Linda Buck

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Unraveling the sense of smell (Nobel lecture)
    Linda B Buck
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Angew Chem Int Ed Engl 44:6128-40. 2005
  2. ncbi request reprint The search for odorant receptors
    Linda B Buck
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Cell 116:S117-9, 1 p following S119. 2004
  3. ncbi request reprint Olfactory receptors and odor coding in mammals
    Linda B Buck
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nutr Rev 62:S184-8; discussion S224-41. 2004
  4. ncbi request reprint Combinatorial effects of odorant mixes in olfactory cortex
    Zhihua Zou
    Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 311:1477-81. 2006
  5. ncbi request reprint Olfactory axon pathfinding: who is the pied piper?
    Rajesh Ranganathan
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Neuron 35:599-600. 2002
  6. ncbi request reprint Unraveling smell
    Linda B Buck
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Harvey Lect 101:117-34. 2005
  7. pmc Odor maps in the olfactory cortex
    Zhihua Zou
    Howard Hughes Medical Institute and Divisions of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:7724-9. 2005
  8. pmc The human olfactory receptor gene family
    Bettina Malnic
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:2584-9. 2004
  9. ncbi request reprint Feedback loops link odor and pheromone signaling with reproduction
    Ulrich Boehm
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 123:683-95. 2005
  10. pmc The mouse olfactory receptor gene family
    Paul A Godfrey
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:2156-61. 2004

Research Grants

  1. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2011
  2. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2005
  3. Molecular Analysis of Olfactory Sensory Imputs
    Linda Buck; Fiscal Year: 2005
  4. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
  5. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2010
  6. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
  7. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 1993
  8. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2000

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Unraveling the sense of smell (Nobel lecture)
    Linda B Buck
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Angew Chem Int Ed Engl 44:6128-40. 2005
  2. ncbi request reprint The search for odorant receptors
    Linda B Buck
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Cell 116:S117-9, 1 p following S119. 2004
  3. ncbi request reprint Olfactory receptors and odor coding in mammals
    Linda B Buck
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nutr Rev 62:S184-8; discussion S224-41. 2004
    ..Another olfactory structure in the nasal septum of animals, the vomeronasal organ, has two additional receptor families that detect pheromones and induce hormonal and behavioral responses through a different projection to the brain...
  4. ncbi request reprint Combinatorial effects of odorant mixes in olfactory cortex
    Zhihua Zou
    Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 311:1477-81. 2006
    ..These findings may explain why odorant mixtures can elicit novel odor percepts in humans...
  5. ncbi request reprint Olfactory axon pathfinding: who is the pied piper?
    Rajesh Ranganathan
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Neuron 35:599-600. 2002
    ..use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate the stereotyped olfactory bulb map are the same as those needed for appropriate expression of the OR...
  6. ncbi request reprint Unraveling smell
    Linda B Buck
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Harvey Lect 101:117-34. 2005
  7. pmc Odor maps in the olfactory cortex
    Zhihua Zou
    Howard Hughes Medical Institute and Divisions of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:7724-9. 2005
    ..Structurally related odorants have highly related representations, suggesting an underlying logic to the mapping of odor identities in the cortex...
  8. pmc The human olfactory receptor gene family
    Bettina Malnic
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:2584-9. 2004
    ..Moreover, many loci encode only one or a few subfamilies, suggesting that different parts of the genome may, to some extent, be involved in the detection of different types of odorant structural motifs...
  9. ncbi request reprint Feedback loops link odor and pheromone signaling with reproduction
    Ulrich Boehm
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 123:683-95. 2005
    ..These studies reveal a complex interplay between reproduction and other functions in which GnRH neurons appear to integrate information from multiple sources and modulate a variety of brain functions...
  10. pmc The mouse olfactory receptor gene family
    Paul A Godfrey
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:2156-61. 2004
    ..This finding suggests that humans and mice recognize many of the same odorant structural motifs, but mice may be superior in odor sensitivity and discrimination...
  11. ncbi request reprint A second class of chemosensory receptors in the olfactory epithelium
    Stephen D Liberles
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nature 442:645-50. 2006
    ..The evolutionary conservation of the TAAR family suggests a chemosensory function distinct from odorant receptors. Ligands identified for TAARs thus far suggest a function associated with the detection of social cues...
  12. ncbi request reprint [The 2004 Nobel Prize for Physiology or Medicine for research into smell receptors and the organization of the olfactory system]
    J P H Burbach
    Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd Farmacologie en Anatomie, Universiteitsweg 110, 3584 CG Utrecht
    Ned Tijdschr Geneeskd 148:2576-9. 2004
    ....

Research Grants24

  1. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2011
    ..Project Narrative The mechanisms that the brain uses to perceive the world around us and to learn and remember are unknown. We will investigate the mechanisms that underlie the sense of smell to gain insight into these questions. ..
  2. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2005
    ....
  3. Molecular Analysis of Olfactory Sensory Imputs
    Linda Buck; Fiscal Year: 2005
    ....
  4. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
    ..Project Narrative The mechanisms that the brain uses to perceive the world around us and to learn and remember are unknown. We will investigate the mechanisms that underlie the sense of smell to gain insight into these questions. ..
  5. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2010
    ..Project Narrative The mechanisms that the brain uses to perceive the world around us and to learn and remember are unknown. We will investigate the mechanisms that underlie the sense of smell to gain insight into these questions. ..
  6. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
    ..Project Narrative The mechanisms that the brain uses to perceive the world around us and to learn and remember are unknown. We will investigate the mechanisms that underlie the sense of smell to gain insight into these questions. ..
  7. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 1993
    ..3) Investigate the developmental acquisition of these organizational features in order to determine the mechanisms by which they are established...
  8. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2000
    ..Finally, we will use the isolated OR genes we have isolated and the information we have accumulated on human OR genes to analyze the extent of variation in OR repertoire in the human population. ..