics, University of Washington, Seattle, WA fInformation Sciences Institute and Computer Science Department, University of Southern California, Marina del Rey, CA gDepartment of Epidemiology, University of Washington, Seattle, WA hCardiovascular Health Research Unit, University of Washington, Seattle, WA iGroup Health Research Institute, Group Health Cooperative, Seattle, WA jOffice of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD kDepartment of Internal Medicine, Ohio State Medical Center, Columbus, OH lDivision of Cardiology, George Washington University, Washington, DC mDepartment of Medicine, Weill Cornell Medical College, New York, NY nDivision of Cardiovascular Medicine, Stanford University, Stanford, CA oDivision of Medicine, University of Washington, Seattle, WA pDivision of Health Services, University of Washington
Epidemiology 25:790-8. 2014..Previous genome-wide association studies in populations of the European descent have identified multiple genetic loci that influence QT, but few have examined these loci in ethnically diverse populations...
- Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe StudyCarolyn M Hutter
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 20:1950-9. 2011..These studies have primarily been conducted in populations of European descent. To fully understand the impact of these loci, it is important to study groups with other genetic ancestries, including African American women...