Luis Sigal

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. doi request reprint CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
    Min Fang
    the Research Institute at Fox Chase Cancer Center, Immune Cell Development and Host Defense Program, Philadelphia, Pennsylvania, USA
    J Virol 89:776-83. 2015
  2. pmc The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
    Ren Huan Xu
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center FCCC, Philadelphia, PA 19111, USA
    J Exp Med 205:981-92. 2008
  3. pmc Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response
    Ren Huan Xu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000768. 2010
  4. pmc Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    Min Fang
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 207:2369-81. 2010
  5. pmc Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
    Ren Huan Xu
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 8:e1002475. 2012
  6. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011
  7. doi request reprint Studying NK cell responses to ectromelia virus infections in mice
    Min Fang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:411-28. 2010

Research Grants

  1. Identification of Genes Involved in Cross-Presentation
    Luis Sigal; Fiscal Year: 2005
  2. Mousepox in Aged Mice
    Luis Sigal; Fiscal Year: 2008
  3. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011

Collaborators

  • J Charles Whitbeck
  • Antonio Alcami
  • Sanda Remakus
  • Min Fang
  • Ren Huan Xu
  • Felicia Roscoe
  • Xueying Ma
  • Daniel Rubio
  • Christopher C Norbury
  • Mary Ellen Truckenmiller
  • Tracy E Krouse
  • Inger K Damon
  • Paul N Hudson
  • Eric Lazear
  • Roselyn J Eisenberg
  • Yong Tang
  • Gary H Cohen
  • Matthew Cohen

Detail Information

Publications7

  1. doi request reprint CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
    Min Fang
    the Research Institute at Fox Chase Cancer Center, Immune Cell Development and Host Defense Program, Philadelphia, Pennsylvania, USA
    J Virol 89:776-83. 2015
    ..Our results may partly explain why the VACV vaccine is so effective...
  2. pmc The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
    Ren Huan Xu
    Program of Viral Pathogenesis, Division of Basic Science, Fox Chase Cancer Center FCCC, Philadelphia, PA 19111, USA
    J Exp Med 205:981-92. 2008
    ....
  3. pmc Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response
    Ren Huan Xu
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 6:e1000768. 2010
    ..These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines...
  4. pmc Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
    Min Fang
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 207:2369-81. 2010
    ....
  5. pmc Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
    Ren Huan Xu
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 8:e1002475. 2012
    ..Thus, our findings provide insights on how T1-IFNs function and are evaded during a viral infection in vivo, and unveil a novel mechanism for antibody-mediated antiviral therapy...
  6. pmc Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response
    Sanda Remakus
    Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Virol 85:12578-84. 2011
    ..Thus, our work shows that CD8(+) T cell immunodominance during VACV infection is not affected by the effects of IFN-γ on the antigen presentation machinery...
  7. doi request reprint Studying NK cell responses to ectromelia virus infections in mice
    Min Fang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 612:411-28. 2010
    ....

Research Grants3

  1. Identification of Genes Involved in Cross-Presentation
    Luis Sigal; Fiscal Year: 2005
    ..In Aim 2, we will use small interfering RNA and retroviral vectors to silence or express those genes and test in a functional assay whether they are involved in cross presentation. ..
  2. Mousepox in Aged Mice
    Luis Sigal; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..