K S Zaret

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi request reprint Liver specification and early morphogenesis
    K S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Mech Dev 92:83-8. 2000
  2. doi request reprint Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Room W410, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Genet 9:329-40. 2008
  3. ncbi request reprint Hepatocyte differentiation: from the endoderm and beyond
    K S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Curr Opin Genet Dev 11:568-74. 2001
  4. doi request reprint Using small molecules to great effect in stem cell differentiation
    Kenneth S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell Stem Cell 4:373-4. 2009
  5. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
  6. pmc JEEM and my evolution in development
    Ken Zaret
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Development 135:2341. 2008
  7. ncbi request reprint Regulatory phases of early liver development: paradigms of organogenesis
    Kenneth S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Genet 3:499-512. 2002
  8. ncbi request reprint Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
    Roque Bort
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dev Biol 290:44-56. 2006
  9. doi request reprint Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010
  10. ncbi request reprint Liver organogenesis promoted by endothelial cells prior to vascular function
    K Matsumoto
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 294:559-63. 2001

Research Grants

Collaborators

  • Stephen Duncan
  • MARKUS C GROMPE
  • S T Smale
  • J Xu
  • Jinhong Chang
  • Alfonso Bellacosa
  • Hong Fu
  • William Mason
  • John B Burch
  • Lorraine Gudas
  • Yoshio Fujitani
  • Maureen A Gannon
  • Daniel C Weinstein
  • Margaret Buckingham
  • Patrick Jacquemin
  • Jonathan Epstein
  • Michael Dyer
  • MARGARET BARON
  • Frederic Relaix
  • Ewa Wandzioch
  • Isabel Cuesta
  • Roque Bort
  • Amelie Calmont
  • Kimberly D Tremblay
  • Paul Gadue
  • Lisa Ann Cirillo
  • Takashi Sekiya
  • Salvatore Cortellino
  • Mounia Lagha
  • Jay D Kormish
  • Peter O Wiebe
  • Deborah A Freedman
  • Michal Jarnik
  • Klaus H Kaestner
  • Konstantin D Taganov
  • Frederic Lemaigre
  • Hideyuki Yoshitomi
  • Deanna Mohn
  • Fereshteh Parviz
  • Xi Lin
  • D Chaya
  • K Matsumoto
  • Xin Cheng
  • Alexei V Tulin
  • Karolin Luger
  • Maria Rosaria Bassi
  • Philip R Streeter
  • Baolin Wang
  • Valerie Gouon-Evans
  • Chengbing Wang
  • Elena Caretti
  • Gordon M Keller
  • Lionel Larue
  • Uma M Muthurajan
  • Delphine Champeval
  • Marie Manceau
  • Didier Rocancourt
  • Venus T Roper
  • Ninche I Alston
  • Pilar Santisteban
  • Roland W Stein
  • Christopher V E Wright
  • Yasushige Kashima
  • Massimo Signore
  • Kimberly Tremblay
  • George Minowada
  • Gail R Martin
  • Juan Pedro Martinez Barbera
  • Richard A Katz
  • Rene Daniel
  • Juan Pedro Martinez-Barbera
  • Rosa S P Beddington
  • Anna Marie Skalka
  • Jennifer M Rossi
  • John W Adamson
  • Christine Matullo
  • Gang Ning
  • Elizabeth Zahradka
  • Wendy D Garrison
  • Kenneth Sahr
  • Siming W Chen
  • Laura Savatski
  • Dora Campos Dias
  • Charles E Ducker
  • Gordon Keller
  • Joonil Jung
  • Frank Robert Lin
  • Dara Friedman
  • Huda Zoghbi
  • Dongcheul Kang

Detail Information

Publications33

  1. ncbi request reprint Liver specification and early morphogenesis
    K S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Mech Dev 92:83-8. 2000
    ..The initial stages of hepatogenesis are therefore beginning to be understood, and serve as a paradigm for the development of other tissues from the endoderm...
  2. doi request reprint Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Room W410, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Genet 9:329-40. 2008
    ....
  3. ncbi request reprint Hepatocyte differentiation: from the endoderm and beyond
    K S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Curr Opin Genet Dev 11:568-74. 2001
    ..Molecular signals that govern the differentiation of hepatocytes from non-endodermal cells and the role of such cells in normal liver physiology remain to be discovered...
  4. doi request reprint Using small molecules to great effect in stem cell differentiation
    Kenneth S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell Stem Cell 4:373-4. 2009
    ..Their combined success helps bypass challenges associated with using natural protein factors and has revealed insights into controlling stem cell differentiation...
  5. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
    ....
  6. pmc JEEM and my evolution in development
    Ken Zaret
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Development 135:2341. 2008
  7. ncbi request reprint Regulatory phases of early liver development: paradigms of organogenesis
    Kenneth S Zaret
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Nat Rev Genet 3:499-512. 2002
    ..The regulatory mechanisms that underlie these phases are common to the development of many organ systems and might be recapitulated or disrupted during stem-cell differentiation and adult tissue pathogenesis...
  8. ncbi request reprint Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
    Roque Bort
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dev Biol 290:44-56. 2006
    ..Thus, Hex promotes endoderm organogenesis by promoting the transition to a pseudostratified epithelium, which in turn allows hepatoblasts to emerge into the stromal environment and continue differentiating...
  9. doi request reprint Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010
    ..The results indicate that the "pioneer" features of FoxA factors involve various chromatin-binding parameters seen in linker histones and that distinguish the factors with respect to their regulatory and mechanistic functions...
  10. ncbi request reprint Liver organogenesis promoted by endothelial cells prior to vascular function
    K Matsumoto
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 294:559-63. 2001
    ..We conclude that vasculogenic endothelial cells and nascent vessels are critical for the earliest stages of organogenesis, prior to blood vessel function...
  11. pmc Dynamic signaling network for the specification of embryonic pancreas and liver progenitors
    Ewa Wandzioch
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 324:1707-10. 2009
    ..These findings may enhance progenitor cell specification from stem cells for biomedical purposes and can help explain incomplete programming in stem cell differentiation protocols...
  12. ncbi request reprint Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues
    Kimberly D Tremblay
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dev Biol 280:87-99. 2005
    ....
  13. pmc Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm
    K S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cold Spring Harb Symp Quant Biol 73:119-26. 2008
    ....
  14. ncbi request reprint An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells
    Amelie Calmont
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Dev Cell 11:339-48. 2006
    ..The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation...
  15. ncbi request reprint Transcription factor FoxA (HNF3) on a nucleosome at an enhancer complex in liver chromatin
    D Chaya
    Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:44385-9. 2001
    ..Because histone H2A on nuclear DNA is only known to exist in nucleosomes, we conclude that transcription factors can form a stable complex on nucleosomes at an active enhancer element in vivo...
  16. ncbi request reprint Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    Roque Bort
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Aveue, Philadelphia, PA 19111, USA
    Development 131:797-806. 2004
    ..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs...
  17. ncbi request reprint Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4
    Lisa Ann Cirillo
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Mol Cell 9:279-89. 2002
    ..Thus, factors that potentiate transcription in development are inherently capable of initiating chromatin opening events...
  18. ncbi request reprint Endothelial cell promotion of early liver and pancreas development
    Deborah A Freedman
    Fox Chase Cancer Center, Cell and Developmental Biology Program, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Novartis Found Symp 283:207-16; discussion 216-9, 238-41. 2007
    ..The diversity of organogenic steps dependent upon endothelial cell signalling suggests that cross-regulation of tissue development with its vasculature is a general phenomenon...
  19. pmc Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm
    Paul Gadue
    Department of Pathology, Center for Cellular and Molecular Therapeutics Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Stem Cells 27:2103-13. 2009
    ....
  20. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
    ..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
  21. ncbi request reprint Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    Hideyuki Yoshitomi
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Development 131:807-17. 2004
    ..Additionally, we find that endothelial cells are necessary for the induction of both the insulin and glucagon genes...
  22. pmc Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
    Konstantin D Taganov
    Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:5848-55. 2004
    ..These distinct properties of integrases may also affect target site selection in vivo, resulting in an important bias against or in favor of integration into actively transcribed host DNA...
  23. ncbi request reprint miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    RNA Biol 1:106-13. 2004
    ..In summary, these studies followed the accumulation during development of miR-122 from its mRNA precursor, hcr, through to identification of what may be a specific mRNA target, CAT-1...
  24. pmc Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA
    Takashi Sekiya
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Dev 23:804-9. 2009
    ..FoxA's distinct nuclear mobility is consistent with its pioneer activity in chromatin...
  25. ncbi request reprint An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Dev Biol 290:189-99. 2006
    ....
  26. ncbi request reprint Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice
    Xi Lin
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:345-51. 2002
    ..We investigated the function of Pccmt during mouse liver development to better understand the embryonic lethality of the null mutation...
  27. pmc Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program
    Mounia Lagha
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 22:1828-37. 2008
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation...
  28. ncbi request reprint Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos
    Deanna Mohn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10128, USA
    Dev Dyn 226:446-59. 2003
    ....
  29. ncbi request reprint Liver development update: new embryo models, cell lineage control, and morphogenesis
    Frederic Lemaigre
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Curr Opin Genet Dev 14:582-90. 2004
    ....
  30. ncbi request reprint Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    Fereshteh Parviz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 34:292-6. 2003
    ..Most importantly, the morphogenetic parameters controlled by Hnf4alpha in hepatocytes are essential for normal liver architecture, including the organization of the sinusoidal endothelium...
  31. pmc The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure
    Isabel Cuesta
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid 28029, Spain
    Mol Cell Biol 27:7302-14. 2007
    ..The presented model extends the reported pioneer activity of the Forkhead factors to processes involved in hormone-induced differentiation...
  32. pmc Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression
    Peter O Wiebe
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA
    Mol Cell Biol 27:4093-104. 2007
    ..5 pancreatic buds. These data strongly suggest that PTF1 is an important early activator of Pdx1 in acinar and endocrine progenitor cells during pancreas development...
  33. pmc Stability and evolution of transcriptional regulatory networks
    Kenneth S Zaret
    Mol Syst Biol 2:2006.0021. 2006

Research Grants5

  1. Gene Regulatory Signals for Beta Cell Development
    Kenneth Zaret; Fiscal Year: 2007
    ..By sharing technology and information from our work with the BCBC, our basic developmental studies will be more rapidly translated to develop cures for diabetes ..
  2. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2007
    ..The findings will apply to diverse developmental contexts and adult pathologies, and enable rational approaches to differentiate proeenitor and stem cell populations for cell-based tissue therapies and research. ..
  3. Gene Regulatory Signals for Beta Cell Development
    Kenneth Zaret; Fiscal Year: 2007
    ..Bysharing technology and information from our work with the BCBC, our basic developmental studies will be more rapidly translated to develop cures for diabetes. ..