Anthony T Yeung

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
  2. pmc APC +/- alters colonic fibroblast proteome in FAP
    Bhavinkumar B Patel
    Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Oncotarget 2:197-208. 2011
  3. pmc Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers
    Kelly A Jones
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States
    J Proteome Res 12:4351-65. 2013
  4. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
  5. pmc Potential prognostic biomarkers of pancreatic cancer
    Kathryn T Chen
    From the Department of Surgical Oncology, Developmental Therapeutics, and Departments of Biostatistics, Pathology, and Gastroenterology, Fox Chase Cancer Center, Philadelphia, PA
    Pancreas 43:22-7. 2014
  6. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
  7. pmc Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics
    Bhavinkumar B Patel
    Developmental Therapeutics Program, Fox Chase Cancer Center, Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, United States
    J Proteome Res 11:5947-58. 2012
  8. pmc Isobaric labeling and data normalization without requiring protein quantitation
    Phillip D Kim
    Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Biomol Tech 23:11-23. 2012
  9. ncbi request reprint Analyzing alkaline proteins in human colon crypt proteome
    Xin ming Li
    Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 3:821-33. 2004
  10. ncbi request reprint Enzymatic mutation detection technologies
    Anthony T Yeung
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Biotechniques 38:749-58. 2005

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  2. pmc APC +/- alters colonic fibroblast proteome in FAP
    Bhavinkumar B Patel
    Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Oncotarget 2:197-208. 2011
    ..The results indicate that heterozygosity for a mutant APC tumor suppressor gene alters the proteomes of both colon-derived normal fibroblasts in a gene-specific manner, consistent with a "one-hit" effect...
  3. pmc Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers
    Kelly A Jones
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States
    J Proteome Res 12:4351-65. 2013
    ....
  4. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  5. pmc Potential prognostic biomarkers of pancreatic cancer
    Kathryn T Chen
    From the Department of Surgical Oncology, Developmental Therapeutics, and Departments of Biostatistics, Pathology, and Gastroenterology, Fox Chase Cancer Center, Philadelphia, PA
    Pancreas 43:22-7. 2014
    ..We evaluated whether pancreatic main duct fluid can provide protein biomarkers with prognostic value...
  6. pmc Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
    Alfonso Bellacosa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Prev Res (Phila) 3:48-61. 2010
    ....
  7. pmc Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics
    Bhavinkumar B Patel
    Developmental Therapeutics Program, Fox Chase Cancer Center, Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, United States
    J Proteome Res 11:5947-58. 2012
    ..However, the more profound immunodepletion achieved with the IgY14+SuperMix may lead to false-positive fold-changes between comparison groups if the reproducibility and efficiency of the depletion of a given protein are not considered...
  8. pmc Isobaric labeling and data normalization without requiring protein quantitation
    Phillip D Kim
    Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Biomol Tech 23:11-23. 2012
    ..To complement this ability to analyze minute samples, we report an optimized iTRAQ labeling protocol for using 5 μg protein as the starting material...
  9. ncbi request reprint Analyzing alkaline proteins in human colon crypt proteome
    Xin ming Li
    Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 3:821-33. 2004
    ..Application of this protocol to the analysis of normal and neoplastic colon crypts will contribute to the proteomic study of colorectal tumorigenesis since a significant portion of the human proteins is in basic pH range...
  10. ncbi request reprint Enzymatic mutation detection technologies
    Anthony T Yeung
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Biotechniques 38:749-58. 2005
    ..Further developments of this and other methods will allow mutation detection to become an integral component of individualized medicine...
  11. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  12. ncbi request reprint Evaluation of dual-labeled fluorescent DNA probe purity versus performance in real-time PCR
    Anthony T Yeung
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Biotechniques 36:266-70, 272, 274-5. 2004
    ..We found that probes that were at least 20% pure had the same efficiency as those near 100% purity, but the sensitivity of the assay was reduced as the level of purity decreased...
  13. ncbi request reprint Molecular mechanisms of action of imatinib mesylate in human ovarian cancer: a proteomic analysis
    Bhavinkumar B Patel
    Division of Basic Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111 2497, USA
    Cancer Genomics Proteomics 5:137-49. 2008
    ..However, there is limited pre-clinical and clinical data on the molecular targets and action of imatinib in ovarian cancer...
  14. pmc Proteomic analyses of pancreatic cyst fluids
    Eileen Ke
    From the Divisions of Basic Science, daggerMedical Science, and double daggerPopulation Science, Fox Chase Cancer Center, Philadelphia, PA
    Pancreas 38:e33-42. 2009
    ..Proteomic analyses were performed to explore pancreatic cyst fluids to yield effective diagnostic biomarkers...
  15. pmc Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection
    Maxim Pimkin
    Basic Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    BMC Biotechnol 7:29. 2007
    ..Previously, CEL I-like activities were described only in a variety of plants and could not be expressed in an active form in bacteria...
  16. ncbi request reprint Characterization of a periplasmic S1-like nuclease coded by the Mesorhizobium loti symbiosis island
    Maxim Pimkin
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Biochem Biophys Res Commun 343:77-84. 2006
    ..The ability of M1 to degrade RNA at neutral pH implies previously unappreciated roles of these nucleases in biological systems...
  17. ncbi request reprint Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines
    Muthu Selvakumaran
    Ovarian Cancer Program, Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 63:1311-6. 2003
    ..These data suggest that it is possible to substantially enhance the cisplatin cytotoxicity by disturbing the NER pathway in cisplatin-resistant cell lines and to enhance the survival capacity of mice in an ovarian cancer xenograft model...
  18. ncbi request reprint Use of fluorescent DNA-intercalating dyes in the analysis of DNA via ion-pair reversed-phase denaturing high-performance liquid chromatography
    Ahmad R Bahrami
    Department of Molecular Biology, The Transgenomic Research Laboratory, Krebs Institute, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Anal Biochem 309:248-52. 2002
    ..Moreover the incorporation of SYBR Green 1 into samples and elution buffers does not impair resolution and has no significant effect on the retention times of DNA fragments compared with dye-free DHPLC...

Research Grants3

  1. Proteomic Biomarkers in Pancreatic Cyst Fluids
    Anthony Yeung; Fiscal Year: 2006
    ..abstract_text> ..
  2. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2006
    ..The Min mouse model genetically mimics humans for colon cancer. The proposed work will demonstrate whether it is a perfect model for the human disease. ..
  3. Proteomic Validation of the Min Mouse Model of Colon Cancer
    Anthony Yeung; Fiscal Year: 2007
    ..The Min mouse model genetically mimics humans for colon cancer. The proposed work will demonstrate whether it is a perfect model for the human disease. ..