William G Carter

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Breast Cancer Res 7:R411-21. 2005
  2. ncbi Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia
    Tod A Brown
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 279:14772-83. 2004
  3. ncbi The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1
    Stacy M Alvares
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochim Biophys Acta 1780:486-96. 2008
  4. ncbi Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5
    Randy O Sigle
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
    J Cell Sci 117:4481-94. 2004
  5. ncbi Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, 1959 NE Pacific Street, Box 356524, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 56:687-96. 2008
  6. ncbi Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes
    Erin G Harper
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
    J Cell Sci 118:3471-85. 2005
  7. ncbi Ultrastructural localization of integrin subunits beta4 and alpha3 within the migrating epithelial tongue of in vivo human wounds
    Robert A Underwood
    University of Washington, Department of Medicine Dermatology, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 57:123-42. 2009
  8. ncbi Morphological evidence for the role of suprabasal keratinocytes in wound reepithelialization
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195 6524, USA
    Wound Repair Regen 13:468-79. 2005
  9. ncbi Characterization of an in vitro model for evaluating the interface between skin and percutaneous biomaterials
    Yuko Fukano
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195 6524, USA
    Wound Repair Regen 14:484-91. 2006
  10. ncbi Senescence-induced alterations of laminin chain expression modulate tumorigenicity of prostate cancer cells
    Cynthia C T Sprenger
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Neoplasia 10:1350-61. 2008

Research Grants

  1. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
  2. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 1993
  3. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005

Collaborators

Detail Information

Publications16

  1. ncbi Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Breast Cancer Res 7:R411-21. 2005
    ..Here, differential expression of laminins was studied in blood vessels and ductal epithelium of the breast...
  2. ncbi Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia
    Tod A Brown
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 279:14772-83. 2004
    ..We suggest that the balance is altered by conversion of gp140 to p80 and by adhesion, providing a novel transmembrane phosphorylation signal in epithelial wounds...
  3. ncbi The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1
    Stacy M Alvares
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biochim Biophys Acta 1780:486-96. 2008
    ..We propose that the clustering of Gp140 and signaling components in membrane microdomains in cell-cell contacts contributes to changes in cell behavior...
  4. ncbi Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5
    Randy O Sigle
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
    J Cell Sci 117:4481-94. 2004
    ..We conclude that the G4/5 domain in the alpha3 chain facilitates deposition of precursor laminin 5 into the PBM in epidermal wounds...
  5. ncbi Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, 1959 NE Pacific Street, Box 356524, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 56:687-96. 2008
    ..A better understanding of molecular mechanisms involved in keratinocyte migration may lead to molecular targets for therapies for impaired wound healing...
  6. ncbi Wounding activates p38 map kinase and activation transcription factor 3 in leading keratinocytes
    Erin G Harper
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109, USA
    J Cell Sci 118:3471-85. 2005
    ..Adhesion to deposits of laminin 5 via alpha6beta4 suppresses P-p38 and activation mRNAs including ATF3. Defects in laminin 5 and alpha6beta4 sustain P-p38 with probable pathological effects on transcription and migration...
  7. ncbi Ultrastructural localization of integrin subunits beta4 and alpha3 within the migrating epithelial tongue of in vivo human wounds
    Robert A Underwood
    University of Washington, Department of Medicine Dermatology, Seattle, WA 98195 6524, USA
    J Histochem Cytochem 57:123-42. 2009
    ..alpha3 integrin, despite its ability to respond to alternate ligands after wounding, does so through a single structure, the filopodia...
  8. ncbi Morphological evidence for the role of suprabasal keratinocytes in wound reepithelialization
    Marcia L Usui
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195 6524, USA
    Wound Repair Regen 13:468-79. 2005
    ..We conclude that this large population of suprabasal keratinocytes actively participates in wound closure...
  9. ncbi Characterization of an in vitro model for evaluating the interface between skin and percutaneous biomaterials
    Yuko Fukano
    Department of Medicine Dermatology, University of Washington, Seattle, Washington 98195 6524, USA
    Wound Repair Regen 14:484-91. 2006
    ..In vitro systematic evaluation of biomaterials for use in animal implant studies is both cost effective and time efficient...
  10. ncbi Senescence-induced alterations of laminin chain expression modulate tumorigenicity of prostate cancer cells
    Cynthia C T Sprenger
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Neoplasia 10:1350-61. 2008
    ..This study demonstrates that senescent prostate epithelial cells can alter the microenvironment and that these changes modulate progression of prostate cancer...
  11. ncbi Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368
    Theresa S Richards
    Division of Basic and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 167:555-62. 2004
    ..Our evidence indicates that PKC-dependent phosphorylation of Cx43 at S368 creates dynamic communication compartments that can temporally and spatially regulate wound healing...
  12. ncbi Laminin 5 deposition regulates keratinocyte polarization and persistent migration
    Diane E Frank
    Fred Hutchinson Cancer Research Center, and the Department of Pathobiology, University of Washington, Seattle, Washington, USA
    J Cell Sci 117:1351-63. 2004
    ..However, at the rear of the cell, stable cell polarization and linear migration was promoted by laminin 5 deposits and integrin alpha 3 beta 1...
  13. ncbi Detection and purification of instructive extracellular matrix components with monoclonal antibody technologies
    Susana G Gil
    Fred Hutchinson Cancer Research Institute, Seattle, Washington 98109, USA
    Methods Cell Biol 69:27-52. 2002
    ..Delineation of cell responses to the instructive ECM will require additional high-resolution technologies including DNA microarrays and targeted disruption of ECM components...
  14. ncbi Topical application of laminin-332 to diabetic mouse wounds
    Stephen R Sullivan
    Department of Surgery Plastic and Reconstructive Surgery, University of Washington, Seattle, WA 98195 6524, United States
    J Dermatol Sci 48:177-88. 2007
    ..Keratinocyte migration and anchorage appears to be mediated by laminin-332 (LM-332). Impaired diabetic wound healing may be due to defective LM-332 mediated keratinocyte migration...
  15. ncbi Basal prostate epithelial cells stimulate the migration of prostate cancer cells
    Hsiao-Man Yu
    Department of Pathology, Weill Medical College of Cornell University, New York, NY, USA
    Mol Carcinog 41:85-97. 2004
    ..Altogether, the possibility that basal epithelial cells assist in the invasion of in situ carcinoma cells is supported by the results from our in vitro system...
  16. ncbi A simplified laminin nomenclature
    Monique Aumailley
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Matrix Biol 24:326-32. 2005
    ..The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered...

Research Grants18

  1. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
    ..these results will define the molecular mechanism through which cell adhesion regulates gene expression and wound repair in epithelium. ..
  2. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 1993
    ..B) Development of assays to evaluate the role of ECM-ECMB interactions in epithelium. (C) The role of ECM-ECMR interactions in expression of epithelial cell characteristics (polarity, migration, differentiation)...
  3. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005
    ..These studies will provide an understanding of components and mechanisms critical for regulating epithelial morphogenesis in development, wound repair and tumor invasion. ..