H Yan

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. ncbi The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication
    S Liao
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Dev 14:2570-5. 2000
  2. ncbi Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex
    Hong Yan
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Biophys J 85:3248-54. 2003
  3. ncbi Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy
    Bin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
    J Ocul Pharmacol Ther 21:107-13. 2005
  4. ncbi Replication focus-forming activity 1 and the Werner syndrome gene product
    H Yan
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Genet 19:375-8. 1998
  5. ncbi Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair
    Hong Yan
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 171:217-27. 2005
  6. ncbi Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repair
    Hong Yan
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 192:251-61. 2011
  7. ncbi Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein
    C Y Chen
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Biol 152:985-96. 2001
  8. ncbi Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
    Shuren Liao
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nucleic Acids Res 36:6091-100. 2008
  9. ncbi Biochemical reconstitution of abasic DNA lesion replication in Xenopus extracts
    Shuren Liao
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nucleic Acids Res 35:5422-9. 2007
  10. ncbi Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis
    Ruzaliya Fazlieva
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nucleic Acids Res 37:2854-66. 2009

Collaborators

Detail Information

Publications13

  1. ncbi The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication
    S Liao
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Dev 14:2570-5. 2000
    ..These results provide the first direct evidence that BLM plays an important role in DNA replication, suggesting that Bloom's syndrome may be the consequence of defective DNA replication...
  2. ncbi Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex
    Hong Yan
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Biophys J 85:3248-54. 2003
    ..The data indicate that even though the substitutions are located on a dynamic wing outside the hydrophobic core sequences, they still globally influence biophysical properties of DNA-free Genesis and its DNA complex...
  3. ncbi Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy
    Bin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
    J Ocul Pharmacol Ther 21:107-13. 2005
    ....
  4. ncbi Replication focus-forming activity 1 and the Werner syndrome gene product
    H Yan
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Genet 19:375-8. 1998
    ..Here we report that FFA-1 has DNA-helicase activity. Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated with premature ageing in humans...
  5. ncbi Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair
    Hong Yan
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 171:217-27. 2005
    ..The assay for single-strand annealing that was developed in this study also provides a powerful biochemical system for mechanistic analysis of homology-dependent DSB repair...
  6. ncbi Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repair
    Hong Yan
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 192:251-61. 2011
    ..These results provide strong biochemical evidence to link RPA to a specific DSB repair pathway and reveal a novel function of RPA in the generation of 3' ss-DNA for homology-dependent DSB repair...
  7. ncbi Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein
    C Y Chen
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Cell Biol 152:985-96. 2001
    ..However, in the presence of the dominant negative mutant proteins, the stimulation is prevented. These results provide the first direct biochemical evidence of an important role for FFA-1 in DNA replication...
  8. ncbi Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
    Shuren Liao
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nucleic Acids Res 36:6091-100. 2008
    ..These results provide strong evidence that xDNA2 is a major nuclease for the resection of DNA ends for homology-dependent DSB repair in eukaryotes...
  9. ncbi Biochemical reconstitution of abasic DNA lesion replication in Xenopus extracts
    Shuren Liao
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nucleic Acids Res 35:5422-9. 2007
    ..It has provided the first direct evidence for the existence of an error-free lesion replication mechanism and also demonstrated that the error-prone mechanism is a major contributor to lesion replication...
  10. ncbi Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis
    Ruzaliya Fazlieva
    Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nucleic Acids Res 37:2854-66. 2009
    ..These results indicate that the exonuclease activity of human Pol delta modulates its intrinsic bypass efficiency on the damaged template, but does not affect the choice of nucleotide to be inserted...
  11. ncbi Mechanistic analysis of a DNA end processing pathway mediated by the Xenopus Werner syndrome protein
    Thomas Toczylowski
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 281:33198-205. 2006
    ....
  12. ncbi Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA
    Wanyun Sheng
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 279:33928-36. 2004
    ..The structure implies that this sequence has to undergo structural changes when it interacts with CREB-binding protein...
  13. ncbi OMWSA: detection of DNA repeats using moving window spectral analysis
    Liping Du
    Department of Electronic Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
    Bioinformatics 23:631-3. 2007
    ..AVAILABILITY: Available on http://www.hy8.com/~tec/sw01/omwsa01.zip. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...