Carolina Berger

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques
    Carolina Berger
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e56268. 2013
  2. pmc New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
    J Transl Med 10:48. 2012
  3. pmc Safety and immunologic effects of IL-15 administration in nonhuman primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 114:2417-26. 2009
  4. pmc Adoptive transfer of virus-specific and tumor-specific T cell immunity
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Curr Opin Immunol 21:224-32. 2009
  5. pmc Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Invest 118:294-305. 2008
  6. ncbi request reprint Genetic modification of T cells for immunotherapy
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA 98109 1024, USA
    Expert Opin Biol Ther 7:1167-82. 2007
  7. pmc Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA
    Blood 107:2294-302. 2006
  8. pmc A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells
    C Berger
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Med Primatol 40:88-103. 2011
  9. ncbi request reprint Adoptive transfer of allogeneic antigen-specific T cells
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 12:9-12. 2006
  10. ncbi request reprint The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation
    Stanley R Riddell
    D3 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood Rev 17:153-62. 2003

Collaborators

Detail Information

Publications16

  1. pmc Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques
    Carolina Berger
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e56268. 2013
    ..These results suggest that homeostatic mechanisms that regulate T cell numbers may interfere with strategies to augment a high-level T cell response by adoptive transfer of CD8(+) T(CM/E) cells in lymphoreplete hosts...
  2. pmc New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
    J Transl Med 10:48. 2012
    ..In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies...
  3. pmc Safety and immunologic effects of IL-15 administration in nonhuman primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 114:2417-26. 2009
    ..These findings demonstrate that IL-15 has profound immunomodulatory properties distinct from those described for IL-2, and suggest that intermittent administration of IL-15 should be considered in clinical studies...
  4. pmc Adoptive transfer of virus-specific and tumor-specific T cell immunity
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Curr Opin Immunol 21:224-32. 2009
    ....
  5. pmc Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Invest 118:294-305. 2008
    ..These results could have significant implications for the selection of T cells to expand or to engineer for adoptive immunotherapy of human infections or malignancy...
  6. ncbi request reprint Genetic modification of T cells for immunotherapy
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA 98109 1024, USA
    Expert Opin Biol Ther 7:1167-82. 2007
    ....
  7. pmc Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA
    Blood 107:2294-302. 2006
    ..The potency of gene-modified T cells to elicit robust and durable immune responses imply this approach might be used for vaccination to elicit T-cell responses to viral or tumor antigens...
  8. pmc A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells
    C Berger
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Med Primatol 40:88-103. 2011
    ..Adoptive immunotherapy with antigen-specific effector T-cell (T(E) ) clones is often limited by poor survival of the transferred cells. We describe here a Macaca nemestrina model for studying transfer of T-cell immunity...
  9. ncbi request reprint Adoptive transfer of allogeneic antigen-specific T cells
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 12:9-12. 2006
    ..Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect...
  10. ncbi request reprint The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation
    Stanley R Riddell
    D3 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood Rev 17:153-62. 2003
    ..The challenge for the future is to continue to build on our understanding of the allogeneic graft versus tumor effect and develop strategies that can be incorporated into clinical practice to augment this effect without GVHD...
  11. ncbi request reprint CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 101:476-84. 2003
    ..Thus, these studies identified a strategy that requires only a brief ex vivo culture and does not use drug selection to obtain large numbers of functional gene-modified polyclonal T cells that can be used for adoptive immunotherapy...
  12. doi request reprint Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition
    Stanley R Riddell
    From the Fred Hutchinson Cancer Research Center, Seattle, WA
    Cancer J 20:141-4. 2014
    ..This review will discuss the rationale for and challenges to using adoptive therapy with genetically modified T cells of defined subset and phenotypic composition. ..
  13. pmc Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 18:617-24. 2010
    ..These assays should be incorporated into future human clinical trials of AAV gene therapy to monitor immune responses...
  14. pmc Identification of MAGE-C1 (CT-7) epitopes for T-cell therapy of multiple myeloma
    Larry D Anderson
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Immunol Immunother 60:985-97. 2011
    ....
  15. pmc Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma
    Lihua E Budde
    Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, United States of America Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America Departments of Medicine and Bioengineering, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e82742. 2013
    ..Our work demonstrates the feasibility and promise of this approach for treating CD20(+) malignancies in a safe and more efficient manner. A phase I clinical trial using this approach in patients with relapsed indolent B-NHL is planned. ..
  16. ncbi request reprint Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model
    Carolina Berger
    Department of Medicine, Klinikum Grosshadern, University of Munich, Germany
    Blood 103:1261-9. 2004
    ..These data demonstrate that chemically induced dimerization can be used to regulate survival of adoptively transferred T cells in vivo...