John Taylor

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Interferon impedes an early step of hepatitis delta virus infection
    Ziying Han
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22415. 2011
  2. ncbi request reprint Hepatitis delta virus
    John M Taylor
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Virology 344:71-6. 2006
  3. pmc Origin of hepatitis delta virus
    John Taylor
    Fox Chase Cancer Center, PA 19111, USA
    Future Microbiol 5:393-402. 2010
  4. ncbi request reprint Structure and replication of hepatitis delta virus RNA
    J M Taylor
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Curr Top Microbiol Immunol 307:1-23. 2006
  5. pmc Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus
    John M Taylor
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e15784. 2010
  6. pmc Properties of subviral particles of hepatitis B virus
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7812-7. 2008
  7. pmc Transcription of hepatitis delta virus RNA by RNA polymerase II
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:1118-27. 2008
  8. pmc Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7276-83. 2008
  9. pmc Assembly of hepatitis B virus envelope proteins onto a lentivirus pseudotype that infects primary human hepatocytes
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 81:10897-904. 2007
  10. pmc Assembly of hepatitis delta virus: particle characterization, including the ability to infect primary human hepatocytes
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 81:3608-17. 2007

Collaborators

Detail Information

Publications32

  1. pmc Interferon impedes an early step of hepatitis delta virus infection
    Ziying Han
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22415. 2011
    ..Thus in vivo, the success of long-term interferon therapy for chronic HDV, may likewise involve blocking HDV spread by interfering with the initiation of productive infection of naïve hepatocytes...
  2. ncbi request reprint Hepatitis delta virus
    John M Taylor
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Virology 344:71-6. 2006
    ..It starts with a brief overview of HDV and its replication, notes some of the major unresolved questions, and directs the interested reader to more detailed reviews...
  3. pmc Origin of hepatitis delta virus
    John Taylor
    Fox Chase Cancer Center, PA 19111, USA
    Future Microbiol 5:393-402. 2010
    ....
  4. ncbi request reprint Structure and replication of hepatitis delta virus RNA
    J M Taylor
    Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Curr Top Microbiol Immunol 307:1-23. 2006
    ..One theme of this review is that such models, even after some revision, deceptively simplify the complexity of HDV replication and can fail to make clear major questions yet to be solved...
  5. pmc Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus
    John M Taylor
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e15784. 2010
    ..Furthermore, since P2X7 activation is known to be a major component of inflammatory responses, it is proposed that HDV and HBV attachment to susceptible cells, might also contribute to inflammation in the liver, that is, hepatitis...
  6. pmc Properties of subviral particles of hepatitis B virus
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7812-7. 2008
    ..However, unlike soluble forms of HBV envelope protein that were potent inhibitors, the SVP did not inhibit the ability of HBV and HDV to infect primary human hepatocytes...
  7. pmc Transcription of hepatitis delta virus RNA by RNA polymerase II
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:1118-27. 2008
    ..Findings include evidence that HDV replication is somehow able to direct the available delta antigen to sites in the nucleoplasm, almost exclusively colocalized with Pol II in what others have described as transcription factories...
  8. pmc Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7276-83. 2008
    ..One interpretation of these data is that host range specificity of HDV is determined entirely by pre-S1 and that the WHV and HBV pre-S1 proteins recognize different receptors on PHH...
  9. pmc Assembly of hepatitis B virus envelope proteins onto a lentivirus pseudotype that infects primary human hepatocytes
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 81:10897-904. 2007
    ..These findings of specific and efficient infection of hepatocytes could be applicable to liver-specific gene therapy and may help clarify the attachment and entry mechanism used by HBV and HDV...
  10. pmc Assembly of hepatitis delta virus: particle characterization, including the ability to infect primary human hepatocytes
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 81:3608-17. 2007
    ..2 GE/cell. In the future, this HDV assembly and infection system can be further developed to better understand the mechanisms shared by HBV and HDV for attachment and entry into host cells...
  11. pmc Parameters of human hepatitis delta virus genome replication: the quantity, quality, and intracellular distribution of viral proteins and RNA
    Severin Gudima
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 76:3709-19. 2002
    ....
  12. pmc Intracellular localization of hepatitis delta virus proteins in the presence and absence of viral RNA accumulation
    Ziying Han
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 83:6457-63. 2009
    ..These studies provide evidence that deltaAg does not interact directly with either Pol II or nucleolin and that forms of deltaAg which support replication are also capable of prior nucleolar transit...
  13. pmc Action of inhibitors on accumulation of processed hepatitis delta virus RNAs
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 80:3205-14. 2006
    ....
  14. pmc Two potentially important elements of the hepatitis B virus large envelope protein are dispensable for the infectivity of hepatitis delta virus
    Severin Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA, and Department of Virology, University of Gottingen, Germany
    J Virol 81:4343-7. 2007
    ..Thus, these two regions are not necessary for HDV infectivity and, by inference, are not needed for HBV attachment and entry into susceptible cells...
  15. pmc Immunoadhesins containing pre-S domains of hepatitis B virus large envelope protein are secreted and inhibit virus infection
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 81:4912-8. 2007
    ..These IA have potential to be part of antiviral therapies against chronic HDV and HBV, and may help understand the attachment and entry mechanisms used by these important human pathogens...
  16. pmc Intrinsic disorder and oligomerization of the hepatitis delta virus antigen
    Carolina Alves
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Virology 407:333-40. 2010
    ..Oligomers of purified δAg were resistant to elevated NaCl and urea concentrations, and bound without specificity to RNA and single- and double-stranded DNAs...
  17. doi request reprint Chapter 3. Replication of the hepatitis delta virus RNA genome
    John M Taylor
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Adv Virus Res 74:103-21. 2009
    ..This chapter is concerned with recent developments in our understanding of the genome replication process...
  18. pmc Evolution of hepatitis delta virus RNA genome following long-term replication in cell culture
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111 2497
    J Virol 79:13310-6. 2005
    ..A model is provided to explain how, in this experimental system, the observed single-nucleotide changes were essentially neutral in terms of their effect on the ability of the HDV genome to carry out continued rounds of replication...
  19. pmc Resistance of human hepatitis delta virus RNAs to dicer activity
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 77:11910-7. 2003
    ..Apparently, for unit-length RNAs of HDV, PSTVd, and ASBVd, it is the extended structure with <100% base pairing that confers significant resistance to dicer action...
  20. ncbi request reprint Replication of human hepatitis delta virus: recent developments
    John M Taylor
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111 2497, USA
    Trends Microbiol 11:185-90. 2003
    ..This mini-review focuses on advances gained over the last 2-3 years, together with an evaluation of HDV questions that are either unsolved or not yet solved satisfactorily...
  21. pmc Reconstitution in cultured cells of replicating HDV RNA from pairs of less than full-length RNAs
    Severin O Gudima
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    RNA 11:90-8. 2005
    ....
  22. pmc In vivo RNA-directed transcription, with template switching, by a mammalian RNA polymerase
    Jinhong Chang
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111 2497, USA
    EMBO J 21:157-64. 2002
    ..Thus, in an in vivo situation, polymerase II has several important capabilities in addition to what is considered typical DNA-directed transcription...
  23. pmc Susceptibility of human hepatitis delta virus RNAs to small interfering RNA action
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 77:9728-31. 2003
    ..In terms of replicating HDV RNAs, it is considered more likely that the genomic and antigenomic RNAs are resistant because their location within the nucleus makes them inaccessible to siRNA-mediated degradation...
  24. pmc Alternative processing of hepatitis delta virus antigenomic RNA transcripts
    Xingcao Nie
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 78:4517-24. 2004
    ..The findings from the two experimental approaches led to significant modifications in the rolling-circle model of HDV genome replication...
  25. pmc Development of a novel system to study hepatitis delta virus genome replication
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 79:8182-8. 2005
    ..These findings and those of other studies that are under way demonstrate the potential applications of this experimental system...
  26. pmc Restoration in vivo of defective hepatitis delta virus RNA genomes
    Severin O Gudima
    Fox Chase Cancer Center, Philadephia, Pennsylvania 19111, USA
    RNA 12:1061-73. 2006
    ....
  27. pmc Features affecting the ability of hepatitis delta virus RNAs to initiate RNA-directed RNA synthesis
    Severin O Gudima
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111 2497, USA
    J Virol 78:5737-44. 2004
    ..In addition, the results from the two experimental strategies provided information on the impact of template switching during RNA-directed transcription...
  28. ncbi request reprint Hepatitis delta virus transfection for the mouse in vivo model
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Med 96:343-49. 2004
  29. ncbi request reprint Therapy for HDV!
    John M Taylor
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Hepatology 38:1581-2. 2003
  30. pmc Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells
    Jinhong Chang
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    J Virol 82:8215-23. 2008
    ..Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells...
  31. ncbi request reprint Small-interfering RNAs in the radar of the interferon system
    Eric G Moss
    Nat Cell Biol 5:771-2. 2003
  32. ncbi request reprint Near death experiences: poxvirus regulation of apoptotic death
    John M Taylor
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Virology 344:139-50. 2006
    ..This review describes the numerous mechanisms by which poxviruses inhibit apoptosis thereby modulating life and death of the cell...