S Arunmozhi Balajee

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi Determination of antifungal drug susceptibilities of Aspergillus species by a fluorescence-based microplate assay
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N D3 100, Seattle, WA 98109, USA
    J Antimicrob Chemother 55:102-5. 2005
  2. ncbi Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole
    Alexander Imhof
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Infect Dis 39:743-6. 2004
  3. pmc Mistaken identity: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109, USA
    J Clin Microbiol 43:5996-9. 2005
  4. pmc Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Benjamin Musher
    University of Washington, Seattle, WA, USA
    J Clin Microbiol 42:5517-22. 2004
  5. pmc Molecular studies reveal frequent misidentification of Aspergillus fumigatus by morphotyping
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
    Eukaryot Cell 5:1705-12. 2006
  6. pmc New methods to assess susceptibilities of Aspergillus isolates to caspofungin
    Alexander Imhof
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Microbiol 41:5683-8. 2003
  7. pmc Aspergillus fumigatus variant with decreased susceptibility to multiple antifungals
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Antimicrob Agents Chemother 48:1197-203. 2004
  8. pmc Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Eukaryot Cell 4:625-32. 2005
  9. ncbi Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants
    Kieren A Marr
    Program of Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 103:1527-33. 2004
  10. pmc Conidial viability assay for rapid susceptibility testing of Aspergillus species
    S Arunmozhi Balajee
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Microbiol 40:2741-5. 2002

Detail Information

Publications20

  1. ncbi Determination of antifungal drug susceptibilities of Aspergillus species by a fluorescence-based microplate assay
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N D3 100, Seattle, WA 98109, USA
    J Antimicrob Chemother 55:102-5. 2005
    ..We have investigated the use of a viability dye, chloromethylfluorescein di-acetate (CMFDA), for antifungal susceptibility testing in a fluorescence microplate (FM) assay format...
  2. ncbi Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole
    Alexander Imhof
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Infect Dis 39:743-6. 2004
    ..Minimal inhibitory concentrations were > or =1 microg/mL for all available isolates. Yeasts and molds with decreased susceptibility to voriconazole may cause invasive infection in patients treated successfully for aspergillosis...
  3. pmc Mistaken identity: Neosartorya pseudofischeri and its anamorph masquerading as Aspergillus fumigatus
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109, USA
    J Clin Microbiol 43:5996-9. 2005
    ..Accurate identification of these organisms may be clinically meaningful, given their potential differences in antifungal susceptibilities...
  4. pmc Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Benjamin Musher
    University of Washington, Seattle, WA, USA
    J Clin Microbiol 42:5517-22. 2004
    ..GM EIA and qPCR assay add to the sensitivity of BAL for diagnosing IPA in high-risk patients, with excellent specificity. Adjunctive use of these tests may reduce dependence on invasive diagnostic procedures...
  5. pmc Molecular studies reveal frequent misidentification of Aspergillus fumigatus by morphotyping
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109, USA
    Eukaryot Cell 5:1705-12. 2006
    ..fumigatus group. Differential antifungal susceptibilities of these species may account for some of the reported poor outcomes of therapy in clinical studies...
  6. pmc New methods to assess susceptibilities of Aspergillus isolates to caspofungin
    Alexander Imhof
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Microbiol 41:5683-8. 2003
    ..Agar dilution is simple and reproducible, and results were consistent with the results of more technically demanding techniques. This method may be appropriate for use in the clinical laboratory...
  7. pmc Aspergillus fumigatus variant with decreased susceptibility to multiple antifungals
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Antimicrob Agents Chemother 48:1197-203. 2004
    ..These data suggest the potential presence of a genetically unique, poorly sporulating variant of A. fumigatus that demonstrates decreased susceptibilities to several antifungals...
  8. pmc Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus
    S Arunmozhi Balajee
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Eukaryot Cell 4:625-32. 2005
    ..fumigatus and is not able to survive at 48 degrees C. Our findings suggest the presence of a previously unrecognized, potentially drug-resistant Aspergillus species that we designate A. lentulus...
  9. ncbi Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants
    Kieren A Marr
    Program of Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 103:1527-33. 2004
    ..69). There was no difference in overall or fungal-free survival. Itraconazole appears to prevent IMI in the subset of patients who tolerate the drug; however, toxicities and poor tolerability limit its success as prophylactic therapy...
  10. pmc Conidial viability assay for rapid susceptibility testing of Aspergillus species
    S Arunmozhi Balajee
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Microbiol 40:2741-5. 2002
    ..e., NCCLS) method. The results of these studies illustrate a method by which AMB susceptibility can be rapidly and reproducibly determined by measuring conidial viability...
  11. ncbi Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance
    Kieren A Marr
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington 98109, USA
    J Infect Dis 190:641-9. 2004
    ..The 0.5 cutoff may allow for better performance as an early diagnostic test...
  12. pmc Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens
    Kieren A Marr
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, 98109, USA
    Infect Immun 71:5280-6. 2003
    ..albicans, but not A. fumigatus. The differential role of MyD88 may represent one mechanism by which macrophages regulate innate responses specific to different pathogenic fungi...
  13. pmc Nonsporulating clinical isolate identified as Petromyces alliaceus (anamorph Aspergillus alliaceus) by morphological and sequence-based methods
    S Arunmozhi Balajee
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Mail stop G 11, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Clin Microbiol 45:2701-3. 2007
    ..This rare Aspergillus sp. was recovered as the etiological agent of invasive pulmonary aspergillosis and had reduced in vitro susceptibilities to amphotericin B and caspofungin, which correlated with clinical failure of therapy...
  14. doi Isolation of Aspergillus udagawae from a fatal case of feline orbital aspergillosis
    Rui Kano
    Mycoses 51:360-1. 2008
    ..Antifungal susceptibility testing results revealed that this isolate had high in vitro MIC to amphotericin B (AMB) that correlated with in vivo failure of therapy with AMB...
  15. pmc GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA
    Infect Immun 74:6761-8. 2006
    ..This may indicate that several secondary metabolites are involved in A. fumigatus virulence...
  16. pmc Characterization of a novel gene for strain typing reveals substructuring of Aspergillus fumigatus across North America
    S Arunmozhi Balajee
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Mail stop G 11, 1600 Clifton Road, Atlanta, GA 30333, USA
    Eukaryot Cell 6:1392-9. 2007
    ..fumigatus isolate Af293, whose genome has been sequenced, possesses a CSP gene structure that is substantially different from those of the other A. fumigatus strains studied here, highlighting the need for further taxonomic study...
  17. ncbi Phenotypic and genotypic identification of human pathogenic aspergilli
    S Arunmozhi Balajee
    Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, GA 30333, USA
    Future Microbiol 1:435-45. 2006
    ..This review focuses on current and future methods of identifying aspergilli, and implications regarding Aspergillus species/strain identification...
  18. ncbi DNA and the classical way: identification of medically important molds in the 21st century
    S Arunmozhi Balajee
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Med Mycol 45:475-90. 2007
    ..At this time, a polyphasic approach to identification that combines morphologic and molecular methods will ensure the greatest success in the management of patients with fungal infections...
  19. doi Utility of a microsatellite assay for identifying clonally related outbreak isolates of Aspergillus fumigatus
    S Arunmozhi Balajee
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    J Microbiol Methods 73:252-6. 2008
    ..We also report for the first time the detection of microvariation events in the A. fumigatus population studied...
  20. pmc LaeA, a regulator of morphogenetic fungal virulence factors
    Jin Woo Bok
    University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 4:1574-82. 2005
    ..LaeA, a conserved protein in filamentous fungi, is a developmental regulator of virulence genes and, possibly, the first antimicrobial target specific to filamentous fungi that are pathogenic to plants and animals...