Luis Sigal

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011

Research Grants

  1. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2009
  2. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010
  3. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
  4. Mousepox in Aged Mice
    Luis Sigal; Fiscal Year: 2007
  5. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2005
  6. Identification of Genes Involved in Cross-Presentation
    Luis Sigal; Fiscal Year: 2005
  7. MHC Class I Antigen Presentation in Viral Infections
    Luis Sigal; Fiscal Year: 2007
  8. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2007
  9. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010

Collaborators

  • Sanda Remakus

Detail Information

Publications1

  1. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011
    ..Thus, our work shows that CD8(+) T cell immunodominance during VACV infection is not affected by the effects of IFN-γ on the antigen presentation machinery...

Research Grants20

  1. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2009
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  2. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  3. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  4. Mousepox in Aged Mice
    Luis Sigal; Fiscal Year: 2007
    ..Furthermore, we intend to find new methods to manipulate the immune response to restore resistance and improve vaccine efficacy in aged mice as a first approach to improve vaccine efficacy in elderly people. ..
  5. Cross-Presentation in CTL Responses to Viral Infections
    Luis Sigal; Fiscal Year: 2005
    ....
  6. Identification of Genes Involved in Cross-Presentation
    Luis Sigal; Fiscal Year: 2005
    ..In Aim 2, we will use small interfering RNA and retroviral vectors to silence or express those genes and test in a functional assay whether they are involved in cross presentation. ..
  7. MHC Class I Antigen Presentation in Viral Infections
    Luis Sigal; Fiscal Year: 2007
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  8. Orthropoxvirus Pathogenesis and Vaccines
    Luis Sigal; Fiscal Year: 2007
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..
  9. Orthropoxvirus Pathogenesis and Vaccines
    Luis J Sigal; Fiscal Year: 2010
    ..These experiments are important because they will dissect the mechanisms of protective immunity induced by infection and test a novel approach to non-infectious anti-OPV vaccines. ..