Antonio Bedalov

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast
    Tonibelle Gatbonton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 2:e35. 2006
  2. pmc Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast
    Elizabeth X Kwan
    Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 7:e1002250. 2011
  3. pmc Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e66283. 2013
  4. ncbi request reprint Neuroscience. NAD to the rescue
    Antonio Bedalov
    Clinical Research Division and J A Simon is in the Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 305:954-5. 2004
  5. ncbi request reprint Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast
    Maki Hirao
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 278:52773-82. 2003
  6. ncbi request reprint Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast
    Jeff Posakony
    Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Comb Chem High Throughput Screen 7:661-8. 2004
  7. pmc Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors
    Sumit S Mahajan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, United States
    J Med Chem 57:3283-94. 2014
  8. pmc A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan
    Elizabeth X Kwan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003329. 2013
  9. pmc Genetic variation shapes protein networks mainly through non-transcriptional mechanisms
    Eric J Foss
    Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Biol 9:e1001144. 2011
  10. ncbi request reprint Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast
    Tonibelle Gatbonton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 2:e35. 2006
    ..Furthermore, our results laid the foundation for studying genetic determinants of telomere length-variation and their roles in human disease...
  2. pmc Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast
    Elizabeth X Kwan
    Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 7:e1002250. 2011
    ..Identification of a polymorphism in BUL2 in this outbred yeast population revealed a link among cellular amino acid availability, chronological lifespan, and telomere length control...
  3. pmc Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e66283. 2013
    ..Our results indicate that SIRT1 acts as a tumor promoter in the APC(+/min) mouse model of intestinal tumorigenesis. ..
  4. ncbi request reprint Neuroscience. NAD to the rescue
    Antonio Bedalov
    Clinical Research Division and J A Simon is in the Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 305:954-5. 2004
  5. ncbi request reprint Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast
    Maki Hirao
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 278:52773-82. 2003
    ..Selectivity was affirmed using whole-genome DNA microarray analysis. This study underscores the power of phenotypic screens in the development and characterization of selective inhibitors of enzyme functions...
  6. ncbi request reprint Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast
    Jeff Posakony
    Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Comb Chem High Throughput Screen 7:661-8. 2004
    ....
  7. pmc Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors
    Sumit S Mahajan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, United States
    J Med Chem 57:3283-94. 2014
    ..In vitro cytotoxicity studies with these compounds as well as EX527, a potent and selective SIRT1 inhibitor, suggest that antilymphoma activity of this compound class may be predominantly due to SIRT2 inhibition. ..
  8. pmc A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan
    Elizabeth X Kwan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003329. 2013
    ....
  9. pmc Genetic variation shapes protein networks mainly through non-transcriptional mechanisms
    Eric J Foss
    Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Biol 9:e1001144. 2011
    ..We conclude that most inter-individual variation in levels of these particular high abundance proteins in this genetically diverse population is not caused by variation of their underlying transcripts...
  10. ncbi request reprint Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    Birgit Heltweg
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 66:4368-77. 2006
    ..Cambinol was well tolerated in mice and inhibited growth of Burkitt lymphoma xenografts. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents...
  11. pmc Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens
    Benjamin Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Methods Mol Biol 548:145-60. 2009
    ..These phenotypic assays, amenable for high throughput small molecule screening, enable identification and characterization of inhibitors of chromatin modifying enzymes largely bypassing traditional biochemical approaches...
  12. ncbi request reprint Inhibitors of Sir2: evaluation of splitomicin analogues
    Jeff Posakony
    Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    J Med Chem 47:2635-44. 2004
    ..Lactone hydrolysis rates were used as a measure of reactivity; hydrolysis rates correlate with inhibitory activity. The most potent Sir2 inhibitors were structurally similar to and had hydrolysis rates similar to 1...
  13. ncbi request reprint Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
  14. pmc NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae
    Antonio Bedalov
    Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 23:7044-54. 2003
    ..These findings suggest that Hst1p serves as a cellular NAD(+) sensor that monitors and regulates cellular NAD(+) levels...
  15. ncbi request reprint Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56
    Safia Thaminy
    Clinical Research Division and Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Biol Chem 282:37805-14. 2007
    ..Both S phase checkpoint and SCC defects are phenocopied by H3K56 point mutants. Our findings demonstrate that Hst3-regulated H3K56 acetylation safeguards genome stability by controlling the S phase DNA damage response and promoting SCC...
  16. pmc Identification and characterization of small-molecule inhibitors of hepsin
    John R Chevillet
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N C3 168, Seattle, WA 98109 1024, USA
    Mol Cancer Ther 7:3343-51. 2008
    ..These compounds may be used as leads to develop even more potent and specific inhibitors of hepsin to prevent prostate cancer progression and metastasis...
  17. ncbi request reprint Genetic basis of proteome variation in yeast
    Eric J Foss
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Genet 39:1369-75. 2007
    ..Loci that influenced protein abundance differed from those that influenced transcript levels, emphasizing the importance of direct analysis of the proteome...
  18. ncbi request reprint Pharmacogenetics: yeast lead the way
    Eric Foss
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA
    Chem Biol 13:236-8. 2006
    ..Their results suggest that drug responses are regulated by a limited number of loci, and that this system can identify clusters of functionally similar molecules...
  19. pmc SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 119:1856-60. 2012
    ..The results of the present study rule out an essential physiologic role for cell-autonomous SIRT1 signaling in the maintenance of the adult HSC compartment in mice...
  20. pmc Sirtuin modulators
    Sumit S Mahajan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Handb Exp Pharmacol 206:241-55. 2011
    ..In this chapter we review the development of pharmacological small molecule activators and inhibitors of the sirtuin family of enzymes...
  21. pmc Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets
    Eric J Foss
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States
    J Proteome Res 11:5005-10. 2012
    ....
  22. ncbi request reprint Sir2 flexes its muscle
    Antonio Bedalov
    Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D2 100, Seattle, WA 98107, USA
    Dev Cell 5:188-9. 2003
    ....
  23. ncbi request reprint Yeast as a model system for anticancer drug discovery
    Julian A Simon
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Rev Cancer 4:481-92. 2004
  24. pmc Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen
    Anthony Arnoldo
    Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada
    PLoS Genet 4:e1000005. 2008
    ..Taken together, our integrated cell-based, chemical-genetic approach demonstrates that such screens can augment traditional drug screening approaches and facilitate the discovery of new compounds against a broad range of human pathogens...

Research Grants4

  1. Development of cambinol analogues as antilymphoma agents
    Antonio Bedalov; Fiscal Year: 2009
    ..Our goal is to use the tools of medicinal chemistry, protein crystallography, biochemistry and cell biology to develop potent and selective inhibitors of SIRT1 as anti-lymphoma drugs. ..
  2. Development of cambinol analogues as antilymphoma agents
    Antonio Bedalov; Fiscal Year: 2010
    ..Our goal is to use the tools of medicinal chemistry, protein crystallography, biochemistry and cell biology to develop potent and selective inhibitors of SIRT1 as anti-lymphoma drugs. ..