LINDA BREEDEN

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state
    Shawna Miles
    Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003854. 2013
  2. pmc Combined analysis reveals a core set of cycling genes
    Yong Lu
    Department of Computer Science, Carnegie Mellon University, Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Genome Biol 8:R146. 2007
  3. ncbi request reprint Cyclin transcription: Timing is everything
    L L Breeden
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Curr Biol 10:R586-8. 2000
  4. ncbi request reprint Periodic transcription: a cycle within a cycle
    Linda L Breeden
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, 98109 1024, Seattle, WA, USA
    Curr Biol 13:R31-8. 2003
  5. pmc Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
    J M Sidorova
    Fred Hutchinson Cancer Research Center FHCRC, Basic Sciences Division, Seattle, Washington 98109 1024, USA
    Genes Dev 11:3032-45. 1997
  6. pmc Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization
    J M Sidorova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Biol Cell 6:1641-58. 1995
  7. ncbi request reprint Cell cycle-dependent transcription of CLN1 involves swi4 binding to MCB-like elements
    J F Partridge
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington 98104, USA
    J Biol Chem 272:9071-7. 1997
  8. pmc Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast
    V L MacKay
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 21:4140-8. 2001
  9. ncbi request reprint Mutation and modeling analysis of the Saccharomyces cerevisiae Swi6 ankyrin repeats
    S P Ewaskow
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, and Department of Biology, Lewis and Clark College, Portland, Oregon 97219, USA
    Biochemistry 37:4437-50. 1998
  10. pmc Characterization of the ECB binding complex responsible for the M/G(1)-specific transcription of CLN3 and SWI4
    Bernard Mai
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 22:430-41. 2002

Research Grants

  1. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2003
  2. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2002
  3. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 1999
  4. Developmental control of cell cycle exit
    LINDA BREEDEN; Fiscal Year: 2009
  5. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2009
  6. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2007
  7. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2005
  8. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2004
  9. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2001
  10. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2000

Collaborators

  • D E Lycan
  • Julia M Sidorova
  • Ziv Bar-Joseph
  • Shaun Mahony
  • William Noble Stafford
  • Shawna Miles
  • Yingying Guo
  • Bernard Mai
  • Tata Pramila
  • Lihong Li
  • Katherine A Braun
  • Yong Lu
  • David L Eaton
  • Helmut Zarbl
  • Jonathan B Schaefer
  • Jerry Davison
  • V L MacKay
  • Roni Rosenfeld
  • Itamar Simon
  • Panayiotis V Benos
  • William Stafford Noble
  • Wenhong Fan
  • Wei Wu
  • S P Ewaskow
  • Lue Ping Zhao
  • Bradley D Preston
  • Tina Quinton
  • J F Partridge
  • Dave Jemiolo
  • Debraj GuhaThakurta
  • L Waters
  • B Mai
  • J Hendle
  • K Y Zhang
  • J C Emery
  • G E Mikesell

Detail Information

Publications21

  1. pmc Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state
    Shawna Miles
    Basic Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003854. 2013
    ..Failure to repress some or all of these targets leads xbp1 cells to enter a permanent arrest or senescence with a shortened lifespan. ..
  2. pmc Combined analysis reveals a core set of cycling genes
    Yong Lu
    Department of Computer Science, Carnegie Mellon University, Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Genome Biol 8:R146. 2007
    ..Combining and comparing data from multiple species is challenging because of noise in expression data, the different synchronization and scoring methods used, and the need to determine an accurate set of homologs...
  3. ncbi request reprint Cyclin transcription: Timing is everything
    L L Breeden
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Curr Biol 10:R586-8. 2000
    ..Recent studies offer insight into the mechanism of cell-cycle-regulated transcription of the mitotic cyclins of budding yeast...
  4. ncbi request reprint Periodic transcription: a cycle within a cycle
    Linda L Breeden
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, 98109 1024, Seattle, WA, USA
    Curr Biol 13:R31-8. 2003
    ..As such, it is worth considering why these regulatory circuits persist in such great number, how they are achieved and what role they may play in the cell cycle...
  5. pmc Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
    J M Sidorova
    Fred Hutchinson Cancer Research Center FHCRC, Basic Sciences Division, Seattle, Washington 98109 1024, USA
    Genes Dev 11:3032-45. 1997
    ..On the basis of these observations, we suggest that the Rad53-dependent phosphorylation of Swi6 may delay the transition to S phase by inhibiting CLN transcription...
  6. pmc Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization
    J M Sidorova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Biol Cell 6:1641-58. 1995
    ..Alanine substitution at position 160 allows nuclear entry of Swi6 throughout the cell cycle. GFP fusions with the N-terminal one-third of Swi6 display the same cell cycle-regulated localization as Swi6...
  7. ncbi request reprint Cell cycle-dependent transcription of CLN1 involves swi4 binding to MCB-like elements
    J F Partridge
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington 98104, USA
    J Biol Chem 272:9071-7. 1997
    ....
  8. pmc Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast
    V L MacKay
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 21:4140-8. 2001
    ..These observations support the view that the coordinated rise of Cln3 and Swi4 levels mediated by ECB-dependent transcription controls the timing of the G(1)-to-S phase transition...
  9. ncbi request reprint Mutation and modeling analysis of the Saccharomyces cerevisiae Swi6 ankyrin repeats
    S P Ewaskow
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, and Department of Biology, Lewis and Clark College, Portland, Oregon 97219, USA
    Biochemistry 37:4437-50. 1998
    ..Ankyrin repeats are unlikely to have inherent protein or DNA binding properties. However, they form a characteristic and stable structure with surfaces that may be tailored for many different macromolecular interactions...
  10. pmc Characterization of the ECB binding complex responsible for the M/G(1)-specific transcription of CLN3 and SWI4
    Bernard Mai
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 22:430-41. 2002
    ..Chromatin immunoprecipitations show that Mcm1 binds in vivo to ECB elements throughout the cell cycle and that binding is sensitive to carbon source changes...
  11. pmc Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1
    Katherine A Braun
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, WA 98109, USA
    Mol Biol Cell 18:1447-56. 2007
    ..Therefore, the nuclear localization of Mcm2-7 is dependent on nascent transcription and translation of Mcm2-7 and the elimination of CDK activity which occurs simultaneously as cells enter G1...
  12. pmc The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle
    Tata Pramila
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 20:2266-78. 2006
    ..As such, Hcm1 fills a significant gap in our understanding of the transcriptional circuitry that underlies the cell cycle...
  13. ncbi request reprint Identification of target genes of a yeast transcriptional repressor
    Bernard Mai
    Genomic Sciences, Sanofi Aventis Group, Frankfurt, Germany
    Methods Mol Biol 317:267-77. 2006
    ..The binding site for Xbp1, previously identified by site selection, was present in these target genes and is conserved phylogenetically...
  14. ncbi request reprint Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Mutat Res 593:121-42. 2006
    ....
  15. pmc Genetic interactions between mediator and the late G1-specific transcription factor Swi6 in Saccharomyces cerevisiae
    Lihong Li
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Genetics 171:477-88. 2005
    ..A truncated form of the essential Srb7 mediator subunit also suppresses swi6 mutations and shows a defect in recruitment of the tail module components Sin4, Pgd1, and Gal11 to the mediator complex...
  16. pmc Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105 6099, USA
    Mol Cell Biol 25:5823-33. 2005
    ..Rev3 appears to mediate AFB1-induced mutagenesis when error-free pathways are compromised. The results further suggest unique roles for Rad5 and abasic endonuclease-dependent DNA intermediates in regulating AFB1-induced mutagenicity...
  17. ncbi request reprint RB from a bud's eye view
    Jonathan B Schaefer
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Cell 117:849-50. 2004
    ..In this issue of Cell, two studies reveal that Whi5 appears to play the role of RB in preventing precocious cell cycle entry in budding yeast...
  18. ncbi request reprint Precocious G1/S transitions and genomic instability: the origin connection
    Julia M Sidorova
    Department of Pathology, University of Washington, K 065, Box 357705, Seattle, WA 98195, USA
    Mutat Res 532:5-19. 2003
    ..Premature exit from G1 can cut short the licensing of origins and the accumulation of resources for the upcoming replication, while giving a cell a false indication that it is metabolically ready to conduct S phase...
  19. pmc Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle
    Tata Pramila
    Fred Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, Washington 98109 1024, USA
    Genes Dev 16:3034-45. 2002
    ..Twenty-eight genes, including MCM2-7, CDC6, SWI4, CLN3, and a number of genes required during late M phase have been identified that are coordinately regulated by this pathway...
  20. pmc Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability
    Julia M Sidorova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genetics 160:123-36. 2002
    ..This regulation becomes essential when S phase is influenced by Swi4-t...
  21. pmc Rad53 checkpoint kinase phosphorylation site preference identified in the Swi6 protein of Saccharomyces cerevisiae
    Julia M Sidorova
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Mol Cell Biol 23:3405-16. 2003
    ..Finally, we present evidence that one of these candidates, the cohesin complex subunit Scc1 undergoes DNA damage-dependent phosphorylation, which is in part dependent on Rad53...

Research Grants17

  1. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2003
    ..We will also determine whether the consensus site for Rad53 phosphorylation that we draw from our studies enables us to predict the sites at which Rad53 modifies other known targets. ..
  2. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2002
    ..We will also determine whether the consensus site for Rad53 phosphorylation that we draw from our studies enables us to predict the sites at which Rad53 modifies other known targets. ..
  3. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 1999
    ..Finally, she will examine what cellular proteins are required to degrade Cln2p during the response to DNA damage. Cln2p degradation will be monitored in strains with mutations in various elements of the proteolytic machinery. ..
  4. Developmental control of cell cycle exit
    LINDA BREEDEN; Fiscal Year: 2009
    ....
  5. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2009
    ..We will use this method to test a series of mutants that deregulate the mitotic start program to see how GO to S and G1 to S differ. ..
  6. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2007
    ..We will use this method to test a series of mutants that deregulate the mitotic start program to see how GO to S and G1 to S differ. ..
  7. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2005
    ..We will also determine whether the consensus site for Rad53 phosphorylation that we draw from our studies enables us to predict the sites at which Rad53 modifies other known targets. ..
  8. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2004
    ..We will also determine whether the consensus site for Rad53 phosphorylation that we draw from our studies enables us to predict the sites at which Rad53 modifies other known targets. ..
  9. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2001
    ..Finally, she will examine what cellular proteins are required to degrade Cln2p during the response to DNA damage. Cln2p degradation will be monitored in strains with mutations in various elements of the proteolytic machinery. ..
  10. CELL CYCLE REGULATION OF THE YEAST HO GENE
    LINDA BREEDEN; Fiscal Year: 2000
    ..Finally, she will examine what cellular proteins are required to degrade Cln2p during the response to DNA damage. Cln2p degradation will be monitored in strains with mutations in various elements of the proteolytic machinery. ..
  11. CELL CYCLE REGULATION OF THE YEAST HO GENE
    Linda L Breeden; Fiscal Year: 2010
    ..We will use this method to test a series of mutants that deregulate the mitotic start program to see how GO to S and G1 to S differ. ..