Luis Sigal

..Thus, our work shows that CD8(+) T cell immunodominance during VACV infection is not affected by the effects of IFN-γ on the antigen presentation machinery...

..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..

..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..

..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..

..Furthermore, we intend to find new methods to manipulate the immune response to restore resistance and improve vaccine efficacy in aged mice as a first approach to improve vaccine efficacy in elderly people. ..

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..In Aim 2, we will use small interfering RNA and retroviral vectors to silence or express those genes and test in a functional assay whether they are involved in cross presentation. ..

..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..

..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..

..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..