Rachel B Brem

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi The landscape of genetic complexity across 5,700 gene expression traits in yeast
    Rachel B Brem
    Division of Human Biology and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:1572-7. 2005
  2. ncbi Genetic interactions between polymorphisms that affect gene expression in yeast
    Rachel B Brem
    Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B876, Seattle, Washington 98109, USA
    Nature 436:701-3. 2005
  3. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center (FHCRC, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
  4. ncbi Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    Gael Yvert
    Howard Hughes Medical Institute and Division of Human Biology, Fred Hutchinson Cancer Research Center, Mailstop D4 100, 1100 Fairview Avenue North, Seattle, Washington 98103 USA
    Nat Genet 35:57-64. 2003
  5. ncbi Local regulatory variation in Saccharomyces cerevisiae
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Genet 1:e25. 2005
  6. ncbi Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
    Jun Zhu
    Rosetta Inpharmatics, LLC, Seattle, Washington 98109, USA
    Nat Genet 40:854-61. 2008
  7. ncbi Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains
    Lazar N Dimitrov
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 183:365-83. 2009
  8. ncbi Genomewide evolutionary rates in laboratory and wild yeast
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 174:541-4. 2006

Collaborators

Detail Information

Publications8

  1. ncbi The landscape of genetic complexity across 5,700 gene expression traits in yeast
    Rachel B Brem
    Division of Human Biology and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:1572-7. 2005
    ..Sixteen percent of highly heritable transcripts exhibit evidence of interacting loci. Our results will aid design of future QTL mapping studies and may shed light on the evolution of quantitative traits...
  2. ncbi Genetic interactions between polymorphisms that affect gene expression in yeast
    Rachel B Brem
    Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B876, Seattle, Washington 98109, USA
    Nature 436:701-3. 2005
    ..Our results indicate that genetic interactions are widespread in the genetics of transcript levels, and that many QTLs will be missed by single-locus tests but can be detected by two-stage tests that allow for interactions...
  3. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center (FHCRC, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  4. ncbi Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    Gael Yvert
    Howard Hughes Medical Institute and Division of Human Biology, Fred Hutchinson Cancer Research Center, Mailstop D4 100, 1100 Fairview Avenue North, Seattle, Washington 98103 USA
    Nat Genet 35:57-64. 2003
    ..Notably, transcription factors showed no enrichment, and trans-regulatory variation seems to be broadly dispersed across classes of genes with different molecular functions...
  5. ncbi Local regulatory variation in Saccharomyces cerevisiae
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Genet 1:e25. 2005
    ..These findings point to the importance of cis-acting variation, but also suggest that there is a diverse set of mechanisms through which local variation can affect gene expression levels...
  6. ncbi Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
    Jun Zhu
    Rosetta Inpharmatics, LLC, Seattle, Washington 98109, USA
    Nat Genet 40:854-61. 2008
    ..We then prospectively validate predictions, providing direct experimental evidence that predictive networks can be constructed by integrating multiple, appropriate data types...
  7. ncbi Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains
    Lazar N Dimitrov
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 183:365-83. 2009
    ..Moreover, the polymorphisms identified in this study open new lines of investigation into mtDNA maintenance...
  8. ncbi Genomewide evolutionary rates in laboratory and wild yeast
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 174:541-4. 2006
    ..It has been suggested that a commonly used S. cerevisiae strain has rapidly accumulated mutations in the lab. We report a low-to-intermediate rate of protein evolution in this strain relative to wild isolates...