Research Topics
| Vidadi YusibovSummaryAffiliation: Fraunhofer USA Country: USA Publications
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Detail Information
Publications
The potential of plant virus vectors for vaccine productionVidadi Yusibov
Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
Drugs R D 7:203-17. 2006..In this review, we discuss the advantages of plant virus vectors, the development of different viruses as vector systems, and the immunological experiments that have demonstrated the principle of plant virus-derived vaccines...- A plant-produced plague vaccine candidate confers protection to monkeysVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 25:3014-7. 2007..pestis. This study clearly demonstrates the efficacy of a plant-produced plague vaccine candidate in a primate model... - Plants as alternative systems for production of vaccinesJessica A Chichester
Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
Hum Vaccin 3:146-8. 2007..This commentary reviews the production and evaluation of antigens made in plants in an attempt to develop vaccines against B. anthracis and Y. pestis... - Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyondVidadi Yusibov
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:313-21. 2011.... 
A launch vector for the production of vaccine antigens in plantsKonstantin Musiychuk
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Newark, DE 19711, USA
Influenza Other Respi Viruses 1:19-25. 2007..We have applied this launch vector/carrier system to engineer and express target antigens from various pathogens, including, influenza A/Vietnam/04 (H5N1) virus...- Recent progress in the development of plant derived vaccinesVidadi Yusibov
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 1971, USA
Expert Rev Vaccines 7:1173-83. 2008..The particular advantages of plant-based vaccines in terms of cost, safety and scalability are discussed in the light of recent successful clinical trials and the likely impact of plant systems on the vaccine industry is evaluated... - Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenzaYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Vaccine 27:1087-92. 2009..Plants could therefore be suitable as a platform for the rapid, large-scale production of influenza vaccines in the face of a pandemic... - A plant-produced influenza subunit vaccine protects ferrets against virus challengeVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Influenza Other Respi Viruses 2:33-40. 2008.... - A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plagueJessica A Chichester
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 27:3471-4. 2009..These immunized animals were subsequently challenged and the LcrV-F1 plant-produced vaccine conferred complete protection against aerosolized Y. pestis... 
A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparumChristine E Farrance
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Clin Vaccine Immunol 18:1351-7. 2011..Our data provide a clear perspective on the clinical development of a Pfs230-based transmission-blocking malaria vaccine...- Plant-expressed HA as a seasonal influenza vaccine candidateYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 26:2930-4. 2008..These results demonstrate that plant-produced HA protein is antigenic and can induce immune responses in mice that correlate with protection... - Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenzaYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:41-50. 2011..These results support the testing of these candidate vaccines in human volunteers and also the utility of our plant expression system for large-scale recombinant influenza vaccine production... - Immunogenicity of hemagglutinin from A/Bar-headed Goose/Qinghai/1A/05 and A/Anhui/1/05 strains of H5N1 influenza viruses produced in Nicotiana benthamiana plantsYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 27:3467-70. 2009..These results suggest the utility of our plant-expression system for recombinant influenza vaccine production... - A non-glycosylated, plant-produced human monoclonal antibody against anthrax protective antigen protects mice and non-human primates from B. anthracis spore challengeVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:183-90. 2011..This study demonstrates the potential of a plant-produced non-glycosylated antibody as a useful tool for the treatment of inhalation anthrax... - Plants as biofactoriesVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Biologicals 36:354-8. 2008..Here we review vaccine antigen production in plant-based systems as was presented by Dr. Vidadi Yusibov of Fraunhofer USA Center for Molecular Biotechnology at the IABS International Scientific Workshop on NEW .. - Co-expression of multiple target proteins in plants from a tobacco mosaic virus vector using a combination of homologous and heterologous subgenomic promotersGourgopal Roy
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Arch Virol 156:2057-61. 2011..These findings suggest that this chimeric vector utilizing the homologous and heterologous subgenomic TMV promoters has a potential for high-level production of multiple therapeutic proteins including monoclonal antibodies... - Immunogenicity of a subunit vaccine against Bacillus anthracisJessica A Chichester
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark DE 19711, USA
Vaccine 25:3111-4. 2007..All animals that received the experimental vaccine developed high antibody titers that were predominantly IgG1 and were able to neutralize the effects of LeTx in vitro... - A plant-based system for rapid production of influenza vaccine antigensYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Influenza Other Respi Viruses 6:204-10. 2012..Current, egg-based, influenza vaccine production is well established and provides an effective product, but has limited capacity and speed... - Plant-produced human growth hormone shows biological activity in a rat modelShailaja Rabindran
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Biotechnol Prog 25:530-4. 2009..With the increasing demand for hGH, accompanied with the need to make this recombinant protein available to a wider population at a more reasonable cost, plants provide a feasible alternative to current production platforms... - Development of a new cucumber mosaic virus-based plant expression vector with truncated 3a movement proteinMasaaki Fujiki
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Virology 381:136-42. 2008..Human growth hormone (hGH), on the other hand, accumulated to ~170 mg/kg of leaf tissue when the same approach was used to deliver the vector... - Transient protein expression in three Pisum sativum (green pea) varietiesBrian J Green
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Biotechnol J 4:230-7. 2009..Expression levels of 420 +/- 26.24 mg GFP/kgFW in the green pea variety speckled pea were achieved. We were also able to express three therapeutic proteins indicating promise for this system in the production of biopharmaceuticals... - Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activityChristine E Farrance
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:191-8. 2011..These data demonstrate the feasibility of expressing Plasmodium antigens in a plant-based system for the economic production of a transmission blocking vaccine against malaria... - Production of recombinant proteins in clonal root cultures using episomal expression vectorsMarina Skarjinskaia
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, Delaware 19711, USA
Biotechnol Bioeng 100:814-9. 2008..This technology shows promise for commercial production of vaccine antigens and therapeutic proteins in contained facilities... - An influenza N1 neuraminidase-specific monoclonal antibody with broad neuraminidase inhibition activity against H5N1 HPAI virusesYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Hum Vaccin 7:199-204. 2011..Specific and effective inhibition of N1 NA could make this mAb a useful therapeutic tool in the treatment of human infection, in particular with oseltamivirand zanamivir-resistant strains of HPAI... - A novel two-component Tobacco mosaic virus-based vector system for high-level expression of multiple therapeutic proteins including a human monoclonal antibody in plantsGourgopal Roy
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Virology 405:93-9. 2010..Our data suggest that dRT-V has a potential for rapid, cost-effective, large-scale manufacturing of multiple therapeutic proteins including mAbs in response to any biological emergencies... - Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase FTarlan Mamedov
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Plant Biotechnol J 10:773-82. 2012..Thus, here, we report for the first time the expression in plants of an active bacterial enzyme PNGase F and the production of recombinant proteins of interest in a non-glycosylated form... - Using plant cells as influenza vaccine substratesJessica A Chichester
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Expert Rev Vaccines 8:493-8. 2009..A particular emphasis of this review will be on the production of recombinant influenza vaccines using transient plant expression systems... - Peptide-based candidate vaccine against respiratory syncytial virusVidadi Yusibov
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Vaccine 23:2261-5. 2005..This approach may validate the use of a novel RSV vaccine delivery vehicle in humans... - Safety and immunogenicity of a plant-produced recombinant hemagglutinin-based influenza vaccine (HAI-05) derived from A/Indonesia/05/2005 (H5N1) influenza virus: a phase 1 randomized, double-blind, placebo-controlled, dose-escalation study in healthy adulJessica A Chichester
Fraunhofer USA, Center for Molecular Biotechnology, Newark, DE 19711, USA
Viruses 4:3227-44. 2012..The immune response elicited by the HAI-05 vaccine was variable with respect to both hemagglutination-inhibition and virus microneutralization antibody titers, with the highest responses observed in the 90 µg unadjuvanted group... - A cryohistological protocol for preparation of large plant tissue sections for screening intracellular fluorescent protein expressionElisabeth Knapp
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Biotechniques 52:31-7. 2012..Overall, this simple cryohistological procedure reduced sample preparation time and allowed processing of tissue sections for high-resolution imaging of targeted fluorescent proteins in all plant tissues... - Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plantsVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
Transgenic Res 16:77-84. 2007..5% of the total soluble protein (TSP). Transient expression in plants has the potential to produce a large amount of human IA-2ic protein at low cost in a short period of time... - Inducible expression in plants by virus-mediated transgene activationAnna K Hull
Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
Transgenic Res 14:407-16. 2005..Transgenic lines harboring the reporter gene were also examined. The VMTA system displayed tight transcriptional control in both transient assays and in transgenic Nicotiana benthamiana plants carrying the TA-inducible reporter... - Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical developmentNatasha Kushnir
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Vaccine 31:58-83. 2012..This article reviews VLP-based vaccines produced in different systems, their immunogenicity in animal models and their status in clinical development... - Human-derived, plant-produced monoclonal antibody for the treatment of anthraxAnna K Hull
Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way Suite 200, Newark, Delaware, DE 19711, USA
Vaccine 23:2082-6. 2005..The resulting antibody was able to neutralize toxin activity in vitro and in vivo at a comparable level to that seen for its hybridoma-produced counterpart...