Ilya G Serebriiskii

Summary

Affiliation: Fox Chase Cancer Center
Country: USA

Publications

  1. pmc A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system
    Marina Sudomoina
    Department of Molecular Biology and Biotechnology, Russian State Medical University, Moscow, Russia
    BMC Biotechnol 4:9. 2004
  2. ncbi request reprint Streamlined yeast colorimetric reporter activity assays using scanners and plate readers
    I G Serebriiskii
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Biotechniques 29:278-9, 282-4, 286-8. 2000
  3. pmc A combined yeast/bacteria two-hybrid system: development and evaluation
    Ilya G Serebriiskii
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Proteomics 4:819-26. 2005
  4. ncbi request reprint A bacterial/yeast merged two-hybrid system: protocol for bacterial screening
    Ilya G Serebriiskii
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 408:291-315. 2007
  5. ncbi request reprint A bacterial/yeast merged two-hybrid system: protocol for yeast screening with single or parallel baits
    Nadezhda Y Tikhmyanova
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 408:257-90. 2007
  6. pmc A novel Cas family member, HEPL, regulates FAK and cell spreading
    Mahendra K Singh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Biol Cell 19:1627-36. 2008
  7. pmc Integrating in silico resources to map a signaling network
    Hanqing Liu
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 1101:197-245. 2014
  8. doi request reprint Aurora kinases in head and neck cancer
    Ranee Mehra
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lancet Oncol 14:e425-35. 2013
  9. pmc Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation
    Anna Sukhanova
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Discov 3:96-111. 2013
  10. pmc Aurora A kinase (AURKA) in normal and pathological cell division
    Anna S Nikonova
    Program in Developmental Therapeutics, Fox Chase Cancer Center, W406, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Cell Mol Life Sci 70:661-87. 2013

Collaborators

Detail Information

Publications23

  1. pmc A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system
    Marina Sudomoina
    Department of Molecular Biology and Biotechnology, Russian State Medical University, Moscow, Russia
    BMC Biotechnol 4:9. 2004
    ..Previous efforts to achieve this goal have explored inducible drug regulation of gene expression, and construction of synthetic promoters based on two-hybrid paradigms, among others...
  2. ncbi request reprint Streamlined yeast colorimetric reporter activity assays using scanners and plate readers
    I G Serebriiskii
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Biotechniques 29:278-9, 282-4, 286-8. 2000
    ..This report describes two simple techniques that employ either a flatbed scanner or a plate reader to quantitate the activity of colorimetric reporters such as LacZ or GusA commonly used in two-hybrid approaches...
  3. pmc A combined yeast/bacteria two-hybrid system: development and evaluation
    Ilya G Serebriiskii
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Proteomics 4:819-26. 2005
    ..In addition, the modified expression vectors we describe in this report should be useful for any application requiring facile expression of a protein of interest in both yeast and bacteria...
  4. ncbi request reprint A bacterial/yeast merged two-hybrid system: protocol for bacterial screening
    Ilya G Serebriiskii
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 408:291-315. 2007
    ..A concise proposal is provided for use of this system in bacteria; a companion article, chapter 15, describes use of the system in yeast...
  5. ncbi request reprint A bacterial/yeast merged two-hybrid system: protocol for yeast screening with single or parallel baits
    Nadezhda Y Tikhmyanova
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 408:257-90. 2007
    ..Protocols of this system for use in yeast are provided; a companion article, Serebriiski et al., describes alternative use of this system in bacteria...
  6. pmc A novel Cas family member, HEPL, regulates FAK and cell spreading
    Mahendra K Singh
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Biol Cell 19:1627-36. 2008
    ..Better understanding of the complete protein family should help inform prediction of cancer incidence and prognosis...
  7. pmc Integrating in silico resources to map a signaling network
    Hanqing Liu
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 1101:197-245. 2014
    ..As we illustrate, generation of composite interaction networks enables investigators to extract significantly more information about a given biological system than utilization of a single database or sole reliance on primary literature. ..
  8. doi request reprint Aurora kinases in head and neck cancer
    Ranee Mehra
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Lancet Oncol 14:e425-35. 2013
    ..We summarise trials of aurora kinase inhibitors in squamous-cell carcinomas of the head and neck, and discuss directions for future drug combination trials and biomarkers to use with drugs that inhibit aurora kinases. ..
  9. pmc Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation
    Anna Sukhanova
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Discov 3:96-111. 2013
    ..Analysis of Nsdhl-deficient Bpa(1H/+) mice confirmed dramatic and selective loss of internalized platelet-derived growth factor receptor in fibroblasts, and reduced activation of EGFR and its effectors in regions of skin lacking NSDHL...
  10. pmc Aurora A kinase (AURKA) in normal and pathological cell division
    Anna S Nikonova
    Program in Developmental Therapeutics, Fox Chase Cancer Center, W406, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Cell Mol Life Sci 70:661-87. 2013
    ..Here we review the mitotic and non-mitotic functions of Aurora A, discuss Aurora A regulation in the context of protein structural information, and evaluate progress in understanding and inhibiting Aurora A in cancer...
  11. pmc Synthetic lethal screen of an EGFR-centered network to improve targeted therapies
    Igor Astsaturov
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Sci Signal 3:ra67. 2010
    ..Such a focused approach can potentially improve the coherent design of combination cancer therapies...
  12. pmc Network analysis identifies an HSP90-central hub susceptible in ovarian cancer
    Hanqing Liu
    Authors Affiliations Developmental Therapeutics Program, Biostatistics Facility, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania and Synta Pharmaceuticals Corp, Lexington, Massachusetts
    Clin Cancer Res 19:5053-67. 2013
    ..Although there have been numerous efforts to apply protein-targeted agents in EOC, these studies have so far documented little efficacy. Our goal was to identify broadly susceptible signaling proteins or pathways in EOC...
  13. ncbi request reprint Analysis of protein-protein interactions utilizing dual bait yeast two-hybrid system
    Ilya G Serebriiskii
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA, USA
    Methods Mol Biol 261:263-96. 2004
    ....
  14. ncbi request reprint Two new members of the bio B superfamily: cloning, sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum
    I G Serebriiskii
    Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia
    Gene 175:15-22. 1996
    ..The results of the database screening suggested that bio B proteins belong to a superfamily of proteins, including biotin and lipoate synthases and some proteins with unidentified functions...
  15. pmc Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer
    Ranee Mehra
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Drug Resist Updat 14:260-79. 2011
    ..Finally, we discuss new strategies to identify effective therapeutic combinations involving EGFR-targeted inhibitors, in the context of new system level data becoming available for analysis of individual tumors...
  16. pmc Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease
    Tamina Seeger-Nukpezah
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 110:12786-91. 2013
    ..These results provide an initial justification for evaluating HSP90 inhibitors as therapeutic agents for ADPKD. ..
  17. pmc Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?
    Tetyana V Bagnyukova
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 10:839-53. 2010
    ..This review discusses the recent advances including integrative systematic biology and RNAi approaches to counteract the chemotherapy resistance and to buttress the selectivity, efficacy and personalization of anti-cancer drug therapy...
  18. pmc NEDD9 promotes oncogenic signaling in mammary tumor development
    Eugene Izumchenko
    Program in Molecular and Translational Medicine, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 69:7198-206. 2009
    ..This study provides the first in vivo evidence of a role for NEDD9 in breast cancer progression and suggests that NEDD9 expression may provide a biomarker for tumor aggressiveness...
  19. pmc Detection of peptides, proteins, and drugs that selectively interact with protein targets
    Ilya G Serebriiskii
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genome Res 12:1785-91. 2002
    ....
  20. ncbi request reprint Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
    Rugang Zhang
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Cell 8:19-30. 2005
    ..These data indicate that HIRA and ASF1a drive formation of macroH2A-containing SAHF and senescence-associated cell cycle exit, via a pathway that appears to depend on flux of heterochromatic proteins through PML bodies...
  21. ncbi request reprint Redefinition of the yeast two-hybrid system in dialogue with changing priorities in biological research
    I G Serebriiskii
    Fox Chase Cancer Center, Philadelphia, PA, USA
    Biotechniques 30:634-6, 638, 640 passim. 2001
    ..Taken in sum, this trajectory emphasizes the point that the creation of tools and the evolution of the idea of what is an interesting biological problem are in intimate dialogue...
  22. ncbi request reprint KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis
    Jon S Zawistowski
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 11:389-96. 2002
    ..Furthermore, these data suggest that KRIT1 might affect cell adhesion processes via integrin signaling in CCM1 pathogenesis...
  23. ncbi request reprint A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks
    Tengchuan Jin
    Department of Biology, Illinois Institute of Technology, Chicago, Illinois 60616, USA
    Proteins 68:427-37. 2007
    ..These data suggest that HEF2/ERH may be an important transcription regulator that also functions in the control of cell-cycle progression...