Joseph R Testa

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
  2. ncbi request reprint AKT signaling in normal and malignant cells
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:7391-3. 2005
  3. pmc Germline BAP1 mutations predispose to malignant mesothelioma
    Joseph R Testa
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Nat Genet 43:1022-5. 2011
  4. ncbi request reprint Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 24:6080-9. 2005
  5. ncbi request reprint Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    Hui Qin Wang
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Oncogene 24:3574-82. 2005
  6. pmc GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt
    Deborah A Altomare
    Women s Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 16:486-96. 2010
  7. pmc Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:9197-206. 2010
  8. pmc Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
    Roman A Timakhov
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genes Chromosomes Cancer 48:786-94. 2009
  9. pmc The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    Guang Hui Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 25:2384-94. 2005
  10. pmc DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC
    Jinfei Xu
    Cancer Signaling and Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 284:20593-601. 2009

Collaborators

Detail Information

Publications68

  1. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  2. ncbi request reprint AKT signaling in normal and malignant cells
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:7391-3. 2005
    ..Additional articles discuss current approaches to identify selective inhibitors of the AKT pathway...
  3. pmc Germline BAP1 mutations predispose to malignant mesothelioma
    Joseph R Testa
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Nat Genet 43:1022-5. 2011
    ..We hypothesize that other cancers may also be involved and that mesothelioma predominates upon asbestos exposure. These findings will help to identify individuals at high risk of mesothelioma who could be targeted for early intervention...
  4. ncbi request reprint Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 24:6080-9. 2005
    ..These findings also suggest that mouse models of MM may be useful for future preclinical studies of pharmaceuticals targeting the PI3K/AKT pathway...
  5. ncbi request reprint Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    Hui Qin Wang
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Oncogene 24:3574-82. 2005
    ..Collectively, our findings are consistent with a working model in which AKT activation regulates FAS expression, at least in part, whereas FAS activity modulates AKT activation...
  6. pmc GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt
    Deborah A Altomare
    Women s Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 16:486-96. 2010
    ..The broad long-term objective of this project was to use preclinical cancer models with precisely defined genetic lesions to elucidate the efficacy of targeting Akt with GSK690693...
  7. pmc Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 70:9197-206. 2010
    ..In addition, DLX5 was found to cooperate with HRAS in the transformation of human ovarian surface epithelial cells. Together, these data suggest that DLX5 plays a significant role in the pathogenesis of some ovarian cancers...
  8. pmc Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
    Roman A Timakhov
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genes Chromosomes Cancer 48:786-94. 2009
    ..These findings suggest that activation of the Akt pathway can act as the initial hit to promote cell survival and genomic instability, whereas the acquisition of T-cell-specific overexpression of Dlx5 or Myc leads to lymphomagenesis...
  9. pmc The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    Guang Hui Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 25:2384-94. 2005
    ....
  10. pmc DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC
    Jinfei Xu
    Cancer Signaling and Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 284:20593-601. 2009
    ..Because DLX5 has a restricted pattern of expression in adult tissues, it may serve as a potential therapeutic target for the treatment of cancers that overexpress DLX5...
  11. pmc Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
    Deborah A Altomare
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18828. 2011
    ..Furthermore, while inactivation of Arf appears to be crucial for MM pathogenesis, the inactivation of both p16(Ink4a) and p19(Arf) cooperate to accelerate asbestos-induced tumorigenesis...
  12. ncbi request reprint RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
    Seiji Mabuchi
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 13:4261-70. 2007
    ..We examined whether mTOR inhibition by RAD001 (everolimus) is therapeutically efficacious in the treatment of ovarian cancer as a single agent and in combination with cisplatin...
  13. pmc Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent
    Deborah A Altomare
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    BMC Cancer 10:34. 2010
    ..However, there may be additional or alternative mechanism(s) of action...
  14. doi request reprint Further evidence for germline BAP1 mutations predisposing to melanoma and malignant mesothelioma
    Mitchell Cheung
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Genet 206:206-10. 2013
    ..In addition, a review of BAP1 cancer syndrome families reported to date indicates that the location of the BAP1 mutation does not have any bearing on the spectrum of cancer types observed, either for mesothelial or melanocytic tumors...
  15. pmc Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genesis 48:531-9. 2010
    ..Collectively, our findings indicate that Appl1 is dispensable for Akt signaling in vivo and T-cell differentiation...
  16. pmc Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 106:3420-5. 2009
    ....
  17. ncbi request reprint AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    Deborah A Altomare
    Human Genetics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 23:5853-7. 2004
    ..Collectively, these findings indicate that active AKT and downstream mTOR represent potentially important therapeutic and/or chemopreventive targets in ovarian cancer...
  18. ncbi request reprint A mouse model recapitulating molecular features of human mesothelioma
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8090-5. 2005
    ....
  19. ncbi request reprint Renal oncocytoma with loss of chromosomes Y and 1 evolving to papillary carcinoma in connection with gain of chromosome 7. Coincidence or progression?
    Tahseen Al-Saleem
    Department of Pathology, Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Genet Cytogenet 163:81-5. 2005
    ..Conventional cytogenetics and FISH demonstrated loss of chromosomes Y and 1 and gains of chromosome 7. We postulate that the PRCC represents a neoplastic progression by the gain of chromosome 7 oncocytoma with -Y and -1...
  20. ncbi request reprint RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
    Seiji Mabuchi
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 67:2408-13. 2007
    ....
  21. pmc Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
    Yinfei Tan
    Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 285:6377-89. 2010
    ..Our studies suggest that Appl1 is dispensable for development and only participate in Akt signaling under certain conditions...
  22. ncbi request reprint Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer
    Ahmad L Subhi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Clin Cancer Res 10:7290-6. 2004
    ..Ornithine decarboxylase is a key enzyme in the regulation of polyamine metabolism. The aim of this study is to analyze MTAP and ornithine decarboxylase (ODC) expression in primary pancreatic tumor specimens...
  23. pmc High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors
    Martin G Belinsky
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Genes Chromosomes Cancer 48:886-96. 2009
    ..These results suggest that GISTs without activating kinase mutations, whether pediatric or adult, generally exhibit a much lower level of cytogenetic progression than that observed in mutant GISTs...
  24. ncbi request reprint Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions
    Binaifer R Balsara
    Cancer Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Carcinogenesis 25:2053-9. 2004
    ..Thus, AKT represents a potentially important target for chemoprevention in individuals at high risk of NSCLC...
  25. ncbi request reprint Perturbations of the AKT signaling pathway in human cancer
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:7455-64. 2005
    ..We also review various pathogenic mechanisms contributing to activation of the AKT pathway in human malignancy as well as current pharmacologic strategies to target therapeutically components of this pathway...
  26. doi request reprint A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice
    Yinfei Tan
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 68:1296-302. 2008
    ..In addition, DLX5, but not DLX6, was found to be abundantly expressed in three of seven human T-cell lymphomas tested. These findings suggest that the Dlx5 can act as an oncogene by cooperating with Akt2 to promote lymphomagenesis...
  27. pmc Combined classical cytogenetics and microarray-based genomic copy number analysis reveal frequent 3;5 rearrangements in clear cell renal cell carcinoma
    Jianming Pei
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genes Chromosomes Cancer 49:610-9. 2010
    ..These findings also suggest that the 5q duplication/3p deficiency resulting from unbalanced 3;5 translocations conveys a proliferative advantage of particular importance in ccRCC tumorigenesis...
  28. pmc Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors
    Chi Tarn
    Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 105:8387-92. 2008
    ....
  29. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  30. ncbi request reprint A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
    Alfonso Bellacosa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 3:268-75. 2004
    ....
  31. ncbi request reprint Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant
    Zachary Piotrowski
    Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Can J Urol 17:5309-12. 2010
    ..A case of the rare, benign, Wilms' tumor (WT) variant, metanephric adenofibroma (MAF), is presented...
  32. ncbi request reprint High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays
    Jianming Pei
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Genet Cytogenet 170:65-8. 2006
    ..These findings demonstrate the utility of SNP-based mapping arrays for high-resolution analysis of genomic imbalances in cancer cells...
  33. pmc Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells
    Baiqing Tang
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 13:1082-90. 2012
    ..Taken together, our data suggest that the addition of MTA to anti-purine-based chemotherapy may greatly increase the therapeutic index of this class of drugs if used specifically to treat MTAP (-) tumors...
  34. pmc FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis
    Craig W Menges
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell Cycle 8:2528-34. 2009
    ..Here, we highlight FAF1's role in NFkappaB signaling and postulate that this pathway has critical connotations for the pathogenesis and treatment of human cancers...
  35. pmc Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways
    Craig W Menges
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cancer Res 10:1178-88. 2012
    ..Collectively, these data suggest that pharmacologic inhibition of group I PAKs may have therapeutic efficacy in tumors characterized by PAK activation...
  36. ncbi request reprint Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype
    Sinoula Apostolou
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Oncogene 23:5032-40. 2004
    ....
  37. ncbi request reprint Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Am J Respir Crit Care Med 167:976-82. 2003
    ..In addition, the patient had no evidence of a renal angiomyolipoma at autopsy and therefore demonstrated for the first time that somatic TSC2 mutations cause LAM in patients without angiomyolipomas...
  38. pmc p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance
    Zaineb R Abdul Razak
    Department of Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Cell Biol 24:5967-77. 2004
    ..We propose that p53 causes transactivation-independent growth inhibition of ALT cells by perturbing telomeric recombination...
  39. pmc Diverse mechanisms of AKT pathway activation in human malignancy
    Mitchell Cheung
    Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Curr Cancer Drug Targets 13:234-44. 2013
    ..In addition, we review recent literature documenting the various ways the AKT signaling pathway is activated in human cancers and consequences for molecularly targeted therapies...
  40. pmc NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA
    Mol Cancer Ther 12:1568-78. 2013
    ..When taken together with the observation that NF-κB signaling is elevated in RCCs, these results provide rationale for the combined use of IFN-γ and bortezomib in the treatment of metastatic RCCs...
  41. pmc Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
    Shuyun Rao
    Blood Cell Development and Cancer Keystone, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Blood 120:3764-73. 2012
    ..Our finding that Rpl22 inactivation promotes transformation by inducing expression of Lin28B provides the first insight into the mechanistic basis by which mutations in Rpl22, and perhaps some other RP genes, increases cancer risk...
  42. ncbi request reprint Chromosome 17p13.2 transfer reverts transformation phenotypes and Fas-mediated apoptosis in breast epithelial cells
    Mohamed H Lareef
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Mol Carcinog 39:234-46. 2004
    ....
  43. ncbi request reprint The genetics of renal oncocytosis: a possible model for neoplastic progression
    Tahseen Al-Saleem
    Department of Pathology, Medical Science Division, Human Genetics Program, Populations Sciences Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Cancer Genet Cytogenet 152:23-8. 2004
    ..To our knowledge, this is the first report of the genetic and cytogenetic findings in oncocytosis not related to BDH syndrome and may suggest a possible model of progression from oncocytoma to chromophobe renal cell carcinoma...
  44. ncbi request reprint Chromosomal imbalances in human lung cancer
    Binaifer R Balsara
    Human Genetics Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Oncogene 21:6877-83. 2002
    ..The molecular implications of consistent chromosome imbalances found in lung cancer to date are also discussed...
  45. ncbi request reprint Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly
    Jianquan Li
    Basic Science Division and Population Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 282:27086-99. 2007
    ..The results demonstrate that the C-terminal domain of NHERF functions as an intramolecular switch that regulates the binding capability of PDZ2, and thus controls the stoichiometry of NHERF to assemble protein complexes...
  46. ncbi request reprint Tumor suppressor genes and the two-hit model of recessive oncogenesis: celebrating Alfred Knudson's 80th birthday
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:286-7. 2003
  47. pmc Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome
    Jia Huang
    Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genes Chromosomes Cancer 50:606-18. 2011
    ..Both mutation as well as copy number changes can be used as predictive markers for this purpose...
  48. ncbi request reprint NF2: the wizardry of merlin
    Guang Hui Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania
    Genes Chromosomes Cancer 38:389-99. 2003
    ..In this review, we summarize the involvement of NF2 inactivation in tumorigenesis. We also discuss observations implicating merlin in cell motility and cell proliferation, with a focus on recent findings linking merlin to Rac signaling...
  49. ncbi request reprint Frequent activation of AKT2 kinase in human pancreatic carcinomas
    Deborah A Altomare
    Human Genetic Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 87:470-6. 2002
    ..Overall, these data suggest that upstream perturbations of the PI3K/AKT pathway contribute to frequent activation of AKT2 in pancreatic cancer, which may contribute to the pathogenesis of this highly aggressive form of human malignancy...
  50. ncbi request reprint Comparative genomic hybridization analysis
    Binaifer R Balsara
    Human Genetics Program, Division of Population Sciences, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Med 68:45-57. 2002
  51. ncbi request reprint p21-activated kinase links Rac/Cdc42 signaling to merlin
    Guang Hui Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 277:883-6. 2002
    ..These biochemical investigations provide insights into the regulation of merlin function and establish a framework for elucidating tumorigenic mechanisms involved in neoplasms associated with merlin inactivation...
  52. ncbi request reprint AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
    Sarah S Bacus
    Ventana Medical Systems, Inc QDL, 610 Oakmont Lane, Westmont, Illinois, IL 60559, USA
    Oncogene 21:3532-40. 2002
    ..These observations suggest that AKT signaling augments resistance to stress-induced apoptosis in breast cancer cells overexpressing HER-2/neu...
  53. ncbi request reprint ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival
    Zeng Qiang Yuan
    Department of Pathology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 280:21483-90. 2005
    ..These data indicate that ArgBP2gamma is a physiological substrate of Akt, functions as an adaptor for Akt and PAK1, and plays a role in Akt/PAK1 cell survival pathway...
  54. pmc TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
    Haining Yang
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:10397-402. 2006
    ....
  55. ncbi request reprint Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance
    Satoshi Tanno
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    Cancer Res 64:3486-90. 2004
    ....
  56. ncbi request reprint The pathogenesis of mesothelioma
    Michele Carbone
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, USA
    Semin Oncol 29:2-17. 2002
    ..Mesothelioma appears to have a complex etiology in which environmental carcinogens (asbestos and erionite), ionizing radiation, viruses, and genetic factors act alone or in concert to cause malignancy...
  57. ncbi request reprint Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts
    Satoru Sumitani
    Department of Molecular Medicine, Osaka University Graduate School of Medicine C 4, Suita, Osaka 565 0871, Japan
    Endocrinology 143:820-8. 2002
    ..PI3K activity, but not mTOR, may regulate transcriptional activity of myogenin. Our data also suggest that Akt1 and Akt2 play distinct roles in myogenic differentiation...
  58. ncbi request reprint SV40 infection induces telomerase activity in human mesothelial cells
    Rudy Foddis
    Cancer Immunology Program, Department of Pathology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, IL 60153, USA
    Oncogene 21:1434-42. 2002
    ..Induction of telomerase activity by SV40 may be related to the very high rate of mesothelial cell immortalization that is characteristically associated with SV40 infection of mesothelial cells...
  59. ncbi request reprint Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation
    Brian Park
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:45361-70. 2002
    ..These results support the concept that the recently identified alpha-catulin protein may modulate Rho pathway signaling in vivo by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor...
  60. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  61. pmc Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation
    Bangdong L Wei
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Virol 79:14976-80. 2005
    ..The finding that Nef induces phosphorylation of the key signaling molecule merlin suggests several possible roles for PAK2 activation in HIV pathogenesis...
  62. ncbi request reprint SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure
    Paola Cacciotti
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, Novara, Italy
    Cancer Res 65:5256-62. 2005
    ....
  63. pmc HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway
    Maria E Ramos-Nino
    University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF 216, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:209-17. 2008
    ..Data suggest that HGF-induced effects in some MM cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway that might explain tumor-specific effects of c-Met inhibitors on MM and other tumors...
  64. ncbi request reprint Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms
    Jay E Johnson
    Department of Laboratory Oncology Research, Curtis and Elizabeth Anderson Cancer Institute, Memorial Health University Medical Center, Savannah, Georgia 31404, USA
    Cancer Res 67:9221-8. 2007
    ..3-q21.2. Taken together, these studies provide insight into the molecular pathways involved in the regulation of ALT and reveal several loci that might be exploited either as prognostic markers or targets of chemotherapeutic intervention...
  65. ncbi request reprint Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Osaka, Japan
    Clin Cancer Res 10:7645-54. 2004
    ....
  66. ncbi request reprint Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling
    Cheryl A Nechamen
    Wadsworth Center, David Axelrod Institute for Public Health, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Biol Reprod 71:629-36. 2004
    ....
  67. ncbi request reprint A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor
    Yumiko Hirokawa
    Ludwig Institute for Cancer Research, Melbourne, Australia
    Cancer J 10:20-6. 2004
    ..NF2 can inhibit Ras-induced malignant transformation. However, the primary (signaling) target of NF2 in the oncogenic pathway has not been previously identified...
  68. pmc Cellular and molecular parameters of mesothelioma
    Maria E Ramos-Nino
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 98:723-34. 2006
    ..These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors...