Vidadi Yusibov

Summary

Affiliation: Fraunhofer USA
Country: USA

Publications

  1. ncbi request reprint The potential of plant virus vectors for vaccine production
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
    Drugs R D 7:203-17. 2006
  2. ncbi request reprint A plant-produced plague vaccine candidate confers protection to monkeys
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 25:3014-7. 2007
  3. ncbi request reprint Plants as alternative systems for production of vaccines
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
    Hum Vaccin 3:146-8. 2007
  4. ncbi request reprint Hybrid viral vectors for vaccine and antibody production in plants
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Curr Pharm Des 19:5574-86. 2013
  5. ncbi request reprint Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:313-21. 2011
  6. doi request reprint A launch vector for the production of vaccine antigens in plants
    Konstantin Musiychuk
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Newark, DE 19711, USA
    Influenza Other Respir Viruses 1:19-25. 2007
  7. doi request reprint Recent progress in the development of plant derived vaccines
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 1971, USA
    Expert Rev Vaccines 7:1173-83. 2008
  8. doi request reprint Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Vaccine 27:1087-92. 2009
  9. doi request reprint A plant-produced influenza subunit vaccine protects ferrets against virus challenge
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Influenza Other Respir Viruses 2:33-40. 2008
  10. doi request reprint A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 27:3471-4. 2009

Collaborators

  • Jessica A Chichester
  • Stephen J Streatfield
  • Shailaja Rabindran
  • Gourgopal Roy
  • Yoko Shoji
  • Tarlan Mamedov
  • Elisabeth Knapp
  • Yimin Wu
  • Rainer Fischer
  • Goran Orozovic
  • Lars R Haaheim
  • Takafumi Tsuboi
  • Hiroki Hirai
  • Mark T Albrecht
  • Richard M Twyman
  • Michael Russell
  • J S Oxford
  • Vadim Mett
  • Konstantin Musiychuk
  • Christine E Farrance
  • R Mark Jones
  • Moneim Shamloul
  • Marina Skarjinskaia
  • Anna K Hull
  • Hong Bi
  • Will Roeffen
  • Robert W Sauerwein
  • Marga van de Vegte-Bolmer
  • NATALIA UGULAVA
  • Gene A Palmer
  • Brian J Green
  • Masaaki Fujiki
  • Jennifer Jaje
  • Natasha Kushnir
  • Satish Sharma
  • Valentina Mett
  • Amy Rhee
  • Adriana Araujo
  • Patricia de la Rosa
  • Karen Ruby
  • April Horsey
  • Abdel Moneim Shamloul
  • Brenden Shaw
  • John Hambor
  • Slobodanka Manceva
  • Tatiana Golovina
  • Stewart Abbot
  • Joey Norikane
  • Vanessa Voskinarian-Berse
  • Rajarajeswari Sivalenka
  • Luipa Khandker
  • Stephen Tottey
  • Xiaokui Zhang
  • Jacob Schnipper
  • Karina Taylor
  • Chang Li
  • Louis J Casta
  • Vengadesan Gopalasamy-Raju
  • Ruiqiang Sun
  • Lin Kang
  • Rosemary Flores
  • Sandra K Gibbs
  • Robert Sinden
  • Louis Miller
  • Slobodanka D Manceva
  • Stanley Goldman
  • Les W J Baillie
  • Michelle L Stewart
  • Patrick Duffy
  • Olga Muratova
  • Carolyn J Reifsnyder
  • Olga V Muratova
  • Jon Kaczmarczyk
  • Susan Underkoffler
  • Geoffrey C Schild
  • Alison Boyers
  • Alex Mann
  • Jon F Kaczmarczyk
  • Jason Karl
  • Robert Lambkin
  • Robert Sherwood
  • Trevor Brasil
  • Zhaohua Zhou
  • Jarred Lyons
  • Ronald Couch
  • Peter Brodelius
  • Natalie Stephenson
  • Maria Brodelius
  • Abner Notkins
  • Gail Chapman

Detail Information

Publications40

  1. ncbi request reprint The potential of plant virus vectors for vaccine production
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
    Drugs R D 7:203-17. 2006
    ..In this review, we discuss the advantages of plant virus vectors, the development of different viruses as vector systems, and the immunological experiments that have demonstrated the principle of plant virus-derived vaccines...
  2. ncbi request reprint A plant-produced plague vaccine candidate confers protection to monkeys
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 25:3014-7. 2007
    ..pestis. This study clearly demonstrates the efficacy of a plant-produced plague vaccine candidate in a primate model...
  3. ncbi request reprint Plants as alternative systems for production of vaccines
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
    Hum Vaccin 3:146-8. 2007
    ..This commentary reviews the production and evaluation of antigens made in plants in an attempt to develop vaccines against B. anthracis and Y. pestis...
  4. ncbi request reprint Hybrid viral vectors for vaccine and antibody production in plants
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Curr Pharm Des 19:5574-86. 2013
    ..This article presents an overview of plant hybrid viral vector expression systems developed so far. ..
  5. ncbi request reprint Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:313-21. 2011
    ....
  6. doi request reprint A launch vector for the production of vaccine antigens in plants
    Konstantin Musiychuk
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Newark, DE 19711, USA
    Influenza Other Respir Viruses 1:19-25. 2007
    ..We have applied this launch vector/carrier system to engineer and express target antigens from various pathogens, including, influenza A/Vietnam/04 (H5N1) virus...
  7. doi request reprint Recent progress in the development of plant derived vaccines
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 1971, USA
    Expert Rev Vaccines 7:1173-83. 2008
    ..The particular advantages of plant-based vaccines in terms of cost, safety and scalability are discussed in the light of recent successful clinical trials and the likely impact of plant systems on the vaccine industry is evaluated...
  8. doi request reprint Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Vaccine 27:1087-92. 2009
    ..Plants could therefore be suitable as a platform for the rapid, large-scale production of influenza vaccines in the face of a pandemic...
  9. doi request reprint A plant-produced influenza subunit vaccine protects ferrets against virus challenge
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Influenza Other Respir Viruses 2:33-40. 2008
    ....
  10. doi request reprint A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 27:3471-4. 2009
    ..These immunized animals were subsequently challenged and the LcrV-F1 plant-produced vaccine conferred complete protection against aerosolized Y. pestis...
  11. doi request reprint Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F
    Tarlan Mamedov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Plant Biotechnol J 10:773-82. 2012
    ..Thus, here, we report for the first time the expression in plants of an active bacterial enzyme PNGase F and the production of recombinant proteins of interest in a non-glycosylated form...
  12. pmc A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum
    Christine E Farrance
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Clin Vaccine Immunol 18:1351-7. 2011
    ..Our data provide a clear perspective on the clinical development of a Pfs230-based transmission-blocking malaria vaccine...
  13. pmc Deletions within the 3' non-translated region of Alfalfa mosaic virus RNA4 do not affect replication but significantly reduce long-distance movement of chimeric Tobacco mosaic virus
    Gourgopal Roy
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Newark, DE 19711, USA
    Viruses 5:1802-14. 2013
    ..benthamiana. These data suggest that the 3' NTR of AlMV sgRNA4 contains potential elements necessary for virus encapsidation. ..
  14. doi request reprint Plant-expressed HA as a seasonal influenza vaccine candidate
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 26:2930-4. 2008
    ..These results demonstrate that plant-produced HA protein is antigenic and can induce immune responses in mice that correlate with protection...
  15. doi request reprint Immunogenicity of hemagglutinin from A/Bar-headed Goose/Qinghai/1A/05 and A/Anhui/1/05 strains of H5N1 influenza viruses produced in Nicotiana benthamiana plants
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 27:3467-70. 2009
    ..These results suggest the utility of our plant-expression system for recombinant influenza vaccine production...
  16. ncbi request reprint Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:41-50. 2011
    ..These results support the testing of these candidate vaccines in human volunteers and also the utility of our plant expression system for large-scale recombinant influenza vaccine production...
  17. pmc Plant-produced human recombinant erythropoietic growth factors support erythroid differentiation in vitro
    Konstantin Musiychuk
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Stem Cells Dev 22:2326-40. 2013
    ..To the best of our knowledge, this is the first report on the generation of all key bioactive cytokines required for the erythroid development in a cost-effective manner using a plant-based expression system...
  18. ncbi request reprint A non-glycosylated, plant-produced human monoclonal antibody against anthrax protective antigen protects mice and non-human primates from B. anthracis spore challenge
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:183-90. 2011
    ..This study demonstrates the potential of a plant-produced non-glycosylated antibody as a useful tool for the treatment of inhalation anthrax...
  19. doi request reprint Plants as biofactories
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Biologicals 36:354-8. 2008
    ..Here we review vaccine antigen production in plant-based systems as was presented by Dr. Vidadi Yusibov of Fraunhofer USA Center for Molecular Biotechnology at the IABS International Scientific Workshop on NEW ..
  20. doi request reprint Co-expression of multiple target proteins in plants from a tobacco mosaic virus vector using a combination of homologous and heterologous subgenomic promoters
    Gourgopal Roy
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Arch Virol 156:2057-61. 2011
    ..These findings suggest that this chimeric vector utilizing the homologous and heterologous subgenomic TMV promoters has a potential for high-level production of multiple therapeutic proteins including monoclonal antibodies...
  21. doi request reprint Plant-produced human growth hormone shows biological activity in a rat model
    Shailaja Rabindran
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Biotechnol Prog 25:530-4. 2009
    ..With the increasing demand for hGH, accompanied with the need to make this recombinant protein available to a wider population at a more reasonable cost, plants provide a feasible alternative to current production platforms...
  22. ncbi request reprint Immunogenicity of a subunit vaccine against Bacillus anthracis
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark DE 19711, USA
    Vaccine 25:3111-4. 2007
    ..All animals that received the experimental vaccine developed high antibody titers that were predominantly IgG1 and were able to neutralize the effects of LeTx in vitro...
  23. doi request reprint A plant-based system for rapid production of influenza vaccine antigens
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Influenza Other Respir Viruses 6:204-10. 2012
    ..Current, egg-based, influenza vaccine production is well established and provides an effective product, but has limited capacity and speed...
  24. doi request reprint Development of a new cucumber mosaic virus-based plant expression vector with truncated 3a movement protein
    Masaaki Fujiki
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Virology 381:136-42. 2008
    ..Human growth hormone (hGH), on the other hand, accumulated to ~170 mg/kg of leaf tissue when the same approach was used to deliver the vector...
  25. doi request reprint Transient protein expression in three Pisum sativum (green pea) varieties
    Brian J Green
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Biotechnol J 4:230-7. 2009
    ..Expression levels of 420 +/- 26.24 mg GFP/kgFW in the green pea variety speckled pea were achieved. We were also able to express three therapeutic proteins indicating promise for this system in the production of biopharmaceuticals...
  26. doi request reprint Production of recombinant proteins in clonal root cultures using episomal expression vectors
    Marina Skarjinskaia
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, Delaware 19711, USA
    Biotechnol Bioeng 100:814-9. 2008
    ..This technology shows promise for commercial production of vaccine antigens and therapeutic proteins in contained facilities...
  27. ncbi request reprint Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity
    Christine E Farrance
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:191-8. 2011
    ..These data demonstrate the feasibility of expressing Plasmodium antigens in a plant-based system for the economic production of a transmission blocking vaccine against malaria...
  28. ncbi request reprint An influenza N1 neuraminidase-specific monoclonal antibody with broad neuraminidase inhibition activity against H5N1 HPAI viruses
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Hum Vaccin 7:199-204. 2011
    ..Specific and effective inhibition of N1 NA could make this mAb a useful therapeutic tool in the treatment of human infection, in particular with oseltamivirand zanamivir-resistant strains of HPAI...
  29. doi request reprint Hairy roots as a vaccine production and delivery system
    Marina Skarjinskaia
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE, 19711, USA
    Adv Biochem Eng Biotechnol 134:115-34. 2013
    ..Lyophilized hairy root cultures expressing vaccine antigens can be stored at ambient temperature for extended periods of time, which should facilitate storage and distribution, ultimately allowing for large populations to be vaccinated. ..
  30. pmc Safety and immunogenicity of a plant-produced recombinant hemagglutinin-based influenza vaccine (HAI-05) derived from A/Indonesia/05/2005 (H5N1) influenza virus: a phase 1 randomized, double-blind, placebo-controlled, dose-escalation study in healthy adul
    Jessica A Chichester
    Fraunhofer USA, Center for Molecular Biotechnology, Newark, DE 19711, USA
    Viruses 4:3227-44. 2012
    ..The immune response elicited by the HAI-05 vaccine was variable with respect to both hemagglutination-inhibition and virus microneutralization antibody titers, with the highest responses observed in the 90 µg unadjuvanted group...
  31. doi request reprint A novel two-component Tobacco mosaic virus-based vector system for high-level expression of multiple therapeutic proteins including a human monoclonal antibody in plants
    Gourgopal Roy
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Virology 405:93-9. 2010
    ..Our data suggest that dRT-V has a potential for rapid, cost-effective, large-scale manufacturing of multiple therapeutic proteins including mAbs in response to any biological emergencies...
  32. pmc A plant-produced Pfs25 VLP malaria vaccine candidate induces persistent transmission blocking antibodies against Plasmodium falciparum in immunized mice
    R Mark Jones
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware, United States of America
    PLoS ONE 8:e79538. 2013
    ..These results support the evaluation of Pfs25-CP VLP as a potential TBV candidate and the feasibility of the 'launch' vector technology for the production of VLP-based recombinant vaccines against infectious diseases. ..
  33. ncbi request reprint Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plants
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Transgenic Res 16:77-84. 2007
    ..5% of the total soluble protein (TSP). Transient expression in plants has the potential to produce a large amount of human IA-2ic protein at low cost in a short period of time...
  34. doi request reprint Using plant cells as influenza vaccine substrates
    Jessica A Chichester
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Expert Rev Vaccines 8:493-8. 2009
    ..A particular emphasis of this review will be on the production of recombinant influenza vaccines using transient plant expression systems...
  35. ncbi request reprint Peptide-based candidate vaccine against respiratory syncytial virus
    Vidadi Yusibov
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Suite 200, Newark, DE 19711, USA
    Vaccine 23:2261-5. 2005
    ..This approach may validate the use of a novel RSV vaccine delivery vehicle in humans...
  36. doi request reprint A cryohistological protocol for preparation of large plant tissue sections for screening intracellular fluorescent protein expression
    Elisabeth Knapp
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Biotechniques 52:31-7. 2012
    ..Overall, this simple cryohistological procedure reduced sample preparation time and allowed processing of tissue sections for high-resolution imaging of targeted fluorescent proteins in all plant tissues...
  37. ncbi request reprint Inducible expression in plants by virus-mediated transgene activation
    Anna K Hull
    Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware 19711, USA
    Transgenic Res 14:407-16. 2005
    ..Transgenic lines harboring the reporter gene were also examined. The VMTA system displayed tight transcriptional control in both transient assays and in transgenic Nicotiana benthamiana plants carrying the TA-inducible reporter...
  38. doi request reprint Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development
    Natasha Kushnir
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Vaccine 31:58-83. 2012
    ..This article reviews VLP-based vaccines produced in different systems, their immunogenicity in animal models and their status in clinical development...
  39. ncbi request reprint Human-derived, plant-produced monoclonal antibody for the treatment of anthrax
    Anna K Hull
    Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way Suite 200, Newark, Delaware, DE 19711, USA
    Vaccine 23:2082-6. 2005
    ..The resulting antibody was able to neutralize toxin activity in vitro and in vivo at a comparable level to that seen for its hybridoma-produced counterpart...
  40. pmc Green algae Chlamydomonas reinhardtii possess endogenous sialylated N-glycans
    Tarlan Mamedov
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    FEBS Open Bio 1:15-22. 2011
    ..reinhardtii algae possess glycoproteins with mammalian-like sialylated N-linked oligosaccharides. These findings suggest that C. reinhardtii may be an attractive system for expression of target proteins...