Luis Sigal

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
    Ren Huan Xu
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center FCCC, Philadelphia, PA 19111, USA
    J Exp Med 205:981-92. 2008
  2. pmc Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response
    Ren Huan Xu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000768. 2010
  3. pmc Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    Min Fang
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 207:2369-81. 2010
  4. pmc Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
    Ren Huan Xu
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 8:e1002475. 2012
  5. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011
  6. doi request reprint Studying NK cell responses to ectromelia virus infections in mice
    Min Fang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:411-28. 2010

Collaborators

  • J Charles Whitbeck
  • Antonio Alcami
  • Sanda Remakus
  • Ren Huan Xu
  • Min Fang
  • Felicia Roscoe
  • Tracy E Krouse
  • Inger K Damon
  • Daniel Rubio
  • Mary Ellen Truckenmiller
  • Paul N Hudson
  • Christopher C Norbury
  • Xueying Ma
  • Yong Tang
  • Eric Lazear
  • Gary H Cohen
  • Roselyn J Eisenberg
  • Matthew Cohen

Detail Information

Publications6

  1. pmc The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
    Ren Huan Xu
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center FCCC, Philadelphia, PA 19111, USA
    J Exp Med 205:981-92. 2008
    ....
  2. pmc Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response
    Ren Huan Xu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000768. 2010
    ..These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines...
  3. pmc Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    Min Fang
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 207:2369-81. 2010
    ....
  4. pmc Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
    Ren Huan Xu
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 8:e1002475. 2012
    ..Thus, our findings provide insights on how T1-IFNs function and are evaded during a viral infection in vivo, and unveil a novel mechanism for antibody-mediated antiviral therapy...
  5. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011
    ..Thus, our work shows that CD8(+) T cell immunodominance during VACV infection is not affected by the effects of IFN-γ on the antigen presentation machinery...
  6. doi request reprint Studying NK cell responses to ectromelia virus infections in mice
    Min Fang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:411-28. 2010
    ....

Research Grants20

  1. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2001
    ....
  2. MHC Class I Antigen Presentation in Viral Infections
    Luis Sigal; Fiscal Year: 2009
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  3. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2009
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  4. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  5. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  6. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  7. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  8. Mousepox in Aged Mice
    Luis Sigal; Fiscal Year: 2007
    ..Furthermore, we intend to find new methods to manipulate the immune response to restore resistance and improve vaccine efficacy in aged mice as a first approach to improve vaccine efficacy in elderly people. ..
  9. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2002
    ....
  10. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2003
    ....
  11. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2004
    ....
  12. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2005
    ....
  13. Identification of Genes Involved in Cross-Presentation
    Luis Sigal; Fiscal Year: 2005
    ..In Aim 2, we will use small interfering RNA and retroviral vectors to silence or express those genes and test in a functional assay whether they are involved in cross presentation. ..
  14. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2006
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  15. MHC Class I Antigen Presentation in Viral Infections
    Luis Sigal; Fiscal Year: 2007
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  16. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2007
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  17. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..